CN219675928U - Full-automatic solid phase extraction-nitrogen blowing combined device - Google Patents
Full-automatic solid phase extraction-nitrogen blowing combined device Download PDFInfo
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- CN219675928U CN219675928U CN202320244399.2U CN202320244399U CN219675928U CN 219675928 U CN219675928 U CN 219675928U CN 202320244399 U CN202320244399 U CN 202320244399U CN 219675928 U CN219675928 U CN 219675928U
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 229910052757 nitrogen Inorganic materials 0.000 title claims abstract description 28
- 238000007664 blowing Methods 0.000 title claims abstract description 25
- 239000007790 solid phase Substances 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 169
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims abstract description 81
- 238000012360 testing method Methods 0.000 claims abstract description 72
- 239000002699 waste material Substances 0.000 claims abstract description 51
- 238000010926 purge Methods 0.000 claims abstract description 43
- 238000012546 transfer Methods 0.000 claims abstract description 32
- 239000007791 liquid phase Substances 0.000 claims abstract description 24
- 238000013519 translation Methods 0.000 claims description 69
- 230000001360 synchronised effect Effects 0.000 claims description 23
- 238000001802 infusion Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 9
- 238000010828 elution Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 6
- 238000001514 detection method Methods 0.000 abstract description 5
- 238000002386 leaching Methods 0.000 abstract description 4
- 238000011068 loading method Methods 0.000 abstract description 4
- 230000004913 activation Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 42
- 230000001105 regulatory effect Effects 0.000 description 8
- 239000003480 eluent Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 238000000605 extraction Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 4
- 238000007599 discharging Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000012074 organic phase Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000000622 liquid--liquid extraction Methods 0.000 description 1
- 238000001172 liquid--solid extraction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Abstract
A full-automatic solid phase extraction-nitrogen blowing combined device belongs to the technical field of solid phase extraction equipment. The method is characterized in that: sample suction means and liquid phase conveyor all set up the upside at solid-phase extraction post (20), and sample suction means and liquid phase conveyor are connected with mobile device, test tube dish (28) set up the downside at solid-phase extraction post (20), waste liquid collection device sets up between test tube dish (28) and solid-phase extraction post (20), waste liquid collection device is connected with and drives its switching device under moving into or shifting out solid-phase extraction post (20), transfer device is connected with test tube dish (28), transfer device sets up between solid-phase extraction post (20) and purge unit. The full-automatic solid phase extraction-nitrogen blowing combined device can automatically complete the processes of activation, sample loading, leaching, elution and nitrogen blowing of solid phase extraction, has high degree of automation and accurate liquid addition, further can accurately control the quantity of samples, has good reproducibility and more accurate detection results.
Description
Technical Field
A full-automatic solid phase extraction-nitrogen blowing combined device belongs to the technical field of solid phase extraction equipment.
Background
Solid-Phase Extraction (SPE) is a sample pretreatment technology developed in recent years, is developed by combining a liquid-Solid Extraction column and a liquid chromatography technology, is mainly used for separating, purifying and concentrating samples, can improve the recovery rate of analytes compared with the traditional liquid-liquid Extraction method, can more effectively separate the analytes from interfering components, reduces the sample pretreatment process, and is simple to operate, time-saving and labor-saving. Widely applied in the fields of medicine, food, environment, business inspection, chemical industry and the like.
The general steps of solid phase extraction generally include: 1) Activating, pre-washing the solid phase extraction column with an activating solution, and discarding filtrate; 2) Loading a sample, sucking a certain amount of extraction sample solution, passing through a column at a certain flow rate, discarding filtrate, and adsorbing a target object on a solid-phase extraction column; 3) Eluting, namely flushing the solid-phase extraction column by using an organic phase, eluting the interfering organic impurities, remaining the target object on the solid-phase extraction column, and discarding filtrate; 4) Eluting, namely eluting the solid phase extraction column by using a mobile phase, and eluting the target object into a corresponding test tube; 5) The liquid received in the tube was purged with nitrogen to near dryness.
The solid phase extraction is currently mainly a manual method, which wastes a great deal of manpower and material resources; the time is long, and a large amount of effective working time is occupied; poor reproducibility, particularly non-uniform liquid flow rates, varies from sample to sample, resulting in very inaccurate detection.
Disclosure of Invention
The utility model aims to solve the technical problems that: the full-automatic solid phase extraction-nitrogen blowing combined device has the advantages that the defects of the prior art are overcome, solid phase extraction can be completed through rotation, the liquid addition amount is conveniently and accurately controlled, and further detection accuracy is guaranteed.
The technical scheme adopted for solving the technical problems is as follows: the full-automatic solid phase extraction-nitrogen blowing combined device is characterized in that: including sample suction means, liquid phase conveyor, solid phase extraction post, the test tube dish, waste liquid collection device, sweep device and transfer device, sample suction means and liquid phase conveyor all set up the upside at the solid phase extraction post, and sample suction means and liquid phase conveyor are connected with mobile device, the test tube dish sets up the downside at the solid phase extraction post, waste liquid collection device sets up between test tube dish and solid phase extraction post, waste liquid collection device is connected with the auto-change over device who drives it and moves into or shift out under the solid phase extraction post, transfer device is connected with the test tube dish, transfer device sets up between solid phase extraction post and sweeps the device.
Preferably, the moving device comprises a rotating device, a longitudinal translation device and a transverse translation device, the rotating device is arranged on the longitudinal translation device, the transverse translation device is arranged on the rotating device, and the sample suction device and the liquid phase conveying device are arranged on the transverse translation device.
Preferably, the horizontal translation device include swivel mount, translation motor and translation hold-in range, the middle part of swivel mount and swivel mount is connected, translation hold-in range is all installed at the both ends of swivel mount, the both ends of translation hold-in range respectively with the translation hold-in range meshing of corresponding side, the translation motor is connected with arbitrary one translation hold-in range, sample suction device and liquid phase conveyor all with translation hold-in range fixed connection, and sample suction device and liquid phase conveyor are located the both sides of swivel mount respectively.
Preferably, the rotating device comprises a rotating motor and a rotating shaft, the rotating shaft is fixedly connected with the transverse translation device, and the rotating motor is connected with the rotating shaft.
Preferably, the waste liquid collecting device comprises a liquid conveying tank and a waste liquid tank, wherein the waste liquid tank is arranged on the side part of the test tube tray, the liquid conveying tank is arranged on the upper side of the waste liquid tank, the liquid inlet end of the liquid conveying tank is arranged under the solid phase extraction column, the liquid outlet end of the liquid conveying tank is positioned right above the waste liquid tank, the liquid conveying tank is in an inclined shape, the liquid inlet end of the liquid conveying tank is higher than the liquid outlet end, and the switching device is connected with the waste liquid tank.
Preferably, the solid phase extraction column has a plurality of that are annular arrangement, and the test tube portion of placing of test tube dish and solid phase extraction column one-to-one to be located the solid phase extraction column that corresponds under, the waste liquid groove encircles the test tube dish setting, and the infusion groove corresponds with the solid phase extraction column one-to-one, and sets up the downside at the solid phase extraction column that corresponds.
Preferably, the test tube tray further comprises a lifting device, wherein the lifting device is arranged on the transfer device and is connected with the test tube tray.
Preferably, the liquid phase conveying device comprises a liquid storage bin, a liquid stop valve and a liquid outlet pipe, wherein the liquid storage bin is higher than the solid phase extraction column, a plurality of liquid storage bins are arranged side by side, the liquid outlet of each liquid storage bin is connected with the liquid outlet pipe, the liquid outlet pipe is arranged on the moving device, and the liquid stop valve is arranged at the liquid outlet of each liquid storage bin.
Preferably, the purging device comprises a purging pipe and a purging disc, a purging cavity is arranged in the purging disc, a plurality of purging ports are arranged at the bottom of the purging disc, and an air outlet of the purging pipe is communicated with the purging cavity of the purging disc.
Compared with the prior art, the utility model has the following beneficial effects:
the full-automatic solid-phase extraction-nitrogen blowing combined device can automatically complete the processes of activation, sample loading, leaching, elution and nitrogen blowing of solid-phase extraction, has high automation degree, is free from manual participation, is convenient to operate, ensures accurate liquid addition due to the fact that the liquid addition amount is conveniently and accurately controlled, further can accurately control the sample amount, is good in reproducibility, and can ensure more accurate detection results due to the fact that the sample amount and the liquid amount are accurately added.
Drawings
Fig. 1 is a schematic diagram of a full-automatic solid-phase extraction-nitrogen blowing combined device in a front cross-sectional view.
Fig. 2 is a partial enlarged view at a in fig. 1.
Fig. 3 is a partial enlarged view at B in fig. 1.
Fig. 4 is a schematic left view of the shaft mounted on a longitudinal translation frame.
FIG. 5 is a schematic top view of the infusion well mounted on the test tube tray.
Fig. 6 is a schematic perspective view of a purge tray.
In the figure: 1. the device comprises a main body 2, a sample frame 3, a bin gate 4, a vacuum pump 5, a pressure regulating valve 6, a liquid storage bin 7, a liquid stop valve 8, a rotating frame 9, a translation synchronous belt 10, a suction lifting electric cylinder 11, a liquid suction needle 12, a liquid outlet pipe lifting electric cylinder 13, a liquid outlet pipe 14, a rotating shaft 15, a cover plate 16, a transfer frame 17, a transfer synchronous belt 18, a test tube tray lifting electric cylinder 19, a test tube 20, a solid phase extraction column 21, a waste liquid tank 22, a transfusion groove 23, a cover body 24, a mounting disc 25, a purging pipe 26, a purging disc 27, a purging port 28, a test tube tray 29, an annular plate 30, a portal frame 31, a rotating motor 32, a longitudinal translation frame 33 and a switching motor.
Detailed Description
The present utility model will be further described with reference to specific embodiments, however, it will be appreciated by those skilled in the art that the detailed description herein with reference to the accompanying drawings is for better illustration, and that the utility model is not necessarily limited to such embodiments, but rather is intended to cover various equivalent alternatives or modifications, as may be readily apparent to those skilled in the art.
Fig. 1 to 6 are diagrams illustrating preferred embodiments of the present utility model, and the present utility model is further described below with reference to fig. 1 to 6.
The utility model provides a full-automatic solid phase extraction-nitrogen blows aggregate unit, including sample suction means, liquid phase conveyor, solid phase extraction post 20, test tube dish 28, waste liquid collection device, sweep device and transfer device, sample suction means and liquid phase conveyor all set up the upside at solid phase extraction post 20, and sample suction means and liquid phase conveyor are connected with mobile device, test tube dish 28 sets up the downside at solid phase extraction post 20, waste liquid collection device sets up between test tube dish 28 and solid phase extraction post 20, waste liquid collection device is connected with the auto-change over device that drives it and moves into or shift out under the solid phase extraction post 20, transfer device is connected with test tube dish 28, transfer device sets up between solid phase extraction post 20 and sweep device. The full-automatic solid-phase extraction-nitrogen blowing combined device can automatically complete the processes of activation, sample loading, leaching, elution and nitrogen blowing of solid-phase extraction, has high automation degree, is free from manual participation, is convenient to operate, ensures accurate liquid addition due to the fact that the liquid addition amount is conveniently and accurately controlled, further can accurately control the sample amount, is good in reproducibility, and can ensure more accurate detection results due to the fact that the sample amount and the liquid amount are accurately added.
Specific: as shown in fig. 1: the full-automatic solid-phase extraction-nitrogen blowing combined device further comprises a main body 1 and a cover body 23, wherein a closed treatment cavity is formed in the right side of the main body 1, an installation cavity is formed in the left side of the main body, and a bin door 3 is arranged in the right side of the main body 1 so as to facilitate installation of an empty test tube 19 on a test tube tray 28 or take out the test tube 19 after purging on the test tube tray 28. At the top of the mounting cavity is mounted a mounting plate 24, and the purge means is spaced to the right of the mounting plate 24. A sample rack 2 is also provided at the top of the main body 1, the sample racks 2 being spaced apart on the left side of the mounting plate 24. The cover 23 is provided on the upper side of the main body 1, and the cover 23 is detachably connected to the main body 1 and covers the mounting plate 24 and the sample holder 2.
The moving means, the liquid phase conveying means and the sample sucking means are all provided in the cover 23, and the moving means is installed between the sample holder 2 and the mounting plate 24. The transfer device, test tube tray 28 and waste collection device are all mounted within the process chamber.
The vacuum pump 4 and the pressure regulating valve 5 are arranged in the mounting cavity, the air inlet of the vacuum pump 4 is connected with the pressure regulating valve 5 in series and then is communicated with the processing cavity, the pressure in the processing cavity can be controlled through the vacuum pump 4 and the pressure regulating valve 5, and then the flow speed of liquid flowing down through the solid-phase extraction column 20 can be controlled.
The sample rack 2 is provided with a plurality of sample bottles side by side and at intervals, and samples are contained in the sample bottles. The fixed extraction columns 20 are mounted on the mounting plate 24, the mounting plate 24 is provided with a plurality of mounting holes in an annular arrangement, the solid-phase extraction columns 20 are in one-to-one correspondence with the mounting holes, the lower ends of the solid-phase extraction columns 20 penetrate through the corresponding mounting holes and extend downwards, and in the embodiment, the mounting holes are in an annular arrangement. The test tubes 19 are arranged on the test tube tray 28, and the test tubes 19 are in one-to-one correspondence with the solid phase extraction columns 20 and are arranged right below the corresponding solid phase extraction columns 20.
As shown in fig. 1, 3 and 4: the moving means comprises rotating means, lateral translating means and longitudinal translating means, the longitudinal translating means being mounted on the body 1, the longitudinal translating means being arranged between the sample holder 2 and the mounting plate 24, the rotating means being mounted on the longitudinal translating means and being reciprocally movable with the longitudinal translating means between the sample holder 2 and the mounting plate 24. The rotating device is arranged on the longitudinal translation device, the transverse translation device is arranged on the rotating device, the transverse translation device is arranged between the sample frame 2 and the mounting plate 24, the liquid phase conveying device and the sample absorbing device are arranged on the transverse translation device, and the liquid phase conveying device and the sample absorbing device are respectively arranged on two sides of the rotating device.
The longitudinal translation device comprises a longitudinal translation frame 32 and a longitudinal electric push rod, a longitudinal translation guide rail is arranged on the main body 1, the longitudinal translation frame 32 is slidably arranged on the longitudinal translation guide rail, the longitudinal electric push rod is parallel to the longitudinal translation guide rail, the longitudinal electric push rod is arranged on the main body 1, and the longitudinal electric push rod is connected with the longitudinal translation frame 32 and pushes the longitudinal translation frame 32 to reciprocate along the longitudinal translation guide rail.
The rotating device comprises a rotating shaft 14 and a rotating motor 31, wherein the rotating shaft 14 is vertically arranged on the upper side of a longitudinal translation frame 32, the lower end of the rotating shaft 14 is rotatably arranged on the longitudinal translation frame 32, the rotating motor 31 is also arranged on the longitudinal translation frame 32, a rotating driving gear is arranged on an output shaft of the rotating motor 31, a rotating driven gear is arranged on the rotating shaft 14, and the rotating driving gear is meshed with the rotating driven gear, so that the rotating shaft 14 rotates along with the rotating motor 31.
Further, the portal frame 30 is mounted on the upper side of the longitudinal translation frame 32, and the middle part of the rotating shaft 14 is rotatably connected with the portal frame 30, so as to ensure that the rotating shaft 14 is kept vertical, and ensure that the rotating shaft 14 is more stable.
The transverse translation device comprises a rotating frame 8, a translation synchronous belt 9 and a translation motor, wherein the middle part of the rotating frame 8 is fixedly connected with the top of a rotating shaft 14 and synchronously rotates along with the rotating shaft 14. Both ends of the rotating frame 8 are rotatably provided with translation synchronous pulleys, both ends of the translation synchronous belt 9 are respectively meshed with the translation synchronous pulleys on the corresponding sides, a translation motor is arranged on the rotating frame 8, and an output shaft of the translation motor is fixedly connected with any one of the translation synchronous pulleys.
The rotating frame 8 is provided with a horizontal transverse translation guide rail, the transverse translation guide rail is slidably provided with transverse translation frames, the transverse translation frames are symmetrically arranged on two sides of the rotating shaft 14, and the two transverse translation frames are fixedly connected with one side of the translation synchronous belt 9 and synchronously move along with the translation synchronous belt 9. The liquid phase conveying device and the sample sucking device are respectively arranged on the two transverse translation frames.
The sample suction device comprises a suction lifting electric cylinder 10 and a suction needle 11, wherein the suction lifting electric cylinder 10 is vertically arranged on a corresponding transverse translation frame, the suction lifting frame is arranged on a piston rod of the suction lifting electric cylinder 10, the suction needle 11 is vertically arranged on the suction lifting frame, and the bottom of the suction needle 11 protrudes downwards from the suction lifting frame so as to facilitate suction of samples in a sample bottle. The suction lifting frame is also provided with a negative pressure pump which is connected with the suction needle 11 to suck the sample into the suction needle 11. The negative pressure pump is a small negative pressure pump.
The liquid phase conveying device comprises a liquid outlet pipe 13 and a liquid storage bin 6, wherein the liquid storage bin 6 is higher than the liquid outlet pipe 13, the top of the liquid storage bin 6 is provided with a liquid adding port, the liquid outlet of the liquid storage bin 6 is communicated with the liquid outlet pipe 13, and the liquid outlet of the liquid storage bin 6 is connected with a liquid stop valve 7, so that the liquid outlet of the liquid storage bin 6 can be controlled to be opened or closed through the liquid stop valve 7, and the liquid discharging speed can be accurately controlled.
The liquid storage bins 6 are arranged side by side to store different liquids, in this embodiment, the liquid storage bins 6 are arranged side by side to store organic solvent, water, activating solution, eluent and eluent in sequence from left to right, the organic solvent and the water are used for cleaning the liquid outlet pipe 13, and the activating solution, the eluent and the eluent are used for solid phase extraction. The liquid outlet of each liquid storage bin 6 is communicated with a liquid outlet pipe 13, and the liquid outlet of each liquid storage bin 6 is connected with a liquid stop valve 7.
The top of the cover body 23 is provided with a cover plate 15, the cover plate 15 is detachably and fixedly connected with the cover body 23, and the cover plate 15 is positioned right above the liquid storage bins 6 so as to facilitate adding liquid into each liquid storage bin 6.
A liquid outlet pipe lifting electric cylinder 12 is arranged on the other transverse translation frame, the liquid outlet pipe lifting electric cylinder 12 is vertically arranged, the liquid outlet end of the liquid outlet pipe 13 is arranged on the liquid outlet pipe lifting electric cylinder 12, and the liquid outlet pipe lifting electric cylinder 12 can drive the liquid outlet end of the liquid outlet pipe 13 to lift so as to conveniently send corresponding liquid into the fixed extraction column 20, ensure that the liquid conveyed by the liquid outlet pipe 13 can be input into the fixed extraction column 20, ensure that the liquid enters into the solid-phase extraction column 20, and ensure that the liquid entering into the solid-phase extraction column 20 is accurate.
A waste liquid tank is arranged at the top of the main body 1 so as to conveniently receive the liquid of the flushing liquid outlet pipe 13. Since the pipette needle 11 is used only for sucking up the sample, no flushing is required.
As shown in fig. 1, 2 and 5: the transfer device comprises a transfer motor, a transfer synchronous belt 17 and a transfer frame 16, wherein a horizontal transfer guide rail is arranged at the bottom of the processing cavity, the transfer frame 16 is slidably arranged on the transfer guide rail, and the transfer guide rails are arranged side by side and at intervals. The synchronous pulley is transported to the equal rotatable installing in bottom both sides of main part 1, and transport the guide rail and be located between the synchronous pulley of transporting of both sides, transport synchronous belt 17's both ends respectively with the synchronous pulley meshing of transporting of corresponding side, transport the motor and install on main part 1, transport the output shaft of motor and arbitrary one transport synchronous pulley and link to each other and drive its rotation. The transfer frame 16 is fixedly connected with the lower side of the transfer synchronous belt 17, so that the transfer frame 16 synchronously moves along with the transfer synchronous belt 17. In this embodiment, the transfer timing belt 17 is provided on one side of the transfer rack 16 to avoid interfering with the mounting of the test tube tray 28.
The transfer frame 16 is provided with test tube tray lifting electric cylinders 18, the test tube tray lifting electric cylinders 18 are vertically arranged, the test tube tray lifting electric cylinders 18 are symmetrically arranged on two sides of the transfer frame 16, and piston rods of the test tube tray lifting electric cylinders 18 are fixedly connected with two sides of the test tube tray 28 so as to drive the test tube tray 28 to lift.
The test tubes 19 are mounted on the test tube placing portion of the test tube tray 28, the test tubes 19 are in one-to-one correspondence with the solid phase extraction columns 20, and the test tubes 19 are disposed on the lower side of the solid phase extraction column 20 on the corresponding side. The cuvette tray 28 has a disc shape.
The waste liquid collecting device comprises a waste liquid tank 21 and an infusion tank 22, wherein the waste liquid tank 21 is arranged around a test tube disc 28, the waste liquid tank 21 and the test tube disc 28 can rotate relatively, the switching device is arranged between the waste liquid tank 21 and the test tube disc 28, and the switching device drives the waste liquid tank 21 and the test tube disc 28 to rotate relatively. The liquid-feeding groove 22 is arranged between the test tube 19 on the test tube tray 28 and the solid-phase extraction column 20, the liquid-feeding grooves 22 are in one-to-one correspondence with the solid-phase extraction columns 20, the liquid-feeding ends of the liquid-feeding grooves 22 extend to the right lower part of the corresponding solid-phase extraction columns 20, the liquid-discharging ends of the liquid-feeding grooves 22 are arranged right above the waste liquid grooves 21, the liquid-feeding grooves 22 are inclined with the liquid-feeding ends higher than the liquid-discharging ends, and the liquid-feeding grooves 22 are fixedly arranged on the waste liquid grooves 21 and synchronously move along with the waste liquid grooves 21.
When the solid phase extraction column 20 is washed, the liquid flowing down from the solid phase extraction column 20 enters the transfusion groove 22 and flows into the waste liquid groove 21 through the transfusion groove 22, and when the solid phase extraction is required to be realized, the switching device drives the waste liquid groove 21 to rotate around the test tube disc 28, so that the transfusion groove 22 is staggered with the solid phase extraction column 20, and the liquid left by the solid phase extraction column 20 enters the test tube 19 which is opposite to the lower side.
The switching device comprises a switching motor 33, a switching gear ring and a switching gear, wherein the switching gear ring is sleeved outside the test tube tray 28, the switching gear ring is fixedly connected with the test tube tray 28, the switching motor 33 is fixedly arranged on the waste liquid tank 21, the switching gear is arranged on an output shaft of the switching motor 33, and the switching gear is meshed with the switching gear ring. The switching motor 33 rotates the switching gear, and thereby the waste liquid tank 21 and the test tube tray 28 can be rotated relatively.
The upper outer edge surrounding the test tube tray 28 is provided with a mounting groove, the test tube tray 28 is rotatably provided with an annular plate 29, the lower part of the annular plate 29 extends into the mounting groove, and the waste liquid tank 21 is arranged on the annular plate 29 and synchronously rotates along with the annular plate 29. The switch motor 33 is also mounted on the annular plate 29.
Further, both ends of the waste liquid tank 21 are provided at intervals, and a switching motor 33 is mounted on the annular plate 29 between both ends of the waste liquid tank 21.
As shown in fig. 1 and 6: the purging device comprises a purging pipe 25 and a purging disc 26, a purging cavity is arranged in the purging disc 26, the purging disc 26 is arranged in the processing cavity, the lower end of the purging pipe 25 penetrates through the main body 1 and stretches into the processing cavity, the lower end of the purging pipe 25 is fixedly connected with the purging disc 26, and the lower end of the purging pipe 25 is communicated with the processing cavity. The purge pipe 25 is provided with a gas shutoff valve. The bottom of purge tray 26 is provided with purge port 27, and purge port 27 encircles purge tray 26 interval and is provided with four, and each purge port 27 is just right with the test tube portion of placing on the test tube tray 28 respectively.
The working process of the full-automatic solid-phase extraction-nitrogen blowing combined device is as follows:
1) The organic phase in the liquid storage bin 6 enters the solid-phase extraction column 20 through the liquid outlet pipe 13 to activate the solid-phase extraction column 20, the pressure of the treatment cavity is controlled through the vacuum pump 4 and the pressure regulating valve 5, the liquid discharging speed of the solid-phase extraction column 20 is regulated, and the liquid discharged by the solid-phase extraction column 20 enters the liquid conveying groove 22 and enters the waste liquid groove 21 through the liquid conveying groove 22. In this example, the organic phase is a methanol solution.
2) The sample is loaded, the liquid suction needle 11 sucks the sample liquid in the sample bottle into the solid phase extraction column 20 for solid phase extraction, the liquid drop speed is controlled through the vacuum pump 4 and the pressure regulating valve 5, and the waste liquid enters the waste liquid tank 21 through the liquid conveying tank 22.
3) After leaching and extraction are completed, the solid-phase extraction column 20 is leached by the eluent in the liquid storage bin 6, the liquid drop speed is controlled by the vacuum pump 4 and the pressure regulating valve 5, and the waste liquid enters the waste liquid tank 21 through the liquid conveying tank 22.
4) After elution and rinsing are completed, the switching motor 33 turns the waste liquid tank 21 to enable the infusion tank 22 to be staggered with the solid-phase extraction column 20, the test tube tray 28 is lifted, the eluent is sent into the solid-phase extraction column 20 for elution, and the target liquid after elution flows into the test tube 19 below to complete solid-phase extraction;
5) The nitrogen blows, the test tube tray 28 is conveyed to the position right below the blowing tray 26 through the transfer device, at the moment, each blowing opening 27 is opposite to the corresponding test tube 19, each test tube 19 is blown by nitrogen, and liquid in the test tube 19 is blown to near dryness.
The above description is only a preferred embodiment of the present utility model, and is not intended to limit the utility model in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to the equivalent embodiments. However, any simple modification, equivalent variation and variation of the above embodiments according to the technical substance of the present utility model still fall within the protection scope of the technical solution of the present utility model.
Claims (9)
1. A full-automatic solid phase extraction-nitrogen blows aggregate unit which characterized in that: including sample suction means, liquid phase conveyor, solid phase extraction post (20), test tube dish (28), waste liquid collection device, sweep device and transfer device, sample suction means and liquid phase conveyor all set up the upside at solid phase extraction post (20), and sample suction means and liquid phase conveyor are connected with mobile device, test tube dish (28) set up the downside at solid phase extraction post (20), waste liquid collection device sets up between test tube dish (28) and solid phase extraction post (20), waste liquid collection device is connected with and drives its switching device under moving into or shifting out solid phase extraction post (20), transfer device is connected with test tube dish (28), transfer device sets up between solid phase extraction post (20) and sweeps the device.
2. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 1, wherein: the moving device comprises a rotating device, a longitudinal translation device and a transverse translation device, wherein the rotating device is arranged on the longitudinal translation device, the transverse translation device is arranged on the rotating device, and the sample suction device and the liquid phase conveying device are arranged on the transverse translation device.
3. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 2, wherein: the transverse translation device comprises a rotating frame (8), a translation motor and a translation synchronous belt (9), wherein the rotating device is connected with the middle of the rotating frame (8), the two ends of the rotating frame (8) are respectively provided with a translation synchronous belt wheel, the two ends of the translation synchronous belt (9) are respectively meshed with the translation synchronous belt wheels on the corresponding sides, the translation motor is connected with any one of the translation synchronous belt wheels, the sample suction device and the liquid phase conveying device are fixedly connected with the translation synchronous belt (9), and the sample suction device and the liquid phase conveying device are respectively positioned on the two sides of the rotating device.
4. A fully automatic solid phase extraction-nitrogen blowing combined device according to claim 2 or 3, characterized in that: the rotating device comprises a rotating motor (31) and a rotating shaft (14), the rotating shaft (14) is fixedly connected with the transverse translation device, and the rotating motor (31) is connected with the rotating shaft (14).
5. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 1, wherein: the waste liquid collecting device comprises a liquid conveying groove (22) and a waste liquid groove (21), wherein the waste liquid groove (21) is arranged on the side part of a test tube tray (28), the liquid conveying groove (22) is arranged on the upper side of the waste liquid groove (21), the liquid inlet end of the liquid conveying groove (22) is arranged right below the solid-phase extraction column (20), the liquid outlet end of the liquid conveying groove (22) is positioned right above the waste liquid groove (21), the liquid inlet end of the liquid conveying groove (22) is higher than the liquid outlet end in an inclined shape, and the switching device is connected with the waste liquid groove (21).
6. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 5, wherein: the solid phase extraction column (20) have a plurality of that are annular arrangement, test tube placement part and the solid phase extraction column (20) one-to-one of test tube dish (28) to be located under corresponding solid phase extraction column (20), waste liquid groove (21) encircle test tube dish (28) setting, infusion groove (22) and solid phase extraction column (20) one-to-one, and set up the downside at corresponding solid phase extraction column (20).
7. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 1, 5 or 6, wherein: the device also comprises a lifting device, wherein the lifting device is arranged on the transferring device and is connected with the test tube tray (28).
8. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 1, wherein: the liquid phase conveying device comprises a liquid storage bin (6), liquid stop valves (7) and liquid outlet pipes (13), wherein the liquid storage bin (6) is higher than the solid phase extraction column (20), the liquid storage bins (6) are arranged side by side, liquid outlets of the liquid storage bins (6) are all connected with the liquid outlet pipes (13), the liquid outlet pipes (13) are arranged on the moving device, and the liquid stop valves (7) are all arranged at the liquid outlet ports of the liquid storage bins (6).
9. The fully automatic solid phase extraction-nitrogen blowing combined device according to claim 1, wherein: the purging device comprises a purging pipe (25) and a purging disc (26), wherein a purging cavity is formed in the purging disc (26), a plurality of purging ports (27) are formed in the bottom of the purging disc (26), and an air outlet of the purging pipe (25) is communicated with the purging cavity of the purging disc (26).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320244399.2U CN219675928U (en) | 2023-02-17 | 2023-02-17 | Full-automatic solid phase extraction-nitrogen blowing combined device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320244399.2U CN219675928U (en) | 2023-02-17 | 2023-02-17 | Full-automatic solid phase extraction-nitrogen blowing combined device |
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| CN219675928U true CN219675928U (en) | 2023-09-12 |
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| CN202320244399.2U Active CN219675928U (en) | 2023-02-17 | 2023-02-17 | Full-automatic solid phase extraction-nitrogen blowing combined device |
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| Country | Link |
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| CN (1) | CN219675928U (en) |
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