CN219783877U - Chiral separation column for fluorinated pyrrolidine - Google Patents
Chiral separation column for fluorinated pyrrolidine Download PDFInfo
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- CN219783877U CN219783877U CN202321300016.5U CN202321300016U CN219783877U CN 219783877 U CN219783877 U CN 219783877U CN 202321300016 U CN202321300016 U CN 202321300016U CN 219783877 U CN219783877 U CN 219783877U
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- separation column
- sealing
- fixedly connected
- positioning
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- 238000000926 separation method Methods 0.000 title claims abstract description 81
- 150000003235 pyrrolidines Chemical class 0.000 title claims abstract description 13
- 238000007789 sealing Methods 0.000 claims abstract description 79
- 238000009434 installation Methods 0.000 claims abstract description 31
- OTWVFHZMWFGHSJ-UHFFFAOYSA-N 1-fluoropyrrolidine Chemical compound FN1CCCC1 OTWVFHZMWFGHSJ-UHFFFAOYSA-N 0.000 claims description 28
- 239000002699 waste material Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 6
- 230000002349 favourable effect Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a chiral separation column for fluorinated pyrrolidine, which comprises a separation column body and mounting sleeves arranged on two sides of the separation column body, wherein a communicating pipe is fixedly connected in the middle of the inside of the mounting sleeves, mounting parts are fixedly connected at two ends of the separation column body, and a sealing block is connected on one side, close to the separation column body, of the mounting sleeves, and the chiral separation column also comprises: sealing block and installation sheathed tube inboard fixed connection, the one end outside that is close to the separation cylinder of communicating pipe is connected with the stopper, wherein, sealing slider has been cup jointed in the outside of communicating pipe, one side fixedly connected with sealing layer of sealing slider, wherein, one side fixedly connected with location slider that sealing slider is close to the sealing block, the location spout has been seted up to the inside of sealing block, has solved the junction of pipeline and chiral separation column and has had certain gap, and the fluorinated pyrrolidine solution can leak out from the gap, has caused the waste of fluorinated pyrrolidine solution, has improved the problem of separation operation cost.
Description
Technical Field
The utility model relates to the technical field of chemical processing, in particular to a chiral separation column for fluorinated pyrrolidine.
Background
The chiral chromatographic column is prepared by fixing optically active monomer on silica gel or other polymers to prepare chiral stationary phase, and in order to detect chiral purity of the fluoropyrrolidine, chiral chromatographic column is generally adopted to separate the racemate, and then the fluoropyrrolidine sample to be detected or separated is added into the chiral column, so that detection or effective separation is carried out.
When carrying out specific separation operation to the fluoro-pyrrolidine solution, need be connected the interface that chiral separation post's both ends and splitter correspond at first, however, there is certain gap in the junction of pipeline and chiral separation post when separating, fluoro-pyrrolidine solution can leak out from the gap, has caused fluoro-pyrrolidine solution's waste, has improved the cost of separation operation, consequently, need a chiral separation post that leakproofness is high to carry out separation operation better.
A chiral separation column for fluoropyrrolidine has been proposed in order to solve the problems set forth above.
Disclosure of Invention
The utility model aims to provide a chiral separation column for fluorinated pyrrolidine, which solves the problems that a certain gap exists at the joint of a pipeline and the chiral separation column, fluorinated pyrrolidine solution possibly leaks out of the gap, so that the fluorinated pyrrolidine solution is wasted and the separation operation cost is increased.
In order to achieve the above purpose, the present utility model provides the following technical solutions: a chiral separation column for fluorinated pyrrolidine comprises a separation column body and mounting sleeves arranged on two sides of the separation column body;
a communicating pipe is fixedly connected in the middle of the inside of the mounting sleeve, mounting parts are fixedly connected at two ends of the separation column, and a sealing block is connected at one side of the mounting sleeve, which is close to the separation column;
further comprises:
the sealing block is fixedly connected with the inner side of the mounting sleeve, and a limiting block is connected with the outer side of one end, close to the separation column, of the communicating pipe;
the sealing slide block is sleeved on the outer side of the communicating pipe, and one side of the sealing slide block is fixedly connected with a sealing layer;
the sealing device comprises a sealing block, a positioning sliding groove and a positioning sliding groove, wherein the positioning sliding block is fixedly connected to one side, close to the sealing block, of the sealing sliding block, and the positioning sliding groove is formed in the sealing block.
Preferably, the communicating pipe is communicated with the inside of the mounting sleeve, the limiting block is fixedly connected with the communicating pipe, the sealing sliding block is in sliding connection with the communicating pipe, the sealing sliding block is positioned between the sealing block and the limiting block, the positioning sliding blocks are symmetrically arranged, and the number of the positioning sliding blocks is not less than four.
Preferably, the positioning sliding groove is attached to one side, far away from the separation column, of the mounting portion, the number of the positioning sliding grooves is matched with that of the positioning sliding blocks, and the positioning sliding blocks are connected with the positioning sliding grooves in a clamping mode.
Preferably, one side of the separation cylinder, which is close to the installation sleeve, is fixedly connected with a connecting pipe, the diameter of the connecting pipe is larger than that of the installation sleeve, a vertical groove is formed in one side of the connecting pipe, which is close to the separation cylinder, a positioning pin is connected in the vertical groove, and a fixing plate is fixedly connected to the top of the positioning pin.
Preferably, one side of keeping away from the locating pin in the bottom of fixed plate is fixedly connected with first spring, one end that the fixed plate was kept away from to first spring and the outside fixed connection of connecting pipe, one side of the fixed plate was kept away from the locating pin is fixedly connected with the pull ring.
Preferably, a positioning groove is formed in one side of the mounting sleeve close to the separation column body, the size of the positioning groove is the same as that of the vertical groove, and the positioning pin is in sliding connection with the positioning groove.
Preferably, the sealing rings are symmetrically connected to two sides of the separation column body, the separation column body is located between the installation part and the connecting pipe, and the installation sleeve is attached to the sealing rings.
Compared with the prior art, the utility model has the beneficial effects that: through setting up sealing block, stopper, sealing slider, sealing layer, location slider, location spout, when the fluoro-pyrrolidine solution was input to inside, can extrude sealing slider for sealing slider removes to the position of sealing block, has consequently realized the sealed of installation sleeve pipe and installation department, has reduced fluoro-pyrrolidine solution's seepage, has improved the sealed effect of device, is favorable to follow-up separation operation to go on smoothly, and its concrete content is as follows:
1. through setting up sealing block, stopper, sealing slider, sealing layer, location slider, location spout, when the fluoro-pyrrolidine solution is input to inside, can extrude sealing slider for sealing slider moves to the position of sealing block, and then drives the inside of location slider card to the location spout, at this moment, sealing layer on the sealing slider closely laminates with the junction of installation department and sealing block, and then realized the sealed of installation sleeve pipe with the installation department, the seepage of fluoro-pyrrolidine solution has been reduced, the sealed effect of device has been improved, be favorable to going on smoothly of follow-up separation operation, the junction that has solved pipeline and chiral separation post has certain gap, fluoro-pyrrolidine solution can leak out from the gap, the waste of fluoro-pyrrolidine solution has been caused, the problem of separation operation's cost has been improved.
2. Be provided with connecting pipe, perpendicular groove, locating pin, fixed plate, first spring, pull ring and constant head tank, pull ring through the pulling both sides can drive the locating pin and deviate from the constant head tank, and then conveniently take out the connecting pipe from the installation sleeve pipe, conveniently tear down the separation cylinder, be provided with the sealing washer, can seal the junction gap of installation sleeve pipe and separation cylinder, further improved the sealed effect of pipeline to the seepage of fluoro-pyrrolidine solution has been reduced.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present utility model in a front section;
FIG. 2 is a schematic view of a connecting pipe installation structure according to the present utility model;
FIG. 3 is an enlarged schematic view of the area A of FIG. 1 according to the present utility model;
FIG. 4 is an enlarged view of area B of FIG. 1 according to the present utility model;
FIG. 5 is a schematic view of the positioning slider mounting structure of the present utility model.
In the figure: 1. a separation column; 2. installing a sleeve; 3. a communicating pipe; 4. a mounting part; 5. a sealing block; 6. a limiting block; 7. a sealing slide block; 8. a sealing layer; 9. positioning a sliding block; 10. positioning a chute; 11. a connecting pipe; 12. a vertical groove; 13. a positioning pin; 14. a fixing plate; 15. a first spring; 16. a pull ring; 17. a positioning groove; 18. and (3) sealing rings.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-5, the present utility model provides the following technical solutions: a chiral separation column for fluoro-pyrrolidine comprises a separation column body 1 and mounting sleeves 2 arranged on two sides of the separation column body 1, wherein a communicating pipe 3 is fixedly connected in the middle of the inside of each mounting sleeve 2, mounting parts 4 are fixedly connected at two ends of the separation column body 1, and a sealing block 5 is connected on one side, close to the separation column body 1, of each mounting sleeve 2.
Communicating pipe 3 is linked together with the inside of installation sleeve 2, and sealing block 5 is connected with the inboard fixed connection of installation sleeve 2, and the one end outside that communicating pipe 3 is close to separation cylinder 1 is connected with stopper 6, stopper 6 and communicating pipe 3 fixed connection, wherein, sealing slider 7 has been cup jointed in the outside of communicating pipe 3, sealing slider 7 and communicating pipe 3 sliding connection, and sealing slider 7 is located between sealing block 5 and stopper 6, and one side fixedly connected with sealing layer 8 of sealing slider 7.
One side of the sealing slide block 7, which is close to the sealing block 5, is fixedly connected with positioning slide blocks 9, the positioning slide blocks 9 are symmetrically arranged, and the number of the positioning slide blocks 9 is not less than four. The inside of sealing block 5 has offered location spout 10, and location spout 10 is laminated mutually with the one side that installation department 4 kept away from separation cylinder 1, and the quantity of location spout 10 matches with location slider 9, and location slider 9 and location spout 10 block are connected.
Through setting up sealing block 5, stopper 6, sealing slider 7, sealing layer 8, location slider 9, location spout 10, when fluoro-pyrrolidine solution is inputed inside, can extrude sealing slider 7, make sealing slider 7 remove to the position of sealing block 5, and then drive the inside of location slider 9 card to location spout 10, at this moment, sealing layer 8 on the sealing slider 7 closely laminates with the junction of installation department 4 and sealing block 5, and then realized the sealed of installation sleeve 2 and installation department 4, the seepage of fluoro-pyrrolidine solution has been reduced, the sealed effect of device has been improved, be favorable to follow-up separation operation to go on smoothly, the junction that has solved pipeline and chiral separation post has certain gap, fluoro-pyrrolidine solution can leak out from the gap, fluoro-pyrrolidine solution's waste has been caused, the problem of separation operation cost has been improved.
One side of the separation column body 1, which is close to the installation sleeve 2, is fixedly connected with a connecting pipe 11, the diameter of the connecting pipe 11 is larger than that of the installation sleeve 2, a vertical groove 12 is formed in one side of the connecting pipe 11, which is close to the separation column body 1, a positioning pin 13 is connected in the vertical groove 12, and the top of the positioning pin 13 is fixedly connected with a fixing plate 14.
One side of keeping away from locating pin 13 in the bottom of fixed plate 14 fixedly connected with first spring 15, the one end of keeping away from fixed plate 14 and the outside fixed connection of connecting pipe 11 of first spring 15, one side of fixed plate 14 keeping away from locating pin 13 fixedly connected with pull ring 16, the inside constant head tank 17 of having seted up in one side that installation sleeve 2 is close to separation cylinder 1, the size of constant head tank 17 is the same with perpendicular groove 12, locating pin 13 and constant head tank 17 sliding connection.
The connecting pipe 11, the vertical groove 12, the locating pin 13, the fixing plate 14, the first spring 15, the pull rings 16 and the locating groove 17 are arranged, the locating pin 13 can be driven to be separated from the locating groove 17 by pulling the pull rings 16 on two sides, and then the connecting pipe 11 is conveniently pulled out of the mounting sleeve 2, and the separating cylinder 1 is conveniently detached.
The sealing rings 18 are symmetrically connected to the two sides of the separation column 1 and located between the mounting part 4 and the connecting pipe 11, the mounting sleeve 2 is attached to the sealing rings 18, and the sealing rings 18 are arranged to seal gaps at the joint of the mounting sleeve 2 and the separation column 1, so that the sealing effect of a pipeline is further improved, and leakage of a fluorinated pyrrolidine solution is reduced.
Working principle:
before using the chiral separation column for fluorinated pyrrolidine, the whole condition of the device needs to be checked first to determine that normal operation can be performed, according to fig. 1-5, the device does not involve parts which are the same as or can be realized by adopting the prior art, firstly, pull rings 16 on two sides are pulled, the pull rings 16 drive a fixing plate 14 to move, the fixing plate 14 drives a positioning pin 13 to move, the positioning pin 13 is separated from a positioning groove 17, meanwhile, the fixing plate 14 pulls a first spring 15 to stretch, then the mounting sleeve 2 is inserted between the mounting part 4 and a connecting pipe 11, then the pull rings 16 are released, the first spring 15 drives the fixing plate 14 to move by elasticity, the fixing plate 14 drives the positioning pin 13 to move inwards, and the positioning pin 13 is clamped into the positioning groove 17 to be fixed, so that the separation column 1 is conveniently connected with separation equipment, and the subsequent separation operation is convenient.
During the use, through communicating pipe 3 to the inside of separation cylinder 1 pouring into the fluoro-pyrrolidine solution, fluoro-pyrrolidine solution enters into the inside of installation department 4, then enter into the inside of separation cylinder 1, simultaneously, partly fluoro-pyrrolidine solution can extrude seal slider 7, make seal slider 7 remove to the position of sealing piece 5, and then drive the inside of location slider 9 card to location spout 10, at this moment, seal layer 8 on the seal slider 7 closely laminates with the junction of installation department 4 and sealing piece 5, and then realized the sealed of installation sleeve pipe 2 and installation department 4, reduced fluoro-pyrrolidine solution's seepage, improved the sealed effect of device, be favorable to follow-up separation operation to go on smoothly.
Although the present utility model has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present utility model.
Claims (7)
1. A chiral separation column for fluorinated pyrrolidine comprises a separation column body (1) and mounting sleeves (2) arranged on two sides of the separation column body (1);
the device is characterized in that a communicating pipe (3) is fixedly connected in the middle of the inside of the mounting sleeve (2), mounting parts (4) are fixedly connected at two ends of the separation column body (1), and a sealing block (5) is connected at one side, close to the separation column body (1), of the mounting sleeve (2);
characterized by further comprising:
the sealing block (5) is fixedly connected with the inner side of the mounting sleeve (2), and a limiting block (6) is connected with the outer side of one end, close to the separation column (1), of the communicating pipe (3);
the sealing slide block (7) is sleeved on the outer side of the communicating pipe (3), and a sealing layer (8) is fixedly connected to one side of the sealing slide block (7);
one side of the sealing slide block (7) close to the sealing block (5) is fixedly connected with a positioning slide block (9), and a positioning slide groove (10) is formed in the sealing block (5).
2. A chiral separation column for fluoropyrrolidine according to claim 1, characterized in that: communicating pipe (3) are linked together with the inside of installation sleeve pipe (2), stopper (6) and communicating pipe (3) fixed connection, sealed slider (7) and communicating pipe (3) sliding connection, sealed slider (7) are located between sealed piece (5) and stopper (6), location slider (9) are the symmetry setting, location slider (9) are not less than four.
3. A chiral separation column for fluoropyrrolidine according to claim 2, characterized in that: the positioning sliding grooves (10) are attached to one side, far away from the separation column body (1), of the mounting portion (4), the number of the positioning sliding grooves (10) is matched with that of the positioning sliding blocks (9), and the positioning sliding blocks (9) are connected with the positioning sliding grooves (10) in a clamping mode.
4. A chiral separation column for fluoropyrrolidine according to claim 1, characterized in that: one side fixedly connected with connecting pipe (11) that separation cylinder (1) is close to installation sleeve (2), the diameter of connecting pipe (11) is greater than installation sleeve (2), vertical groove (12) have been seted up to one side inside that connecting pipe (11) is close to separation cylinder (1), the internal connection in vertical groove (12) has locating pin (13), the top fixedly connected with fixed plate (14) of locating pin (13).
5. A chiral separation column for fluoropyrrolidine according to claim 4, characterized in that: one side that locating pin (13) was kept away from to the bottom of fixed plate (14) is fixedly connected with first spring (15), one end that fixed plate (14) was kept away from to first spring (15) and the outside fixed connection of connecting pipe (11), one side that locating pin (13) was kept away from to fixed plate (14) is fixedly connected with pull ring (16).
6. A chiral separation column for fluoropyrrolidine according to claim 5, characterized in that: the installation sleeve (2) is close to one side of the separation column body (1), a positioning groove (17) is formed in the installation sleeve, the size of the positioning groove (17) is the same as that of the vertical groove (12), and the positioning pin (13) is in sliding connection with the positioning groove (17).
7. A chiral separation column for fluoropyrrolidine according to claim 6, characterized in that: the two sides of the separation column body (1) are symmetrically connected with sealing rings (18) and are positioned between the mounting part (4) and the connecting pipe (11), and the mounting sleeve (2) is attached to the sealing rings (18).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321300016.5U CN219783877U (en) | 2023-05-26 | 2023-05-26 | Chiral separation column for fluorinated pyrrolidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321300016.5U CN219783877U (en) | 2023-05-26 | 2023-05-26 | Chiral separation column for fluorinated pyrrolidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219783877U true CN219783877U (en) | 2023-10-03 |
Family
ID=88184706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321300016.5U Active CN219783877U (en) | 2023-05-26 | 2023-05-26 | Chiral separation column for fluorinated pyrrolidine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219783877U (en) |
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2023
- 2023-05-26 CN CN202321300016.5U patent/CN219783877U/en active Active
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