CN219424116U - Quick extraction element of antibody - Google Patents
Quick extraction element of antibody Download PDFInfo
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- CN219424116U CN219424116U CN202320569924.8U CN202320569924U CN219424116U CN 219424116 U CN219424116 U CN 219424116U CN 202320569924 U CN202320569924 U CN 202320569924U CN 219424116 U CN219424116 U CN 219424116U
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Abstract
The utility model relates to the technical field of antibody development and discloses a rapid antibody extraction device. According to the utility model, multistage filtration can be carried out on antigen stock solution through the first filtering bag and the second filtering bag, the filtering effect is improved, the antigen stock solution can be collected and stored through the liquid storage tank, the air pressure at the bottoms of filter membranes in the first filtering bag and the second filtering bag can be reduced through the vacuum pump matched with a plurality of exhaust pipes, the filtered antigen stock solution can be received through the receiving measuring cylinder, the receiving measuring cylinder can be prevented from moving easily through the limiting cylinder, the antigen stock solution can be filtered through the filter membrane, the entry of the antigen stock solution into the exhaust pipes can be prevented through the liquid level monitoring device, the liquid level of the antigen stock solution can be monitored through the suspension blocks, the substances in the antigen stock solution can be crushed by ultrasonic wave through the ultrasonic wave patch, and the multistage filtering groups in the device can be prevented from being communicated through the electric valve.
Description
Technical Field
The utility model relates to the technical field of antibody development, in particular to a rapid antibody extraction device.
Background
An antibody refers to a protein having a protective effect produced by the body due to stimulation of an antigen, which is a large Y-shaped protein secreted by plasma cells and used by the immune system to identify and neutralize foreign substances such as bacteria or viruses, etc., found only in body fluids such as blood of vertebrates, and the cell membrane surface of B cells thereof. The antibody can be used as in vitro diagnostic reagent, medicine for treating diseases, ligand for immunoaffinity chromatography, etc.
The patent document of the public number of authorizing discloses a quick extraction element of antibody, including antibody inlet, the bottom fixedly connected with ultrasonic wave breaker of antibody inlet, the bottom swing joint of ultrasonic wave breaker has broken appearance outlet valve, the right side swing joint of broken appearance outlet valve has the ooff valve, the bottom swing joint of broken appearance outlet valve has the liquid mouth that divides. The antibody quick extraction device is characterized in that an antibody stock solution is placed into an ultrasonic breaker from an antibody liquid inlet through arrangement, coarse separation and fine separation are carried out by a primary separation extraction device and a secondary separation extraction device, and finally the antibody stock solution flows out from a total outlet valve and enters an extraction container, so that the effect of strong extraction capacity is achieved, and the three primary separation extraction devices and the secondary separation extraction devices are arranged in total through the extraction device and can work simultaneously, so that the problem that the antibody extraction speed is slower is effectively solved.
With respect to the related art in the above, the inventors consider that there are the following drawbacks:
the device can not increase the efficiency of the original liquid of antibody flowing through the filter membrane, is difficult to further improve extraction effect.
Disclosure of Invention
The utility model provides a rapid antibody extraction device, which aims to solve the technical problem that the device cannot increase the efficiency of an antibody raw liquid flowing through a filter membrane.
The utility model is realized by adopting the following technical scheme: an antibody rapid extraction device comprising: a case; the support frame is fixedly arranged at the top of the box body; the liquid storage tank is arranged on the support frame; the first filter bags are detachably arranged in the box body; the plurality of second filter bags are detachably arranged in the box body; the infusion tubes are detachably arranged between the first filter bags and the second filter bags respectively; the pressure regulating device is arranged in the box body and is used for regulating the air pressure in the first filtering bag and the second filtering bag.
Through above-mentioned technical scheme, can carry out multistage filtration through first filtration bag and second filtration bag to antigen stock solution, increase the filter effect, can collect the storage processing through the liquid storage jar to antigen stock solution.
As a further improvement of the scheme, the pressure regulating device comprises a vacuum pump and a plurality of exhaust pipes, wherein the vacuum pump is fixedly arranged in the box body, the exhaust pipes are respectively detachably arranged on the first filter bags and the second filter bags and are communicated with each other, and any exhaust pipe is fixedly connected with the air inlet end of the vacuum pump.
Through above-mentioned technical scheme, through vacuum pump cooperation a plurality of blast pipes, can reduce the inside filter membrane bottom atmospheric pressure of first filtration bag and second filtration bag, make the antibody stoste more quick through the filter membrane to increase filtration efficiency.
As a further improvement of the scheme, a limiting cylinder is fixedly arranged on the inner wall of the bottom of the box body, a material receiving measuring cylinder is arranged in the limiting cylinder, and the material receiving measuring cylinder is arranged corresponding to the liquid discharge end of the infusion tube.
Through above-mentioned technical scheme, can accept the antibody stoste that filters the completion through receiving the material graduated flask, can prevent to receive the material graduated flask to remove easily through spacing section of thick bamboo.
As a further improvement of the scheme, the filter membranes are fixedly arranged in the first filter bags and the second filter bags, the exhaust pipes are respectively positioned below the filter membranes, and the liquid level monitoring devices are arranged in the first filter bags and the second filter bags.
According to the technical scheme, the antigen stock solution can be filtered through the filter membrane, and the antigen stock solution can be prevented from entering the exhaust pipe through the liquid level monitoring device.
As a further improvement of the scheme, the liquid level monitoring device comprises two support rods, two limiting blocks, a suspension block and a sealing plate, wherein the two support rods are fixedly installed in the first filtering bag, the two limiting blocks are fixedly installed at the bottoms of the two support rods respectively, the suspension block is movably sleeved on the two support rods, and the sealing plate is fixedly installed at the top of the suspension block and is correspondingly arranged with the air inlet end of the exhaust pipe.
Through the technical scheme, the liquid level of the antibody stock solution is monitored through the suspension block, and when the liquid level of the antibody stock solution is higher, the suspension block rises to enable the sealing plate to seal the air inlet end of the exhaust pipe.
As a further improvement of the scheme, a plurality of ultrasonic patches are arranged on the outer wall of the liquid storage tank, a liquid inlet bucket is arranged at the top of the liquid storage tank, and the liquid inlet bucket is connected with the liquid storage tank through a liquid conveying pipe.
According to the technical scheme, substances in the body stock solution can be crushed by ultrasonic waves through the ultrasonic patches, so that the substances can more easily pass through the filter membrane.
As a further improvement of the scheme, the plurality of infusion tubes are provided with electric valves.
Through above-mentioned technical scheme, can prevent through the motorised valve that multistage filtration group from being linked together in this device.
Compared with the prior art, the utility model has the beneficial effects that:
according to the utility model, multistage filtration can be carried out on antigen stock solution through the first filtering bag and the second filtering bag, the filtering effect is improved, the antigen stock solution can be collected and stored through the liquid storage tank, the air pressure at the bottoms of filter membranes in the first filtering bag and the second filtering bag can be reduced through the vacuum pump matched with a plurality of exhaust pipes, so that the antibody stock solution can pass through the filter membranes more quickly, the filtering efficiency is improved, the filtered antibody stock solution can be received through the receiving measuring cylinder, the receiving measuring cylinder can be prevented from moving easily through the limiting cylinder, the antibody stock solution can be filtered through the filter membranes, the antibody stock solution can be prevented from entering the exhaust pipes through the liquid level monitoring device, the liquid level of the antibody stock solution is monitored through the suspension blocks, when the liquid level of the antibody stock solution is higher, the air inlet ends of the exhaust pipes are blocked by the suspension blocks, the substances in the antibody stock solution can be broken through ultrasonic wave by the ultrasonic wave patch, the antibody stock solution can be prevented from passing through the filter membranes more easily, and the multistage filtering groups in the device can be prevented from being communicated through the electric valve.
Drawings
FIG. 1 is a schematic diagram showing a front sectional structure of an antibody rapid extraction device according to the present utility model;
FIG. 2 is a schematic elevational cross-sectional view of a second filter capsule of the present utility model;
FIG. 3 is an enlarged schematic view of the structure of FIG. 2A;
fig. 4 is a schematic three-dimensional structure of a second filter capsule according to the present utility model.
Main symbol description:
1. a case; 2. a support frame; 3. a liquid storage tank; 4. an ultrasonic patch; 5. a liquid inlet hopper; 6. a first filter capsule; 7. a second filter capsule; 8. an infusion tube; 9. an electric valve; 10. a limiting cylinder; 11. receiving a material measuring cylinder; 12. an exhaust pipe; 13. a vacuum pump; 14. a filter membrane; 15. a support rod; 16. a limiting block; 17. a suspension block; 18. and (5) a sealing plate.
Detailed Description
The present utility model will be further described with reference to the accompanying drawings and detailed description, wherein it is to be understood that, on the premise of no conflict, the following embodiments or technical features may be arbitrarily combined to form new embodiments.
Examples:
referring to fig. 1 to 4, the antibody rapid extraction apparatus of the present embodiment includes a case 1; the support frame 2 is fixedly arranged at the top of the box body 1; the liquid storage tank 3 is arranged on the support frame 2; the first filter bags 6 are detachably arranged in the box body 1; a plurality of second filter bags 7, wherein the second filter bags 7 are detachably arranged in the box body 1; a plurality of infusion tubes 8, the plurality of infusion tubes 8 being detachably mounted between the plurality of first filter bags 6 and the plurality of second filter bags 7, respectively; the pressure regulating device is arranged in the box body 1 and is used for regulating the air pressure in the first filtering bag 6 and the second filtering bag 7, multistage filtering can be carried out on antigen stock solution through the first filtering bag 6 and the second filtering bag 7, the filtering effect is improved, and the antigen stock solution can be collected and stored through the liquid storage tank 3.
The pressure regulating device comprises a vacuum pump 13 and a plurality of exhaust pipes 12, wherein the vacuum pump 13 is fixedly arranged in the box body 1, the exhaust pipes 12 are respectively detachably arranged on the first filter bags 6 and the second filter bags 7 and are communicated with each other, any exhaust pipe 12 is fixedly connected with the air inlet end of the vacuum pump 13, the air pressure at the bottom of the filter film 14 inside the first filter bags 6 and the second filter bags 7 can be reduced by matching the vacuum pump 13 with the exhaust pipes 12, so that the antibody stock solution passes through the filter film 14 more rapidly, and the filtering efficiency is increased.
The bottom inner wall of the box body 1 is fixedly provided with a limiting cylinder 10, a material receiving measuring cylinder 11 is arranged in the limiting cylinder 10, the material receiving measuring cylinder 11 is correspondingly arranged with the liquid discharging end of the infusion tube 8, filtered antibody stock solution can be received through the material receiving measuring cylinder 11, and the material receiving measuring cylinder 11 can be prevented from moving easily through the limiting cylinder 10.
The filter membranes 14 are fixedly arranged in the first filter bags 6 and the second filter bags 7, the exhaust pipes 12 are respectively positioned below the filter membranes 14, liquid level monitoring devices are arranged in the first filter bags 6 and the second filter bags 7, the antigen stock solution can be filtered through the filter membranes 14, and the antigen stock solution can be prevented from entering the exhaust pipes 12 through the liquid level monitoring devices.
The liquid level monitoring device comprises two supporting rods 15, two limiting blocks 16, a suspension block 17 and a sealing plate 18, wherein the two supporting rods 15 are fixedly installed in the first filtering bag 6, the two limiting blocks 16 are fixedly installed at the bottoms of the two supporting rods 15 respectively, the suspension block 17 is movably sleeved on the two supporting rods 15, the sealing plate 18 is fixedly installed at the top of the suspension block 17 and is correspondingly arranged with the air inlet end of the exhaust pipe 12, the liquid level of the antibody stock solution is monitored through the suspension block 17, and when the liquid level of the antibody stock solution is higher, the suspension block 17 rises to enable the sealing plate 18 to seal the air inlet end of the exhaust pipe 12.
Be provided with a plurality of ultrasonic wave paster 4 on the outer wall of liquid storage pot 3, the top of liquid storage pot 3 is provided with feed liquor fill 5, and feed liquor fill 5 is connected with liquid storage pot 3 through transfer line 8, can carry out the ultrasonic wave through ultrasonic wave paster 4 to the material in the antigen stock solution and break, makes it pass filter membrane 14 more easily.
The electric valves 9 are arranged on the infusion tubes 8, and the electric valves 9 can prevent the multi-stage filtration groups in the device from being communicated.
The implementation principle of the antibody rapid extraction device in the embodiment of the application is as follows: when the anti-virus antibody liquid filling device is used, stock solution is poured into the liquid inlet hopper 5, the anti-virus antibody liquid flows into the liquid conveying pipe 8, the ultrasonic patch 4 is opened to break substances in the anti-virus antibody liquid, the anti-virus antibody liquid is respectively discharged to the first filtering bag 6 and the second filtering bag 7 for graded filtering, the filtered anti-virus antibody liquid is discharged to the material receiving measuring cylinder 11, the vacuum pump 13 is started during filtering to reduce the air pressure at the bottom of the filter membrane 14 in the filtering bag, the anti-virus antibody liquid passes through the filter membrane 14 more rapidly, the filtering efficiency is improved, the liquid level of the anti-virus antibody liquid is monitored through the suspension block 17, and when the liquid level of the anti-virus antibody liquid is higher, the suspension block 17 is lifted to enable the sealing plate 18 to seal the air inlet end of the exhaust pipe 12, so that the anti-virus antibody liquid is prevented from entering the exhaust pipe 12.
The above embodiments are only preferred embodiments of the present utility model, and the scope of the present utility model is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present utility model are intended to be within the scope of the present utility model as claimed.
Claims (7)
1. An antibody rapid extraction device, comprising:
a case;
the supporting frame is fixedly arranged at the top of the box body;
the liquid storage tank is arranged on the support frame;
the first filter bags are detachably arranged in the box body;
the second filter bags are detachably arranged in the box body;
the infusion tubes are detachably arranged between the first filter bags and the second filter bags respectively;
the pressure regulating device is arranged in the box body and is used for regulating the air pressure in the first filter bag and the air pressure in the second filter bag.
2. The rapid antibody extraction device according to claim 1, wherein the pressure regulating device comprises a vacuum pump and a plurality of exhaust pipes, the vacuum pump is fixedly installed in the box body, the exhaust pipes are detachably installed on the first filter bags and the second filter bags respectively and are communicated with each other, and any exhaust pipe is fixedly connected with an air inlet end of the vacuum pump.
3. The rapid antibody extraction device according to claim 1, wherein a limiting cylinder is fixedly arranged on the inner wall of the bottom of the box body, a material receiving measuring cylinder is arranged in the limiting cylinder, and the material receiving measuring cylinder is arranged corresponding to the liquid discharge end of the infusion tube.
4. The rapid antibody extraction device according to claim 2, wherein a plurality of filter bags are fixedly provided with filter membranes in the first filter bags and the second filter bags, the exhaust pipes are respectively positioned below the filter membranes, and liquid level monitoring devices are respectively arranged in the first filter bags and the second filter bags.
5. The rapid antibody extraction device according to claim 4, wherein the liquid level monitoring device comprises two support rods, two limiting blocks, a suspension block and a sealing plate, wherein the two support rods are fixedly installed in the first filtering bag, the two limiting blocks are fixedly installed at the bottoms of the two support rods respectively, the suspension block is movably sleeved on the two support rods, and the sealing plate is fixedly installed at the top of the suspension block and is arranged corresponding to an air inlet end of the exhaust pipe.
6. The rapid antibody extraction device of claim 1, wherein a plurality of ultrasonic patches are arranged on the outer wall of the liquid storage tank, a liquid inlet bucket is arranged at the top of the liquid storage tank, and the liquid inlet bucket is connected with the liquid storage tank through the infusion tube.
7. The rapid antibody extraction device of claim 1, wherein a plurality of said infusion tubes are each provided with an electrically operated valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320569924.8U CN219424116U (en) | 2023-03-22 | 2023-03-22 | Quick extraction element of antibody |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320569924.8U CN219424116U (en) | 2023-03-22 | 2023-03-22 | Quick extraction element of antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219424116U true CN219424116U (en) | 2023-07-28 |
Family
ID=87331200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320569924.8U Active CN219424116U (en) | 2023-03-22 | 2023-03-22 | Quick extraction element of antibody |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219424116U (en) |
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2023
- 2023-03-22 CN CN202320569924.8U patent/CN219424116U/en active Active
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