CN219369669U - Automatic sample injection system for continuous reaction on-line liquid chromatography detection - Google Patents
Automatic sample injection system for continuous reaction on-line liquid chromatography detection Download PDFInfo
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- CN219369669U CN219369669U CN202320187689.8U CN202320187689U CN219369669U CN 219369669 U CN219369669 U CN 219369669U CN 202320187689 U CN202320187689 U CN 202320187689U CN 219369669 U CN219369669 U CN 219369669U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
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Abstract
The utility model provides an automatic sample injection system for continuous reaction on-line liquid chromatography detection, which is applied to the field of continuous reaction detection, and the technical scheme is as follows: comprises a mounting table; set up in mount table: a mixer; the device comprises a first multichannel injection pump, wherein the channels of the first multichannel injection pump comprise a plurality of a-type channels connected with a plurality of detection sites through pipelines and a b-type channel connected with a mixer; a second multi-channel syringe pump, the channels of the second multi-channel syringe pump comprising a c-type channel connected to the mixer and a d-type channel connected to the diluent storage location; the quantitative ring of the six-way sample injection valve is connected with the mixer, and the six-way sample injection valve rotates to the sample injection position of the liquid chromatograph under the drive of the motor; the method has the technical effects that: can replace manual work to sample, dilute, send out and examine the work to the reaction liquid.
Description
Technical Field
The utility model relates to the field of continuous reaction detection, in particular to an automatic sample injection system for continuous reaction on-line liquid chromatography detection.
Background
In the field of pharmaceutical fine chemical industry, continuous processes are increasingly paid attention to, and the continuous processes are increasingly applied to industrial production practice due to the advantages of intrinsic safety, environmental protection, automation, large capacity and the like, as shown in a conceptual diagram of continuous reaction in fig. 1, various reactants are conveyed to a continuous reaction device 11 through respective conveying pumps 10 for reaction, the reaction device comprises a plurality of reaction components, the reaction components are connected through pipelines, and the reaction components are collected through the pipelines to a receiving device 12 after being reacted; in industrial production, it is necessary to constantly understand the stability of the production process of the production device, and thus, it is necessary to provide a plurality of detection sites 13 on the pipeline, and continuously or periodically sample and analyze the detection sites 13.
In the development process of continuous process, the optimal residence time of reaction and the change condition of components after changing reaction parameters are known, the reaction liquid is needed to be analyzed, and most of the works are manually sampled and diluted at present, and then liquid chromatography analysis is carried out, so that the workload and error probability of an analyzer are certainly increased.
The liquid chromatography is a mature quantitative analysis technology, has higher requirements on quantitative accuracy in the analysis process in the fields of pharmacy, fine chemical industry and the like, and the continuous process development process is used for detecting the concentration change of feed liquid, the content of related substances and the like, and the liquid chromatography is certainly the most advantageous analysis method, so that a universal online sampling and sample injection system applied to a continuous reaction system is needed to replace manual operation.
Disclosure of Invention
The utility model aims to provide an automatic sample injection system for continuous reaction on-line liquid chromatography detection, which has the advantages of being capable of replacing manual sampling, dilution and inspection work of reaction liquid.
To achieve the above and other related objects, the present utility model provides the following technical solutions: an automatic sample injection system for continuous reaction on-line liquid chromatography detection comprises a mounting table;
still including set up in the mount pad:
a mixer;
the channel of the first multichannel injection pump comprises a plurality of a-type channels connected with a plurality of detection sites through pipelines and a b-type channel connected with the mixer;
a second multi-channel syringe pump, the channels of the second multi-channel syringe pump comprising a c-type channel connected to the mixer and a d-type channel connected to a diluent storage location; the method comprises the steps of,
the quantitative ring of the six-way sample injection valve is connected with the mixer, and the six-way sample injection valve rotates to the sample injection position of the liquid chromatograph under the drive of the motor.
Through the technical scheme, the first multichannel injection pump firstly extracts the reaction liquid from the detection site, then drives the reaction liquid into the mixer, meanwhile, the second multichannel injection pump extracts the dilution solvent from the dilution solvent storage position, then drives the dilution solvent into the mixer, the reaction liquid and the dilution solvent are mixed in the mixer, the reaction liquid is diluted and then conveyed to the six-way sampling valve, the diluted reaction liquid is accumulated in the quantitative ring, the liquid exceeding the quantitative ring is discharged from the liquid outlet of the six-way sampling valve, and the six-way sampling valve is rotated to the sample injection position of the liquid chromatograph under the drive of the motor, so that the sampling and conveying processes of the reaction liquid are completed.
In an embodiment of the utility model, the device further comprises a first waste liquid bottle, wherein the first waste liquid bottle is placed on the mounting table, and the channel of the first multi-channel injection pump further comprises an e-type channel connected with the first waste liquid bottle.
Through the technical scheme, the first multichannel injection pump drives the residual reaction liquid into the first waste liquid bottle through the e-type channel after the primary sampling detection is finished, so that the residual reaction liquid is prevented from interfering the next sampling detection result.
In an embodiment of the present utility model, the cleaning agent injection device further includes a cleaning agent storage box, the cleaning agent storage box is disposed on the mounting table, and the channel of the second multi-channel injection pump further includes an f-type channel connected to the cleaning agent storage box.
Through the technical scheme, after the system finishes one-time sampling detection, the cleaning agent can be pumped by the second multichannel injection pump, and then the cleaning agent is pumped into the follow-up device and the pipeline to clean the follow-up device and the pipeline, so that the system has a self-cleaning function.
In an embodiment of the utility model, the device further comprises a second waste liquid bottle, wherein the second waste liquid bottle is placed on the mounting table, and the liquid outlet of the six-way sample injection valve is connected with the second waste liquid bottle through a pipeline.
Through the technical scheme, the redundant waste liquid discharged from the liquid outlet of the six-way sample injection valve enters the second waste liquid bottle for collection, so that the system is clean in operation.
In an embodiment of the utility model, the first multi-channel injection pump, the second multi-channel injection pump and the six-way injection valve are connected with the PLC through a communication program.
Through the technical scheme, the communication program and the PLC control the first multichannel injection pump, the second multichannel injection pump and the six-way sampling valve to automatically operate, so that the system can automatically sample and detect, and manual operation is avoided.
As described above, the automatic sample injection system for continuous reaction on-line liquid chromatography detection has the following beneficial effects:
the first multichannel injection pump firstly extracts the reaction liquid from the detection site, then drives the reaction liquid into the mixer, meanwhile, the second multichannel injection pump extracts the dilution solvent from the dilution solvent storage position, then drives the dilution solvent into the mixer, the reaction liquid and the dilution solvent are mixed in the mixer, the reaction liquid is diluted and then is conveyed to the six-way sampling valve, the diluted reaction liquid is accumulated in the quantitative ring, the liquid exceeding the quantitative ring is discharged from the liquid outlet of the six-way sampling valve, and the six-way sampling valve is rotated to the sample injection position of the liquid chromatograph under the drive of the motor, so that the sampling and conveying processes of the reaction liquid are completed.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present utility model.
Reference numerals: 1. a mixer; 2. a first multichannel syringe pump; 3. a second multi-channel syringe pump; 4. a diluent solvent storage location; 5. a six-way sample injection valve; 6. a liquid chromatograph; 7. a first waste liquid bottle; 8. a detergent storage box; 9. a second waste liquid bottle; 10. a transfer pump; 11. a continuous reaction device; 12. a receiving device; 13. a detection site; 14. and (5) a mounting table.
Detailed Description
Further advantages and effects of the present utility model will become apparent to those skilled in the art from the disclosure of the present utility model, which is described by the following specific examples.
Please refer to fig. 1. It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the utility model to the extent that it can be practiced, since modifications, changes in the proportions, or otherwise, used in the practice of the utility model, are not intended to be critical to the essential characteristics of the utility model, but are intended to fall within the spirit and scope of the utility model. Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the utility model, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the utility model may be practiced.
Referring to fig. 1, the present utility model provides an automatic sample injection system for continuous reaction online liquid chromatography detection, comprising: a mounting table 14.
Referring to fig. 1, the mixer 1 is further provided to be screwed to the mounting table 14.
Referring to fig. 1, the device further includes a first multi-channel injection pump 2 disposed on the workbench, where channels of the first multi-channel injection pump 2 include a plurality of a-type channels connected to a plurality of detection sites 13 through a pipeline and a b-type channel connected to the mixer 1 through a pipeline, in this embodiment, four detection sites 13 are provided, and four a-type channels are correspondingly provided; the channel of the first multi-channel syringe pump 2 also comprises a first waste liquid bottle 7 and an e-type channel connected with the first waste liquid bottle 7 through a pipeline.
Referring to fig. 1, the device further comprises a second multi-channel injection pump 3 placed on the workbench, wherein the channels of the second multi-channel injection pump 3 comprise a c-type channel connected with the mixer 1 through a pipeline and a d-type channel connected with the diluent storage position 4 through a pipeline; also included is a detergent storage box 8, and the channels of the second multi-channel syringe pump 3 also include a class f channel connected to the detergent storage box 8 by tubing.
Referring to fig. 1, the liquid chromatograph further comprises a six-way sample injection valve 5, wherein the stator part is fixed on the mounting table 14 through screws, a quantitative ring of the six-way sample injection valve 5 is connected with the mixer 1 through a pipeline, and the six-way sample injection valve 5 rotates to a sample injection position of the liquid chromatograph 6 under the drive of a motor; the liquid discharge port of the six-way sample injection valve 5 is connected with the second liquid discharge bottle 9 through a pipeline, and the second liquid discharge bottle 9 collects liquid exceeding the volume of the quantitative ring.
Referring to fig. 1, a first multi-channel injection pump 2, a second multi-channel injection pump 3 and a six-way sampling valve 5 are connected with a PLC through a communication program, and the communication program and the PLC control the first multi-channel injection pump 2, the second multi-channel injection pump 3 and the six-way sampling valve 5 to operate automatically, so that the system can perform sampling detection automatically, and manual operation is avoided.
The use process is briefly described: the first multichannel injection pump 2 firstly extracts the reaction liquid from the detection site 13, then pumps the reaction liquid into the mixer 1, meanwhile, the second multichannel injection pump 3 extracts the dilution solvent from the dilution solvent storage position 4, then pumps the dilution solvent into the mixer 1, the reaction liquid and the dilution solvent are mixed in the mixer 1, the reaction liquid is diluted and then is conveyed to the six-way sampling valve, the diluted reaction liquid is accumulated in the quantitative ring, the liquid exceeding the quantitative ring is discharged from the liquid outlet of the six-way sampling valve, and the six-way sampling valve is rotated to the sample injection position of the liquid chromatograph 6 under the drive of the motor, so that the sampling and conveying processes of the reaction liquid are completed.
In conclusion, the utility model can replace manual sampling, dilution and inspection work of the reaction liquid. Therefore, the utility model effectively overcomes various defects in the prior art and has high industrial utilization value.
The above embodiments are merely illustrative of the principles of the present utility model and its effectiveness, and are not intended to limit the utility model. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the utility model. Accordingly, it is intended that all equivalent modifications and variations of the utility model be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (5)
1. An automatic sample injection system for continuous reaction on-line liquid chromatography detection comprises a mounting table (14);
the device is characterized by further comprising a mounting table (14):
a mixer (1);
the device comprises a first multichannel injection pump (2), wherein the channels of the first multichannel injection pump (2) comprise a plurality of a-type channels connected with a plurality of detection sites (13) through pipelines and a b-type channel connected with the mixer (1);
a second multi-channel syringe pump (3), the channels of the second multi-channel syringe pump (3) comprising a c-channel connected to the mixer (1) and a d-channel connected to a diluent solvent storage location (4); the method comprises the steps of,
the six-way sample injection valve (5), the quantitative ring of the six-way sample injection valve (5) is connected with the mixer (1), and the six-way sample injection valve (5) rotates to the sample injection position of the liquid chromatograph (6) under the drive of the motor.
2. The automated sample injection system for continuous reaction on-line liquid chromatography detection of claim 1, wherein: still include first waste liquid bottle (7), first waste liquid bottle (7) place in mount table (14), the passageway of first multichannel syringe pump (2) still include with e class passageway that first waste liquid bottle (7) are connected.
3. The automated sample injection system for continuous reaction on-line liquid chromatography detection of claim 1, wherein: still include cleaner storage box (8), cleaner storage box (8) set up in mount table (14), the passageway of second multichannel syringe pump (3) still include with cleaner storage box (8) be connected f type passageway.
4. The automated sample injection system for continuous reaction on-line liquid chromatography detection of claim 1, wherein: the device also comprises a second waste liquid bottle (9), wherein the second waste liquid bottle (9) is arranged on the mounting table (14), and the liquid outlet of the six-way sample injection valve (5) is connected with the second waste liquid bottle (9) through a pipeline.
5. The automated sample injection system for continuous reaction on-line liquid chromatography detection of claim 1, wherein: the first multichannel injection pump (2), the second multichannel injection pump (3) and the six-way sampling valve (5) are connected with the PLC through communication programs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202320187689.8U CN219369669U (en) | 2023-02-10 | 2023-02-10 | Automatic sample injection system for continuous reaction on-line liquid chromatography detection |
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| CN202320187689.8U CN219369669U (en) | 2023-02-10 | 2023-02-10 | Automatic sample injection system for continuous reaction on-line liquid chromatography detection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220236235A1 (en) * | 2021-01-27 | 2022-07-28 | Agilent Technologies, Inc. | Mounting a sample separation unit by a swivel mechanism |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220236235A1 (en) * | 2021-01-27 | 2022-07-28 | Agilent Technologies, Inc. | Mounting a sample separation unit by a swivel mechanism |
| US11921093B2 (en) * | 2021-01-27 | 2024-03-05 | Agilent Technologies, Inc. | Mounting a sample separation unit by a swivel mechanism |
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