CN219272204U - Purification device is used in heparin sodium production - Google Patents
Purification device is used in heparin sodium production Download PDFInfo
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- CN219272204U CN219272204U CN202320380048.4U CN202320380048U CN219272204U CN 219272204 U CN219272204 U CN 219272204U CN 202320380048 U CN202320380048 U CN 202320380048U CN 219272204 U CN219272204 U CN 219272204U
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Abstract
The utility model provides a purification device for heparin sodium production, which comprises a shell, wherein an inner cavity of the shell is fixedly connected with a pretreatment bin and a separation bin respectively, a mixing mechanism is arranged at the top of the shell, a supporting plate is fixedly connected to one side of the shell, a filtering mechanism and a first conveying pump are respectively arranged at the top of the supporting plate, a filtering block is arranged in the inner cavity of the filtering mechanism, a second conveying pump and a third conveying pump are respectively arranged at one side of the shell, a crystallization tank is arranged at one side of the second conveying pump, an oscillator is fixedly connected to the inner wall of the shell, and an interception net is fixedly connected to one side of the oscillator. The purification device for heparin sodium production provided by the utility model solves the problems that the filtration structure of the conventional heparin sodium crude product separation and purification equipment is inconvenient to replace and the purification efficiency is affected.
Description
Technical Field
The utility model relates to the technical field of heparin sodium, in particular to a purification device for heparin sodium production.
Background
Heparin sodium has an anticoagulant effect in vivo and in vitro in a plurality of links of the coagulation process, has a complex action mechanism, and enhances the inhibition effect of the latter on activated II, IX, X, XI and XII coagulation factors mainly by combining with antithrombin III, and the result thereof relates to inhibition of platelet aggregation and destruction, inhibition of formation of thromboplastin, inhibition of prothrombin to thrombin and inhibition of thrombin, thereby inhibiting fibrinogen to fibrin, thereby playing an anticoagulant effect.
The heparin sodium is prepared by purifying the crude heparin sodium after removing impurities, and the heparin sodium is searched for with the authorization number of: the patent document of CN215585697U discloses "a heparin sodium crude product separation and purification equipment", through setting up pretreatment mechanism with heparin sodium crude product solution and through the liquid medicine pond separation impurity of dissolving in heparin sodium crude product liquid, improve the separation efficiency of purifier organism, the heparin sodium crude product purity after the separation is high, the heparin sodium product quality of obtaining is good, be provided with the filter screen pipe that is used for filtering in its pretreatment tank, because filter screen pipe is located the pretreatment tank, and be located pretreatment tank inner chamber bottom position, after filter screen pipe reaches the number of times of use, inconvenient change of filter screen pipe, still further improvement space.
Therefore, it is necessary to provide a new purification device for heparin sodium production to solve the above technical problems.
Disclosure of Invention
In order to solve the technical problems, the utility model provides a purification device for heparin sodium production, which is convenient for replacing a filter element.
The utility model provides a purification device for heparin sodium production, which comprises a shell, wherein an inner cavity of the shell is fixedly connected with a pretreatment bin and a separation bin respectively, a mixing mechanism is arranged at the top of the shell, a supporting plate is fixedly connected to one side of the shell, a filtering mechanism and a first conveying pump are respectively arranged at the top of the supporting plate, a filtering block is arranged in the inner cavity of the filtering mechanism, a second conveying pump and a third conveying pump are respectively arranged at one side of the shell, a crystallization tank is arranged at one side of the second conveying pump, an oscillator is fixedly connected to the inner wall of the shell, and an interception net is fixedly connected to one side of the oscillator.
As the purification device for heparin sodium production, the utility model provides a purification device for heparin sodium production, and the purification device is characterized in that the mixing mechanism comprises a motor, wherein the motor is positioned at the top of a shell, the output end of the motor is fixedly connected with a mixing shaft, and the bottom of an inner cavity of a bottom separation bin of the mixing shaft is rotationally connected.
The utility model provides a purification device for heparin sodium production, preferably, the filtering mechanism comprises a filtering box, the filtering block is positioned in an inner cavity of the filtering box, a top cover is arranged at the top of the filtering box, first fixing blocks are fixedly connected to two sides of the top cover, fixing bolts are connected to the inner cavity of the first fixing blocks in a threaded mode, second fixing blocks are connected to the outer sides of the fixing bolts in a threaded mode, and one side of each second fixing block is fixedly connected with one side of the filtering box.
The utility model provides a purification device for heparin sodium production, preferably, the bottom of a top cover is fixedly connected with a sealing gasket, the top of a filter box is provided with a sealing groove, and the outer side of the sealing gasket is in sliding connection with the inner wall of the sealing groove.
The utility model provides a purification device for heparin sodium production, preferably, the bottom of the shell is fixedly connected with a vertical plate, and the bottom of the vertical plate is fixedly connected with a contact plate.
As the purification device for heparin sodium production, the utility model provides a purification device for heparin sodium production, preferably, the bottom of the supporting plate is fixedly connected with a stabilizer bar, and one end of the stabilizer bar is fixedly connected with one side of the shell.
As the purification device for heparin sodium production provided by the utility model, preferably, the inner wall of the pretreatment bin is fixedly connected with the installation block, and one side of the installation block is fixedly connected with the heating plate.
Compared with the prior art, the utility model has the beneficial effects that:
this purifier is used in heparin sodium production adds heparin sodium crude granule in to the pretreatment storehouse through the material throwing pipe at pretreatment storehouse top, then add water, drive the hybrid shaft through the motor work and rotate, can mix heparin sodium crude granule and water in the pretreatment storehouse through the hybrid blade in the hybrid shaft outside, accelerate the dissolution rate of heparin sodium crude granule, and the accessible hot plate heats, further improved the dissolution rate, liquid after the pretreatment storehouse is accomplished can pass through first delivery pump and carry to the separation storehouse in, when liquid gets into the separation storehouse, continue to drive the hybrid shaft through the motor and rotate, can make heparin sodium crude liquid and ethanol solution intensive mixing, be convenient for separate out the impurity that dissolves in heparin sodium crude liquid, the liquid in the separation storehouse is carried to the crystallization tank, make heparin sodium crude from liquid conversion into solid particle, then through the graininess crystal in the third delivery pump extraction crystallization tank, carry to interception net department, carry out the screening to heparin sodium crude granule crystal, reach the use number of times at the filter block, when need changing, the user can close the filter box and the pretreatment pipeline and connect the bolt, then remove the fixed top cap, the fixed top cover is removed to the fixed top cover, thereby the purification device can be removed.
Drawings
FIG. 1 is a schematic diagram of a purification apparatus for heparin sodium production according to a preferred embodiment of the present utility model;
FIG. 2 is a schematic view of the connection structure of the top cover and the filter cartridge of the present utility model;
FIG. 3 is a schematic view of a filter mechanism according to the present utility model;
fig. 4 is a schematic structural view of the housing of the present utility model.
Reference numerals in the drawings: 1. a housing; 2. a pretreatment bin; 3. a separation bin; 4. a mixing mechanism; 401. a motor; 402. a mixing shaft; 5. a support plate; 6. a filtering mechanism; 601. a filter box; 602. a top cover; 603. a first fixed block; 604. a fixing bolt; 605. a second fixed block; 7. a first transfer pump; 8. a second transfer pump; 9. a crystallization tank; 10. a third transfer pump; 11. an oscillator; 12. an interception net; 13. a filter block; 14. a sealing gasket; 15. sealing grooves; 16. a vertical plate; 17. a contact plate; 18. a stabilizer bar; 19. a mounting block; 20. and (5) heating the plate.
Detailed Description
The utility model will be further described with reference to the drawings and embodiments.
Referring to fig. 1, fig. 2, fig. 3 and fig. 4 in combination, fig. 1 is a schematic structural diagram of a purification device for heparin sodium production according to a preferred embodiment of the present utility model; FIG. 2 is a schematic view of the connection structure of the top cover and the filter cartridge of the present utility model; FIG. 3 is a schematic view of a filter mechanism according to the present utility model; fig. 4 is a schematic structural view of the housing of the present utility model. The purification device for heparin sodium production comprises a shell 1, wherein an inner cavity of the shell 1 is fixedly connected with a pretreatment bin 2 and a separation bin 3 respectively, a mixing mechanism 4 is arranged at the top of the shell 1, one side of the shell 1 is fixedly connected with a supporting plate 5, a filtering mechanism 6 and a first conveying pump 7 are respectively arranged at the top of the supporting plate 5, a filtering block 13 is arranged in the inner cavity of the filtering mechanism 6, a second conveying pump 8 and a third conveying pump 10 are respectively arranged at one side of the shell 1, a crystallization tank 9 is arranged at one side of the second conveying pump 8, an oscillator 11 is fixedly connected to the inner wall of the shell 1, and an interception net 12 is fixedly connected to one side of the oscillator 11;
the bottom of the shell 1 is fixedly connected with a vertical plate 16, and the bottom of the vertical plate 16 is fixedly connected with a contact plate 17;
the bottom of backup pad 5 fixedly connected with stabilizer bar 18, the one end of stabilizer bar 18 and one side fixed connection of shell 1.
It should be noted that: one side of the shell 1 is rotationally connected with a box door through a hinge, an observation window is arranged in an inner cavity of the box door, the stability of the shell 1 in the use process is conveniently improved by arranging a vertical plate 16 and a contact plate 17, the supporting effect of the supporting plate 5 on the filtering mechanism 6 and the first conveying pump 7 is improved by arranging a stabilizer bar 18 at the bottom of the supporting plate 5, and the tops of the pretreatment bin 2 and the separation bin 3 are communicated with a feeding pipe for feeding.
In the implementation process, as shown in fig. 1, the mixing mechanism 4 comprises a motor 401, the motor 401 is positioned at the top of the shell 1, the output end of the motor 401 is fixedly connected with a mixing shaft 402, and the bottom of the inner cavity of the separation bin 3 at the bottom of the mixing shaft 402 is rotationally connected;
the inner wall of the pretreatment bin 2 is fixedly connected with a mounting block 19, and one side of the mounting block 19 is fixedly connected with a heating plate 20.
It should be noted that: the contact surface between the outer side of the mixing shaft 402 and the pretreatment bin 2 and the separation bin 3 is provided with a sealing ring, when the device is used, the raw heparin sodium particles are added into the pretreatment bin 2 through the feeding pipe at the top of the pretreatment bin 2, then water is added, the motor 401 works to drive the mixing shaft 402 to rotate, the raw heparin sodium particles and the water in the pretreatment bin 2 can be mixed through the mixing blades at the outer side of the mixing shaft 402, the dissolution speed of the raw heparin sodium particles is accelerated, and the raw heparin sodium particles can be heated through the heating plate 20, so that the dissolution speed is further improved.
Referring to fig. 1, 2 and 3, the filtering mechanism 6 comprises a filtering box 601, a filtering block 13 is positioned in an inner cavity of the filtering box 601, a top cover 602 is arranged at the top of the filtering box 601, two sides of the top cover 602 are fixedly connected with a first fixing block 603, the inner cavity of the first fixing block 603 is in threaded connection with a fixing bolt 604, the outer side of the fixing bolt 604 is in threaded connection with a second fixing block 605, and one side of the second fixing block 605 is fixedly connected with one side of the filtering box 601;
the bottom fixedly connected with sealed pad 14 of top cap 602, seal groove 15 has been seted up at the top of rose box 601, and the outside of sealed pad 14 and the inner wall sliding connection of seal groove 15.
It should be noted that: one side of the filter tank 601 is communicated with the bottom of the pretreatment bin 2 through a pipeline, the other side of the filter tank 601 is communicated with the water inlet of the first conveying pump 7 through a pipeline, the water outlet of the first conveying pump 7 is communicated with the separation bin 3 through a pipeline, the water inlet of the second conveying pump 8 is communicated with the separation bin 3 through a pipeline, the water outlet of the second conveying pump 8 is communicated with the crystallization tank 9 through a pipeline, the water inlet of the third conveying pump 10 is communicated with the crystallization tank 9 through a pipeline, the water outlet of the third conveying pump 10 is communicated with the shell 1 through a pipeline, ethanol solution is preset in the separation bin 3, the treated liquid in the pretreatment bin 2 can be conveyed into the separation bin 3 through the first conveying pump 7, when the liquid in the pretreatment bin 2 passes through the filter tank 601, the filter block 13 in the filter tank 601 can filter the liquid, when the liquid enters the separation bin 3, the motor 401 is used for continuously driving the mixing shaft 402 to rotate, so that the liquid of the crude heparin sodium product and the ethanol solution are fully mixed, impurities dissolved in the liquid of the crude heparin sodium product are conveniently separated out, the liquid in the separation bin 3 is conveyed into the crystallization tank 9 by the second conveying pump 8, the crystallization tank 9 is rapidly cooled by chilled water or coolant water in an interlayer to enable the liquid to crystallize, the crude heparin sodium product is converted into solid particles from the liquid state, then the granular crystals in the crystallization tank 9 are pumped by the third conveying pump 10 and conveyed to the interception net 12, the two oscillators 11 are started to drive the interception net 12 to vibrate up and down, the small particle crystals of the crude heparin sodium product are screened, when the filter block 13 reaches the use times and needs to be replaced, a user can close a valve at the outer side of a pipeline at the joint of the filter box 601 and the pretreatment bin 2, then the fixing bolt 604 is rotated to enable the fixing bolt 604 to be moved out of the second fixing block 605, thus, the fixing of the top cover 602 is released, and then the user can remove the top cover 602 from the top of the filter tank 601, so as to take out the filter block 13 for replacement, and the sealing property between the top cover 602 and the filter tank 601 is improved by providing the sealing gasket 14 and the sealing groove 15.
The utility model provides a purification device for heparin sodium production, which has the following working principle:
when the device is used, the raw heparin sodium particles can be added into the pretreatment bin 2 through the feeding pipe at the top of the pretreatment bin 2, then water is added, the motor 401 is used for driving the mixing shaft 402 to rotate, the raw heparin sodium particles and water in the pretreatment bin 2 can be mixed through the mixing blades at the outer side of the mixing shaft 402, the dissolution speed of the raw heparin sodium particles is accelerated, the heating plate 20 can be used for heating, the dissolution speed is further improved, the liquid after the treatment in the pretreatment bin 2 can be conveyed into the separation bin 3 through the first conveying pump 7, when the liquid in the pretreatment bin 2 passes through the filter box 601, the liquid can be filtered through the filter block 13 in the filter box 601, when the liquid enters the separation bin 3, the motor 401 is used for continuously driving the mixing shaft 402 to rotate, the raw heparin sodium liquid and the ethanol solution can be fully mixed, the impurities dissolved in the raw heparin sodium liquid can be conveniently separated out, the second delivery pump 8 delivers the liquid in the separation bin 3 to the crystallization tank 9, the crystallization tank 9 rapidly reduces the temperature through chilled water or chilled water in an interlayer to crystallize the liquid, the crude heparin sodium is converted into solid particles from the liquid state, then the granular crystals in the crystallization tank 9 are pumped by the third delivery pump 10 and delivered to the interception net 12, the two oscillators 11 are started to drive the interception net 12 to vibrate up and down, the small granular crystals of the crude heparin sodium are screened, when the filter block 13 reaches the use times and needs to be replaced, a user can close a valve at the outer side of a pipeline at the joint of the filter box 601 and the pretreatment bin 2, then the fixing bolt 604 is rotated to enable the fixing bolt 604 to be moved out of the second fixing block 605, so that the fixing of the top cover 602 is released, then the user can move the top cover 602 out of the top of the filter box 601, and the filter block 13 is taken out for replacement, by providing the gasket 14 and the seal groove 15, sealability between the top cover 602 and the filter tank 601 is improved.
The foregoing description is only illustrative of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structures or equivalent processes or direct or indirect application in other related technical fields are included in the scope of the present utility model.
Claims (7)
1. The utility model provides a purification device is used in heparin sodium production, its characterized in that, including shell (1), the inner chamber of shell (1) is fixedly connected with respectively handles storehouse (2) and separation storehouse (3), the top of shell (1) is provided with mixing mechanism (4), one side fixedly connected with backup pad (5) of shell (1), the top of backup pad (5) is provided with filtering mechanism (6) and first delivery pump (7) respectively, the inner chamber of filtering mechanism (6) is provided with filter block (13), one side of shell (1) is provided with second delivery pump (8) and third delivery pump (10) respectively, one side of second delivery pump (8) is provided with crystallization jar (9), the inner wall fixedly connected with oscillator (11) of shell (1), one side fixedly connected with interception net (12) of oscillator (11).
2. The purification device for heparin sodium production according to claim 1, wherein the mixing mechanism (4) comprises a motor (401), the motor (401) is located at the top of the shell (1), the output end of the motor (401) is connected with a mixing shaft (402), and the bottom of the inner cavity of the bottom separation bin (3) of the mixing shaft (402) is rotationally connected.
3. The purification device for heparin sodium production according to claim 1, wherein the filtering mechanism (6) comprises a filtering box (601), the filtering block (13) is located an inner cavity of the filtering box (601), a top cover (602) is arranged at the top of the filtering box (601), first fixing blocks (603) are fixedly connected to two sides of the top cover (602), fixing bolts (604) are connected to the inner cavity of the first fixing blocks (603) in a threaded mode, second fixing blocks (605) are connected to the outer side of the fixing bolts (604) in a threaded mode, and one side of the second fixing blocks (605) is fixedly connected to one side of the filtering box (601).
4. The purification device for heparin sodium production according to claim 3, wherein a sealing gasket (14) is fixedly connected to the bottom of the top cover (602), a sealing groove (15) is formed in the top of the filter tank (601), and the outer side of the sealing gasket (14) is slidably connected with the inner wall of the sealing groove (15).
5. Purification device for heparin sodium production according to claim 1, characterized in that the bottom of the housing (1) is fixedly connected with a riser (16), the bottom of the riser (16) is fixedly connected with a contact plate (17).
6. Purification device for heparin sodium production according to claim 1, characterized in that the bottom of the support plate (5) is fixedly connected with a stabilizer bar (18), one end of the stabilizer bar (18) is fixedly connected with one side of the housing (1).
7. Purification device for heparin sodium production according to claim 1, characterized in that the inner wall of the pretreatment bin (2) is fixedly connected with a mounting block (19), and one side of the mounting block (19) is fixedly connected with a heating plate (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320380048.4U CN219272204U (en) | 2023-03-03 | 2023-03-03 | Purification device is used in heparin sodium production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320380048.4U CN219272204U (en) | 2023-03-03 | 2023-03-03 | Purification device is used in heparin sodium production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219272204U true CN219272204U (en) | 2023-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320380048.4U Active CN219272204U (en) | 2023-03-03 | 2023-03-03 | Purification device is used in heparin sodium production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219272204U (en) |
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- 2023-03-03 CN CN202320380048.4U patent/CN219272204U/en active Active
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