CN219486292U

CN219486292U - Combined die for preparing medical and aesthetic microneedle patch

Info

Publication number: CN219486292U
Application number: CN202123452733.3U
Authority: CN
Inventors: 潘书婷; 游卫龙; 崔雪
Original assignee: Zhejiang Deqing Wahaha Science And Technology Innovation Center Co ltd
Current assignee: Zhejiang Deqing Wahaha Science And Technology Innovation Center Co ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2023-08-08
Anticipated expiration: 2031-12-31

Abstract

The utility model relates to the technical field of medical and aesthetic microneedle patches, and particularly discloses a combined die for preparing medical and aesthetic microneedle patches, which comprises a die body and a microneedle array arranged on the die body, wherein a micropin hole groove which is sealed in the circumferential direction is formed in the surface of the die body, the micropin hole array is arranged in the micropin hole groove, the combined die also comprises a second die matched with the die body for use, a female die hole is formed in the middle of the second die, and the second die is covered in the micropin hole groove. The combined die provided by the utility model allows the preparation of a basic die with universal microneedle array arrangement, and can realize the preparation of medical microneedle patch products of different types by only adjusting the types of the second die, so that the working efficiency is improved, and the processing cost is obviously reduced.

Description

Combined die for preparing medical and aesthetic microneedle patch

Technical Field

The utility model relates to the technical field of medical and medical microneedle patches, in particular to a combined die for preparing medical and medical microneedle patches.

Background

Microneedle transdermal is a novel drug delivery technology, and the principle is that a drug is loaded on the microneedle, or a bioactive substance such as hyaluronic acid is directly prepared into the microneedle, and the drug is delivered into a body by penetrating the stratum corneum of the skin with the microneedle. Because the tip of the microneedle is thin, and the penetration depth is generally only on the stratum corneum, the microneedle penetration cannot contact nerve endings, does not produce pain, has the characteristic of painless and minimally invasive, and is increasingly focused, so that the microneedle has great prospect in aspects of microneedle cosmetology and vaccine administration. At present, a plurality of microneedle medical and aesthetic products such as microneedle beauty eye patches, statue texture patches, facial masks and the like appear on the market.

When the microneedle medical product is prepared, a basic metal mold is generally prepared, a metal microneedle array is arranged on the metal mold or a metal microneedle array is arranged on the metal mold, wherein the metal microneedle array is used for generating the medical product after a female mold is obtained through reverse molding, and the metal microneedle array can be used for directly producing the medical product. However, the shapes of the parts of the human body corresponding to different medical products are different, such as the stature is in a half moon shape, the eye mask is in a curved shape corresponding to the eye socket, and in the prior art, a basic metal mold with a microneedle array or a microneedle array which are arranged in a corresponding shape is often required to be prepared, or a cutting process is often required to be introduced after a whole microneedle array is processed. The preparation workload of the metal micro-needle array or micro-needle hole array with the specific shape is large, the working efficiency is low, and the processing cost is high; the introduction of cutting not only adds additional processing steps, but also puts stringent requirements on the cutting integrity, edge flatness, mechanical properties of the microneedle patch itself, and the like.

Disclosure of Invention

The utility model aims to provide a combined die for preparing medical and aesthetic microneedle patches, which can be prepared by adopting a conventional and conveniently processed basic die of a microneedle array, and does not need to prepare a basic die with a specific shape.

The utility model provides the following technical scheme:

the utility model provides a combined die for preparing medical and aesthetic micro needle subsides, includes the mould body and sets up the micropin hole array on the mould body, the surface of mould body is equipped with circumference confined micropin hole groove, micropin hole array arranges in the micropin hole inslot, combined die still includes the second matrix that the cooperation mould body used, the middle part of second matrix is equipped with the female die hole, the second matrix covers in the micropin hole inslot.

In the combined die, a die body with a microperforated groove is arranged, a microperforated array is arranged in the microperforated groove, and then a second die provided with a female die hole is matched to form the combined die. The die body can be obtained by reverse molding of high polymer resin such as polydimethylsiloxane, polytetrafluoroethylene, polycarbonate or polymethyl methacrylate on a basic microneedle metal die with a microneedle array. Because the shape of the female die hole of the second die plate can be set according to the shape of medical products to be prepared, the second die plate with different female die hole shapes can be used for producing medical microneedle patch products of different types only by changing the second die plate according to design requirements, the universality of a die body prepared by a basic metal die is improved, the die body used for the medical microneedle patch products of different shapes is allowed to be prepared by a basic microneedle metal die of a conventional shape, the working efficiency is greatly improved, and the processing cost is reduced.

Preferably, the edge of the second die is spaced from the edge of the micropin groove. The position of the second die in the microneedle recess is conveniently adjusted and the spreading of the second die is facilitated.

Preferably, the upper surface of the second die is positioned in a micropin well.

Preferably, the material of the second die is polydimethylsiloxane, polytetrafluoroethylene, polystyrene, polyacrylic acid, polycarbonate or polymethyl methacrylate. And when the second matrix is prepared, pouring the polydimethylsiloxane PDMS or the solution of the second matrix around the second matrix template, solidifying and demolding. The second die template has the same shape as the medical product to be prepared, such as a half moon shape. The shape of the second template is set more simply than the preparation of the basic microneedle metal mould with a specific shape, and the workload and the cost are greatly reduced.

Preferably, the combined die further comprises a die pressing plate for flatly pressing the second die, and the surface flatness of the die pressing surface of the die pressing plate is 0.5-10 mu m. And placing the second die into the microperforated hole groove, paving, and then placing the die pressing plate for light pressing to keep the flatness of the second die.

As the preferable mode of the utility model, the depth of the micro pinholes is 50-1000 mu m, and the distance between the micro pinholes is 10-5000 mu m.

Preferably, the microperforations are of a reverse pyramid shape, or the microperforations are of an upper pyramid shape and a lower reverse pyramid shape.

Preferably, the length of each side of the hole edge of the microperforated hole is 10-1000 mu m.

In a preferred embodiment of the present utility model, the edge rows of the micropin array are spaced apart from the micropin grooves.

Preferably, the medical microneedle patch is one of an eye patch, a stature patch, a vaccinia patch, a facial mask patch and a head raising patch.

The beneficial effects of the utility model are as follows:

the combined die provided by the utility model allows the preparation of the basic die arranged by the universal microneedle array, and can realize the preparation of medical products of different types by only adjusting the types of the second die, so that the working efficiency is improved, and the processing cost is obviously reduced.

Drawings

Fig. 1 is a plan view of the mold assembly of example 1.

Fig. 2 is a structural view of the mold body and eye-ward second mold sheet of example 1.

Fig. 3 is a structural view of the eye mask female die hole.

Fig. 4 is a cross-sectional view at A-A in fig. 1.

Fig. 5 is an enlarged view at B in fig. 4.

Fig. 6 is a structural view of the second negative mold of the embossed pattern of example 2.

In the figure, 1, a die body, 11, a microperforation groove, 12, a microperforation array, 13, microperforations, 2, a second eye mask die, 21, a female eye mask hole, 2', a second French pattern die, 21', a female French pattern hole, 3 and a die pressing plate.

Detailed Description

The following is a further description of embodiments of the utility model.

Unless otherwise indicated, all starting materials used in the present utility model are commercially available or are commonly used in the art, and unless otherwise indicated, the methods in the examples below are all conventional in the art.

Example 1

A combined die for preparing medical and aesthetic micro-needle patches is shown in fig. 1, and is a die for producing micro-needle eye patches, and comprises a die body 1 which is made of PDMS. As shown in fig. 2, a rectangular microperforated groove 11 is provided on the upper surface of the die body, the microperforated groove is a concave pit formed by recessing the upper surface of the die body, and a microperforated array 12 is provided in the microperforated groove. An eye mask second die plate 2 made of PDMS is arranged in the micro-pinhole groove, and is completely arranged in the micro-pinhole groove and covers the micro-pinhole groove. As shown in fig. 3, the middle part of the second die is a female die hole 21 of the eye patch, which is a through hole with a lower eyelid shape, but may be provided with an upper eyelid shape. The micro pinholes in the eye mask female die holes are exposed, the rest part of the micro pinholes are covered by the eye mask second die, and the edge of the eye mask second die is not contacted with the side wall of the micro pinhole groove. As shown in fig. 4 and 5, the microperforations consist of an upper quadrangular pyramid section and a lower quadrangular pyramid section, so that the prepared micropins are sharp-pointed bottom prisms and top pyramids. The depth of the microperforations may be 50-1000 μm, each side length of the hole edge may be 10-1000 μm, the spacing of the microperforations may be 10-5000 μm, in this embodiment, the depth of the microperforations is 800 μm, each side length of the hole edge is 200 μm, and the spacing of the prismatic microperforations is 300 μm. For making the second die can be fine pave in the micropin hole inslot, the assembling die still includes a free stamping plate 3, stamping plate surface roughness is 0.5 ~ 10 mu m, is 1 mu m in this embodiment.

The manufacturing process of the combined die is as follows: firstly preparing a basic stainless steel mold, wherein the stainless steel mold is provided with a stainless steel microneedle array which has the same arrangement rule as the microneedle array, and then pouring and demolding PDMS on the stainless steel mold to obtain a mold body made of PDMS; pouring PDMS solution around the stainless steel template with lower eyelid, solidifying, demoulding to obtain a second template with upper eyelid female hole in the middle, coating the surface of the second template with adhesive solution, spreading in the microperforated hole of the mould body, and lightly pressing with the template plate to make the second template closely adhere to the mould body.

The use process of the combined die is as follows: taking the prepared microneedle material of the eye patch as hyaluronic acid as an example, taking down the molding plate, pouring hyaluronic acid solution into the female mold hole, standing for molding, and demolding to obtain the microneedle eye patch.

Example 2

A combined mold for preparing medical and aesthetic microneedle patches, which is a mold for producing microneedle embossing patches, is different from example 1 in that a second mold piece is used as an embossing second mold piece 2', as shown in fig. 6, the middle part of the embossing second mold piece is an embossing female mold hole 21', and the embossing female mold hole is a half-moon-shaped through hole.

Claims

1. The utility model provides a combined die for preparing medical and aesthetic micro needle subsides, includes the mould body and sets up the micropin hole array on the mould body, its characterized in that, the surface of mould body is equipped with circumference confined micropin hole groove, micropin hole array arranges in the micropin hole inslot, combined die still includes the second matrix that the cooperation mould body used, the middle part of second matrix is equipped with the female die hole, the second matrix covers in the micropin hole inslot.

2. The combination mold for preparing medical microneedle patch of claim 1, wherein the edge of the second mold sheet is spaced from the edge of the microneedle hole slot.

3. The combination mold for preparing a medical microneedle patch according to claim 1 or 2, wherein the upper surface of the second mold sheet is positioned in the microneedle hole groove.

4. The combination mold for preparing the medical and aesthetic microneedle patch according to claim 1, wherein the second mold sheet is made of polydimethylsiloxane, polytetrafluoroethylene, polystyrene, polyacrylic acid, polycarbonate or polymethyl methacrylate.

5. The combination die for preparing medical microneedle patches of claim 4, further comprising a die plate for flatly pressing the second die, wherein the die plate has a die surface with a surface flatness of 0.5-10 μm.

6. The combined die for preparing medical and aesthetic microneedle patches according to claim 1, wherein the depth of the microperforations is 50-1000 micrometers, and the distance between the microperforations is 10-5000 micrometers.

7. The combination mold for preparing medical microneedle patch according to claim 1 or 6, wherein the microperforations are in the shape of a pyramid or the microperforations are in the shape of an upper prism or a lower pyramid.

8. The assembling die for preparing medical micro needle patches according to claim 7, wherein the length of each edge of the hole edges of the micro needle holes is 10-1000 μm.

9. The combination mold for preparing medical and aesthetic microneedle patches according to claim 1, wherein the edge rows of the microneedle array are spaced from the microneedle grooves.

10. The combination mold for preparing the medical microneedle patch of claim 1, wherein the medical microneedle patch is one of an eye patch, a stature patch, a vaccinia patch, a mask patch, and a head-up patch.