CN219804461U - Multistage nanofiltration enrichment facility of pharmacy solution - Google Patents
Multistage nanofiltration enrichment facility of pharmacy solution Download PDFInfo
- Publication number
- CN219804461U CN219804461U CN202320546876.0U CN202320546876U CN219804461U CN 219804461 U CN219804461 U CN 219804461U CN 202320546876 U CN202320546876 U CN 202320546876U CN 219804461 U CN219804461 U CN 219804461U
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- Prior art keywords
- pipe
- cooling
- nanofiltration
- machine
- storage tank
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- 238000001728 nano-filtration Methods 0.000 title claims abstract description 61
- 238000001816 cooling Methods 0.000 claims abstract description 70
- 239000007788 liquid Substances 0.000 claims abstract description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 239000000243 solution Substances 0.000 claims abstract description 13
- 239000003186 pharmaceutical solution Substances 0.000 claims abstract description 10
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims abstract description 3
- 230000000007 visual effect Effects 0.000 claims description 6
- 239000000498 cooling water Substances 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 3
- 239000002826 coolant Substances 0.000 claims description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims 2
- 235000017491 Bambusa tulda Nutrition 0.000 claims 2
- 241001330002 Bambuseae Species 0.000 claims 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims 2
- 239000011425 bamboo Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract description 12
- 238000002390 rotary evaporation Methods 0.000 abstract description 7
- 238000000746 purification Methods 0.000 abstract description 6
- 108700021293 carbetocin Proteins 0.000 description 9
- 229960001118 carbetocin Drugs 0.000 description 9
- NSTRIRCPWQHTIA-DTRKZRJBSA-N carbetocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSCCCC(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(OC)C=C1 NSTRIRCPWQHTIA-DTRKZRJBSA-N 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000110 cooling liquid Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000008054 signal transmission Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101800000989 Oxytocin Proteins 0.000 description 1
- 102400000050 Oxytocin Human genes 0.000 description 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The utility model relates to a pharmaceutical solution multistage nanofiltration concentration device, which comprises a multistage nanofiltration machine, wherein a cooling mechanism is arranged on the outer side of a liquid inlet pipe of the nanofiltration machine, the cooling mechanism comprises a liquid storage tank and cooling pipes, the liquid storage tank is arranged above a machine body of the nanofiltration machine, the cooling pipes are divided into two groups, water inlets of the two groups of cooling pipes are connected with a water supply pipe through a distribution pipe, the water supply pipe is connected with the liquid storage tank through a booster pump, each group of cooling pipes extends from the liquid inlet pipe of a first-stage nanofiltration cylinder to the liquid inlet pipe of a last-stage nanofiltration cylinder and extends towards the liquid inlet pipe of the first-stage nanofiltration cylinder to form a serpentine arrangement, and water outlets of each group of cooling pipes are connected with the liquid storage tank through a water outlet pipe. According to the utility model, the cooling mechanism is additionally arranged on the multistage nanofiltration machine, so that the solution directly enters the nanofiltration machine for nanofiltration after rotary evaporation, and is cooled by the cooling pipe outside the liquid inlet pipe of the nanofiltration machine, and the solution is not independently cooled in the cooling tank, so that the purification step of the Bei Gongsu element acetate is simplified, and the labor and time are saved.
Description
Technical Field
The utility model relates to the technical field of pharmacy, in particular to a multistage nanofiltration concentration device for a pharmaceutical solution.
Background
Carbetocin acetate is a synthetic long-acting oxytocin nine peptide analogue with agonist properties, which is generally synthesized by a solid-phase polypeptide synthesis method, namely, a carbetocin linear peptide is synthesized by the solid-phase polypeptide synthesis method, and then the carbetocin acetate linear peptide is cyclized to obtain carbetocin acetate.
In order to improve the purity of carbetocin acetate, the synthesized crude carbetocin acetate needs to be purified, and the purification process is generally as follows: dissolving the crude carbetocin acetate, carrying out cation exchange chromatography, solid-liquid separation, gel filtration chromatography, cyclization treatment, reverse phase chromatography, rotary evaporation, nanofiltration and freeze-drying to obtain pure carbetocin acetate. The solution after rotary evaporation needs to be filtered after being cooled in time so as to ensure the activity of carbetocin acetate, therefore, the solution after rotary evaporation is placed in a cooling tank for cooling in the purification process and then pumped into a nanofiltration machine for nanofiltration.
Disclosure of Invention
The utility model provides a pharmaceutical solution multistage nanofiltration concentration device capable of cooling a solution, aiming at the defects and the shortcomings of the background technology.
In order to achieve the above purpose, the utility model provides a pharmaceutical solution multistage nanofiltration concentration device, which comprises a multistage nanofiltration machine, wherein a cooling mechanism is arranged on the outer side of a liquid inlet pipe of the nanofiltration machine, the cooling mechanism comprises a liquid storage tank for storing cooling liquid and cooling pipes, the liquid storage tank is arranged above a machine body of the nanofiltration machine, the cooling pipes are divided into two groups, the two groups of cooling pipes are respectively attached to two sides of the outer wall of the liquid inlet pipe and completely cover the liquid inlet pipe, water inlets of the two groups of cooling pipes are connected with a water supply pipe through a distribution pipe, the water supply pipe is connected with the liquid storage tank through a booster pump, each group of cooling pipes extends from the liquid inlet pipe of a first-stage nanofiltration cylinder to the liquid inlet pipe of a last-stage nanofiltration cylinder and extends in the direction of the liquid inlet pipe of the first-stage nanofiltration cylinder to form a snake-shaped arrangement, and water outlets of each group of cooling pipes are connected with the liquid storage tank through a water outlet pipe. By additionally arranging the cooling mechanism on the multi-stage nanofiltration machine, the solution directly enters the nanofiltration machine for nanofiltration after rotary evaporation, is cooled by the cooling pipe outside the liquid inlet pipe of the nanofiltration machine, and is not required to be independently cooled in the cooling tank, so that the purification step of the Bei Gongsu element acetate is simplified, and the labor and time are saved. The temperature sensor is arranged in the liquid storage tank, the audible and visual alarm is arranged outside the liquid storage tank, the temperature sensor is in signal connection with the signal input end of the controller, and the output end of the controller is in signal connection with the audible and visual alarm.
Preferably, a water inlet pipe and a water outlet pipe are arranged on one side of the liquid storage tank, the water inlet pipe is connected with a cooling water source, a liquid level sensor is arranged on the upper portion of the inner wall of one side plate of the liquid storage tank, and electromagnetic valves are arranged on the water outlet pipe and the water outlet pipe.
Preferably, a temperature sensor is arranged in the liquid storage tank, the temperature sensor and the liquid level sensor are respectively connected with the signal input end of the controller, and the two electromagnetic valves are respectively connected with the output end of the controller.
Preferably, the cooling pipe is arranged in a cooling box, and the cooling box is fixed on the machine body of the nanofiltration machine.
Preferably, heat insulation layers are arranged on the outer walls of the distribution pipe, the water supply pipe and the water outlet pipe which are positioned outside the cooling tank and on the outer surface of the liquid storage tank.
The beneficial effects of the utility model are as follows:
1. according to the utility model, the cooling mechanism is additionally arranged on the multistage nanofiltration machine, so that the solution directly enters the nanofiltration machine for nanofiltration after rotary evaporation, and is cooled by the cooling pipe outside the liquid inlet pipe of the nanofiltration machine, and the solution does not need to be independently cooled in the cooling tank, so that the purification step of the Bei Gongsu element acetate is simplified, and the labor and time are saved;
2. the utility model only needs to be modified on the original nanofiltration machine, and has simple structure, easy implementation and low modification cost.
Drawings
FIG. 1 is a schematic diagram of a multi-stage nanofiltration concentration device for pharmaceutical solutions according to the present utility model;
fig. 2 is a schematic structural diagram of a multi-stage nanofiltration concentration device (cooling tank) for pharmaceutical solutions according to the present utility model.
In the figure: 1. the multi-stage nanofiltration machine comprises a multi-stage nanofiltration machine 101, a liquid inlet pipe 110, a one-stage nanofiltration cylinder of the multi-stage nanofiltration machine 120, a final-stage nanofiltration cylinder of the multi-stage nanofiltration machine 2, a cooling mechanism 201, a liquid storage tank 202, a cooling pipe 203, a distribution pipe 204, a water supply pipe 205, a water outlet pipe 3, a water pump 4 and a cooling tank.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
The specific implementation method comprises the following steps: the utility model provides a multistage nanofiltration enrichment facility of pharmacy solution, including multistage nanofiltration machine 1, be provided with cooling mechanism 2 in the feed liquor pipe 101 outside of nanofiltration machine 1, cooling mechanism 2 is including the liquid reserve tank 201 and the cooling tube 202 that are used for storing the coolant liquid, liquid reserve tank 201 sets up in the organism top of nanofiltration machine 1, cooling tube 202 sets up in cooling tank 4, the cooling tube accessible buckle is connected on the inner wall of cooling tank 4, cooling tank 4 is fixed on the organism of nanofiltration machine 1, cover has the heat preservation on the inner wall of cooling tank 4, set up cooling tank one and play the effect of heat preservation, second is play the effect of fixed cooling tube. The cooling pipes 202 are divided into two groups, the two groups of cooling pipes 202 are respectively attached to two sides of the outer wall of the liquid inlet pipe 101 and completely cover the liquid inlet pipe 101, water inlets of the two groups of cooling pipes 202 are connected with a water supply pipe 204 through a distribution pipe 203, the water supply pipe 204 is connected with a liquid storage tank 201 through a booster pump 3, each group of cooling pipes 201 extends from the liquid inlet pipe 101 of the first-stage nano filter cylinder 110 to the liquid inlet pipe 101 of the last-stage nano filter cylinder 120 and extends towards the liquid inlet pipe 101 of the first-stage nano filter cylinder 110 to form a serpentine arrangement, water outlets of each group of cooling pipes 202 are connected with the liquid storage tank 201 through a water outlet pipe 205, and the cooling pipes 201 adopt copper pipes. The inside of the liquid storage tank 1 is provided with a temperature sensor, the outside of the liquid storage tank is provided with an audible and visual alarm, the temperature sensor is in signal connection with a signal input end of a controller, and an output end of the controller is in signal connection with the audible and visual alarm.
In this embodiment, a water inlet pipe and a water outlet pipe are arranged on one side of the liquid storage tank 1, the water inlet pipe is connected with a cooling water source, and since many reactions are exothermic reactions in a pharmaceutical workshop, the workshop can purchase a cooling unit and store the water cooled by the cooling unit into a cold water tank, and the water inlet pipe of the utility model can be connected with the cold water tank to provide cold water for the liquid storage tank 1. The upper part of the inner wall of one side plate of the liquid storage tank 1 is provided with a liquid level sensor, and the water inlet pipe and the water outlet pipe are respectively provided with an electromagnetic valve.
The inside at liquid reserve tank 201 is provided with temperature sensor, and temperature sensor and the signal input part signal connection of controller, two ports of controller's output are connected with the solenoid valve respectively, and temperature signal transmission that temperature sensor detected gives the controller, and when the temperature of water in liquid reserve tank 201 exceeded 20 ℃, the solenoid valve on the inlet tube was given with signal transmission to the controller, opened the solenoid valve and supplied cold water, and when the temperature was less than 12 ℃, closed the solenoid valve on the inlet tube stopped supplying cold water. In this embodiment, a liquid level sensor is further disposed in the liquid storage tank 201, the liquid level sensor is connected with a signal input end of the controller through a cable, when the water level in the liquid storage tank 201 exceeds the highest water level, the controller transmits a signal to the electromagnetic valve on the drain pipe to open the electromagnetic valve so as to drain water in the liquid storage tank 201, and when the cold water is replenished, the liquid storage tank 201 is prevented from being damaged due to overfilling of the liquid storage tank 201.
In order to reduce the heat transferred to the cooling liquid when the cooling water flows in the water pipe, insulation layers are provided on the outer walls of the distribution pipe 203, the water supply pipe 204 and the water outlet pipe 205, which are positioned outside the cooling tank 4, and on the outer surface of the liquid storage tank 201.
According to the utility model, the cooling mechanism is additionally arranged on the multistage nanofiltration machine, so that the solution directly enters the nanofiltration machine for nanofiltration after rotary evaporation, and is cooled by the cooling pipe outside the liquid inlet pipe of the nanofiltration machine, and the solution is not independently cooled in the cooling tank, so that the purification step of the Bei Gongsu element acetate is simplified, and the labor and time are saved.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (5)
1. The utility model provides a multistage nanofiltration enrichment facility of pharmacy solution, includes multistage nanofiltration machine, its characterized in that is provided with cooling mechanism in the feed liquor pipe outside of nanofiltration machine, cooling mechanism is including liquid reserve tank and the cooling tube that is used for storing the coolant liquid, the liquid reserve tank sets up in the organism top of nanofiltration machine, the cooling tube divide into two sets of, and two sets of cooling tubes are attached respectively in the outer wall both sides of feed liquor pipe to cover this feed liquor pipe completely, two sets of the water inlet of cooling tube passes through the distributing pipe and is connected with the delivery pipe, the delivery pipe pass through the booster pump with the liquid reserve tank is connected, every group the cooling tube is by the feed liquor pipe that the one-level was received and is strained the feed liquor pipe that the section of thick bamboo was received to its last level is received to the feed liquor pipe direction extension shape of receiving the section of thick bamboo is serpentine arrangement, the delivery port of every group cooling tube all pass through the outlet pipe with the liquid reserve tank is connected.
2. The pharmaceutical solution multistage nanofiltration concentration device according to claim 1, wherein: the temperature sensor is arranged in the liquid storage tank, the audible and visual alarm is arranged outside the liquid storage tank, the temperature sensor is in signal connection with the signal input end of the controller, and the output end of the controller is in signal connection with the audible and visual alarm.
3. The pharmaceutical solution multistage nanofiltration concentration device according to claim 2, wherein: one side of the liquid storage tank is provided with a water inlet pipe and a water outlet pipe, the water inlet pipe is connected with a cooling water source, a liquid level sensor is arranged on the upper portion of the inner wall of one of the side plates of the liquid storage tank, and electromagnetic valves are arranged on the water inlet pipe and the water outlet pipe.
4. The pharmaceutical solution multistage nanofiltration concentration device according to claim 1, wherein: the cooling pipe is arranged in the cooling box, and the cooling box is fixed on the machine body of the nanofiltration machine.
5. The multi-stage nanofiltration concentration device for pharmaceutical solutions according to claim 4, wherein: and heat preservation layers are arranged on the outer walls of the distribution pipe, the water supply pipe and the water outlet pipe which are positioned outside the cooling box and on the outer surface of the liquid storage box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320546876.0U CN219804461U (en) | 2023-03-20 | 2023-03-20 | Multistage nanofiltration enrichment facility of pharmacy solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320546876.0U CN219804461U (en) | 2023-03-20 | 2023-03-20 | Multistage nanofiltration enrichment facility of pharmacy solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219804461U true CN219804461U (en) | 2023-10-10 |
Family
ID=88217306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320546876.0U Active CN219804461U (en) | 2023-03-20 | 2023-03-20 | Multistage nanofiltration enrichment facility of pharmacy solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219804461U (en) |
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2023
- 2023-03-20 CN CN202320546876.0U patent/CN219804461U/en active Active
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