CN219539471U - Crystallization device suitable for high-viscosity system - Google Patents

Abstract

The utility model provides a crystallization device suitable for a high-viscosity system, which comprises: the wet grinding machine comprises a first reaction kettle, a gear pump, a wet grinding machine and a second reaction kettle, wherein the first reaction kettle, the gear pump, the wet grinding machine and the second reaction kettle are sequentially connected through pipelines, the wet grinding machine is provided with a first wet grinding machine feed inlet which is positioned at the top and is connected with a gear pump discharge port of the gear pump, a second wet grinding machine feed inlet which is connected with a second reaction kettle discharge port of the second reaction kettle, and a wet grinding machine discharge port which is positioned at the lower side and is connected with a second reaction kettle feed inlet of the second reaction kettle. According to the utility model, through the optimal configuration and recombination of the existing instruments and equipment of a factory, the crystallization device which can enable the existing conventional reaction kettle to be suitable for a high-viscosity system is obtained, the existing conventional reaction kettle can meet the crystallization of the high-viscosity system, the materials which are easy to form balls during crystallization can be scattered, and meanwhile, the particle sizes are uniform.

Description

Crystallization device suitable for high-viscosity system

Technical Field

The utility model relates to the technical field of pharmaceutical chemical production equipment, in particular to a crystallization device suitable for a high-viscosity system.

Background

In the production process of chemical products or medicines, crystallization is a very important unit operation. However, the existing conventional reaction kettle cannot achieve a good dispersing effect for a crystallization system with high viscosity and easy balling, and cannot obtain a uniform product.

Disclosure of Invention

The utility model aims to solve the technical problem of providing a crystallization device suitable for a high-viscosity system, which can enable the existing conventional reaction kettle to meet the crystallization of the high-viscosity system, can scatter materials which are easy to form balls during crystallization, and simultaneously enables the particle sizes to be equal.

In order to solve the above technical problems, the crystallization device suitable for a high viscosity system provided by the present utility model comprises: the wet grinding machine comprises a first reaction kettle, a gear pump, a wet grinding machine and a second reaction kettle which are sequentially connected through pipelines, wherein the wet grinding machine is provided with a first wet grinding machine feed inlet which is positioned at the top and connected with a gear pump discharge port of the gear pump, a second wet grinding machine feed inlet which is connected with a second reaction kettle discharge port of the second reaction kettle, and a wet grinding machine discharge outlet which is positioned at the bottom and connected with a second reaction kettle feed inlet of the second reaction kettle.

Specifically, the first feed inlet of the wet mill and the second feed inlet of the wet mill are arranged on the same three-way pipe, and the other interface of the three-way pipe is welded at the top of the wet mill so that the first feed inlet of the wet mill and the second feed inlet of the wet mill are communicated with the inside of the wet mill.

Specifically, the pipeline is provided with a check valve.

Specifically, the check valve is arranged in the middle of all pipelines connected with the discharge port and the feed port.

Specifically, the check valves are four in total.

Specifically, the crystallization device is made of stainless steel, glass lining or hastelloy.

Specifically, the inner diameter of the pipeline is 25-40 cm.

Specifically, the first feed port of the wet mill is also provided with an extension pipe which is sleeved in the pipeline, and the extension pipe is inserted into the vicinity of a cutter head in the wet mill from the first feed port of the wet mill, so that the solution of the high-viscosity system is rapidly dispersed while crystallization is carried out, and the larger occurrence of blockage of crystallization particles at the second feed port of the wet mill is prevented.

Specifically, the materials of the pipeline and the extension pipe are respectively selected from stainless steel, hastelloy, polytetrafluoroethylene, polypropylene or soluble polytetrafluoroethylene.

In particular, the high viscosity system has a viscosity in the range of 50000-500000 cp.

According to the utility model, through the optimal configuration and recombination of the existing instruments and equipment of a factory, the crystallization device which can enable the existing conventional reaction kettle to be suitable for a high-viscosity system is obtained.

Compared with the prior art, the utility model has the beneficial effects that:

1. the crystallization device suitable for the high-viscosity system provided by the utility model uses the gear pump to control the feeding speed of the high-viscosity solution, and finishes crystallization in a wet mill, thereby avoiding direct crystallization in a reaction kettle to form pellets.

2. The crystallization device suitable for the high-viscosity system provided by the utility model can finish wet grinding of materials while crystallization is carried out, and can effectively control the particle size of the materials.

3. The crystallization device suitable for the high-viscosity system provided by the utility model has the advantages that the reaction kettle, the wet mill and the gear pump are sequentially connected in series through the pipelines to form a set of serial complete circulation pipelines, crystallization is completed, and meanwhile, the crystallization device has the advantages of simplified structure, convenience in disassembly, small space occupation, simplicity and convenience in operation, labor cost saving and the like.

Drawings

In order to more clearly illustrate the technical solutions of the present utility model, the following brief description of the drawings is given for the purpose of the present utility model, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and that other drawings can be obtained according to these drawings without the need for inventive work for a person skilled in the art.

FIG. 1 is a crystallization apparatus suitable for use in a high viscosity system according to the present utility model.

Symbol description

1 first reaction kettle

11 first reaction kettle discharge port

2 pipeline

21 check valve

3 gear pump

31 gear pump feed inlet

32 gear pump discharge gate

4 wet mill

41 wet mill first feed inlet

42 wet mill second feed inlet

43 wet mill discharge gate

5 second reaction kettle

51 second reaction kettle feed inlet

52 second reaction kettle discharge port

Detailed Description

The following description of the embodiments of the present utility model will be made more apparent and fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Example 1

Referring to fig. 1, there is shown a crystallization apparatus suitable for a high viscosity system according to the present utility model, comprising: the first reaction kettle 1, the gear pump 3, the wet mill 4 and the second reaction kettle 5 are sequentially connected through the pipeline 2, the wet mill 4 is provided with a wet mill first feed port 41 positioned at the top and connected with the gear pump discharge port 32 of the gear pump 3, a wet mill second feed port 42 connected with the second reaction kettle discharge port 52 of the second reaction kettle 5, and a wet mill discharge port 43 positioned at the bottom and connected with the second reaction kettle feed port 51 of the second reaction kettle 5.

The first feeding port 41 of the wet grinder and the second feeding port 42 of the wet grinder are arranged on the same three-way pipe, and the other port of the three-way pipe is welded at the top of the wet grinder 4 so that the first feeding port 41 of the wet grinder and the second feeding port 42 of the wet grinder are communicated with the inside of the wet grinder 4. The pipeline 2 is provided with check valves 21, the check valves 21 are arranged in the middle of all the pipelines 2 connecting the discharge port and the feed port, and the check valves 21 are four in total. The crystallization device of the utility model is made of stainless steel or hastelloy. The inner diameter of the pipeline is 25-40 cm. The first feed inlet 41 of the wet mill is also provided with an extension pipe which is sleeved in the pipeline 2, and the extension pipe is inserted into the wet mill 4 from the first feed inlet 41 of the wet mill to the vicinity of a cutter head in the wet mill 4, so that the solution of a high-viscosity system is rapidly dispersed while crystallization is carried out, and the occurrence of blockage of larger crystallization particles at the second feed inlet 42 of the wet mill is prevented. The materials of the pipeline 2 and the extension pipe are respectively selected from stainless steel, hastelloy, polytetrafluoroethylene, polypropylene or soluble polytetrafluoroethylene. The device is suitable for high-viscosity systems with a viscosity in the range of 50000-500000 cp.

Example two

The application principle of the utility model is as follows:

the solution of the high-viscosity system is discharged from a first reaction kettle discharge port 11 of the first reaction kettle 1; enters the gear pump 3 through the gear pump feed inlet 31 and then comes out from the gear pump discharge outlet 32; then enters the wet mill 4 through the first feed inlet 41 of the wet mill and then exits through the discharge outlet 43 of the wet mill; then enters the second reaction kettle 5 through the second reaction kettle feed inlet 51 and then comes out from the second reaction kettle discharge outlet 52; finally, the crystals enter the wet mill 4 through the second feed port 42 of the wet mill to finish the pipeline flow of the whole device, and meanwhile, the crystals are separated out from the second feed port 42 of the wet mill.

After all the solutions of the high-viscosity system in the first reaction kettle 1 are added, the gear pump 3 is closed, at this time, the reverse solution coming out of the discharge port 52 of the second reaction kettle can also enter the wet mill 4 through the second feed port 42 of the wet mill alone, so that the crystals precipitated at the second feed port 42 of the wet mill enter the wet mill 4 to be ground into crystal particles with more uniform particles, then come out of the discharge port 43 of the wet mill, and then enter the second reaction kettle 5 through the feed port 51 of the second reaction kettle, thereby completing the small circulation of only the wet mill 4 and the second reaction kettle 5, and completing the precipitation of the crystals at the second feed port 42 of the wet mill. The crystals meeting the requirements after the small circulation are transferred to a centrifugal machine or three-in-one from the second reaction kettle 5 for solid-liquid separation, and the separation of the crystals is completed.

The foregoing description of the preferred embodiments of the utility model is not intended to limit the scope of the utility model, but rather to cover any modifications, equivalents, improvements or the like within the spirit and scope of the present utility model.

Claims (10)

1. A crystallization apparatus suitable for use in a high viscosity system, comprising: the wet grinding machine comprises a first reaction kettle, a gear pump, a wet grinding machine and a second reaction kettle, wherein the first reaction kettle, the gear pump, the wet grinding machine and the second reaction kettle are sequentially connected through pipelines, the wet grinding machine is provided with a first wet grinding machine feed inlet which is positioned at the top and is connected with a gear pump discharge port of the gear pump, a second wet grinding machine feed inlet which is connected with a second reaction kettle discharge port of the second reaction kettle, and a wet grinding machine discharge port which is positioned at the lower side and is connected with a second reaction kettle feed inlet of the second reaction kettle.

2. The crystallization apparatus according to claim 1, wherein the first wet mill feed port and the second wet mill feed port are provided on a same tee pipe, and the other port of the tee pipe is welded to the top of the wet mill so that the first wet mill feed port and the second wet mill feed port are communicated with the inside of the wet mill.

3. The crystallization apparatus according to claim 1, wherein the piping is provided with a check valve.

4. The crystallization apparatus according to claim 3, wherein the check valve is disposed in the middle of all the pipes connecting the discharge port and the feed port.

5. The crystallization apparatus according to claim 3, wherein the check valves are four in total.

6. The crystallization apparatus according to claim 1, wherein the crystallization apparatus is made of stainless steel, glass lining or hastelloy.

7. The crystallization apparatus according to claim 1, wherein the inner diameter of the tube is 25-40 cm.

8. The crystallization apparatus according to claim 1, wherein an extension pipe is further provided at the first inlet of the wet mill and is sleeved in the pipe, and the extension pipe is inserted into the wet mill from the first inlet of the wet mill to the vicinity of a cutter head in the wet mill.

9. The crystallization apparatus according to claim 8, wherein the piping and the extension pipe are each made of a material selected from the group consisting of stainless steel, hastelloy, polytetrafluoroethylene, polypropylene and soluble polytetrafluoroethylene.

10. The crystallization apparatus according to claim 1, wherein the high viscosity system has a viscosity in the range of 50000-500000 cp.