CN219289769U

CN219289769U - Auxiliary device for back drug administration of laboratory mice

Info

Publication number: CN219289769U
Application number: CN202222662418.1U
Authority: CN
Inventors: 徐启翔; 马秋曦; 鲁静; 张雪峰; 窦德虎
Original assignee: Jiangsu Dingtai Pharmaceutical Research Group Co ltd
Current assignee: Jiangsu Dingtai Pharmaceutical Research Group Co ltd
Priority date: 2022-10-10
Filing date: 2022-10-10
Publication date: 2023-07-04
Anticipated expiration: 2032-10-10

Abstract

The utility model provides an auxiliary device for back drug administration of an experimental mouse, which comprises a bottom plate; the bearing plate is positioned above the bottom plate, and the upper end surface of the bearing plate is an upward arched cambered surface and is used for bearing the laboratory mice; a limb fixing member, a first end of each limb fixing member is connected to a terminal of one of limbs of the laboratory mouse, and a second end is connected to the base plate, so that a back of the laboratory mouse is in a tensed state; an adjusting mechanism is arranged between the bottom plate and the bearing plate, and can be operated to deform the bearing plate, so that the radian of the cambered surface is changed to adapt to experimental mice with different sizes; the experimental mouse lies prone on the spandrel board that has the camber, four limbs are fixed by traction, because spandrel board's camber makes the back after the experimental mouse is fixed be in the camber state to make the back skin of experimental mouse spread, the staff of being convenient for administer the injection.

Description

Auxiliary device for back drug administration of laboratory mice

Technical Field

The utility model relates to the technical field of animal experiment auxiliary equipment, in particular to an auxiliary device for back drug administration of an experimental mouse.

Background

The laboratory mouse is the most commonly used laboratory animal in scientific research, and relates to a plurality of scientific research fields such as medicine, pharmacology, pathology, biology, microbiology and the like. When a drug test is performed on a laboratory mouse, back administration is generally selected, and when administration is performed, the laboratory mouse needs to be fixed and the skin of an injection site of the laboratory mouse needs to be grasped by hands so as to tighten the skin of the injection site.

The existing laboratory mice are fixed, the laboratory mice are generally placed on the back of the body and then are fixed on the wax plate through the pin, and the back skin of the laboratory mice is extruded and contracted together after being fixed in a flat state, so that administration injection is inconvenient for operators.

Therefore, the utility model provides the auxiliary device for back administration of the laboratory mice, which can spread the back of the laboratory mice to ensure that the skin of the back of the laboratory mice is in a tight state and is convenient for operators to administer and inject.

Disclosure of Invention

The utility model aims at overcoming the defects of the prior art and provides an auxiliary device for back administration of a laboratory mouse, which comprises the following components:

a bottom plate;

the supporting plate is an elastic thin plate and is positioned above the bottom plate, and the upper end surface of the supporting plate is an upward arched cambered surface and is used for supporting an experiment mouse lying on the upper surface of the cambered surface;

limb fixing members respectively provided corresponding to limbs of the laboratory mice, wherein a first end of each limb fixing member is connected to a distal end of one of the limbs of the laboratory mice, and a second end is connected to a side surface of the base plate;

an adjusting mechanism is arranged between the bottom plate and the bearing plate, penetrates through the bottom plate and extends to be connected with the bottom of the bearing plate; the adjustment mechanism can be operated to move up or down to adjust the arc of the support plate.

As an alternative embodiment, the carrier plate comprises an arcuate stainless steel elastomeric sheet.

As an alternative embodiment, an anti-slip cushion layer is attached to the upper surface of the stainless steel elastic sheet.

As an alternative embodiment, the anti-slip cushion is a rubber cushion or silica gel cushion with a thickness of 0.5-2 mm.

As an alternative embodiment, the two ends of the supporting plate are provided with flat parts, the flat parts are respectively and movably clamped into sliding grooves arranged on two sides of the bottom plate, the locking positions are locked by locking bolts arranged on two sides of the bottom plate, and the locking bolts penetrate through the lower surface of the bottom plate to enter the sliding grooves and can be screwed into the flat parts of the supporting plate on the corresponding side.

As an alternative embodiment, a connecting bracket is arranged at the middle position of the bottom end of the supporting plate, and the connecting bracket is provided with internal threads;

the adjusting mechanism adopts an inverted T-shaped stud, penetrates through the bottom plate and is in threaded connection with the connecting bracket.

As an alternative embodiment, the limb fixation means comprises a tether and a bolt, the first end of each tether tethering the end of one of the limbs of the laboratory mouse;

along the length direction of limbs of the mice, a plurality of bolts are respectively arranged on two side surfaces of the bottom plate at equal intervals, and the second end of each lead is fastened on the bolt in the corresponding direction of the limbs.

As an alternative embodiment, the lead is connected to the second end of the bolt, and is prefabricated into a hollow circular ring, and the inner diameter of the hollow circular ring is larger than the outer diameter of the bolt so as to be sleeved on the bolt.

As an alternative implementation mode, two side edges of the bottom plate are provided with a plurality of screw holes, and the bolts are connected into the screw holes.

As an alternative embodiment, the drawstring is an elastic string.

Compared with the prior art, the auxiliary device for back drug administration of the experimental mouse has the remarkable beneficial effects that:

(1) By arranging the elastic supporting plate with adjustable radian, the supporting surface of the supporting plate is an arc surface, the experimental mouse is prone to lie on the supporting plate with the arched radian, the limbs are pulled and fixed, and the back of the experimental mouse after being fixed is in an arched state due to the arched radian of the supporting plate, so that the back skin of the experimental mouse is spread, and the experimental mouse is convenient for staff to administer and inject;

(2) The arched radian of the bearing plate can be adjusted according to the sizes of the experimental mice so as to meet the fixing requirements of the experimental mice (experimental rats and experimental mice) with different sizes, and the practicability is good.

Drawings

The drawings are not intended to be drawn to scale. In the drawings, each identical or nearly identical component that is illustrated in various figures may be represented by a like numeral. For purposes of clarity, not every component may be labeled in every drawing. Embodiments of various aspects of the utility model will now be described, by way of example, with reference to the accompanying drawings, in which:

FIG. 1 is a front view of an accessory device for back administration of experimental mice shown in an embodiment of the present utility model;

FIG. 2 is a front view of an auxiliary device for experimental rat back administration according to an embodiment of the present utility model;

fig. 3 is a top view of an auxiliary device for back administration of laboratory mice according to the first embodiment of the present utility model.

In the drawings, the meaning of the reference numerals is as follows:

1. a bottom plate; 2. a bearing plate; 21. a connection bracket; 22. a chute; 23. a locking bolt; 3. a limb fixation member; 31. a rope; 32. a bolt; 4. an adjusting mechanism;

100. an experimental mouse;

200. a syringe.

Detailed Description

For a better understanding of the technical content of the present utility model, specific examples are set forth below, along with the accompanying drawings.

An auxiliary device for back administration of laboratory mice in connection with the embodiment shown in fig. 1-3 comprises a base plate 1, a carrier plate 2, a limb fixation means 3 and an adjustment mechanism 4.

Wherein the bearing plate 2 adopts an elastic thin plate and is positioned above the bottom plate 1.

In the example of the utility model, the upper end surface of the supporting plate 2 is an upwardly arched cambered surface for supporting the laboratory mice lying on the upper surface of the cambered surface.

The limb fixing members 3 are provided corresponding to the limbs of the laboratory mice, respectively, and each limb corresponds to one limb fixing member 3. The first end of each limb fixation member 3 is attached to the end of one of the limbs of the laboratory mouse, for example by knotting and fastening, and the second end is attached to the side of the base plate 1 corresponding to the limb direction, thereby achieving fixation of the limbs.

With reference to fig. 1 and 2, an adjusting mechanism 4 is arranged between the bottom plate 1 and the supporting plate 2, and the adjusting mechanism 4 penetrates through the bottom plate 1 and extends to be connected with the bottom of the supporting plate 2. The adjusting mechanism 4 can be operated to move up or down to adjust the radian of the supporting plate 2, and is suitable for experimental mice with different sizes, such as rats and mice, which belong to different biological branches, and belong to different experimental products in different pharmacological, toxicological and other drug experiments. For example, SD rats, ICR mice, etc., which have different characteristics in body size, growth cycle, body weight, habit, natural drug resistance, etc., are also selected differently in different drug experiments (e.g., respiratory tract drugs, infectious disease drugs, breast cancer drugs, cardiovascular disease drugs, hypertension drugs, digestive tract drugs, etc.).

Bottom plate

In the example of the present utility model, the base plate 1 is mainly used for installing the support plate 2, the limb fixing member 3 and the adjusting mechanism 4, and in practical use, the base plate 1 may be made of plastic or metal, and in this embodiment, a PP base plate is used as an example.

Screw holes are formed in two side edges of the bottom plate 1 and are mainly used for being matched with the limb fixing parts 3. For example, a plurality of bolts 32 are provided at equal intervals on both sides of the base plate 1 in the field direction along the limb of the laboratory mouse. The bolts 32 are attached into the screw holes.

The limb fixation means 3 comprises a tether 31 and a bolt 32, the first end of each tether 31 tethering the end of one of the limbs of the laboratory mouse.

The second end of each of the lead wires 31 is fastened to a bolt 32 in a corresponding direction along the length of the limb of the test mouse.

Thus, the four limb fixing members 3 can be used to fix the four limbs, thereby forming a binding as shown in fig. 3 for the experimental mice, and facilitating back administration.

As an alternative embodiment, the lead 31 is connected to the second end of the bolt 32, and is prefabricated as a hollow circular ring with an inner diameter larger than the outer diameter of the bolt 32, so as to be conveniently sleeved on the bolt 32.

In this embodiment, the drawstring 31 is an elastic string, such as a bungee cord, rubber cord, or the like.

Bearing plate

Referring to fig. 1 and 2, a support plate 2 is disposed above the bottom plate 1, and an upper end surface of the support plate 2 is an upwardly arched arc surface for supporting an experiment rat lying on the upper surface of the support plate.

As an alternative example, the support plate 2 is made of an elastic material and is prefabricated into an arc-shaped elastic thin plate with a certain curvature in an initial state. Optionally, the experimental mouse is made of PP or stainless steel, so that the experimental mouse is prone to lie on the supporting plate 2, and the back of the experimental mouse is arched and stretched by the middle of the supporting plate 2, so that administration and injection are facilitated.

In an alternative embodiment, an anti-slip cushion layer, such as a rubber cushion or a silica gel cushion with the thickness of 0.5-2mm, can be added on the upper surface of the supporting plate 2, so as to prevent the experimental mouse from sliding when lying on the upper surface, play an anti-slip effect, and improve the stability and efficiency of injection.

As an alternative example, the initial height of the curved elastic sheet is 3cm, this condition is suitable for experimental mouse support, and the length of the mouse is 4-6cm.

In the operation, as shown in the example of fig. 3, when the back administration is performed on the laboratory mouse, the laboratory mouse is first laid on the supporting plate 2, the back is kept upward, the limbs are outwards stretched, the first ends of the four lead wires 31 are respectively fastened on the two front limbs and the two rear limbs of the laboratory mouse, and the second ends are respectively sleeved on the four bolts 32 in the corresponding directions of the limbs, so that the holding of the laboratory mouse on the supporting plate 2 is completed.

Adjusting mechanism

Further, as shown in fig. 1 and 2, since the laboratory mice generally include mice and rats used in different experiments, the laboratory mice are very small in size, the required arch radian is high, the required arch radian of the laboratory rats is low, the arch radian of the laboratory rats is different from the arch radian of the floor support plate 2, and in order to meet the bearing requirements of the laboratory mice with different sizes, an adjusting mechanism 4 is provided between the floor 1 and the floor support plate 2, and as mentioned above, the adjusting mechanism 4 penetrates through the floor 1 and extends to be connected with the bottom of the floor support plate 2, and the adjusting mechanism 4 can be operated to move up or down to adjust the radian of the floor support plate 2, so that the radian of the arc surface of the floor support plate 2 is changed, for example, the height of the floor support plate 2 is adjusted to 2cm.

In an alternative embodiment, the two ends of the support plate 2 are provided with flat parts which are respectively movably clamped into sliding grooves 22 arranged on two sides of the bottom plate 1, so that the flat parts are clamped in the sliding grooves 22 and cannot fall out of the sliding grooves when moving. It will be appreciated that the chute 22 may be designed to be located below the upper surface of the base plate 1 and below the carrier plate 2 to facilitate the two ends of the carrier plate 2 being able to be suitably accommodated within the chute as the adjustment mechanism 4 moves up and down. At the same time, the flat parts at both ends of the support plate 2 can be locked by the locking bolts 23 provided at both sides, respectively, and the locking bolts penetrate through the lower surface of the bottom plate 1 into the sliding grooves 22, and can be screwed into the flat parts of the support plate 2 at the corresponding side. Therefore, in normal use, the locking position is locked by the locking bolt 23, and when the radian position of the bearing plate 2 needs to be adjusted, the locking state of the two ends of the bearing plate 2 is released by rotating the locking bolt 23, so that the bearing plate can slide in the sliding groove. After the supporting plate 2 is adjusted in place, the locking bolts 23 can be screwed again to lock the two ends of the supporting plate 2, so that the whole adjusting process is completed.

For example, the adjustment mechanism 4 is located at the middle position of the bottom end of the support plate 2, the length of the experimental rat is 6-8cm, the experimental rat is longer than the experimental rat and wider than the back of the experimental rat, the experimental rat cannot be well supported by the support plate 2 with large curvature in the initial state, the curvature of the support plate 2 needs to be adjusted, the middle part of the support plate 2 is pulled downwards by the adjustment mechanism 4, the curvature of the support plate 2 is reduced, the arched radian is more gentle, the contact area between the experimental rat and the back of the experimental rat is more suitable when the back of the experimental rat is prone to be bent to be in a tight state, and the experimental rat back is suitable for back administration injection.

In an alternative embodiment, as shown in fig. 1 and 2, a connection socket 21 is provided at a bottom end intermediate position of the carrier plate 2, the connection socket 21 having an internal thread. The adjusting mechanism 4 is an inverted T-shaped stud which passes through the base plate 1 and is screwed to the connection socket 21.

The stud is defined to rotate clockwise to be heightened, and rotate anticlockwise to be lowered, as shown in fig. 2, by rotating the stud anticlockwise, the stud can be moved downwards, and the arch in the middle of the bearing plate 2 can move downwards along with the stud through the connecting bracket 21, so that the arch height of the bearing plate 2 is reduced, and the bearing plate can be used for bearing the rat. On the contrary, referring to fig. 1 and 2, the stud can be lifted upwards by rotating the stud clockwise, and the arch in the middle of the support plate 2 can be moved upwards, so that the arch height of the support plate 2 can be increased, and the support requirement of the mice can be met.

As shown in fig. 1 to 3, 100 is a laboratory mouse and 200 is a syringe.

As shown in fig. 1, 100 in the drawing is an experimental mouse, and as shown in fig. 2, 100 in the drawing is an experimental rat. Specifically, the dosage of each injection of the laboratory mice is generally within 1ml/100g, and the maximum dosage is not more than 2ml/100g, and the injection device is usually a 6-gauge needle and a 1-5ml syringe.

While the utility model has been described with reference to preferred embodiments, it is not intended to be limiting. Those skilled in the art will appreciate that various modifications and adaptations can be made without departing from the spirit and scope of the present utility model. Accordingly, the scope of the utility model is defined by the appended claims.

Claims

1. An auxiliary device for back administration of laboratory mice, comprising:

a bottom plate (1);

the supporting plate (2) is an elastic thin plate and is positioned above the bottom plate (1), and the upper end surface of the supporting plate (2) is an upward arched cambered surface and is used for supporting an experiment mouse lying on the upper surface of the cambered surface;

limb fixation members (3) respectively provided corresponding to limbs of a laboratory mouse, wherein a first end of each limb fixation member (3) is connected to an end of one of the limbs of the laboratory mouse, and a second end is connected to a side surface of the base plate (1);

an adjusting mechanism (4) is arranged between the bottom plate (1) and the bearing plate (2), and the adjusting mechanism (4) penetrates through the bottom plate (1) and extends to be connected with the bottom of the bearing plate (2); the adjustment mechanism (4) can be operated to move up or down to adjust the arc of the support plate (2).

2. The auxiliary device for back administration of laboratory mice according to claim 1, characterized in that the carrier plate (2) comprises an arc-shaped stainless steel elastic sheet.

3. The auxiliary device for back administration of laboratory mice according to claim 2, wherein an anti-slip mat is attached to an upper surface of the stainless steel elastic sheet.

4. An auxiliary device for back administration of laboratory mice according to claim 3, wherein the anti-slip mat is a rubber mat or a silica gel mat having a thickness of 0.5-2 mm.

5. Auxiliary device for back administration of laboratory mice according to claim 1, characterized in that the two ends of the support plate (2) are provided with flat parts, which are respectively movably snapped into slide grooves (22) provided on both sides of the bottom plate (1) and locked in place by locking bolts (23) provided on both sides, respectively, which locking bolts (23) penetrate the lower surface of the bottom plate (1) into the slide grooves (22) and can be screwed into the flat parts of the support plate (2) on the corresponding side.

6. The auxiliary device for back administration of laboratory mice according to claim 1, characterized in that a connection bracket (21) is provided in the middle of the bottom end of the support plate (2), the connection bracket (21) having an internal thread;

the adjusting mechanism (4) adopts an inverted T-shaped stud, penetrates through the bottom plate (1) and is in threaded connection with the connecting bracket (21).

7. The auxiliary device for back administration of laboratory mice according to any of claims 1-6, characterized in that the limb fixation means (3) comprises a lead (31) and a bolt (32), a first end of each lead (31) being tethered to an end of one of the extremities of the laboratory mice;

along the length direction of limbs of the mice, a plurality of bolts (32) are respectively arranged on two side surfaces of the bottom plate (1) at equal intervals, and the second end of each lead (31) is fastened on the bolt (32) in the corresponding direction of the limbs.

8. The auxiliary device for back administration of laboratory mice according to claim 7, characterized in that said lead (31) is connected to the second end of said bolt (32), is prefabricated as a hollow circular ring, and has an inner diameter larger than the outer diameter of said bolt (32) so as to fit over said bolt (32).

9. The auxiliary device for back administration of laboratory mice according to claim 7, characterized in that the two side edges of the bottom plate (1) are provided with a plurality of screw holes, and the bolts (32) are connected into the screw holes.

10. Auxiliary device for back administration of laboratory mice according to claim 7, characterized in that the lead (31) is an elastic cord.