CN219651685U - NK cell activity detection kit - Google Patents

Abstract

The utility model relates to the technical field of NK cell activity detection and discloses an NK cell activity detection kit, which comprises a shell and a cover plate, wherein the surface on one side of the cover plate is hinged with the surface on one side of the shell, the bottom of the cover plate is contacted with the top of the shell, the surface of the shell is rotationally connected with a handle, the surface on the other side of the shell is provided with a cavity, the surface of the inner wall of the cavity is slidingly connected with a storage box, a heat preservation sponge layer is arranged in the storage box, and the surface on one side of the storage box is fixedly connected with a vertical plate; the balance of the shell can be effectively ensured when the kit is used, and meanwhile, workers can replace the low-temperature ice bag layer and the heat preservation sponge layer, so that the problems that when the traditional detection kit is used, the stability is poor, a reagent tube storing NK cells is easy to influence, and the workers are inconvenient to replace the low-temperature ice bag layer and the heat preservation sponge layer which are used for a long time are solved.

Description

NK cell activity detection kit

Technical Field

The utility model relates to the technical field of NK cell activity detection, in particular to an NK cell activity detection kit.

Background

NK cells are short for natural killer cells, which are important immune cells of the organism, are involved not only in anti-tumor, anti-viral infection and immune regulation, but also in the occurrence of hypersensitivity and autoimmune diseases in some cases, and generally, the activity of NK cells is decreased after reaching a peak around 20 years old, and if the activity of NK cells is decreased, the function of killing cancer cells is also decreased, so that it is necessary to focus on the detection of the activity of NK cells.

Through searching, for example, chinese patent literature discloses a mesenchymal stem cell activity detection kit [ application number: CN202222931720.2; publication No.: CN218401656U ]. The mesenchymal stem cell activity detection kit comprises a detection kit body, a closed box cover, a handle supporting plate, a rotation holding handle, a detection kit component and a detection garbage storage component, wherein the detection kit component comprises a rotating rod fixing seat, a reinforcing plate rotating rod, a rotation reinforcing plate, a reinforcing plate fixing groove, a low-temperature ice bag layer, a heat preservation sponge layer, a connecting buckle supporting block, a fixing plate connecting buckle, a reagent tube fixing plate, a reagent tube storage hole, a telescopic clamping spring and a reagent tube fixing clamping plate, and the detection garbage storage component comprises a rotating shaft support, a connecting rotating shaft, a garbage box connecting plate, a garbage storage box, a garbage box fixing buckle and a fixing connecting block.

The detection kit disclosed in the patent is convenient to fix and store a reagent tube and conveniently stores the reagent at low temperature, but when the worker uses the detection kit to detect the activity of NK cells, if the detection garbage storage component is directly rotated out, the stability of the detection kit body cannot be guaranteed, if the detection garbage storage component is not rotated out, the placement of the garbage by the worker can be influenced, the worker needs to collect the garbage after the detection operation is finished, in addition, the setting of the fixing plate connecting buckle is adopted in the detection kit, so that the worker is inconvenient to replace a low-temperature ice bag layer and a heat preservation sponge layer after long-time use, and therefore, the low-temperature preservation effect of the detection kit on the reagent can be influenced after long-time use.

Disclosure of Invention

The utility model aims to provide an NK cell activity detection kit, the balance of a shell can be effectively ensured when the kit is used, and meanwhile, a worker can replace a low-temperature ice bag layer and a heat preservation sponge layer, so that the problems that the existing detection kit is poor in stability, a reagent tube storing NK cells is easy to influence and the worker cannot conveniently replace the low-temperature ice bag layer and the heat preservation sponge layer which are used for a long time when the kit is used are solved.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides an NK cell activity detect reagent box, includes casing and apron, the surface of apron one side is articulated with the surface of casing one side, the bottom of apron contacts with the top of casing, the surface rotation of casing is connected with the handle, the cavity has been seted up on the surface of casing opposite side, the surface sliding connection of cavity inner wall has the case, the inside of case is provided with the heat preservation sponge layer, the fixed surface of case one side is connected with vertical board, the guide way has been seted up on the surface of vertical board, the inner wall fixedly connected with stop gear of guide way, the spacing groove has been seted up to one side of cavity inner wall bottom, the top fixedly connected with fixed plate of cavity inner wall, logical groove has been seted up at the top of fixed plate, and the quantity of logical groove is a plurality of, the surface fixedly connected with first compression spring of logical groove inner wall, the other end fixedly connected with grip block of first compression spring, one side fixedly connected with bottom plate of casing bottom, the opposite side of casing bottom runs through and is provided with the pivot, pivot and casing rotation connection, bottom fixedly connected with slewing mechanism, slewing mechanism has seted up the bottom of pivot and the bottom of casing, the bottom fixedly connected with top of slewing mechanism has seted up with top of the top of casing.

Preferably, the rotating mechanism comprises a rotating plate and a bearing plate, the rotating plate is fixedly connected to the bottom of the rotating shaft, the surface on one side of the bearing plate is fixedly connected with the surface on one side of the rotating plate, the tops of the bearing plate and the rotating plate are both rotationally connected with the bottom of the shell, and the storage groove is formed in one side of the top of the bearing plate.

Preferably, the stop gear includes second compression spring, diaphragm and limiting plate, the surface of diaphragm and the inner wall sliding connection of guide way, limiting plate fixed connection is in the bottom of diaphragm, the limiting plate runs through vertical board and rather than sliding connection, the bottom of limiting plate extends to the below of vertical board, the both ends of second compression spring respectively with the top of diaphragm and the top fixed connection of guide way inner wall, the below of limiting plate surface contacts with the inner wall of guide way.

Preferably, an auxiliary groove is formed in the surface of one side of the bottom plate, and the distance between the inner walls of the two sides of the auxiliary groove is larger than the width of the rotating mechanism.

Preferably, the distance between the top of the inner wall of the guide groove and the bottom of the vertical plate is greater than the sum of the heights of the transverse plate and the limiting plate, and the width of the transverse plate is greater than the width of the vertical plate.

Preferably, the height of the clamping plate is equal to that of the fixing plate, and the length of the inner wall of the heat preservation sponge layer is greater than the distance between the through grooves at two sides.

Compared with the prior art, the utility model has the following beneficial effects:

according to the utility model, through the arrangement of the bottom plate and the rotating mechanism, a worker can operate on the receiving plate when detecting the activity of NK cells, meanwhile, the worker can also put the garbage generated in the process into the storage tank in time so as to be cleaned uniformly later, meanwhile, the balance of the shell can be effectively ensured, and meanwhile, the device can conveniently replace the low-temperature ice bag layer and the heat preservation sponge layer through the arrangement of the vertical plate, the limiting mechanism and the storage box, so that the problem that the existing detection kit is poor in stability, the reagent tube storing the NK cells is easily influenced and the worker is inconvenient to replace the low-temperature ice bag layer and the heat preservation sponge layer which are used for a long time is solved.

Drawings

FIG. 1 is a schematic perspective view of the present utility model;

FIG. 2 is a schematic perspective view of the present utility model after the rotation mechanism is rotated out;

FIG. 3 is a schematic view of a partial perspective structure of the present utility model;

FIG. 4 is a schematic view of a partial perspective cross-sectional structure of the present utility model;

fig. 5 is a schematic perspective view of a rotation mechanism and a base plate in the present utility model.

In the figure: 1. a housing; 2. a cavity; 3. a bottom plate; 4. an auxiliary groove; 5. a rotating mechanism; 51. a rotating plate; 52. a receiving plate; 6. a storage tank; 7. a storage box; 8. a vertical plate; 9. a limiting mechanism; 91. a second compression spring; 92. a cross plate; 93. a limiting plate; 10. a guide groove; 11. a limit groove; 12. a cover plate; 13. a fixing plate; 14. a clamping plate; 15. a first compression spring; 16. and a heat preservation sponge layer.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to FIGS. 1-5, an NK cell activity detection kit comprises a housing 1 and a cover plate 12, wherein the surface on one side of the cover plate 12 is hinged with the surface on one side of the housing 1, the bottom of the cover plate 12 is contacted with the top of the housing 1, the surface of the housing 1 is rotatably connected with a handle, a cavity 2 is formed on the surface on the other side of the housing 1, a storage box 7 is slidingly connected with the surface on the inner wall of the cavity 2, a heat preservation sponge layer 16 is arranged in the storage box 7, a vertical plate 8 is fixedly connected with the surface on one side of the storage box 7, a guide groove 10 is formed on the surface of the vertical plate 8, a limit mechanism 9 is fixedly connected with the inner wall of the guide groove 10, a limit groove 11 is formed on one side of the bottom of the inner wall of the cavity 2, a fixing plate 13 is fixedly connected with the upper part of the inner wall of the cavity 2, through grooves are formed in number on the top of the fixing plate 13, a first compression spring 15 is fixedly connected with the surface on the inner wall of the through grooves, the other end fixedly connected with grip block 14 of the first compression spring 15, one side fixedly connected with bottom plate 3 of bottom of body 1, another side of body 1 bottom runs through and is provided with the spindle, the spindle rotates with body 1 to be connected, the spindle fixedly connected with rotary mechanism 5 bottom, the top of rotary mechanism 5 rotates with bottom of body 1 to be connected, the top of the storage box 7 contacts with bottom of the fixed plate 13, one side of the top of rotary mechanism 5 has offered the storage tank 6, the utility model, through setting up of bottom plate 3 and rotary mechanism 5, staff can operate on the adapting plate 52 while detecting the activity of NK cells, staff can also place rubbish produced in this process in time in the storage tank 6 at the same time, so that follow-up unified clear up, at the same time the equilibrium of body 1 can be guaranteed effectively, the device is through the vertical plate 8, the setting of stop gear 9 and case 7 to the staff can change low temperature ice bag layer and heat preservation sponge layer 16, and it is relatively poor to have solved current detection kit when using, deposits the reagent pipe of NK cell and is easily influenced, and the inconvenient low temperature ice bag layer and the heat preservation sponge layer 16 of using for a long time of staff's problem of changing.

The rotating mechanism 5 comprises a rotating plate 51 and a receiving plate 52, the rotating plate 51 is fixedly connected to the bottom of the rotating shaft, the surface on one side of the receiving plate 52 is fixedly connected with the surface on one side of the rotating plate 51, the tops of the receiving plate 52 and the rotating plate 51 are both rotatably connected with the bottom of the shell 1, the storage groove 6 is formed in one side of the top of the receiving plate 52, in this embodiment, after the rotating plate 51 and the receiving plate 52 are rotated out by a worker, the activity detection operation of NK cells, namely NK cells and reagents, can be carried out on the receiving plate 52, namely, the NK cells and the reagents are injected into the reagent tube, and when the rotating plate 51 and the receiving plate 52 are rotated, the rotating shaft can rotate in the shell 1 so as to provide a rotating point for the rotation of the rotating plate 51 and the receiving plate 52.

The stop gear 9 includes second compression spring 91, diaphragm 92 and limiting plate 93, the surface of diaphragm 92 and the inner wall sliding connection of guide way 10, limiting plate 93 fixed connection is in the bottom of diaphragm 92, limiting plate 93 runs through vertical board 8 and sliding connection with it, the bottom of limiting plate 93 extends to the below of vertical board 8, the both ends of second compression spring 91 respectively with the top of diaphragm 92 and the top fixed connection of guide way 10 inner wall, the below on limiting plate 93 surface contacts with the inner wall of spacing groove 11, in this embodiment, staff's lifting diaphragm 92, the bottom of limiting plate 93 can break away from by the inside of spacing groove 11, then staff alright pull out case 7 through vertical board 8, after the staff places case 7 again in the inside of casing 1, at this moment under the effect of second compression spring 91 elastic force, the below of limiting plate 93 can get into spacing groove 11, the position of case 7 can be fixed according to this.

The auxiliary groove 4 has been seted up on the surface of bottom plate 3 one side, and the distance between the inner wall of auxiliary groove 4 both sides is greater than the width of slewing mechanism 5, and in this embodiment, the distance between the inner wall of auxiliary groove 4 both sides is greater than the width of accepting plate 52, through the setting of auxiliary groove 4 to the staff can rotate accepting plate 52 smoothly, can increase slewing mechanism 5's practicality according to this.

The distance between guide way 10 inner wall top to the vertical board 8 bottom is greater than the height between diaphragm 92 and limiting plate 93 and the width of diaphragm 92 is greater than the width of vertical board 8, in this embodiment, through the setting to the distance between guide way 10 inner wall top to the vertical board 8 bottom, so that the staff when pulling diaphragm 92, the restriction of limiting groove 11 can break away from smoothly in the below of vertical board 8, with this practicality that increases stop gear 9, can be convenient for the staff through the setting to diaphragm 92 width to the diaphragm 92 pulling 92.

The height of grip block 14 is equal with the height of fixed plate 13, and the length of heat preservation sponge layer 16 inner wall is greater than the distance between the both sides logical groove, and in this embodiment, through the setting to grip block 14 height, can avoid case 7 to collide with grip block 14, through the setting to heat preservation sponge layer 16 inner wall length to the reagent pipe that places in the both sides logical groove in fixed plate 13 top both sides can all be located the inside of heat preservation sponge layer 16.

Working principle: when the kit is used by a worker, the bearing plate 52 and the rotating plate 51 can be rotated firstly, the bearing plate 52 and the rotating plate 51 are rotated to be in a state shown in the attached drawing 2, then the worker can open the cover plate 12, the fixing plate 13 is exposed, then the worker can hold the vertical plate 8 while lifting the transverse plate 92, the storage box 7 is pulled out, so that the worker can place a low-temperature ice bag layer between the storage box 7 and the heat preservation sponge layer 16, then the worker can place the storage box 7 in the shell 1 again, when the worker stops lifting the transverse plate 92, the limiting plate 93 moves downwards under the action of the elastic force of the second compression spring 91, the bottom of the limiting plate 93 can enter the inside of the limiting groove 11, accordingly, the position of the storage box 7 can be fixed, then the worker can finish detection operation on NK cell activity at the top of the bearing plate 52, in the process, NK cells and reagents are injected into the inside of the reagent tube, the worker can place generated garbage in the storage groove 6, finally the worker can place the NK cells and the reagents in the inside of the reagent tube through the heat preservation sponge layer 16 under the action of the elastic force of the elastic tube, and the reagent tube can be held in the position of the heat preservation sponge layer 14 under the action of the elastic tube, and the reagent tube can be held in the position of the inside the heat preservation tube, and the reagent tube can be held by the inside the elastic tube, and the reagent tube.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises an element.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. An NK cell activity detection kit comprises a shell (1) and a cover plate (12), and is characterized in that: the surface of apron (12) one side is articulated with the surface of casing (1) one side, the bottom of apron (12) is contacted with the top of casing (1), the surface rotation of casing (1) is connected with the handle, cavity (2) have been seted up on the surface of casing (1) opposite side, the surface sliding connection of cavity (2) inner wall has case (7), the inside of case (7) is provided with heat preservation sponge layer (16), the fixed surface of case (7) one side is connected with vertical board (8), guiding groove (10) have been seted up on the surface of vertical board (8), guiding groove (10)'s inner wall fixedly connected with stop gear (9), limiting groove (11) have been seted up to one side of cavity (2) inner wall bottom, the top fixedly connected with fixed plate (13) of cavity (2) inner wall, the through groove is a plurality of the surface fixedly connected with first compression spring (15) of through groove inner wall, the fixed surface of first compression spring (15) other end (14) are connected with bottom plate (1) and bottom plate (1), bottom plate (1) are connected with pivot (5) are connected with one side of rotation, bottom plate (1) are connected with pivot (5), the top of the rotating mechanism (5) is rotationally connected with the bottom of the shell (1), the top of the storage box (7) is contacted with the bottom of the fixed plate (13), and a storage groove (6) is formed in one side of the top of the rotating mechanism (5).

2. The NK cell activity assay kit of claim 1, wherein: the rotating mechanism (5) comprises a rotating plate (51) and a bearing plate (52), the rotating plate (51) is fixedly connected to the bottom of the rotating shaft, the surface of one side of the bearing plate (52) is fixedly connected with the surface of one side of the rotating plate (51), the tops of the bearing plate (52) and the rotating plate (51) are both rotatably connected with the bottom of the shell (1), and the storage groove (6) is formed in one side of the top of the bearing plate (52).

3. The NK cell activity assay kit of claim 1, wherein: stop gear (9) are including second compression spring (91), diaphragm (92) and limiting plate (93), the surface of diaphragm (92) and the inner wall sliding connection of guide way (10), limiting plate (93) fixed connection is in the bottom of diaphragm (92), limiting plate (93) run through vertical board (8) and rather than sliding connection, the bottom of limiting plate (93) extends to the below of vertical board (8), the both ends of second compression spring (91) respectively with the top of diaphragm (92) and the top fixed connection of guide way (10) inner wall, the below on limiting plate (93) surface contacts with the inner wall of spacing groove (11).

4. The NK cell activity assay kit of claim 1, wherein: an auxiliary groove (4) is formed in the surface of one side of the bottom plate (3), and the distance between the inner walls of the two sides of the auxiliary groove (4) is larger than the width of the rotating mechanism (5).

5. A kit for NK cell activity assay as defined in claim 3, wherein: the distance between the top of the inner wall of the guide groove (10) and the bottom of the vertical plate (8) is larger than the sum of the heights of the transverse plate (92) and the limiting plate (93), and the width of the transverse plate (92) is larger than the width of the vertical plate (8).

6. The NK cell activity assay kit of claim 1, wherein: the height of the clamping plate (14) is equal to that of the fixing plate (13), and the length of the inner wall of the heat insulation sponge layer (16) is greater than the distance between the through grooves at two sides.