CN219849454U - High-airtight dry-method granulator - Google Patents

Abstract

The utility model relates to the technical field of powder granulation, and provides a high-tightness dry-method granulator, wherein a main body frame is provided with an installation position; the isolation cover is arranged on the main body frame and positioned at one side of the installation position, a sealed isolation cavity is arranged in the isolation cover, the sealed isolation cavity is arranged opposite to the installation position, the sealed isolation cavity is communicated with the installation position in a sealing way, and the interior of the sealed isolation cavity is kept in a negative pressure environment; the power mechanism is arranged on the installation position and comprises a driving device and a fan assembly, the driving device is used for providing power for the high-tightness dry-method granulator, the fan assembly is connected with the driving device, and the fan assembly is used for providing turbulent airflow for the sealed isolation cavity; the granulating mechanism is arranged in the sealed isolation cavity, is sealed and in transmission connection with the power mechanism, and is used for pressing raw materials into granules. The utility model effectively isolates active substances from operators, prevents dust from being inhaled and harmed to human bodies, avoids dust cross contamination and protects the safety of external environment and indoor personnel.

Description

High-airtight dry-method granulator

Technical Field

The utility model relates to the technical field of powder granulation, in particular to a high-airtight dry-method granulator.

Background

The dry granulation is a granulation process in which raw material powder is directly compressed and molded through mechanical extrusion and then crushed and granulated.

With the progress and development of modern society, various compounds with new therapeutic functions are found in a large number, and the toxicity is also becoming larger, so that pharmaceutical enterprises have to face the problem of better protecting operators in the process of granulating solid preparation powder, especially for biopharmaceuticals and anticancer drugs containing active ingredients, the part of drugs not only can harm operators, but also damage living environment, and in addition, part of drugs are produced in the general environment and polluted, and the curative effect is destroyed. In the related art, drugs are generally classified into 5 classes (i.e., OEB1-OEB 5) according to the dangerous category, so as to define the sealing measures required to be used by the related production equipment and the sealing conditions to be achieved. In order to protect personnel safety of operators, medicines with OEB3 grade (OEL < 100 mu g/m 3) need to be evaluated in the production process to determine whether to perform high-tightness production, and medicines with OEB4 (OEL < 10 mu g/m 3) and OEB5 (OEL < 1 mu g/m 3) need to apply high-tightness production equipment and technology in the production process. Therefore, how to protect operators, environment and medicines is an increasingly important problem for pharmaceutical equipment manufacturers. However, the structural tightness of the existing research laboratory granulation equipment is insufficient, the leakage risk is easy to generate, and the high tightness required in the production process of the product cannot be realized.

Disclosure of Invention

The utility model provides a high-airtight dry-method granulator which is used for solving the defect of insufficient structural tightness in the prior art, realizing isolation of active substances and operators, preventing dust from being inhaled into a human body, avoiding dust cross contamination and protecting the safety of external environment and indoor personnel.

The utility model provides a high-airtight dry-method granulator, which comprises the following components:

a main body frame having a mounting location;

the isolation cover is arranged on the main body frame and positioned at one side of the installation position, a sealed isolation cavity is arranged in the isolation cover, the sealed isolation cavity is arranged opposite to the installation position, the sealed isolation cavity is communicated with the installation position in a sealing way, and a negative pressure environment is kept in the sealed isolation cavity;

the power mechanism is arranged on the installation position and comprises a driving device and a fan assembly, the driving device is used for providing power for the high-tightness dry-method granulator, the fan assembly is connected with the driving device, and the fan assembly is used for providing turbulent airflow for the sealed isolation cavity; and

the granulating mechanism is arranged in the sealed isolation cavity and is in sealed transmission connection with the power mechanism, and the granulating mechanism is used for pressing raw materials into granules.

According to the high-tightness dry-method granulator provided by the utility model, the sealed isolation cavity comprises the working area and the operation area, the working area is positioned between the operation area and the main body frame, the isolation cover is provided with the air inlet and the air outlet, and the air inlet and the air outlet are arranged on the outer peripheral side of the isolation cover.

According to the high-tightness dry-method granulator provided by the utility model, the air outlet is communicated with the sealed isolation cavity through the air exhaust pipeline, the air exhaust filter is arranged at the air outlet and is used for filtering air flow flowing through the air outlet, the fan assembly is arranged on the air exhaust pipeline and is used for driving the air to flow through the air exhaust filter and then to be discharged out of the sealed isolation cavity, so that the sealed isolation cavity is maintained in a negative pressure state.

According to the high-tightness dry-method granulator provided by the utility model, the air inlet is communicated with the sealed isolation cavity through the air inlet pipeline, the air inlet is provided with the air inlet filter, the air inlet filter is used for filtering air flow flowing through the air inlet, and the air inlet pipeline is provided with the pneumatic valve for controlling the on-off of the air inlet pipeline.

According to the high-tightness dry-method granulator provided by the utility model, the high-tightness dry-method granulator further comprises an industrial personal computer, wherein the industrial personal computer is electrically connected with the fan assembly and is used for controlling the rotation frequency of the fan assembly so as to enable the air flow of the operation area to flow through the working area in a turbulent flow mode.

According to the high-airtight dry-method granulator provided by the utility model, the granulating mechanism comprises a vacuum feeding machine, a hopper, a stirring paddle, a material conveying screw, a pinch roller assembly, a crushing assembly and a secondary granule grading net which are sequentially arranged, wherein the vacuum feeding machine is configured to convey mixed materials into the hopper, the stirring paddle is arranged in the hopper, the material conveying screw is arranged between the hopper and the pinch roller assembly, the crushing assembly is arranged at the discharge end of the pinch roller assembly, and the secondary granule grading net is arranged at the lower end of the crushing assembly to screen the materials.

According to the high-tightness dry-method granulator provided by the utility model, the high-tightness dry-method granulator further comprises a cleaning device, a pneumatic element mounting plate and a cleaning pipeline, wherein the pneumatic element mounting plate and the cleaning pipeline are arranged on the main body frame, the cleaning device is arranged in the sealed isolation cavity, the cleaning device comprises an air gun and a cleaning water gun, the air gun is connected with the pneumatic element mounting plate, and the cleaning water gun is connected with the cleaning pipeline.

According to the high-tightness dry-method granulator provided by the utility model, the cleaning device further comprises the spray header, wherein the spray header is arranged above the sealed isolation cavity, the spray header is connected with the cleaning pipeline, and a water outlet is arranged below the sealed isolation cavity.

According to the high-tightness dry-method granulator provided by the utility model, the isolation operation windows are arranged on the isolation cover corresponding to the positions of the granulating mechanisms, the operation gloves are arranged on the isolation operation windows, the continuous bagging is further arranged on the isolation cover corresponding to the outer side edges of the positions of the granulating mechanisms, and the continuous bagging is used for entering and exiting tools or other objects in the operation process.

According to the high-tightness dry-method granulator provided by the utility model, the high-tightness dry-method granulator further comprises a humidity sensor and a pressure difference sensor, wherein the humidity sensor and the pressure difference sensor are arranged above the sealed isolation cavity and are electrically connected with the industrial control computer.

The high-tightness dry-method granulator comprises a main body frame, an isolation cover, a power mechanism and a granulating mechanism, wherein the main body frame is provided with an installation position; the isolation cover is arranged on the main body frame and positioned at one side of the installation position, a sealed isolation cavity is arranged in the isolation cover, the sealed isolation cavity is arranged opposite to the installation position, the sealed isolation cavity is communicated with the installation position in a sealing way, and a negative pressure environment is kept in the sealed isolation cavity; the power mechanism is arranged on the installation position and comprises a driving device and a fan assembly, the driving device is used for providing power for the high-tightness dry-method granulator, the fan assembly is connected with the driving device, and the fan assembly is used for providing turbulent airflow for the sealed isolation cavity; the granulating mechanism is arranged in the sealed isolation cavity, is in sealed and transmission connection with the power mechanism, and is used for pressing raw materials into granules. According to the utility model, the main body frame is provided with the installation position and the isolation cover, wherein the power mechanism is arranged at the installation position, and the granulating mechanism is arranged in the isolation sealing cavity of the isolation cover, so that the granulating mechanism and the power mechanism are separated and sealed, and the pollution of materials by lubricating oil and the like is avoided; meanwhile, the sealed isolation cavity is used for keeping the granulating mechanism to work in a negative pressure environment through stable turbulent airflow provided by the fan assembly, so that the powder produced by the granulating mechanism in the processing process is prevented from flying dust, active substances are prevented from leaking into the external environment to harm people and the environment, and the safety of the external environment and indoor personnel is protected.

Drawings

In order to more clearly illustrate the utility model or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a high-tightness dry granulator provided by the utility model;

FIG. 2 is a schematic view of the cage of FIG. 1;

FIG. 3 is a left side view of the isolation cover of FIG. 2;

FIG. 4 is a top view of the cage of FIG. 2;

FIG. 5 is a partial cross-sectional view at A-A of FIG. 4;

FIG. 6 is a partial cross-sectional view at B-B in FIG. 4;

FIG. 7 is a partial cross-sectional view taken at C-C of FIG. 4;

fig. 8 is a schematic structural view of the granulation mechanism provided by the present utility model.

Reference numerals:

100. a high-tightness dry-method granulator;

110. a main body frame; 111. a mounting position;

120. an isolation cover; 121. isolating the sealed cavity; 122. an air inlet; 122a, an air intake filter; 123. an air outlet; 123a, an exhaust filter; 124. a water outlet; 125. isolating the operating window; 126. an operating glove; 127. continuously bagging; 128. a feed inlet; 129 discharge port;

130. a power mechanism; 131. a driving device; 132. a fan assembly;

140. a granulating mechanism; 141. a hopper; 142. a material conveying screw; 143. a pinch roller assembly; 144. a crushing assembly; 145. coarse finishing net; 146. fine finishing net;

150. an industrial personal computer;

160. a cleaning device; 161. cleaning a pipeline; 162. an air gun; 163. cleaning a water gun; 164. a spray header;

170. a humidity sensor;

180. a differential pressure sensor;

190. an illuminating lamp.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present utility model, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In describing embodiments of the present utility model, it should be noted that the terms "first" and "second" are used for clarity in describing the numbering of the product components and do not represent any substantial distinction unless explicitly stated or defined otherwise. The directions of the upper and the lower are all the directions shown in the drawings. The specific meaning of the above terms in the embodiments of the present utility model will be understood by those of ordinary skill in the art according to specific circumstances. Furthermore, the meaning of "plurality" is two or more. In the description and claims, "and/or" means at least one of the connected objects, and the character "/", generally indicates that the associated object is an "or" relationship.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

The dry granulation is a granulation process in which raw material powder is directly compressed and molded through mechanical extrusion and then crushed and granulated.

With the progress and development of modern society, various compounds with new therapeutic functions are found in a large number, and the toxicity is also becoming larger, so that pharmaceutical enterprises have to face the problem of better protecting operators in the process of granulating solid preparation powder, especially for biopharmaceuticals and anticancer drugs containing active ingredients, the part of drugs not only can harm operators, but also damage living environment, and in addition, part of drugs are produced in the general environment and polluted, and the curative effect is destroyed. In the related art, drugs are generally classified into 5 classes (i.e., OEB1-OEB 5) according to the dangerous category, so as to define the sealing measures required to be used by the related production equipment and the sealing conditions to be achieved. In order to protect personnel safety of operators, medicines with OEB3 grade (OEL < 100 mu g/m 3) need to be evaluated in the production process to determine whether to perform high-tightness production, and medicines with OEB4 (OEL < 10 mu g/m 3) and OEB5 (OEL < 1 mu g/m 3) need to apply high-tightness production equipment and technology in the production process. Therefore, how to protect operators, environment and medicines is an increasingly important problem for pharmaceutical equipment manufacturers. However, the structural tightness of the existing research laboratory granulation equipment is insufficient, the leakage risk is easy to generate, and the high tightness required in the production process of the product cannot be realized.

The utility model provides a high-tightness dry-method granulator.

In an embodiment of the present utility model, as shown in fig. 1 to 8, a high-airtight dry granulator 100 includes a main body frame 110, an isolation cover 120, a power mechanism 130, and a granulating mechanism 140, the main body frame 110 having a mounting position 111; the isolation cover 120 is arranged on the main body frame 110 and is positioned at one side of the installation position 111, a sealed isolation cavity is arranged in the isolation cover 120, the sealed isolation cavity is arranged opposite to the installation position 111, the sealed isolation cavity is communicated with the installation position 111 in a sealing way, and a negative pressure environment is kept in the sealed isolation cavity; the power mechanism 130 is arranged on the installation position 111, the power mechanism 130 comprises a driving device 131 and a fan assembly 132, the driving device 131 is used for providing power for the high-tightness dry-method granulator 100, the fan assembly 132 is connected with the driving device 131, and the fan assembly 132 is used for providing turbulent airflow for the sealed isolation cavity; the granulating mechanism 140 is arranged in the sealed isolation cavity, is in sealed and transmission connection with the power mechanism 130, and the granulating mechanism 140 is used for pressing raw materials into granules.

Specifically, in the embodiment of the present utility model, the high-airtight dry granulator 100 includes a main body frame 110, an isolation cover 120, a power mechanism 130 and a granulating mechanism 140, where the main body frame 110 is provided with a mounting position 111 for mounting and fixing the power mechanism 130, the mounting position 111 of the main body frame may also be provided with a hydraulic system, a vacuum system, a cleaning pipeline 161, a pipeline for cooling the machine, etc., the front part of the main body frame 110 is provided with a feeding system, a pinch roller assembly 144, a crushing system, a granulating system, a protection cover, etc., and the granulating mechanism 140 assembly for completing the granulating process is mounted on the front part of the main body frame 110, the isolation cover 120 is integrally provided with a sealing isolation cover 120 for completing the granulating process, the isolation cover 120 is connected with the front part of the main body frame 110 by bolts, and the joint is provided with an inflatable seal, and the interfaces of the isolation cover 120 are sealed, so as to ensure the sealing property of the interior.

In the embodiment of the utility model, the power mechanism 130 comprises a driving device 131 and a fan assembly 132, the driving device 131 is used for providing power for the high-airtight dry granulator 100, the fan assembly 132 is connected with the driving device 131, the fan assembly 132 is communicated with the sealed isolation cavity and is used for providing turbulent airflow for the sealed isolation cavity so as to enable compact air to blow through the sealed isolation cavity and form a negative pressure environment in the sealed isolation cavity, thereby playing a role in preventing dust emission on medicinal powder generated in the processing process of the granulating mechanism 140, avoiding active substances from leaking into the outside environment to harm people and the environment, and protecting the safety of external environment and indoor personnel.

The high-tightness dry granulator 100 provided by the utility model comprises a main body frame 110, an isolation cover 120, a power mechanism 130 and a granulating mechanism 140, wherein the main body frame 110 is provided with an installation position 111; the isolation cover 120 is arranged on the main body frame 110 and is positioned at one side of the installation position 111, a sealed isolation cavity is arranged in the isolation cover 120, the sealed isolation cavity is arranged opposite to the installation position 111, the sealed isolation cavity is communicated with the installation position 111 in a sealing way, and a negative pressure environment is kept in the sealed isolation cavity; the power mechanism 130 is arranged on the installation position 111, the power mechanism 130 comprises a driving device 131 and a fan assembly 132, the driving device 131 is used for providing power for the high-tightness dry-method granulator 100, the fan assembly 132 is connected with the driving device 131, and the fan assembly 132 is used for providing turbulent airflow for the sealed isolation cavity; the granulating mechanism 140 is arranged in the sealed isolation cavity, is in sealed and transmission connection with the power mechanism 130, and the granulating mechanism 140 is used for pressing raw materials into granules. The utility model sets the installation position 111 and the isolation cover 120 on the main body frame, wherein, the power mechanism 130 is set at the installation position 111, and the granulating mechanism 140 is set at the isolation sealing cavity 121 of the isolation cover 120, thus the granulating mechanism 140 and the power mechanism 130 are separated and sealed, thus avoiding the pollution of materials by lubricating oil and the like; meanwhile, the sealed isolation cavity provides stable turbulent airflow through the fan assembly 132 to keep the granulating mechanism 140 working in a negative pressure environment, so that the powder produced by the granulating mechanism 140 in the processing process has the effect of dust prevention, active substances are prevented from leaking into the external environment to harm people and the environment, and the safety of the external environment and indoor personnel is protected.

Referring to fig. 5 and 7, in some embodiments of the present utility model, the hermetic isolation chamber includes a working area and an operation area, the working area is located between the operation area and the main body frame 110, the isolation cover 120 has an air inlet 122 and an air outlet 123, and the air inlet 122 and the air outlet 123 are disposed at an outer circumferential side of the isolation cover 120. It will be appreciated that the granulating mechanism 140 is disposed in the sealed and isolated chamber and is connected to the front side of the main frame 110, and the side of the granulating mechanism 140 facing away from the main frame 110 is provided with a parameter setting of the granulating mechanism 140 for convenience adjustment, and samples are taken during the granulating process, so that the sealed and isolated chamber is divided into a working area and an operating area, the granulating mechanism 140 is located in the working area, and the operating area is biased towards the operator setting. The air inlet 122 and the air outlet 123 are disposed on the isolation cover 120, and the air inlet 122 and the air outlet 123 may be disposed at two opposite ends of the isolation cover 120, or may be disposed at the same side of the isolation cover 120 at the same time. The air inlet 122 and the air outlet 123 are arranged to be matched with the fan assembly 132 to provide clean air flow for the working area and the operation area, and then the negative pressure environment is kept in the sealed isolation cavity by controlling the flow velocity of the air outlet 123 and the air inlet 122, so that dust emission is prevented, active substances are prevented from overflowing into the external environment, and the safety of the high-airtight dry granulator 100 is improved.

Referring to fig. 4 and 5, in some embodiments of the present utility model, an exhaust port 123 is in communication with a sealed and isolated chamber through an exhaust pipeline, an exhaust filter 123a is disposed at the exhaust port 123, the exhaust filter 123a is used for filtering the air flow flowing through the exhaust port 123, a fan assembly 132 is disposed on the exhaust pipeline, and the fan assembly 132 is used for driving the air flow flowing through the exhaust filter 123a to be discharged out of the sealed and isolated chamber, so as to maintain the sealed and isolated chamber in a negative pressure state. Therefore, the air flow in the sealed and isolated cavity and the outside keep dynamic circulation, and the negative pressure environment in the sealed and isolated cavity is kept, so that dust generated by granulating is prevented from flying, and a high-clean working environment is formed. In this embodiment, a high-efficiency filter element is disposed in the exhaust filter 123a, and the air flows through the exhaust filter 123a and then enters the exhaust pipeline to ensure isolation of active substances and operators, prevent dust from damaging human body, avoid dust cross contamination, and protect the safety of external environment and indoor personnel. Further, in other embodiments, a pneumatic valve is further disposed on the exhaust pipe, and is used for controlling on-off of the exhaust pipe.

Referring to fig. 4 and 7, in some embodiments of the present utility model, the air inlet 122 is communicated with the sealed isolation cavity through an air inlet pipeline, an air inlet filter 122a is disposed at the air inlet 122, the air inlet filter 122a is used for filtering the air flow flowing through the air inlet 122, and a pneumatic valve is disposed on the air inlet pipeline for controlling the on-off of the air inlet pipeline. It can be appreciated that the air inlet filter 122a is internally provided with a high-efficiency filter element, and the air inlet filter 122a can filter the air flow entering the sealed isolation cavity, so that dust cross contamination is avoided, the curative effect of the medicine is destroyed, and the granulating reliability of the high-airtight dry-method granulator 100 is improved.

Referring to fig. 1, in one embodiment, the high-containment dry granulator 100 further comprises an industrial personal computer 150, wherein the industrial personal computer 150 is electrically connected to the fan assembly 132 for controlling the rotational frequency of the fan assembly 132 so that the air flow in the operation area flows through the operation area in a turbulent manner. In this embodiment, the industrial personal computer 150 controls the rotation frequency of the fan assembly 132, so that the air flow entering from the air inlet 122 generates turbulence, and thus the air flow in the working area and the operation area is relatively stable and smooth. Further, the industrial personal computer 150 can also control the pressure of the pressing wheel, the rotating speed of the pressing wheel, the gap, the rotating speed of the material conveying screw 143, the rotating speed of the stirring paddle 142, the rotating speed of the grain sizing knife, the frequency of the fan, the negative pressure of the sealed isolation cavity and the like, so as to control and adjust the production requirements of different materials.

Referring to fig. 8, in an embodiment, the granulating mechanism 140 includes a vacuum feeder, a hopper 141, a stirring paddle 142, a conveying screw 143, a pinch roller assembly 144, a crushing assembly 145, and a secondary granule-finishing screen sequentially disposed, wherein the vacuum feeder is configured to feed the mixed material into the hopper 141, the stirring paddle 142 is disposed in the hopper 141, the conveying screw 143 is disposed between the hopper 141 and the pinch roller assembly 144, the crushing assembly 145 is disposed at a discharge end of the pinch roller assembly 144, and the secondary granule-finishing screen is disposed at a lower end of the crushing assembly 145 to screen the material. It is understood that the secondary particle size screen includes a coarse screen for primary particles and a fine screen for secondary particles. Specifically, in the high-airtight dry granulator 100 of the embodiment, the powder obtained by mixing the medicine and the auxiliary materials according to a certain proportion is added into a hopper 141 by a vacuum feeding machine, stirred by a stirring paddle 142 in the hopper 141, then conveyed between two high-pressure pinch roller gaps of a pinch roller assembly 144 by a conveying screw 143, extruded into a high-density large sheet, crushed by a crushing assembly 145, and subjected to screening to form granules with the required size by a coarse screen of primary granules and a fine screen of secondary granules.

Specifically, the upper end face of the isolation cover 120 is provided with a feed inlet 128, the upper end face of the isolation cover 120 is provided with a discharge outlet 129, the discharge outlet 129 is opposite to the discharge end of the secondary granule straightening net, and the feed inlet 128 is opposite to the vacuum feeding machine. In some embodiments, flexible connections are employed between the inlet 128 and the hopper 141 and between the outlet 129 and the main frame 110 or the cage 120, reducing installation accuracy requirements and improving tightness.

Referring to fig. 2 to 7, according to some embodiments of the present utility model, the high-airtight dry granulator 100 further includes a cleaning device 160, a pneumatic element mounting plate, and a cleaning pipeline 161, the pneumatic element mounting plate and the cleaning pipeline 161 are disposed on the main frame 110, the cleaning device 160 is disposed in the sealed and isolated cavity, the cleaning device 160 includes an air gun 162 and a cleaning water gun 163, the air gun 162 is connected with the pneumatic element mounting plate, the cleaning water gun 163 is connected with the cleaning pipeline 161, the cleaning device 160 further includes a spray header 164, the spray header 164 is disposed above the sealed and isolated cavity, the spray header 164 is connected with the cleaning pipeline 161, and a water outlet 124 is disposed below the sealed and isolated cavity. Through setting up in the belt cleaning device 160 of top to seal isolation chamber and pelletization system wash, the sewage after the washing is discharged from outlet 124 to realize carrying out online cleaning to equipment, specifically, the casing of cage 120 is panel beating welding top individual layer, and other parts are double-deck, and inside turning circular arc transition does not have the dead angle. The bottom of the right side is provided with a water outlet 124, and the bottom layer is provided with an inclined angle by controlling a pneumatic valve, so that water can be conveniently discharged.

Specifically, hooks of an air gun 162 and a cleaning gun 163 are also welded in the isolation cover 120 for taking and placing.

Referring to fig. 1 and 2, according to the high-tightness dry granulator 100 provided by the utility model, each position of the isolation cover 120 corresponding to the granulating mechanism 140 is provided with an isolation operation window 125, the isolation operation window 125 is provided with an operation glove 126, the outer side edge of the isolation cover 120 corresponding to the granulating mechanism 140 is also provided with a continuous bagging 127, and the continuous bagging 127 is used for entering and exiting tools or other objects in the operation process. Specifically, the isolation operation window 125 is a glass door arranged in front of the isolation cover 120 and comprises an aluminum alloy glass installation frame and toughened glass, a locking handle is arranged, the isolation operation window 125 can be inflated and sealed, a sterile operation glove 126 is arranged on the isolation operation window 125, and the opening is vertical oval, so that the operation is convenient.

Referring to fig. 7, in some embodiments, the high-closure dry granulator 100 further comprises a humidity sensor 170 and a pressure differential sensor 180, wherein the humidity sensor 170 and the pressure differential sensor 180 are disposed above the sealed and isolated chamber, and the humidity sensor 170 and the pressure differential sensor 180 are electrically connected to the industrial personal computer 150. It can be appreciated that the humidity sensor 170 and the pressure difference sensor 180 are disposed above the sealed and isolated cavity, so as to be used for sealing and isolating the humidity and the air pressure of the cavity, feeding data back to the industrial personal computer 150 in time, and adjusting the humidity and the pressure of the sealed and isolated cavity by the industrial personal computer 150, thereby improving the operation efficiency.

Specifically, the interior of the cage 120 may also be configured with an illumination lamp 190 for providing illumination for ease of operation.

In embodiments of the utility model, unless expressly specified and limited otherwise, a first feature "up" or "down" on a second feature may be that the first and second features are in direct contact, or that the first and second features are in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.

Claims (10)

1. A high-containment dry granulator, comprising:

a main body frame having a mounting location;

the isolation cover is arranged on the main body frame and positioned at one side of the installation position, a sealed isolation cavity is arranged in the isolation cover, the sealed isolation cavity is arranged opposite to the installation position, the sealed isolation cavity is communicated with the installation position in a sealing way, and a negative pressure environment is kept in the sealed isolation cavity;

the power mechanism is arranged on the installation position and comprises a driving device and a fan assembly, the driving device is used for providing power for the high-tightness dry-method granulator, the fan assembly is connected with the driving device, and the fan assembly is used for providing turbulent airflow for the sealed isolation cavity; and

the granulating mechanism is arranged in the sealed isolation cavity, is in sealed and transmission connection with the power mechanism, and is used for pressing raw materials into granules.

2. The high-tightness dry granulator according to claim 1, wherein the sealed isolation chamber comprises a working area and an operating area, the working area is located between the operating area and the main body frame, the isolation cover has an air inlet and an air outlet, and the air inlet and the air outlet are arranged on the outer peripheral side of the isolation cover.

3. The high-tightness dry granulator according to claim 2, wherein the air outlet is communicated with the sealed isolation cavity through an air exhaust pipeline, an air exhaust filter is arranged at the air outlet and used for filtering air flow flowing through the air outlet, the fan assembly is arranged on the air exhaust pipeline and used for driving air to flow through the air exhaust filter and then to be discharged out of the sealed isolation cavity, so that the sealed isolation cavity is maintained in a negative pressure state.

4. The high-tightness dry granulator according to claim 2, wherein the air inlet is communicated with the sealed isolation cavity through an air inlet pipeline, an air inlet filter is arranged at the air inlet and used for filtering air flow flowing through the air inlet, and a pneumatic valve is arranged on the air inlet pipeline and used for controlling on-off of the air inlet pipeline.

5. The high-containment dry granulator of claim 2 further comprising an industrial personal computer electrically connected to the fan assembly for controlling the rotational frequency of the fan assembly to cause the air flow of the operating zone to flow through the working zone in a turbulent flow.

6. The high-tightness dry granulator according to any of claims 1-5, wherein the granulating mechanism comprises a vacuum feeder, a hopper, a stirring paddle, a feeding screw, a pinch roller assembly, a crushing assembly and a secondary granule-finishing net which are sequentially arranged, wherein the vacuum feeder is configured to feed the mixed material into the hopper, the stirring paddle is arranged in the hopper, the feeding screw is arranged between the hopper and the pinch roller assembly, the crushing assembly is arranged at the discharge end of the pinch roller assembly, and the secondary granule-finishing net is arranged at the lower end of the crushing assembly to screen the material.

7. The high-tightness dry granulator according to any of claims 1 to 5, further comprising a cleaning device, a pneumatic element mounting plate and a cleaning pipeline, wherein the pneumatic element mounting plate and the cleaning pipeline are arranged on the main body frame, the cleaning device is arranged in the sealed isolation cavity, the cleaning device comprises an air gun and a cleaning water gun, the air gun is connected with the pneumatic element mounting plate, and the cleaning water gun is connected with the cleaning pipeline.

8. The high-tightness dry granulator according to claim 7, wherein the cleaning device further comprises a spray header, wherein the spray header is arranged above the sealed isolation cavity, the spray header is connected with the cleaning pipeline, and a water outlet is arranged below the sealed isolation cavity.

9. The high-tightness dry granulator according to any of claims 1 to 5, wherein the isolation cover is provided with isolation operation windows corresponding to the granulation mechanism, the isolation operation windows are provided with operation gloves, and the isolation cover is further provided with continuous bags corresponding to the outer side edges of the granulation mechanism, wherein the continuous bags are used for the in-out of tools or other objects in the operation process.

10. The high-tightness dry granulator according to claim 5, further comprising a humidity sensor and a pressure difference sensor, wherein the humidity sensor and the pressure difference sensor are arranged above the sealed isolation cavity, and the humidity sensor and the pressure difference sensor are electrically connected with the industrial control computer.