CN219356555U

CN219356555U - Exosome separation extraction element

Info

Publication number: CN219356555U
Application number: CN202320936609.4U
Authority: CN
Inventors: 孔祥梅; 张艳
Original assignee: Shandong Huasi Biotechnology Co ltd
Current assignee: Shandong Huasi Biotechnology Co ltd
Priority date: 2023-04-24
Filing date: 2023-04-24
Publication date: 2023-07-18
Anticipated expiration: 2033-04-24

Abstract

The utility model relates to the field of exosomes, and discloses an exosome separation and extraction device, which effectively solves the problems that a separating cylinder is not easy to take out and liquid in the separating cylinder is inconvenient to take out due to the fact that the separating cylinder is fixedly installed with a transmission rod at present.

Description

Exosome separation extraction element

Technical Field

The utility model belongs to the field of exosomes, and particularly relates to an exosome separation and extraction device.

Background

According to the grant publication number of CN217120560U, the utility model is named as a serum exosome separation and extraction device, and the specification of the serum exosome separation and extraction device is as follows: in the actual use process, serum is directly poured into the separating cylinder, and then the cylinder cover is closed; the motor is started to work through the controller, the motor drives the transmission rod to rotate, and the transmission rod drives the whole separation cylinder to rotate through the fixed block, so that serum in the whole separation cylinder rotates along with the transmission rod; carry out centrifugal work in the rotation process, the exosome that accords with the dimensional requirement throws away from the centrifugal hole, and wherein separating drum and transfer line fixed mounting have following defect:

because the separating cylinder is fixedly arranged with the transmission rod, the separating cylinder is not easy to be taken out, thereby being inconvenient to take out liquid in the separating cylinder.

Disclosure of Invention

Aiming at the situation, in order to overcome the defects of the prior art, the utility model provides the exosome separation and extraction device, which effectively solves the problems that the prior separation barrel is not easy to take out and the liquid in the separation barrel is inconvenient to take out due to the fact that the separation barrel is fixedly arranged with the transmission rod.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the exosome separation and extraction device comprises an outer barrel, wherein a support frame is arranged on the inner bottom wall of the outer barrel, and a centrifugal separation assembly is arranged at the top end of the support frame;

the centrifugal separation assembly comprises a motor arranged at the top end of the supporting frame, a rotary drum is arranged at the top end of an output shaft of the motor, filtering holes are uniformly formed in the outer wall of the rotary drum, a clamping piece is arranged at the bottom end of the rotary drum, and a clamping assembly is arranged at the outer side of the rotary drum.

Preferably, the clamping piece comprises a mounting groove arranged at the bottom end of the rotary drum, and limit grooves are symmetrically formed in two sides of the mounting groove.

Preferably, the output shaft joint of motor is in the inside of mounting groove, and the stopper is installed to the output shaft bilateral symmetry of motor, stopper and spacing groove sliding connection.

Preferably, the clamping assembly comprises a bearing disc arranged on the outer side of the rotary drum, the top end of one side, close to the rotary drum, of the bearing disc is positioned below the filtering holes, an air cylinder is arranged below the bearing disc, the output end of the air cylinder is in contact with the bottom wall of the bearing disc, and the air cylinder is arranged on the outer cylinder.

Preferably, clamping grooves are symmetrically formed in two sides of the bearing plate, and clamping rods are clamped in the clamping grooves.

Preferably, the clamping rod is movably connected with the outer cylinder, a limiting plate is arranged at one end of the clamping rod, which is positioned outside the outer cylinder, a spring is arranged at one side of the limiting plate, which is close to the outer cylinder, and one end of the spring is fixedly connected with the outer wall of the outer cylinder.

Preferably, the first baffle is installed on the outer side of the rotary drum, the second baffle is installed on one side, close to the rotary drum, of the receiving disc, and the bottom wall of the second baffle is in contact with the top wall of the first baffle.

Compared with the prior art, the utility model has the beneficial effects that:

(1) According to the utility model, the rotary drum is arranged on the output shaft of the motor along the limiting block and the limiting groove, the bearing disc is sleeved on the outer side of the rotary drum, so that the clamping rod fixedly clamps the bearing disc, and the second baffle plate on the bearing disc is positioned above the first baffle plate on the rotary drum, so that the rotary drum is positioned, the rotation stability of the rotary drum is improved, the rotary drum can be disassembled and assembled, and the rotary drum is convenient to use;

(2) This novel outside pull out the kelly of both sides, open the cylinder to make the output of cylinder upwards stretch out the back, upwards push out the tray that will accept, thereby make things convenient for the take out of tray that accepts, improve treatment effeciency.

Drawings

The accompanying drawings are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the embodiments of the utility model, serve to explain the utility model.

In the drawings:

FIG. 1 is a schematic diagram of an exosome separation and extraction device according to the present utility model;

FIG. 2 is a schematic view of the internal structure of the outer cylinder of the present utility model;

FIG. 3 is a schematic view of the structure of the receiving tray of the present utility model;

FIG. 4 is a schematic view of a drum structure according to the present utility model;

FIG. 5 is a schematic view of the structure of a first baffle and a second baffle according to the present utility model;

in the figure: 1. an outer cylinder; 2. a support frame; 3. a centrifugal separation assembly; 301. a motor; 302. a rotating drum; 303. a filter hole; 304. a limiting block; 305. a mounting groove; 306. a limit groove; 307. a first baffle; 308. a second baffle; 4. a clamping assembly; 401. a receiving tray; 402. a cylinder; 403. a clamping groove; 404. a clamping rod; 405. a limiting plate; 406. and (3) a spring.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model; all other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

1-5, the utility model comprises an outer cylinder 1, a supporting frame 2 is arranged on the inner bottom wall of the outer cylinder 1, a centrifugal separation component 3 is arranged at the top end of the supporting frame 2, the centrifugal separation component 3 comprises a motor 301 arranged at the top end of the supporting frame 2, a rotary drum 302 is arranged at the top end of an output shaft of the motor 301, filtering holes 303 are uniformly arranged on the outer wall of the rotary drum 302, a clamping piece is arranged at the bottom end of the rotary drum 302, a clamping component 4 is arranged at the outer side of the rotary drum 302, the clamping piece comprises a mounting groove 305 arranged at the bottom end of the rotary drum 302, limit grooves 306 are symmetrically arranged at two sides of the mounting groove 305, the output shaft of the motor 301 is clamped in the mounting groove 305, limit blocks 304 are symmetrically arranged at two sides of the output shaft of the motor 301, the limit blocks 304 are in sliding connection with the limit grooves 306, the clamping component 4 comprises a bearing disc 401 arranged at the outer side of the rotary drum 302, the top end of one side of the receiving disc 401, which is close to the rotary drum 302, is positioned below the filtering holes 303, an air cylinder 402 is arranged below the receiving disc 401, the output end of the air cylinder 402 is in contact with the bottom wall of the receiving disc 401, the air cylinder 402 is arranged on the outer drum 1, clamping grooves 403 are symmetrically formed in two sides of the receiving disc 401, clamping rods 404 are clamped in the clamping grooves 403, the clamping rods 404 are movably connected with the outer drum 1, a limiting plate 405 is arranged at one end of the clamping rods 404, which is positioned at the outer side of the outer drum 1, a spring 406 is arranged at one side of the limiting plate 405, which is close to the outer drum 1, one end of the spring 406 is fixedly connected with the outer wall of the outer drum 1, a first baffle 307 is arranged at the outer side of the rotary drum 302, a second baffle 308 is arranged at one side of the receiving disc 401, which is close to the rotary drum 302, and the bottom wall of the second baffle 308 is in contact with the top wall of the first baffle 307;

the rotary drum 302 is installed on the output shaft of the motor 301 along the limiting block 304 and the limiting groove 306, the bearing disc 401 is sleeved on the outer side of the rotary drum 302, the clamping rod 404 is used for fixedly clamping the bearing disc 401, the second baffle 308 on the bearing disc 401 is located above the first baffle 307 on the rotary drum 302, so that the rotary drum 302 is positioned, the rotation stability of the rotary drum 302 is improved, the rotary drum 302 can be disassembled and assembled, the use is convenient, the clamping rods 404 on two sides are pulled outwards, the air cylinder 402 is started, the output end of the air cylinder 402 extends upwards, and then the bearing disc 401 is ejected upwards, so that the bearing disc 401 is conveniently taken out, and the processing efficiency is improved.

Working principle: when the rotary drum 302 is used, the rotary drum 302 is arranged on the output shaft of the motor 301 along the limiting block 304 and the limiting groove 306, the clamping rods 404 on two sides of the outer drum 1 are pulled out, then the bearing disc 401 is put into the outer drum 1, the bearing disc 401 is sleeved on the outer side of the rotary drum 302, and then the clamping rods 404 are loosened, so that the clamping rods 404 are clamped with the clamping grooves 403 on the bearing disc 401 under the action of the elastic force of the springs 406, and the second baffle 308 on the bearing disc 401 is positioned above the first baffle 307 on the rotary drum 302, so that the rotary drum 302 is positioned, the rotation stability of the rotary drum 302 is improved, the rotary drum 302 can be disassembled and assembled, and the rotary drum 302 is convenient to use;

when the centrifugal separation type blood serum separating device is used, serum needing to be centrifugally separated is added into the rotary drum 302, the motor 301 is started, the rotary drum 302 is driven to rotate by the rotation of the output shaft of the motor 301, so that exosomes smaller than the aperture of the filtering hole 303 are thrown out from the filtering hole 303, enter the receiving disc 401, are convenient to separate and extract, after separation is finished, clamping rods 404 on two sides are pulled outwards, then the air cylinder 402 is started, the output end of the air cylinder 402 stretches out upwards, the receiving disc 401 is pushed upwards, the receiving disc 401 is convenient to take out, the processing efficiency is improved, and finally the rotary drum 302 is taken out.

Claims

1. The utility model provides an exosome separation extraction element, includes urceolus (1), its characterized in that: a supporting frame (2) is arranged on the inner bottom wall of the outer cylinder (1), and a centrifugal separation assembly (3) is arranged at the top end of the supporting frame (2);

the centrifugal separation assembly (3) comprises a motor (301) arranged at the top end of the supporting frame (2), a rotary drum (302) is arranged at the top end of an output shaft of the motor (301), filtering holes (303) are uniformly formed in the outer wall of the rotary drum (302), clamping pieces are arranged at the bottom end of the rotary drum (302), and clamping assemblies (4) are arranged on the outer side of the rotary drum (302).

2. An exosome separation and extraction device according to claim 1, wherein: the clamping piece comprises a mounting groove (305) formed in the bottom end of the rotary drum (302), and limit grooves (306) are symmetrically formed in two sides of the mounting groove (305).

3. An exosome separation and extraction device according to claim 2, wherein: the output shaft of motor (301) joint is in the inside of mounting groove (305), and stopper (304) are installed to the output shaft bilateral symmetry of motor (301), stopper (304) and spacing groove (306) sliding connection.

4. An exosome separation and extraction device according to claim 1, wherein: the clamping assembly (4) comprises a bearing disc (401) arranged on the outer side of the rotary drum (302), the top end of one side, close to the rotary drum (302), of the bearing disc (401) is located below the filtering holes (303), an air cylinder (402) is arranged below the bearing disc (401), the output end of the air cylinder (402) is in contact with the bottom wall of the bearing disc (401), and the air cylinder (402) is mounted on the outer cylinder (1).

5. The exosome separation and extraction device according to claim 4, wherein: clamping grooves (403) are symmetrically formed in two sides of the receiving disc (401), and clamping rods (404) are clamped in the clamping grooves (403).

6. The exosome separation and extraction device according to claim 5, wherein: the clamping rod (404) is movably connected with the outer cylinder (1), a limiting plate (405) is arranged at one end of the clamping rod (404) located outside the outer cylinder (1), a spring (406) is arranged at one side of the limiting plate (405) close to the outer cylinder (1), and one end of the spring (406) is fixedly connected with the outer wall of the outer cylinder (1).

7. The exosome separation and extraction device according to claim 4, wherein: a first baffle (307) is arranged on the outer side of the rotary drum (302), a second baffle (308) is arranged on one side, close to the rotary drum (302), of the tray (401), and the bottom wall of the second baffle (308) is in contact with the top wall of the first baffle (307).