CN219258086U

CN219258086U - Kit for detecting polypeptide with reduced immunogenicity

Info

Publication number: CN219258086U
Application number: CN202223449490.2U
Authority: CN
Inventors: 刘家权; 王嘉晟; 芦伟
Original assignee: Shenzhen Zhongjianlian New Drug Testing Co ltd
Current assignee: Shenzhen Zhongjianlian New Drug Testing Co ltd
Priority date: 2022-12-21
Filing date: 2022-12-21
Publication date: 2023-06-27
Anticipated expiration: 2032-12-21

Abstract

The utility model discloses a kit for detecting polypeptide for reducing immunogenicity, which comprises a box body, wherein the front end of the box body is fixedly connected with two first fixing frames, the opposite ends of the two first fixing frames are respectively provided with a clamping groove, a protection assembly is clamped in the two clamping grooves together, the rear inner wall of the box body is fixedly connected with four second fixing frames which are symmetrically distributed in pairs, the upper ends of the four second fixing frames are respectively provided with a sliding groove, the two sliding grooves on the same horizontal plane are respectively provided with an automatic pushing assembly in a sliding way, and the upper end of the box body is fixedly connected with a lifting handle. According to the kit for detecting the polypeptide, which is disclosed by the utility model, the purposes of automatically performing operation and reducing labor burden of personnel are achieved by arranging the automatic pushing-out assembly; through setting up the protection subassembly, reach the inside reagent of protection and not receive the pollution, improve the purpose of detection precision.

Description

Kit for detecting polypeptide with reduced immunogenicity

Technical Field

The utility model relates to the technical field of kits, in particular to a kit for detecting polypeptide with reduced immunogenicity.

Background

The engineered polypeptide may bind to albumin, so that the compound may be sequestered (e.g., bound to albumin) while in circulation, resulting in an increase in duration of action due to, for example, reduced renal clearance and/or degradation. Diseases amenable to such treatment include obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, short bowel syndrome, alzheimer's disease, fatty liver disease, parkinson's disease, cardiovascular disease and other central nervous system disorders or combinations thereof.

The in-process of extracting polypeptide needs to take a sample, and products such as detection kit can be used in the sample detection process, and current kit for detection generally needs to be taken by people, uses comparatively inconveniently, and manual operation can cause the error to influence the detection, and current kit leakproofness is relatively poor simultaneously, can not isolate substances such as bacterium effectively. Therefore, we propose a kit for detecting polypeptides with reduced immunogenicity.

Disclosure of Invention

The utility model mainly aims to provide a polypeptide detection kit for reducing immunogenicity, which can effectively solve the problems in the background technology.

In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows:

the utility model provides a reduce kit for polypeptide detection of immunogenicity, includes the box body, the front end fixedly connected with of box body two first mounts, two the draw-in groove has all been seted up to the opposite end of first mount, two joint has the protection component jointly in the draw-in groove, the back inner wall fixedly connected with of box body four second mounts, and four second mounts two by two are bilateral symmetry distribution, four the spout has all been seted up to the upper end of second mount, two of same horizontal plane spout common slidable mounting has automatic ejecting subassembly, the upper end fixedly connected with of box body carries the handle.

Preferably, the protection component comprises a protection plate, the upper end of the protection plate is fixedly connected with a protection plate handle, the front end of the protection plate is provided with two through grooves in a penetrating mode, the left side and the right side of each through groove are fixedly connected with fixing blocks, and the two fixing blocks on the same horizontal plane are connected with a baffle in a common rotation mode.

Preferably, the two baffles are correspondingly matched with the positions and the sizes of the two through grooves, and the protection plates are made of glass.

Preferably, the size of the protection plate is matched with the size of the clamping groove, and the height of the protection plate is matched with the height of the box body.

Preferably, the automatic pushing-out assembly comprises a motor, the motor is provided with two, two the output of motor runs through corresponding second mount and fixedly connected with threaded rod, two the equal threaded connection of surface of threaded rod has the screw thread cover piece, two the common fixedly connected with reagent of upper end of screw thread cover piece places the board, the upper end that the board was placed to the reagent runs through and has seted up a plurality of standing groove.

Preferably, the size of the thread sleeve block is matched with the size of the chute, the size of the reagent placing plate is matched with the size of the through groove, and a plurality of placing grooves are distributed in rectangular equal size.

Compared with the prior art, the utility model has the following beneficial effects:

1. according to the utility model, the automatic pushing-out assembly is arranged, the output ends of the two motors simultaneously drive the corresponding threaded rods to rotate by starting the motors, the threaded rods drive the threaded sleeve blocks which are correspondingly in threaded connection with the outer surfaces of the threaded rods to slide in the sliding grooves, so that the reagent placing plate is pushed out, and the purposes of automatically operating and relieving the labor burden of personnel are achieved;

2. according to the utility model, the protection component is arranged, the component is mounted in a clamping manner, the front end of the component is provided with the through groove, so that the reagent placing plate can be pushed out conveniently, the front end of the through groove is rotationally connected with the baffle, and when the device is not used, the baffle naturally falls down, so that the purposes of protecting internal reagents from pollution and improving detection precision are achieved.

Drawings

FIG. 1 is a schematic diagram showing the overall structure of a kit for detecting a polypeptide having reduced immunogenicity according to the present utility model;

FIG. 2 is a schematic structural diagram showing the fixing members of a kit for detecting a polypeptide of the present utility model for reducing immunogenicity;

FIG. 3 is a schematic structural diagram of a protective component of a kit for detecting polypeptides with reduced immunogenicity according to the present utility model;

FIG. 4 is a schematic diagram showing the structure of an automatic pushing assembly of a kit for detecting polypeptides with reduced immunogenicity according to the present utility model.

In the figure: 1. a case body; 2. a first fixing frame; 3. a protective assembly; 4. the second fixing frame; 5. a lifting handle; 6. an automatic push-out assembly; 21. a clamping groove; 31. a protection plate; 32. a guard plate handle; 33. a through groove; 34. a fixed block; 35. a baffle; 41. a chute; 61. a motor; 62. a threaded rod; 63. a threaded sleeve block; 64. a reagent placement plate; 65. and (5) placing a groove.

Detailed Description

The utility model is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the utility model easy to understand.

In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific direction, be configured and operated in the specific direction, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "provided," "connected," and the like are to be construed broadly, and may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

As shown in fig. 1-4, a kit for detecting polypeptide for reducing immunogenicity comprises a box body 1, wherein the front end of the box body 1 is fixedly connected with two first fixing frames 2, opposite ends of the two first fixing frames 2 are respectively provided with a clamping groove 21, a protection component 3 is jointly clamped in the two clamping grooves 21, the rear inner wall of the box body 1 is fixedly connected with four second fixing frames 4, the four second fixing frames 4 are symmetrically distributed in pairs, the upper ends of the four second fixing frames 4 are respectively provided with a sliding groove 41, two sliding grooves 41 on the same horizontal plane are jointly and slidably provided with an automatic pushing component 6, and the upper end of the box body 1 is fixedly connected with a lifting handle 5.

In this embodiment, the protection component 3 includes a protection plate 31, the upper end of the protection plate 31 is fixedly connected with a protection plate handle 32, two through slots 33 are formed in the front end of the protection plate 31 in a penetrating manner, two fixing blocks 34 are fixedly connected to the left and right sides of the two through slots 33, two fixing blocks 34 on the same horizontal plane are connected with a baffle 35 in a rotating manner together, the two baffles 35 are correspondingly matched with the positions and the sizes of the two through slots 33, the protection plate 31 is made of glass, the size of the protection plate 31 is matched with the size of the clamping slot 21, and the height of the protection plate 31 is matched with the height of the box body 1; in the use, utilize guard plate handle 32 with guard plate 31 joint in draw-in groove 21, two logical groove 33 have been seted up to guard plate 31's front end, two logical groove 33 correspond with the position of automatic release subassembly 6, two fixed blocks 34 and baffle 35 of same group rotate to be connected, and the in-process baffle 35 that release subassembly 6 released is rotated and is opened, and when automatic release subassembly 6 all withdraws, can protect box body 1 front end whole, prevent that bacterium etc. from getting into in the box body 1.

In this embodiment, the automatic pushing component 6 includes two motors 61, the output ends of the two motors 61 penetrate through the corresponding second fixing frames 4 and are fixedly connected with threaded rods 62, the outer surfaces of the two threaded rods 62 are all in threaded connection with threaded sleeve blocks 63, the upper ends of the two threaded sleeve blocks 63 are fixedly connected with reagent placing plates 64 together, a plurality of placing grooves 65 are formed in the upper ends of the reagent placing plates 64 in a penetrating manner, the size of the threaded sleeve blocks 63 is matched with the size of the sliding grooves 41, the size of the reagent placing plates 64 is matched with the size of the through grooves 33, and the plurality of placing grooves 65 are distributed in rectangular equal sizes; the corresponding motors 61 are started, the two motors 61 in the same group are simultaneously started to drive the corresponding threaded rods 62 to rotate, the threaded rods 62 drive the threaded sleeve blocks 63 which are in threaded connection with the outer surfaces of the threaded rods to slide in the sliding grooves 41, so that the two threaded sleeve blocks 63 simultaneously drive the reagent placing plates 64 to move out, and the reagent tubes are placed in the placing grooves 65, so that the reagent tubes can be automatically pushed out and automatically retracted, direct contact of operators is avoided, and time and labor are saved.

It should be noted that, in this process, the corresponding motor 61 is started first, the two motors 61 of the same group are started simultaneously to drive the corresponding threaded rods 62 to rotate, the threaded rods 62 drive the threaded sleeve blocks 63 which are correspondingly connected with the external surfaces of the threaded rods to slide in the sliding grooves 41, so that the two threaded sleeve blocks 63 simultaneously drive the reagent placing plate 64 to move out, and the reagent tube is placed in the placing groove 65, so that the reagent tube can be automatically pushed out and automatically retracted, direct contact of operators is avoided, time and labor are saved, in the use process, the protection plate 31 is clamped in the clamping groove 21 by the protection plate handle 32, the front end of the protection plate 31 is provided with the two through grooves 33, the two through grooves 33 correspond to the positions of the automatic pushing-out assembly 6, the two fixed blocks 34 of the same group are rotationally connected with the baffle 35, the baffle 35 is rotationally opened in the pushing-out process of the automatic pushing-out assembly 6, when the automatic pushing-out assembly 6 is completely retracted, the front end of the box body 1 can be integrally protected from entering the box body 1, bacteria and the like, the upper end of the box body 1 is fixedly connected with the handle 5, and the box body 1 is conveniently pulled and carried by the handle 5.

The foregoing has shown and described the basic principles and main features of the present utility model and the advantages of the present utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides a reduce kit for polypeptide detection of immunogenicity, includes box body (1), its characterized in that: the novel portable electronic device comprises a box body (1), wherein the front end of the box body (1) is fixedly connected with two first fixing frames (2), clamping grooves (21) are formed in opposite ends of the two first fixing frames (2), a protection assembly (3) is clamped in the two clamping grooves (21) together, four second fixing frames (4) are fixedly connected to the rear inner wall of the box body (1), the four second fixing frames (4) are symmetrically distributed in pairs, sliding grooves (41) are formed in the upper ends of the four second fixing frames (4), an automatic pushing assembly (6) is arranged on the two sliding grooves (41) of the same horizontal plane in a sliding mode, and a lifting handle (5) is fixedly connected to the upper end of the box body (1);

the protection assembly (3) comprises a protection plate (31), a protection plate handle (32) is fixedly connected to the upper end of the protection plate (31), two through grooves (33) are formed in the front end of the protection plate (31) in a penetrating mode, fixing blocks (34) are fixedly connected to the left side and the right side of each through groove (33), and a baffle (35) is connected to the two fixing blocks (34) on the same horizontal plane in a co-rotation mode;

the automatic pushing-out assembly (6) comprises two motors (61), wherein the two motors (61) are arranged, the output ends of the two motors (61) penetrate through corresponding second fixing frames (4) and are fixedly connected with threaded rods (62), the two threaded rods (62) are respectively and fixedly connected with a threaded sleeve block (63) on the outer surfaces, the two upper ends of the threaded sleeve blocks (63) are fixedly connected with a reagent placing plate (64) together, and a plurality of placing grooves (65) are formed in the upper ends of the reagent placing plates (64) in a penetrating mode.

2. The kit for detecting a polypeptide having reduced immunogenicity according to claim 1, wherein: the two baffles (35) are correspondingly matched with the positions and the sizes of the two through grooves (33), and the protection plates (31) are made of glass.

3. The kit for detecting a polypeptide having reduced immunogenicity according to claim 1, wherein: the size of the protection plate (31) is matched with the size of the clamping groove (21), and the height of the protection plate (31) is matched with the height of the box body (1).

4. The kit for detecting a polypeptide having reduced immunogenicity according to claim 1, wherein: the size of the thread sleeve block (63) is matched with the size of the sliding groove (41), the size of the reagent placing plate (64) is matched with the size of the through groove (33), and a plurality of placing grooves (65) are distributed in rectangular equal sizes.