CN219302370U - Expiration detection device based on gas chromatography principle - Google Patents
Expiration detection device based on gas chromatography principle Download PDFInfo
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- CN219302370U CN219302370U CN202223257107.3U CN202223257107U CN219302370U CN 219302370 U CN219302370 U CN 219302370U CN 202223257107 U CN202223257107 U CN 202223257107U CN 219302370 U CN219302370 U CN 219302370U
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Abstract
The utility model discloses an expiration detection device based on a gas chromatography principle, which belongs to the technical field of expiration detection and comprises: a fourth line for inputting a gas sample; the air outlet end of the fourth pipeline is connected with the air inlet end of the sample chamber; a sample chamber for collecting and exchanging a gas sample; a first line for injecting a gas sample into the capillary column; the air outlet end of the capillary column is fixedly connected with the air inlet end of the sensor; a sensor for performing detection of a gas sample; and a data processor for reading the detection result of the sensor and processing and recording the detection result. Through the mode, the utility model designs the expiration detection device based on the principle of gas chromatography, which can be used for breath gas analysis, halitosis diagnosis and detection of known halitosis-marking gaseous compounds such as hydrogen sulfide, methyl mercaptan or dimethyl sulfide in a gas sample.
Description
Technical Field
The utility model relates to the technical field of expiration detection, in particular to an expiration detection device based on a gas chromatography principle.
Background
Traditional bad breath diagnosis methods are to smell the air exhaled from the mouth and nose separately and compare the two. This method is widely used but not accurate.
Gas chromatography is a well-established analytical technique commonly used to separate and detect various chemical components present in gases and low boiling liquids. The technology is widely applied to organic chemistry research, drug development and forensic specimen analysis. Gas chromatography systems typically have five main components: carrier gas, sample injector, gas chromatography column, detector and data processing system. Wherein the carrier gas, also referred to as the mobile phase, is a high purity and relatively inert gas, such as helium; the carrier gas flows through the column throughout the separation process. A sample injector for introducing a gaseous sample into a carrier gas flowing through the chromatographic column; gaseous samples typically comprise a number of different chemical components intended to be separated by a gas chromatograph. To achieve such separation, the chromatographic column is internally coated with a stationary phase, which can adsorb different chemical components in the sample to varying degrees; these adsorption differences result in different propagation delays of the chemical components as they move down the column, thereby achieving physical separation of the sample into its chemical components. The detector is located after the chromatographic column for detecting various chemical components in the sample as they flow out of the chromatographic column at different times. A data processing system for reading the detector and typically capable of storing, processing and recording the results.
In order to better use the gas chromatography principle for detecting halitosis, the utility model designs an expiration detecting device based on the gas chromatography principle to solve the problems.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present utility model provides an exhalation detection device based on the principle of gas chromatography.
In order to achieve the above purpose, the utility model is realized by the following technical scheme:
an exhalation detection apparatus based on gas chromatography principles, comprising:
a fourth line for inputting a gas sample; the air outlet end of the fourth pipeline is connected with the air inlet end of the sample chamber;
a sample chamber for collecting and exchanging a gas sample;
a first line for injecting a gas sample into the capillary column; the air inlet end of the first pipeline is connected with the air outlet end of the sample chamber, and the air outlet end of the first pipeline is connected with the air inlet end of the capillary column;
the air outlet end of the capillary column is fixedly connected with the air inlet end of the sensor;
a sensor for performing detection of a gas sample;
and a data processor for reading the detection result of the sensor and processing and recording the detection result.
Furthermore, the fourth pipeline, the first pipeline and the sample chamber are all detachably connected.
Furthermore, the air outlet end of the sensor is fixedly connected with an air outlet pipe.
Further, the air inlet end of the fourth pipeline is fixedly connected with a third pipeline; the other end of the third pipeline is fixedly connected with an air inlet pipe, a control valve is fixedly arranged on the air inlet pipe, and a two-way valve is fixedly arranged on the fourth pipeline.
Further, a three-way valve is arranged between the first pipeline and the capillary column, the air outlet end of the first pipeline and the air inlet end of the capillary column are respectively connected with two ends of the three-way valve, the other end of the three-way valve is connected with the air outlet end of the second pipeline, and the air inlet end of the second pipeline is fixedly communicated with the third pipeline.
Still further, still include the casing, sample room, first pipeline, capillary column, sensor, data processor, two-way valve, three-way valve, second pipeline, control valve, third pipeline and fourth pipeline are all fixed mounting in the inside of casing, and outlet duct and intake pipe are all pegged graft fixed connection on the casing.
Further, the pressures in the air inlet pipe, the third pipeline, the fourth pipeline and the sample chamber are all controlled to be 0.1-0.3 bar.
Further, the length of the capillary column is 1-5 m, the width is 25-100 μm, and the height is 40-200 μm.
Still further, the sensor is a semiconductor gas sensor selected from the group consisting of silicon microfabricated sensors.
Further, the data processor adopts a microcontroller capable of automatically controlling the measurement time sequence.
Advantageous effects
The gas sample to be analyzed is filled into the sample chamber, and the two-way valve is opened to pressurize the gas sample in the sample chamber; injecting an isobaric gas sample to be analyzed into a first pipeline from a sample chamber, injecting the sample into a second pipeline for conveying a carrier gas flow through the first pipeline, opening a three-way valve, conveying the sample into a capillary column with a controlled temperature by carrier gas, and separating gas compounds along with the time; electronically controlling the gas sample in the first pipeline to be injected into the capillary column within preset time through a three-way valve; gaseous compounds are detected by a sensor at the outlet end of the capillary column.
The utility model designs an expiration detection device based on the principle of gas chromatography, which can be used for breath gas analysis, halitosis diagnosis and detection of known halitosis-mark gaseous compounds such as hydrogen sulfide, methyl mercaptan or dimethyl sulfide in a gas sample. Can be used as supplement to traditional sensory measurement.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is evident that the drawings in the following description are only some embodiments of the present utility model and that other drawings may be obtained from these drawings without inventive effort for a person of ordinary skill in the art.
Fig. 1 is a schematic structural diagram of an exhalation detecting apparatus based on the gas chromatography principle of the present utility model.
Reference numerals in the drawings represent respectively:
1. the device comprises a housing 2, a sample chamber 3, a first pipeline 4, a capillary column 5, a sensor 6, a data processor 7, a two-way valve 8, a three-way valve 9, a second pipeline 10, an air outlet pipe 11, an air inlet pipe 12, a control valve 13, a third pipeline 14 and a fourth pipeline.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present utility model more clear, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. It will be apparent that the described embodiments are some, but not all, embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
The utility model is further described below with reference to examples.
Example 1
Referring to fig. 1 of the drawings, an exhalation detection apparatus based on gas chromatography principle includes:
a fourth line 14 for inputting a gas sample; the air outlet end of the fourth pipeline 14 is connected with the air inlet end of the sample chamber 2;
a sample chamber 2 for collecting and exchanging a gas sample;
a first line 3 for injecting a gas sample into the capillary column 4; the air inlet end of the first pipeline 3 is connected with the air outlet end of the sample chamber 2, and the air outlet end of the first pipeline 3 is connected with the air inlet end of the capillary column 4;
the air outlet end of the capillary column 4 is fixedly connected with the air inlet end of the sensor 5;
a sensor 5 for performing detection of a gas sample;
a data processor 6 for reading the detection result of the sensor 5 and processing and recording the detection result;
preferably, the fourth pipeline 14, the first pipeline 3 and the sample chamber 2 are all detachably connected;
the gas sample is collected in a specific volume, replaceable sample chamber 2, the sample chamber 2 being used for collecting and transporting carrier gas, the pressure in the sample chamber 2 typically being set between 0.1 and 0.3 bar;
the sample chamber 2 may employ a pre-concentrator element in which specific compounds of the gas sample may be captured at room temperature and released by heating the pre-concentrator wall;
the air outlet end of the sensor 5 is fixedly connected with an air outlet pipe 10;
the air inlet end of the fourth pipeline 14 is fixedly connected with the third pipeline 13; the other end of the third pipeline 13 is fixedly connected with an air inlet pipe 11, a control valve 12 is fixedly arranged on the air inlet pipe 11, and a two-way valve 7 is fixedly arranged on a fourth pipeline 14;
a three-way valve 8 is arranged between the first pipeline 3 and the capillary column 4, the air outlet end of the first pipeline 3 and the air inlet end of the capillary column 4 are respectively connected with two ends of the three-way valve 8, the other end of the three-way valve 8 is connected with the air outlet end of the second pipeline 9, and the air inlet end of the second pipeline 9 is fixedly communicated with the third pipeline 13;
the sample of gas to be analyzed is filled into the sample chamber 2, and after closing the two-way valve 7, different sample chambers 2 can be exchanged between the two measurements; preferably, the two ends of the sample chamber 2 are detachably connected with a pipe with a sealing cover, and when a sample is collected, a test object breathes directly into the pipe of the sample chamber 2 and can be transported by closing the sealing cover; when the detection is carried out, the sealing covers of the pipes at the two ends of the sample chamber 2 are taken down and are respectively spliced and fixed with the fourth pipeline 14 and the first pipeline 3; thereafter, the control valve 12 and the two-way valve 7 are opened to pressurize the gas sample in the sample chamber 2;
injecting an isobaric gas sample to be analyzed from the sample chamber 2 into the first line 3, the sample being injected through the first line 3 at the second line 9 carrying a flow of carrier gas, optionally pressurized ambient air or synthetic air; opening a three-way valve 8, and conveying a sample into the temperature-controlled capillary column 4 by carrier gas to separate gas compounds along with the time; electronically controlling the injection of the gas sample in the first pipeline 3 into the capillary column 4 within a preset time through the three-way valve 8; typically, the injection time is selected between 0.5s and 3 s; setting the starting point of the injection time as the starting point of the measurement time; gaseous compounds are detected by the sensor 5 at the outlet end of the capillary column 4.
The utility model designs an expiration detection device based on the principle of gas chromatography, which can be used for breath gas analysis, halitosis diagnosis and detection of known halitosis-mark gaseous compounds such as hydrogen sulfide, methyl mercaptan or dimethyl sulfide in a gas sample. Can be used as supplement to traditional sensory measurement.
Example 2
On the basis of example 1, referring to fig. 1 of the specification, it is preferable that the pressures in the air inlet pipe 11, the third pipe 13, the fourth pipe 14 and the sample chamber 2 are controlled to be 0.1-0.3 bar, and the pressures can be generated by a pump or a carrier gas container; supplying synthetic or ambient air into the system at a constant pressure;
preferably, capillary column 4 is a commercially available, well-established microfabricated separation column with a polymer coating; the interior of the capillary column 4 is coated with a polymer, such as PDMS (polydimethylsiloxane); the length, width and height of the capillary column 4 are designed for the particular gaseous compound to be separated and detected within a selected measurement time, typically between 1 and 5m in length, between 25 and 100 μm (microns) in width and between 40 and 200 μm (microns) in height;
the pressure of the carrier gas, the length of the capillary column 4, the temperature and the inner wall coating are chosen to achieve sufficient separation of the target compounds in as short a sample analysis time as possible.
Example 3
On the basis of the embodiment 2, referring to fig. 1 of the specification, the device further comprises a shell 1, a sample chamber 2, a first pipeline 3, a capillary column 4, a sensor 5, a data processor 6, a two-way valve 7, a three-way valve 8, a second pipeline 9, a control valve 12, a third pipeline 13 and a fourth pipeline 14 are fixedly arranged in the shell 1, and an air outlet pipe 10 and an air inlet pipe 11 are fixedly connected to the shell 1 in a plugging manner;
preferably, the sensor 5 uses a miniature gas sensor with high sensitivity having a fast response and recovery time; the sensor 5 is highly sensitive to volatile organic compounds;
preferably, sensor 5 may be a commercially available mature silicon micro-manufactured (mes) semiconductor gas sensor, the sensor signal being recorded by data processor 6, allowing identification and quantification of the compound by automatic peak detection, concentration being estimated from specific calibration using a reference gas in combination with peak area comparison calculations;
preferably, the data processor 6 may employ a microcontroller capable of automatically controlling the measurement timing (e.g., sample injection time, measurement time), and the data processor 6 may be further configured to read the detection result of the sensor 5 and store, process, and record the detection result.
The above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.
Claims (10)
1. An exhalation detection device based on the principle of gas chromatography, comprising:
a fourth line (14) for inputting a gas sample; the air outlet end of the fourth pipeline (14) is connected with the air inlet end of the sample chamber (2);
a sample chamber (2) for collecting and exchanging a gas sample;
a first line (3) for injecting a gaseous sample into the capillary column (4); the air inlet end of the first pipeline (3) is connected with the air outlet end of the sample chamber (2), and the air outlet end of the first pipeline (3) is connected with the air inlet end of the capillary column (4);
the air outlet end of the capillary column (4) is fixedly connected with the air inlet end of the sensor (5);
a sensor (5) for performing detection of a gas sample;
and a data processor (6) for reading the detection result of the sensor (5) and processing and recording the detection result.
2. The device according to claim 1, wherein the fourth line (14), the first line (3) and the sample chamber (2) are all detachably connected.
3. The exhalation detecting device based on the gas chromatography principle according to claim 1 or 2, characterized in that the air outlet end of the sensor (5) is fixedly connected with an air outlet pipe (10).
4. An exhalation detection apparatus based on the principle of gas chromatography according to claim 3, characterized in that the air inlet end of the fourth pipeline (14) is fixedly connected with a third pipeline (13); the other end of the third pipeline (13) is fixedly connected with an air inlet pipe (11), a control valve (12) is fixedly arranged on the air inlet pipe (11), and a two-way valve (7) is fixedly arranged on the fourth pipeline (14).
5. The exhalation detecting device based on the gas chromatography principle according to claim 4, wherein a three-way valve (8) is installed between the first pipeline (3) and the capillary column (4), the air outlet end of the first pipeline (3) and the air inlet end of the capillary column (4) are respectively connected with two ends of the three-way valve (8), the other end of the three-way valve (8) is connected with the air outlet end of the second pipeline (9), and the air inlet end of the second pipeline (9) is fixedly communicated with the third pipeline (13).
6. The device for detecting expiration based on the principle of gas chromatography according to claim 5, further comprising a housing (1), wherein the sample chamber (2), the first pipeline (3), the capillary column (4), the sensor (5), the data processor (6), the two-way valve (7), the three-way valve (8), the second pipeline (9), the control valve (12), the third pipeline (13) and the fourth pipeline (14) are fixedly installed in the housing (1), and the air outlet pipe (10) and the air inlet pipe (11) are fixedly connected to the housing (1) in a plugging manner.
7. The exhalation detection apparatus based on the gas chromatography principle according to claim 5 or 6, characterized in that the pressure in the air inlet tube (11), the third line (13), the fourth line (14) and the sample chamber (2) is controlled between 0.1 and 0.3bar.
8. The device according to claim 7, wherein the capillary column (4) has a length of 1-5 m, a width of 25-100 μm and a height of 40-200 μm.
9. An exhalation detection apparatus based on gas chromatography principle according to claim 1, 2, 4, 5, 6 or 8, characterized in that the sensor (5) is chosen from semiconductor gas sensors made of silicon micro-fabrication.
10. The exhalation detection apparatus based on the gas chromatography principle according to claim 9, characterized in that the data processor (6) employs a microcontroller capable of automatically controlling the measurement timing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223257107.3U CN219302370U (en) | 2022-12-06 | 2022-12-06 | Expiration detection device based on gas chromatography principle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223257107.3U CN219302370U (en) | 2022-12-06 | 2022-12-06 | Expiration detection device based on gas chromatography principle |
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| Publication Number | Publication Date |
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| CN219302370U true CN219302370U (en) | 2023-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202223257107.3U Active CN219302370U (en) | 2022-12-06 | 2022-12-06 | Expiration detection device based on gas chromatography principle |
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| CN (1) | CN219302370U (en) |
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- 2022-12-06 CN CN202223257107.3U patent/CN219302370U/en active Active
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