CN219783971U - Filter device for removing endotoxin - Google Patents
Filter device for removing endotoxin Download PDFInfo
- Publication number
- CN219783971U CN219783971U CN202321351174.3U CN202321351174U CN219783971U CN 219783971 U CN219783971 U CN 219783971U CN 202321351174 U CN202321351174 U CN 202321351174U CN 219783971 U CN219783971 U CN 219783971U
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- China
- Prior art keywords
- fixedly connected
- filtering
- filter
- box
- filter box
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- 239000002158 endotoxin Substances 0.000 title claims abstract description 34
- 238000001914 filtration Methods 0.000 claims abstract description 53
- 210000002966 serum Anatomy 0.000 claims abstract description 39
- 239000007788 liquid Substances 0.000 claims description 28
- 239000010865 sewage Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 230000008093 supporting effect Effects 0.000 claims description 4
- 238000005192 partition Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 5
- 238000011013 endotoxin removal Methods 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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- External Artificial Organs (AREA)
Abstract
The utility model relates to the field of endotoxin removal, and discloses a filtering device for removing endotoxin, which comprises a filtering box, wherein a filtering mechanism is arranged in the filtering box and is used for filtering serum; and the left end of the filter box is provided with a valve mechanism which is used for switching on and off of the guide pipe. The utility model adopts a design combining filtration and cleaning, solves the technical problem that the conventional endotoxin removing device is inconvenient to clean after removing the endotoxin, is practical and is suitable for wide popularization and use.
Description
Technical Field
The utility model belongs to the technical field of endotoxin removal, and particularly relates to a filtering device for removing endotoxin.
Background
Endotoxin, a component of the cell wall of gram-negative bacteria, is called lipopolysaccharide. Lipopolysaccharide is toxic to the host. Endotoxins are released only after the bacteria die and dissolve or the bacterial cells are destroyed manually, and are therefore called endotoxins. The toxic component is mainly lipid A. Endotoxin is located on the outermost layer of the cell wall and covers the cell wall's mucin. The endotoxin of various bacteria has weaker toxic effects and almost the same effect, and can cause fever, microcirculation disturbance, endotoxin shock, disseminated intravascular coagulation and the like;
the serum contains endotoxin, which is unfavorable for cell growth, and when the serum is extracted during vaccine production, the endotoxin in the serum needs to be removed, so that the conventional device for removing the endotoxin is inconvenient to clean after the endotoxin is removed, and a filtering device for removing the endotoxin is provided for solving the problems.
Disclosure of Invention
In order to solve the technical problem that the conventional device for removing the endotoxin is inconvenient to clean after the endotoxin is removed, the utility model adopts the technical scheme that:
the filtering device for removing endotoxin comprises a filtering box, wherein a filtering mechanism is arranged in the filtering box and is used for filtering serum; and the left end of the filter box is provided with a valve mechanism which is used for switching on and off of the guide pipe.
As a preferred implementation mode of the utility model, the filtering mechanism comprises a filter screen, the filter screen is fixedly connected to the lower end inside the filter box, the upper end of the filter box is fixedly connected with a first hydraulic cylinder, a telescopic rod of the first hydraulic cylinder penetrates through the upper surface of the filter box, the lower end of the telescopic rod is fixedly connected with a piston, and the inner side wall of the filter box at the lower end of the piston is fixedly connected with a limit ring.
As a preferred implementation mode of the utility model, the side wall of the left end of the filter box is fixedly connected with a liquid inlet joint, a small ball is arranged in the liquid inlet joint, and the inner wall of the liquid inlet joint at the right end of the small ball is fixedly connected with a baffle rod.
As a preferred implementation mode of the utility model, the lower end of the filter box is fixedly connected with a liquid outlet connector, a one-way silica gel ring is fixedly arranged in the liquid outlet connector, and the one-way silica gel ring is in a barb shape.
As a preferred embodiment of the utility model, the valve mechanism comprises a valve seat, the lower end of the valve seat is fixedly connected with a second hydraulic cylinder, a telescopic rod at the upper end of the second hydraulic cylinder penetrates through the valve seat and the internal partition plate and is sealed by a sealing ring, an upper rubber valve core and a lower rubber valve core are fixedly connected to the left side of the telescopic rod, and the rubber valve cores correspond to a catheter interface at the left end of the valve seat and are in sliding connection with the catheter interface.
As a preferred implementation mode of the utility model, the lower ends of the four guide pipes at the left end of the valve seat are fixedly connected with a serum tank, a clean water tank, a filtration storage tank and a sewage tank in sequence from left to right.
As a preferred implementation mode of the utility model, the left side and the right side of the upper end of the filter box are fixedly connected with a support frame, the left end of the support frame is fixedly connected with a valve seat, and the lower end of the support frame is fixedly connected on a tabletop or other table boards.
Compared with the prior art, the utility model has the following beneficial effects:
the utility model adopts a design combining filtration and cleaning, and solves the technical problem that the conventional endotoxin removal device is inconvenient to clean after removing the endotoxin.
The following describes the embodiments of the present utility model in further detail with reference to the accompanying drawings.
Drawings
In the drawings:
FIG. 1 is a front cross-sectional view of a filter device for removing endotoxin;
FIG. 2 is a schematic view of a valve mechanism of a filter device for removing endotoxin;
FIG. 3 is a schematic diagram of a filtration device for endotoxin removal;
FIG. 4 is an enlarged view of portion A of a filter device for removing endotoxin;
in the figure: 1. a serum tank; 2. a clean water tank; 3. a filtration storage tank; 4. a sewage tank; 5. a support frame; 6. a filter screen; 7. a limit ring; 8. a filter box; 9. a piston; 10. a first hydraulic cylinder; 11. rubber balls; 12. a telescopic rod; 13. a rubber valve core; 14. a valve seat; 15. a conduit; 16. a second hydraulic cylinder; 17. a liquid inlet joint; 18. a liquid outlet joint; 19. a unidirectional silica gel ring.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and the following embodiments are used to illustrate the present utility model.
As shown in fig. 1 to 4, a filtering device for removing endotoxin comprises a filtering box 8, wherein a filtering mechanism is arranged inside the filtering box 8 and is used for filtering serum; and a valve mechanism is arranged at the left end of the filter box 8 and used for switching on and off of the guide pipe 15.
In the arrangement, before the device is used, the rubber valve core 13 is firstly ensured to be positioned at the corresponding pipe joint of the clean water tank 2 and the sewage tank 4, then the first hydraulic cylinder 10 is started to drive the piston 9 to move upwards, at the moment, the air pressure in the filter box 8 is lowered, so that unfiltered serum in the serum tank 1 is sucked into the filter box 8 through the pipe 15, meanwhile, the one-way silica gel ring 19 at the lower end of the filter box 8 is in a closed state to prevent liquid diversion, and immediately after the first hydraulic cylinder 10 drives the piston 9 to move downwards, the internal serum is filtered through the filter screen 6, and meanwhile, the pressure causes the one-way silica gel ring 19 at the lower end of the filter box 8 to be unfolded to form a passage for blood to pass through, at the same time, the small ball 11 in the liquid inlet joint 17 at the left end of the filter box 8 is moved to the left end due to the pressure to block the liquid inlet to prevent the serum from flowing backwards, and the filtered serum can flow to the filter storage tank 3 through the pipe 15 at the lower end of the filter box 8; after the filtration is completed, when the inside of the filtration mechanism is required to be cleaned, the second hydraulic cylinder 16 is only required to be started to drive the telescopic rod 12 and the rubber valve core 13 in the valve seat 14 to move upwards, the corresponding conduit ports of the serum tank 1 and the filtration storage tank 3 are blocked, the conduit 15 corresponding to the clean water tank 2 and the sewage tank 4 form a passage, the steps are repeated, cleaning liquid in the clean water tank 1 passes through the filtration box 8 to clean the inside, and the cleaned sewage flows to the sewage tank 4 through the conduit 15 at the lower end of the filtration box 8.
As shown in fig. 1 to 4, in a specific embodiment, the filtering mechanism includes a filter screen 6, the filter screen 6 is fixedly connected to the lower end inside a filter box 8, the upper end of the filter box 8 is fixedly connected with a first hydraulic cylinder 10, a telescopic rod of the first hydraulic cylinder 10 penetrates through the upper surface of the filter box 8, the lower end of the telescopic rod is fixedly connected with a piston 9, and a limit ring 7 is fixedly connected to the inner side wall of the filter box 8 at the lower end of the piston 9.
In this setting, ensure earlier before using this equipment that rubber case 13 is in the pipe interface department that water pitcher 2 and sewage jar 4 correspond, then start first pneumatic cylinder 10 and drive piston 9 and shift up, this moment filter the inside atmospheric pressure of box 8 and become low, cause the unfiltered serum in the serum jar 1 to be inhaled inside the box 8 through pipe 15, simultaneously, the one-way silica gel circle 19 of box 8 lower extreme is in closed condition, prevent the liquid water conservancy diversion, immediately first pneumatic cylinder 10 drives piston 9 and shift down, the inside serum is filtered through filter screen 6 this moment, simultaneously because of pressure causes the one-way silica gel circle 19 of box 8 lower extreme to expand, form the passageway, supply blood and clear through, simultaneously, the inside ball 11 of feed liquor joint 17 of box 8 left end is because of pressure removes to the left end, the shutoff feed liquor mouth, prevent serum backward flow, the serum after filtering can flow to filter the storage tank 3 through the pipe 15 of box 8 lower extreme.
As shown in fig. 1 to 4, in the specific embodiment, a liquid inlet connector 17 is fixedly connected to the left end side wall of the filter box 8, a small ball 11 is installed in the liquid inlet connector 17, and a baffle rod is fixedly connected to the inner wall of the liquid inlet connector 17 at the right end of the small ball 11.
In this setting, the inside ball 11 of feed liquor joint 17 of filter cartridge 8 left end removes to the left end because of pressure, blocks up the inlet, prevents serum refluence.
As shown in fig. 1 to 4, in a specific embodiment, a liquid outlet connector 18 is fixedly connected to the lower end of the filter box 8, and a unidirectional silica gel ring 19 is fixedly installed inside the liquid outlet connector 18, and the unidirectional silica gel ring 19 has a barb shape.
In this setting, first pneumatic cylinder 10 drives piston 9 and moves down, and inside serum filters through filter screen 6 this moment, causes the one-way silica gel circle 19 of filter cassette 8 lower extreme to expand because of the pressure simultaneously, forms the passageway, and blood serum passes through.
As shown in fig. 1 to 4, in the specific embodiment, the valve mechanism includes a valve seat 14, the lower end of the valve seat 14 is fixedly connected with a second hydraulic cylinder 16, a telescopic rod 12 at the upper end of the second hydraulic cylinder 16 penetrates through the valve seat 14 and an internal partition plate and is sealed by a sealing ring, an upper rubber valve core 13 and a lower rubber valve core 13 are fixedly connected at the left side of the telescopic rod 12, and the rubber valve cores 13 correspond to a conduit interface at the left end of the valve seat 14 and are in sliding connection with the conduit interface.
In this setting, after the filtration is accomplished, when need wash filter mechanism inside, only need start second pneumatic cylinder 16, drive the telescopic link 12 and the rubber valve core 13 of disk seat 14 inside and upwards move, block up the pipe mouth that corresponds with serum jar 1 and filtration holding vessel 3 to make the pipe 15 that clean water jar 2 and sewage jar 4 correspond form the passageway, repeat above-mentioned step, wash the washing liquid in the clean water jar 1 through filter box 8, wash inside, the sewage after the washing flows to sewage jar 4 through the pipe 15 of filter box 8 lower extreme.
As shown in fig. 1 to 4, in the specific embodiment, the lower ends of four pipes 15 at the left end of the valve seat 14 are fixedly connected with the serum tank 1, the clean water tank 2, the filtration storage tank 3 and the sewage tank 4 in sequence from left to right.
In this arrangement, the serum tank 1, the clean water tank 2, the filtration storage tank 3 and the sewage tank 4 function to store unfiltered serum, washing liquid, filtered serum and washed sewage, respectively.
As shown in fig. 1 to 4, in the embodiment, the left and right sides of the upper end of the filter box 8 are fixedly connected with the support frame 5, the left end of the support frame 5 is fixedly connected with the valve seat 14, and the lower end of the support frame 5 is fixedly connected on a table top or other table top.
In this arrangement, the support 5 is mainly intended to provide a supporting effect for the filter mechanism and the valve mechanism.
The implementation principle of the filtering device for removing endotoxin in the embodiment is as follows:
the serum tank 1, the clean water tank 2, the filtration storage tank 3 and the sewage tank 4 are respectively used for storing unfiltered serum, cleaning liquid, filtered serum and cleaned sewage; before the device is used, the rubber valve core 13 is firstly ensured to be positioned at the corresponding conduit interfaces of the clean water tank 2 and the sewage tank 4, then the first hydraulic cylinder 10 is started to drive the piston 9 to move upwards, at the moment, the internal air pressure of the filter box 8 becomes low, so that unfiltered serum in the serum tank 1 is sucked into the filter box 8 through the conduit 15, meanwhile, the one-way silica gel ring 19 at the lower end of the filter box 8 is in a closed state to prevent liquid diversion, and immediately after the first hydraulic cylinder 10 drives the piston 9 to move downwards, at the moment, the internal serum is filtered through the filter screen 6, and meanwhile, the one-way silica gel ring 19 at the lower end of the filter box 8 is unfolded to form a passage for blood circulation, at the same time, the small ball 11 in the liquid inlet joint 17 at the left end of the filter box 8 is blocked to the left end due to the pressure, so that the serum backflow is prevented, and the filtered serum flows to the filter storage tank 3 through the conduit 15 at the lower end of the filter box 8; after the filtration is completed, when the inside of the filtration mechanism is required to be cleaned, the second hydraulic cylinder 16 is only required to be started to drive the telescopic rod 12 and the rubber valve core 13 in the valve seat 14 to move upwards, the corresponding conduit ports of the serum tank 1 and the filtration storage tank 3 are blocked, the conduit 15 corresponding to the clean water tank 2 and the sewage tank 4 form a passage, the steps are repeated, cleaning liquid in the clean water tank 1 passes through the filtration box 8 to clean the inside, and the cleaned sewage flows to the sewage tank 4 through the conduit 15 at the lower end of the filtration box 8.
Claims (7)
1. A filter device for removing endotoxin, comprising:
the blood serum filter comprises a filter box (8), wherein a filter mechanism is arranged in the filter box (8) and is used for filtering serum;
and the left end of the filter box (8) is provided with a valve mechanism which is used for switching on and off of the conduit (15).
2. The filtering device for removing endotoxin according to claim 1, wherein the filtering mechanism comprises a filter screen (6), the filter screen (6) is fixedly connected to the lower end inside the filter box (8), the upper end of the filter box (8) is fixedly connected with a first hydraulic cylinder (10), a telescopic rod of the first hydraulic cylinder (10) penetrates through the upper surface of the filter box (8), the lower end of the telescopic rod is fixedly connected with a piston (9), and a limit ring (7) is fixedly connected to the inner side wall of the filter box (8) at the lower end of the piston (9).
3. The filtering device for removing endotoxin according to claim 2, wherein a liquid inlet joint (17) is fixedly connected to the left end side wall of the filtering box (8), a small ball (11) is installed in the liquid inlet joint (17), and a baffle rod is fixedly connected to the inner wall of the liquid inlet joint (17) at the right end of the small ball (11).
4. The filtering device for removing endotoxin according to claim 2, wherein the lower end of the filtering box (8) is fixedly connected with a liquid outlet joint (18), a unidirectional silica gel ring (19) is fixedly arranged in the liquid outlet joint (18), and the unidirectional silica gel ring (19) has a barb shape.
5. The filtering device for removing endotoxin according to claim 1, wherein the valve mechanism comprises a valve seat (14), a second hydraulic cylinder (16) is fixedly connected to the lower end of the valve seat (14), a telescopic rod (12) at the upper end of the second hydraulic cylinder (16) penetrates through the valve seat (14) and the inner partition plate and is sealed through a sealing ring, an upper rubber valve core (13) and a lower rubber valve core (13) are fixedly connected to the left side of the telescopic rod (12), and the rubber valve cores (13) correspond to a catheter interface at the left end of the valve seat (14) and are in sliding connection with the catheter interface.
6. The filtering device for removing endotoxin according to claim 5, wherein the lower ends of the four guide pipes (15) at the left end of the valve seat (14) are fixedly connected with a serum tank (1), a clear water tank (2), a filtering storage tank (3) and a sewage tank (4) in sequence from left to right.
7. The filtering device for removing endotoxin according to claim 2, wherein the left side and the right side of the upper end of the filtering box (8) are fixedly connected with the supporting frame (5), the left end of the supporting frame (5) is fixedly connected with the valve seat (14), and the lower end of the supporting frame (5) is fixedly connected with a table top or other table tops.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321351174.3U CN219783971U (en) | 2023-05-30 | 2023-05-30 | Filter device for removing endotoxin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321351174.3U CN219783971U (en) | 2023-05-30 | 2023-05-30 | Filter device for removing endotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219783971U true CN219783971U (en) | 2023-10-03 |
Family
ID=88152401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321351174.3U Active CN219783971U (en) | 2023-05-30 | 2023-05-30 | Filter device for removing endotoxin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219783971U (en) |
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2023
- 2023-05-30 CN CN202321351174.3U patent/CN219783971U/en active Active
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