CN219168155U

CN219168155U - Heat preservation incubation device

Info

Publication number: CN219168155U
Application number: CN202223590081.4U
Authority: CN
Inventors: 赵小军; 胡继猛; 庞海河; 石笑弋; 廖孝曙; 刘志军; 王雪洋; 彭伟
Original assignee: Hunan Kelun Pharmaceutical Co Ltd
Current assignee: Hunan Kelun Pharmaceutical Co Ltd
Priority date: 2022-12-27
Filing date: 2022-12-27
Publication date: 2023-06-13
Anticipated expiration: 2032-12-27

Abstract

The application discloses incubation device keeps warm, include: the device comprises a heating tank, an injection water tank, a raw material tank and an incubation tank, wherein the injection water tank is communicated to the incubation tank through a first pipeline, and the first pipeline is provided with a first pump; the material tank is communicated to the incubation tank through a second pipeline, and the second pipeline is provided with a second pump; the heating tank is communicated with the injection water tank through a circulating pipeline, the circulating pipeline is provided with a circulating power mechanism, and the heating tank is used for injecting hot water into the injection water tank and receiving water flowing into the injection water tank. The heat preservation incubation device that this application provided utilizes the heating jar to heat injection water, makes the temperature of injection water be in the target scope, makes human serum albumin incubate under suitable temperature condition and opens, forms the condition of carrying medicine, is suitable for continuous, the stable incubation of raw materials such as human serum albumin.

Description

Heat preservation incubation device

Technical Field

The application relates to the technical field of medicinal production equipment, in particular to a heat preservation incubation device.

Background

The albumin nanoparticle medicine takes albumin as a carrier, encapsulates or adsorbs the medicine to form a solid colloid medicine release system with the particle size of 10-1000nm, and is solidified and separated to form a solid sphere. The albumin material has the characteristics of safety, no toxicity, no immunogenicity, biodegradability, good biocompatibility and the like, so that the albumin material has a plurality of advantages in the aspect of liquid medicine delivery, for example, the albumin material can slowly release medicines so as to prolong the action time of the medicines; the target conveying purpose can be achieved; the administration dosage can be reduced on the premise of ensuring the drug action, thereby reducing or avoiding toxic and side effects; can improve the stability of the medicine and is beneficial to the storage of the medicine liquid.

The drug loading mechanism of human serum albumin is as follows: human serum albumin consists of three regions with similar three-dimensional structures, wherein domains i and ii are almost perpendicular to each other, forming a T-type assembly, and domains ii and iii form a Y-type assembly. Because of the bagged structure formed by the hydrophobic and positively charged groups in the domains I and III, favorable space conditions are created for embedding and carrying the hydrophobic drugs, and albumin can be tightly and reversibly combined with substances through non-covalent bonds. The human serum albumin is utilized to melt and wrap the medicine in a high-temperature environment and then is closed in a low-temperature environment, so that the effect of medicine encapsulation can be realized. Wherein, the temperature is a key factor influencing the incubation and drug carrying effects of human serum albumin.

Disclosure of Invention

To solve the above technical problems, a first object of the present utility model is to provide a thermal insulation incubation device; the heat preservation incubation device that this application provided utilizes the heating jar to heat injection water, makes the temperature of injection water in the target scope to make mixed human serum albumin and temperature of water also be in the target scope, make human serum albumin incubate under suitable temperature condition and open, form the condition of carrying medicine, be suitable for continuous, the stable incubation of raw materials such as human serum albumin.

The technical scheme provided by the utility model is as follows:

a thermal incubation device comprising: a heating tank, a water tank for injection, a raw material tank and an incubation tank,

the water tank for injection is communicated to the incubation tank through a first pipeline, and the first pipeline is provided with a first pump;

the material tanks are respectively communicated with the incubation tank through second pipelines, and the second pipelines are provided with second pumps;

the heating tank is communicated with the injection water tank through a circulating pipeline, the circulating pipeline is provided with a circulating power mechanism, and the heating tank is used for injecting hot water into the injection water tank and receiving water flowing back from the injection water tank.

Preferably, the circulating pipeline comprises two branch pipes, two ends of the two branch pipes are respectively communicated with the heating tank and the water tank for injection, and the circulating power mechanism is arranged on one of the branch pipes.

Preferably, the first pump, the second pump and the circulation power mechanism are peristaltic pumps.

Preferably, the heating tank and the water tank for injection are respectively provided with a temperature sensor.

Preferably, the first pipeline and the second pipeline are respectively provided with a flowmeter.

Preferably, the first pipeline and the second pipeline are combined into a main pipeline, and the main pipeline is communicated with the incubation tank.

Preferably, the first pipeline, the second pipeline and the main pipeline are all provided with heat insulation layers.

Preferably, the incubation tank is provided with a heat-insulating jacket, and the incubation tank is insulated by flowing water for injection in the heat-insulating jacket.

Preferably, the water outlet of the heating tank is provided with a heating rod.

The application provides a device is hatched in heat preservation, include: the device comprises a heating tank, an injection water tank, a raw material tank and an incubation tank, wherein the injection water tank is communicated to the incubation tank through a first pipeline, and the first pipeline is provided with a first pump; the material tank is communicated to the incubation tank through a second pipeline, and the second pipeline is provided with a second pump; the heating tank is communicated with the injection water tank through a circulating pipeline, the circulating pipeline is provided with a circulating power mechanism, and the heating tank is used for injecting hot water into the injection water tank and receiving water flowing back from the injection water tank. According to the heat preservation incubation device, the heating tank is used for heating the water for injection and conveying the water for injection through the circulating power mechanism, so that the temperature of the water for injection in the water tank for injection is kept in a target range; the water for injection enters a first pipeline from a water tank for injection under the power action of a first pump; meanwhile, raw materials for production (taking human serum albumin as an example) enter a second pipeline from a raw material tank under the action of a second pump, and water for injection and the raw materials for production are respectively conveyed into an incubation tank to be mixed. The temperature of the water for injection is within the target range, and the mixed human serum albumin and water can be controlled to be within the target range, and the mixture is heated by the temperature of the water for injection, so that the human serum albumin can be incubated and opened under the proper temperature condition, and the condition of carrying medicine is formed.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a thermal incubation apparatus according to an embodiment of the present utility model;

reference numerals: 1-heating a tank; 11-a circulation line; 111-branch pipes; 2-a water tank for injection; 21-a first line; 3-a raw material tank; 31-a second line; 4-incubation tank; 41-a heat preservation jacket; 5-a first pump; 6-a second pump; 7-a circulation power mechanism; 8-main pipeline.

Detailed Description

In order to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present application and simplify description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be configured and operated in a particular orientation, and therefore should not be construed as limiting the present application.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, the meaning of "a plurality" or "a number" is two or more, unless explicitly defined otherwise.

It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the scope of the present disclosure, since any structural modifications, proportional changes, or dimensional adjustments made by those skilled in the art should not be made in the present disclosure without affecting the efficacy or achievement of the present disclosure.

As shown in the figure, an embodiment of the present utility model provides a thermal insulation incubation device, including: a heating tank 1, a water tank 2 for injection, a raw material tank 3 and an incubation tank 4,

the water tank 2 for injection is communicated to the incubation tank 4 through a first pipeline 21, and the first pipeline is provided with a first pump 5;

the raw material tank 3 is communicated to the incubation tank 4 through a second pipeline 31, and the second pipeline is provided with a second pump 6;

the heating tank 1 is communicated with the water tank 2 for injection through a circulation pipeline 11, the circulation pipeline 11 is provided with a circulation power mechanism 7, the heating tank 1 is used for injecting hot water into the water tank 2 for injection, and receiving water flowing back from the water tank 2 for injection.

The application provides a device is hatched in heat preservation, include: the heating tank 1, the water tank 2 for injection, the raw material tank 3 and the incubation tank 4, wherein the water tank 2 for injection is communicated to the incubation tank 4 through a first pipeline 21, and the first pipeline is provided with a first pump 5; the material tanks 3 are respectively communicated with the incubation tank 4 through second pipelines 31, and the second pipelines are provided with second pumps 6; the heating tank 1 is communicated with the water tank 2 for injection through a circulation pipeline 11, the circulation pipeline 11 is provided with a circulation power mechanism 7, the heating tank 1 is used for injecting hot water into the water tank 2 for injection, and receiving water flowing back from the water tank 2 for injection. The heat preservation incubation device provided by the application utilizes the heating tank 1 to heat the water for injection, and the water for injection is conveyed through the circulating power mechanism 7, so that the temperature of the water for injection in the water tank 2 for injection is kept in a target range; the water for injection enters the first pipeline 21 from the water tank 2 for injection under the power action of the first pump 5; at the same time, raw materials for production (for example, human serum albumin) enter the second pipeline 31 from the raw material tank 3 under the action of the second pump 6, and water for injection and raw materials for production are respectively conveyed into the incubation tank 4 for mixing. The temperature of the water for injection is within the target range, and the mixed human serum albumin and water can be controlled to be within the target range, and the mixture is heated by the temperature of the water for injection, so that the human serum albumin can be incubated and opened under the proper temperature condition, and the condition of carrying medicine is formed.

Through the heat preservation incubation device that this application provided, can conveniently, control the temperature of injection water steadily, can guarantee to begin to the incubation quality homogeneity and unanimity of ending whole in-process human albumin from production to ensure that the production is preceding in the whole batch and the back carries the medicine quality unanimous, makes the incubation quality solidification of human albumin, promotes human albumin and incubates the quality and improves and carry the medicine effect, thereby promotes the yield of albumin nanoparticle type product, and possesses continuous manufacturing advantage.

The human serum albumin is used as a medicine package carrier, so that the medicine with poor water solubility can be easily dispersed in a human body, thereby achieving the therapeutic effect of the medicine. To encapsulate the drug in human serum albumin, the human serum albumin is heated to a suitable temperature to open the structure and encapsulate the drug, and then cooled to restore the structure to the original state, wherein the drug is encapsulated in the protein structure. The heat preservation incubation device that this application provided utilizes the circulation between heating jar 1 and the injection water pitcher 2, heats injection water for when raw materials in injection water and the feed tank get into incubation jar 4 under the drive of pump, the incubation temperature of human serum albumin is reached to the mixture to the heat that injection water takes, thereby stable, convenient incubation. The incubated human serum albumin is used in other procedures from the incubation tank 4.

Preferably, the circulation pipeline 11 comprises two branch pipes 111, two ends of the two branch pipes 111 are respectively communicated with the heating tank 1 and the water tank 2 for injection, and the circulation power mechanism 7 is arranged on one of the branch pipes 111.

The circulation pipeline 11 comprises two branch pipes 111, and one branch pipe 111 is provided with the circulation power mechanism 7, so that the circulation power mechanism 7 works, hot water in the heating tank 1 (which also accords with the water injection standard) can be added into the water tank 2 for injection, and water which does not flow out of the water tank 2 for injection through the first pipeline 21 flows back into the heating tank 1 for heating under the action of gravity, so that even if the temperature of the water in the water tank 2 for injection is reduced due to the fact that the time is long, the water can be supplemented after being heated in the heating tank 1 through the water for injection, and the temperature of the water in the water tank 2 for injection can be kept within a proper range.

When the amount of water for injection flowing into the first pipe 21 is large or the water temperatures in the water tank for injection 2 and the heating tank 1 reach a set standard, new water for injection can be replenished into the heating tank 1 and/or the water tank for injection 2.

Preferably, the first pump 5, the second pump 6, and the circulation power mechanism 7 are peristaltic pumps.

The peristaltic pump is preferably used for the first pump 5, the second pump 6, and the circulation power mechanism 7. The peristaltic pump has the advantages of no contact with liquid and no pollution, and has high precision, good sealing performance, low shearing force and simple maintenance, thereby being suitable for conveying injection water and materials.

Preferably, the heating tank 1 and the water tank 2 for injection are respectively provided with temperature sensors.

Preferably, the heating tank 1 and the injection water tank 2 are provided with temperature sensors, respectively, to monitor the temperatures in the heating tank 1 and the injection water tank 2, and to control whether the heating tank 1 is heated or not, or whether the circulation power mechanism 7 is operated or not, so as to maintain the temperatures within a target range.

Preferably, the first and

second pipelines

21 and 31 are each provided with a flow meter.

The first pipeline 21 and the second pipeline 31 can be respectively provided with a flowmeter for monitoring the flow of the water for injection or the raw material, and the first pump 5 and the second pump 6 are adjusted according to the data, so that the proper proportion of the amount of the water for injection and the amount of the raw material flowing into the incubation tank 4 in unit time, the incubation temperature and the concentration of the mixed raw material and the water for injection are ensured.

Preferably, the first line 21 merges with the second line 31 into a main line 8, which main line 8 in turn communicates with the incubation tank 4.

Preferably, the first line 21 merges with the second line 31 into a main line 8, which main line 8 in turn communicates with the incubation tank 4. The first pump 5 and the second pump 6 provide driving force in the first pipeline 21 and the second pipeline 31 respectively, so that liquid flows, when the liquid enters the main pipeline 8, the liquid is naturally mixed, and the liquid can be mixed to the extent just before or after flowing into the incubation tank 4.

Preferably, the first line 21, the second line 31 and the main line 8 are each provided with an insulation layer.

In order to ensure the temperature of the liquid, heat insulation layers are preferably arranged on the first pipeline 21, the second pipeline 31 and the main pipeline 8, so that the influence of the external environment on the temperature in the pipeline transmission process is reduced.

Preferably, the incubation tank 4 is provided with a heat-insulating jacket 41, and the incubation tank 4 is insulated by flowing water for injection in the heat-insulating jacket 41.

The human serum albumin is at normal temperature, and the temperature of the solution can be reduced when the human serum albumin is mixed with water for injection, so that the incubation tank is insulated by the water for injection, which is provided with an insulation jacket and flows through, and the effect of avoiding the temperature reduction of the albumin after mixing is poor, and the medicine carrying quality is low. The water for injection in the insulating jacket 41 comes from another water source for injection, not the heating tank 1 or the water tank 2 for injection, avoiding the influence on the incubation of albumin.

Preferably, the water outlet of the heating tank 1 is provided with a heating rod.

Preferably, a heating rod is provided at the water outlet of the heating tank 1 to heat the water flowing into the injection water tank 2. The water outlet of the heating tank 1 is a port directly communicated with the circulation power system 7, and water of the heating tank 1 flows to the circulation power system 7 from the port when the circulation power system 7 works and is heated by the heating rod in the process.

When two branch pipes 111 are arranged, the water outlet of the heating tank 1 is the opening of the branch pipe provided with the circulating power system 7 communicated with the heating tank 1.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present utility model. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the utility model. Thus, the present utility model is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A thermal incubation device, comprising: a heating tank (1), a water tank (2) for injection, a raw material tank (3) and an incubation tank (4),

the water tank (2) for injection is communicated to the incubation tank (4) through a first pipeline (21), and the first pipeline is provided with a first pump (5);

the raw material tank (3) is communicated to the incubation tank (4) through a second pipeline (31), and the second pipeline is provided with a second pump (6);

the heating tank (1) is communicated with the water tank (2) for injection through a circulating pipeline (11), the circulating pipeline (11) is provided with a circulating power mechanism (7), the heating tank (1) is used for injecting hot water into the water tank (2) for injection and receiving water flowing back from the water tank (2) for injection.

2. The incubation device according to claim 1, wherein the circulation line (11) comprises two branch pipes (111), two ends of the two branch pipes (111) are respectively communicated with the heating tank (1) and the water tank (2) for injection, and the circulation power mechanism (7) is arranged on one of the branch pipes (111).

3. The incubation device according to claim 1, wherein the first pump (5), the second pump (6), and the circulation power mechanism (7) are peristaltic pumps.

4. A device according to any one of claims 1-3, characterized in that the heating tank (1) and the water tank (2) for injection are each provided with a temperature sensor.

5. The incubation device according to claim 4, wherein the first and second lines (21, 31) are each provided with a flow meter.

6. A device according to claim 1 or 5, characterized in that the first line (21) merges with the second line (31) into a main line (8), which main line (8) is in turn connected to the incubation tank (4).

7. The incubation device according to claim 6, wherein the first line (21), the second line (31) and the main line (8) are each provided with an incubation layer.

8. A device according to claim 1, characterized in that the incubation tank (4) is provided with a heat-insulating jacket (41), the incubation tank (4) being insulated by flowing water for injection in the heat-insulating jacket (41).

9. The incubation device according to claim 1, wherein the water outlet of the heating tank (1) is provided with a heating rod.