CN219595408U

CN219595408U - Dialysis pipeline structure and dialysis pipeline external member

Info

Publication number: CN219595408U
Application number: CN202221925992.5U
Authority: CN
Inventors: 王泽亚; 冉彬杉; 孙鹏
Original assignee: Qiande Biomedical Technology Chongqing Co ltd
Current assignee: Qiande Biomedical Technology Chongqing Co ltd
Priority date: 2022-07-25
Filing date: 2022-07-25
Publication date: 2023-08-29
Anticipated expiration: 2032-07-25

Abstract

The utility model provides a dialysis pipeline structure and a dialysis pipeline suite, and belongs to the technical field of dialysis appliances. Dialysis tubing structure comprising: the first pipeline is used for blood circulation, the second pipeline is connected in parallel to the first pipeline, and the absorber is arranged on the second pipeline; the first pipeline and the second pipeline are respectively provided with two through-stop devices, and the two through-stop devices are respectively arranged in front of and behind the adsorber. The utility model provides a dialysis pipeline external member, includes arterial pipeline, venous pipeline, arterial pipeline has arterial proximal end pipeline and arterial distal end pipeline, arterial distal end pipeline with communicate between the arterial proximal end pipeline has foretell dialysis pipeline structure. The utility model has simple operation, does not need to detach or access additional devices, reduces the workload of medical staff and reduces the possible clinical treatment risk in the detaching and connecting process.

Description

Dialysis pipeline structure and dialysis pipeline external member

Technical Field

The utility model belongs to the technical field of dialysis appliances, and particularly relates to a dialysis pipeline structure and a dialysis pipeline suite.

Background

The blood of the patient is led out of the body and passed through one or several purifying devices to remove some pathogenic substances, so as to purify the blood and attain the goal of curing diseases. Blood purification is one of the most effective measures for treating chronic renal failure, namely uremia, acute renal failure such as drug poisoning, food poisoning and the like, and is also the most widely applied treatment means in clinical kidney substitution treatment. Currently, for patients suffering from acute or chronic renal failure, only hemodialysis and blood perfusion can be connected in series for effectively removing small-molecule urotoxins in the blood of the patients and removing medium-molecule urotoxins or large-molecule urotoxins or protein-bound urotoxins, and hemodialysis treatment and blood perfusion treatment can be simultaneously carried out. Hemodialysis and blood perfusion are complicated in serial operation, and the workload of medical staff and the clinical treatment risk are increased.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, an object of the present utility model is to provide a dialysis tubing structure and a dialysis tubing set for solving the problems of complicated serial operation of hemodialysis and hemoperfusion in the prior art.

To achieve the above and other related objects, the present utility model provides a dialysis tubing structure comprising:

a first conduit for the circulation of blood,

a second pipeline connected in parallel with the first pipeline, and

an adsorber disposed on the second pipeline;

the adsorber is the adsorption kettle, be provided with the adsorbent that is used for adsorbing toxin in the blood in the adsorption kettle, first pipeline with be provided with respectively on the second pipeline and lead to the end ware, the end ware on the second pipeline is two, two lead to the end ware and be provided with respectively the adsorber front and back.

Optionally, an arterial kettle is arranged on the first pipeline.

Optionally, the number of the through-stoppers on the first pipeline is two, and the two through-stoppers are respectively arranged at the front and the rear of the arterial kettle.

Optionally, the stopper is a Robert clamp.

Optionally, a filter screen for blocking the adsorbents is further arranged in the adsorption kettle, two filter screens are provided, and the adsorbents are filled between the two filter screens.

The present utility model also provides a dialysis tubing structure comprising:

a three-way valve having a first opening, a second opening, and a third opening, the first opening being in communication with the second opening and the third opening,

a first line for blood circulation, an

The second pipeline is provided with an absorber;

the adsorption device comprises an adsorption kettle, wherein adsorbents for adsorbing toxins in blood are arranged in the adsorption kettle, two three-way valves are arranged, two ends of a first pipeline are respectively communicated with second openings of the two three-way valves, and two ends of the second pipeline are respectively communicated with third openings of the two three-way valves.

Optionally, an arterial kettle is arranged on the first pipeline.

The utility model also provides a dialysis pipeline kit, which comprises an arterial pipeline, wherein the arterial pipeline is provided with an arterial proximal pipeline and an arterial distal pipeline, and the dialysis pipeline structure as described in any one of the above is communicated between the arterial distal pipeline and the arterial proximal pipeline.

Optionally, the device further comprises a venous pipeline, wherein a dialysis connector for being connected with the dialyzer is arranged on one end of the venous pipeline, and a flushing connector is arranged on the other end of the venous pipeline.

Optionally, a drug infusion pipeline, a heparin pipeline and a pump pipe are further arranged on the artery proximal pipeline.

As described above, the dialysis tubing structure and the dialysis tubing set of the present utility model have the following beneficial effects:

because the first pipeline is provided with the second pipeline in parallel, and the second pipeline is provided with the absorber, when toxin in blood needs to be absorbed, the blood can flow through the absorber on the second pipeline, and the absorber can absorb the toxin in the blood, so that the purpose of removing the toxin in the blood is achieved. The duration of adsorption is usually less than that of dialysis, and when adsorption is finished, blood can flow through the first pipeline, so that adsorption of the blood is stopped, and dialysis efficiency is guaranteed. The utility model has simple operation, does not need to detach or access additional devices, reduces the workload of medical staff and reduces the possible clinical treatment risk in the detaching and connecting process.

Drawings

FIG. 1 is a schematic diagram of an arterial line according to an embodiment of the present utility model;

FIG. 2 is a schematic view of a venous line according to an embodiment of the present utility model;

FIG. 3 is a schematic diagram of an adsorption kettle according to an embodiment of the present utility model;

fig. 4 is a schematic diagram of an arterial line according to an embodiment of the present utility model.

Reference numerals illustrate:

puncture outfit protective sheath 1, pre-flush line 2, sliding joint 3, robert clamp 4, sampling port 5, drug infusion line 6, heparin line 7, pump line 8, Y-shaped tube 9, fluid infusion line 10, three-way valve 11, arterial kettle 12, adsorption kettle 13, dialysis joint 14, dialysis joint cap 15, flush joint 16, venous kettle 17, pressure sensor line 18, sensor protective cover 19, filter screen 20, adsorbent 21.

Detailed Description

Further advantages and effects of the present utility model will become apparent to those skilled in the art from the disclosure of the present utility model, which is described by the following specific examples.

Please refer to fig. 1 to 3. It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the utility model to the extent that it can be practiced, since modifications, changes in the proportions, or adjustments of the sizes, which are otherwise, used in the practice of the utility model, are included in the spirit and scope of the utility model which is otherwise, without departing from the spirit or scope thereof. Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the utility model, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the utility model may be practiced.

To describe the present utility model in detail, first, the environment in which the present utility model is used will be specifically described below:

at present, hemodialysis and hemodiafiltration are mainly used for removing small-molecule uremic toxins such as urea and creatinine in blood of patients suffering from acute and chronic renal failure, and the removal of large-molecule uremic toxins in beta 2-Microglobulin (beta 2-MG), parathyroid hormone (Parathyroid Hormone, PTH) and the like is limited. Blood perfusion IS mainly used for removing middle and large molecular urotoxins (such as beta 2-MG, PTH, interleukin 6 (IL-6), interleukin 8 (IL-8) and the like) and protein-bound urotoxins (such as Hippuric Acid (HA), p-cresol sulfate (PCS), indoxyl Sulfate (IS), 3-carboxyl-4-Methyl-5-Propyl-2-furanopropionic Acid (3-Carboxy-4-Methyl-5-Propyl-2-Furanpropionic Acid, CMPF) and the like of patients with acute and chronic renal failure. Hemodialysis and hemodiafiltration mainly use an extracorporeal circulation blood path (hereinafter referred to as a "dialysis line") of a blood purifying device, a dialyzer, dialysis equipment, and other instruments, wherein the dialysis line provides a blood path for extracorporeal blood circulation for a patient; the dialyzer is used for filtering and purifying blood and removing small molecular toxins in the blood; the dialysis equipment mainly provides power for the whole treatment process, monitors the whole treatment process and ensures the safety and effectiveness of the whole treatment process. The blood perfusion mainly uses the apparatus such as dialysis pipeline, perfusion apparatus, etc., wherein dialysis pipeline offer the blood path of extracorporeal blood circulation for patient; the perfusion device is used for filtering and purifying blood and adsorbing medium and large molecular toxins and protein-bound toxoids in the blood; the perfusion equipment mainly provides power for the whole treatment process, monitors the whole treatment process and ensures the safe and orderly operation of the whole treatment process. If one wants to remove both small-molecule urotoxins from patients with renal failure and large-molecule urotoxins from patients, one must connect hemodialysis and hemodiafiltration in series, while performing both hemodialysis and hemodiafiltration therapy. Therefore, a plurality of medical instruments such as an extracorporeal circulation pipeline, a dialyzer, a perfusion device, hemodialysis, perfusion equipment and the like are needed, so that clinical operation of medical staff is complicated, and clinical treatment risks such as pollution and the like exist in the disassembly and assembly process.

In view of the above, referring to fig. 1 to 3, a dialysis circuit structure is provided in the present embodiment, and includes a first circuit, a second circuit and an adsorber. The first pipeline is used for blood circulation, and the second pipeline is connected in parallel on the first pipeline. The absorber is arranged on the second pipeline and is used for absorbing toxins in blood flowing through the second pipeline. The first pipeline and the second pipeline are respectively provided with two through-stopping devices, and the two through-stopping devices are respectively arranged in front of and behind the absorber.

When the toxins in the blood are required to be adsorbed, the blood can flow through the absorber on the second pipeline by adjusting the through-stop device, and the absorber can adsorb the toxins in the blood, so that the purpose of removing the toxins in the blood is achieved. The duration of adsorption is usually less than the duration of dialysis, and when adsorption is finished, blood can flow through the first pipeline through adjusting the stopper, and adsorption of the blood is stopped, so that dialysis efficiency is ensured. The stopper is easy to operate, does not need to detach or access an additional device, reduces the workload of medical staff, and simultaneously avoids possible clinical treatment risks in the detaching and connecting process.

Specifically, when the toxin in the blood needs to be adsorbed, two through-stopping devices on the second pipeline are opened, the through-stopping devices on the first pipeline are closed, the blood flows through the second pipeline and the absorber on the second pipeline, and the absorber is used for absorbing the toxin in the blood. After the adsorption is finished, the two through-stoppers on the second pipeline are closed, the through-stoppers on the first pipeline are opened, and the blood flows through the first pipeline to stop the adsorption. When the two through stoppers are closed, substances such as coagulated blood clots in the adsorbers can be prevented from entering the circulating blood from both ends of the second pipeline.

The stopper can also meet the treatment requirements of various emergency situations in the clinical treatment process. For example, after coagulation in the adsorption kettle 13, the blood flow path can be switched from the second line directly to the first line by means of the stopper or the three-way valve 11, and conventional hemodialysis treatment can be performed without changing the dialysis line.

In one embodiment, an arterial kettle 12 is provided on the first line. The arterial kettle 12 is capable of collecting air bubbles, preventing air from entering the blood. In this embodiment, there are two openers on the first line, which are respectively disposed before and after the arterial kettle 12. When both stoppers are closed, the substances in the arterial kettle 12 are prevented from entering the circulating blood through the first conduit. Specifically, the stopper is a Robert clamp 4. Correspondingly, the first pipeline and the second pipeline are hoses, the material of the Robert clamp 4 is usually polyoxymethylene or polypropylene, and the hose has a simple structure and can be used for regulating and stopping the flow of the hoses.

The main material used for the pipeline can be polyvinyl chloride (Polyvinyl Chloride, abbreviated as PVC), but the plasticizer thereof in the market at present is mainly Di (2-ethylhexyl) phthalate (Di-2-ethylhexyl phthalate, abbreviated as DEHP). DEHP belongs to phthalate compounds (PAEs for short), is a colorless oily viscous liquid with specific gravity of 0.985, has good conductivity and low-temperature volatility, and is very easy to dissolve in organic solvents. It is used as plasticizer in food package material, medical article, artificial leather, etc. and may be used as additive in perfume, cosmetics, finishing material, etc. Among them, the most important ones are the most important ones for human body, or the ones used as plasticizers, and the DEHP is usually used in PVC plastic films in an amount of 30% to 50%. Because DEHP is simply combined with PVC polymers by hydrogen bonding or van der waals forces during the processing of plastics, it is very easily released when encountering water or organic solvents during use, and volatilizes into the atmosphere, soil and water, thereby causing environmental pollution. In addition, it can be enriched in and cause damage to organisms such as fish, amphibians, aquatic invertebrates, and the like. In recent years, many data indicate that DEHP is an environmental endocrine disrupter, has reproductive toxicity, and can lead to reduced reproductive capacity and genital deformities. Meanwhile, DEHP also has genotoxicity, neurotoxicity, embryotoxicity, carcinogenesis, teratogenic mutation toxicity to organisms.

In order to solve the problem caused by biotoxicity such as reproductive toxicity of o-benzene plasticizers such as DEHP, a non-o-benzene plasticizer is used instead of o-benzene plasticizers, in this embodiment, a pipeline is a PVC plastic plasticized by a non-o-benzene environment-friendly plasticizer such as trioctyl trimellitate (Trioctyl Trimellitate, TOTM), or acetyl Tri (2-ethylhexyl) Citrate (Acetyl Trioctyl Citrate, ATOC), or acetyl Tri-n-butyl Citrate (Acetyl Tributyl Citrate, ATBC), or butyrylated Tri-n-hexyl Citrate (BTHC), or cyclohexane1, 2-diisononyl phthalate (Di-isononyl cyclohexane1, 2-dicarbonate, DINCH) or Di (2-ethylhexyl) terephthalate (Di-2-Ethylhexyl Terephthalate, DEHT).

As shown in fig. 3, in this embodiment, the adsorber is an adsorption pot 13, in which an adsorbent for adsorbing toxins in blood and a filter screen 20 for blocking the adsorbent 21 are provided in the adsorption pot 13, the number of the filter screens 20 is two, and the adsorbent 21 is filled between the two filter screens. Specifically, the adsorbent can be polystyrene-divinylbenzene macroporous adsorption resin, and collodion or polyvinylpyrrolidone (Polyvinyl Pyrrolidone, PVP for short) is used for coating modification, so that the blood compatibility of the adsorption resin is improved. The adsorbent is used for adsorbing middle-large molecular urotoxins and/or protein-binding toxoids in blood of patients with renal failure. The filter screen 20 serves to retain the adsorbent 21 and clot so as to prevent the adsorbent 21 and clot from flowing with blood into the dialyzer, clogging and damaging the dialyzer, causing the dialyzer to lose its function of removing small molecule urotoxins. At the same time, the screen 20 also prevents the adsorption resin and its debris from flowing back into the patient along with the venous line, damaging the patient.

As shown in fig. 4, in an embodiment, a dialysis tubing structure is further provided, which includes a first tubing, a second tubing, and a three-way valve 11, wherein the first tubing and the second tubing are used for blood circulation. The three-way valve 11 has a first opening, a second opening and a third opening, the first opening can be switched between the second opening and the third opening, so that the two three-way valves 11 are communicated with the second opening or the third opening, two ends of a first pipeline are respectively communicated with the second openings of the two three-way valves 11, and two ends of a second pipeline are respectively communicated with the third openings of the two three-way valves 11. The second pipeline is provided with an absorber which is used for absorbing toxins in blood flowing through the second pipeline.

When the toxins in the blood are required to be adsorbed, the three-way valve 11 can be adjusted to enable the blood to flow through the absorber on the second pipeline, and the absorber can adsorb the toxins in the blood, so that the purpose of removing the toxins in the blood is achieved. The duration of adsorption is usually less than the duration of dialysis, and when adsorption is finished, the three-way valve 11 can be adjusted to enable blood to flow through the first pipeline, so that adsorption of the blood is stopped, and dialysis efficiency is guaranteed. The three-way valve 11 is simple to operate, does not need to be disassembled or connected into an additional device, reduces the workload of medical staff, and simultaneously avoids possible clinical treatment risks in the disassembly and connection process.

Specifically, when the toxin in the blood needs to be adsorbed, the first openings of the two three-way valves 11 are communicated with the respective third openings, the blood enters the second pipeline through the first opening and the third opening of the first three-way valve 11, flows through the adsorber on the second pipeline, the adsorber absorbs the toxin in the blood, and the adsorbed blood flows out through the third opening and the first opening of the other three-way valve 11 in sequence.

After the adsorption is finished, the three-way valves 11 can be adjusted to enable the first openings of the two three-way valves 11 to be respectively communicated with the second openings, blood enters the first pipeline through the first opening and the second opening of the first three-way valve 11, and then flows out through the second opening and the first opening of the other three-way valve 11 in sequence, so that the adsorption is stopped. When the two three-way valves 11 are adjusted to the state that the first opening is communicated with the second opening, the adsorber is isolated, and substances such as coagulated blood clots in the adsorber can be prevented from entering the blood circulation from the two ends of the second pipeline.

The utility model also provides a dialysis pipeline kit, which comprises an arterial pipeline, wherein the arterial pipeline is provided with an arterial proximal pipeline and an arterial distal pipeline, and the dialysis pipeline structure of any one of the above is communicated between the arterial distal pipeline and the arterial proximal pipeline.

Specifically, one end of an arterial proximal end pipeline is connected with a first pipeline and a second pipeline in the dialysis pipeline structure, a bottle stopper puncture outfit is arranged at the other end of the arterial proximal end pipeline, and a protective sleeve is arranged on the bottle stopper puncture outfit. The arterial proximal pipeline comprises a pre-flushing pipeline 2, a sliding joint 3, a Robert clamp 4, a sampling port 5, a drug infusion pipeline 6, a heparin pipeline 7, a pump pipe 8 and a Y-shaped pipe 9 in sequence, and the arterial proximal pipeline is connected with a first pipeline and a second pipeline respectively through the Y-shaped pipe 9. The first pipeline and the second pipeline are respectively connected with a fluid supplementing pipeline 10 and a medicine infusion pipeline 6. One end of the arterial distal pipeline is provided with a Y-shaped pipe 9 and is respectively connected with the first pipeline and the second pipeline through the Y-shaped pipe 9, the other end of the arterial distal pipeline is provided with a dialysis connector 14, and the dialysis connector 14 is used for being connected with a dialyzer. The dialysis connector 14 is provided with a dialysis connector cap 15, and when the dialysis pipeline suite is not used, the dialysis connector cap 15 is arranged on the dialysis connector 14 in a covering mode, so that the dialysis connector 14 is prevented from being damaged and polluted.

When the three-way valve 11 is included in the dialysis tubing set, the arterial proximal tubing and arterial distal tubing are connected to the first openings of the two three-way valves 11, respectively. The arterial proximal pipeline and the arterial distal pipeline are respectively connected with the first pipeline and the second pipeline through three-way valve 11 pipes.

In some embodiments, the dialysis tubing set further comprises a venous tubing having a dialysis adapter 14 disposed on one end for connection to the dialyzer and a flush adapter 16 disposed on the other end of the venous tubing. The venous line is provided with a venous pot 17, and a blood filter screen is arranged in the venous pot 17 and can be used for filtering coagulated blood clots in the return blood. The venous line is provided with a Robert clamp 4 and a sliding joint 3 between the flushing joint 16 and the venous kettle 17, and the Robert clamp 4 can be used for opening or stopping the venous line. The venous line is provided with a sampling port 5 between the venous pot 17 and the dialysis adapter 14 and is connected with a pressure sensor line 18, and the pressure sensor line 18 is provided with a sensor protection cover 19. The venous kettle 17 is connected with a fluid supplementing pipeline 10.

Compared with the traditional dialysis tubing, the adsorption kettle 13 is added, so that the tubing not only provides an extracorporeal circulation blood path for a patient like the traditional dialysis tubing in the clinical hemodialysis treatment process, but also can adsorb middle and large molecular urotoxins and/or protein-binding toxoids in the blood of the patient. Therefore, the kidney failure patient can achieve the treatment effect of the traditional hemodialysis and hemodiafiltration serial blood perfusion by using the dialysis pipeline suite, the dialyzer and the dialysis equipment for hemodialysis treatment. Thus, the workload of clinical medical staff is reduced, the risk of clinical treatment in the disassembly and assembly process is reduced, and the treatment cost of patients is reduced.

In summary, in the dialysis pipeline structure and the dialysis pipeline kit provided in the embodiment, the first pipeline is connected with the second pipeline in parallel, and the second pipeline is provided with the adsorber, so that when the toxin in the blood needs to be adsorbed, the blood can flow through the adsorber on the second pipeline through the three-way valve 11 or the stopper, and the adsorber can adsorb the toxin in the blood, thereby achieving the purpose of removing the toxin in the blood. The duration of adsorption is usually less than that of dialysis, and after adsorption is finished, blood can flow through the first pipeline through the three-way valve 11 or the stopper, so that the adsorption of the blood is stopped, and the dialysis efficiency is ensured. The three-way valve 11 or the stopper is simple to operate, does not need to be disassembled or connected into an additional device, reduces the workload of medical staff, and reduces the possible clinical treatment risk in the disassembly process.

The above embodiments are merely illustrative of the principles of the present utility model and its effectiveness, and are not intended to limit the utility model. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the utility model. Accordingly, it is intended that all equivalent modifications and variations of the utility model be covered by the claims of this utility model, which are within the skill of those skilled in the art, can be made without departing from the spirit and scope of the utility model disclosed herein.

Claims

1. A dialysis tubing structure comprising:

a first conduit for the circulation of blood,

a second pipeline connected in parallel with the first pipeline, and

an adsorber disposed on the second pipeline;

2. The dialysis tubing arrangement of claim 1, wherein: an arterial kettle is arranged on the first pipeline.

3. The dialysis tubing arrangement of claim 2, wherein: the number of the through-stopping devices on the first pipeline is two, and the two through-stopping devices are respectively arranged at the front and the rear of the arterial kettle.

4. A dialysis tubing arrangement according to any one of claims 1-3, wherein: the stopper is a Robert clamp.

5. A dialysis tubing arrangement according to any one of claims 1-3, wherein: the adsorption kettle is internally provided with two filter screens for blocking the adsorbents, and the adsorbents are filled between the two filter screens.

6. A dialysis tubing structure comprising:

a first line for blood circulation, an

The second pipeline is provided with an absorber;

7. The dialysis tubing arrangement of claim 6, wherein: an arterial kettle is arranged on the first pipeline.

8. A dialysis tubing set, characterized in that: comprising an arterial line having an arterial proximal line and an arterial distal line, wherein a dialysis line structure according to any one of claims 1-7 is in communication between the arterial distal line and the arterial proximal line.

9. The dialysis tubing set of claim 8, further comprising a venous tubing having a dialysis fitting disposed on one end for connection to a dialyzer and a flush fitting disposed on the other end of the venous tubing.

10. The dialysis tubing set according to claim 8, wherein: and a drug infusion pipeline, a heparin pipeline and a pump pipe are also arranged on the artery proximal pipeline.