CN219163322U - Light guide device suitable for protein chip processor - Google Patents
Light guide device suitable for protein chip processor Download PDFInfo
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- CN219163322U CN219163322U CN202223470139.1U CN202223470139U CN219163322U CN 219163322 U CN219163322 U CN 219163322U CN 202223470139 U CN202223470139 U CN 202223470139U CN 219163322 U CN219163322 U CN 219163322U
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Abstract
The application relates to a light guide device suitable for a protein chip processor, which mainly relates to the technical field of mass spectrometers, and comprises a support base, a side plate, an illumination assembly and an array assembly, wherein the side plate is perpendicular to the ground and is arranged at one end of the support base; the array assembly is provided with a plurality of liquid storage holes, and the liquid storage holes are uniformly formed along the length direction of the array assembly. The device has the advantages of simple structure, convenient disassembly and assembly and capability of simplifying the protein detection operation of the mass spectrometer.
Description
Technical Field
The application relates to the technical field of mass spectrometers, in particular to a light guide device suitable for a protein chip processor.
Background
Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF, matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry) is a novel soft ionization biological mass spectrometry analyzer developed in recent years. The device has high sensitivity and high quality detection range, and the detectable relative molecular weight is hundreds of thousands, so that the detection of biological macromolecules and polymer molecules is possible. Matrix-assisted laser desorption ionization time-of-flight mass spectrometers have been widely used for analysis of biological samples such as tissue slices, cells, microorganisms, proteins, polypeptides, nucleic acids, etc., and are an analytical instrument used in the fields of chemistry, biology, and pharmacy.
In detecting biological samples using matrix-assisted laser desorption ionization time-of-flight mass spectrometers, protein extraction of the biological samples is required first using a protein chip processor. The method specifically comprises the steps of respectively adding a protein chip and a processed biological sample into a protein chip processor, and combining the biological sample with the protein chip after full mixing. The area of the joint between the protein chip and the biological sample is only 3 square millimeters, so that the accuracy of subsequent detection is ensured, and after the biological sample solution is added into the protein chip processor, the joint of the protein chip is also required to be observed, and whether bubbles exist on the surface of the joint is observed. Because the hole site of the protein chip processor of the matrix assisted laser desorption ionization time-of-flight mass spectrometer is deeper, the work of observing bubbles is usually carried out with the aid of the lamp light of an illuminating lamp. In addition, the solution surface can generate light reflection, which further increases the difficulty of bubble observation and increases the requirement for operators.
In view of the above related art, the inventor considers that when detecting a biological sample by using the existing matrix-assisted laser desorption ionization time-of-flight mass spectrometer, the operation of observing bubbles at the binding point of the protein chip needs to use extra light, which is inconvenient to operate and has a defect of high requirement for operators.
Disclosure of Invention
In order to simplify the bubble observation work of the bonding point of the protein chip and reduce the operation difficulty of the matrix-assisted laser desorption ionization time-of-flight mass spectrometer, the application provides a light guide device suitable for a protein chip processor.
The application provides a light guide device suitable for protein chip processor adopts following technical scheme:
a light guide device suitable for a protein chip processor comprises a supporting base, a side plate, an illumination assembly and an array assembly, wherein the side plate is perpendicular to the ground and arranged at one end of the supporting base; the array assembly is provided with a plurality of liquid storage holes, and the liquid storage holes are uniformly formed along the length direction of the array assembly.
Through adopting above-mentioned technical scheme, support the base and play the effect of supporting and spacing to other partial structures of this application, install the curb plate on supporting the base and play support and spacing effect to lighting assembly, lighting assembly who installs on the curb plate can produce light, light array assembly's bottom, thereby make whether the protein chip juncture has the bubble and observe more easily, stock solution hole in the array assembly can be used for holding biological sample solution, lighting assembly's light incident angle has avoided biological sample solution surface reflection of light's problem, the bubble of simplifying the juncture of protein chip observes the work, reduce the matrix-assisted laser desorption ionization time of flight mass spectrometer's the operation degree of difficulty's utility model purpose, can not cause the influence to subsequent detection operation simultaneously.
Optionally, the lighting assembly includes a board clamped on the side board and a plurality of lamp beads arranged on the board.
Through adopting above-mentioned technical scheme, picture peg in the lighting assembly provides the mounted position for the installation of lamp pearl, and a plurality of lamp pearls of installing on the picture peg can produce the light beam after the circular telegram and illuminate array assembly's bottom, and picture peg and curb plate joint's structural design can simplify the installation and dismantle the process of this application.
Optionally, light holes are formed in the side plates, and the vertical heights of the light holes correspond to the vertical heights of the lamp beads.
Through adopting above-mentioned technical scheme, the light trap structure of seting up on the curb plate with lamp pearl vertical height correspondence can make things convenient for the light that the lamp pearl produced to penetrate directly on the array component, avoids the curb plate structure to cause the illumination of lamp pearl to shelter from, makes the bubble condition in the array component stock solution hole easier to observe.
Optionally, a yielding chute is arranged on the side plate; the depth of the abdication chute is consistent with the thickness of the lamp bead, and the abdication chute is communicated with the light hole.
Through adopting above-mentioned technical scheme, the spout structure of stepping down of seting up on the curb plate has played dodging the effect to the lamp pearl, avoids the lamp pearl to suffer extrusion and wearing and tearing when the picture peg inserts in the recess of curb plate.
Optionally, the side plate is detachably connected with the support base.
Through adopting above-mentioned technical scheme, the curb plate has further promoted the flexibility and the environmental suitability of this application with the structural design that support base can dismantle the connection, makes this application dismouting more easily.
Optionally, limit sliding blocks are symmetrically arranged on two sides of the array component.
Through adopting above-mentioned technical scheme, the spacing slider structure that array subassembly bilateral symmetry set up has played spacing effect to the sliding connection structure between array subassembly and the support base, has improved the gesture stability of array subassembly when taking place relative slip with the support base.
Optionally, a bump is arranged at the top of the array component; the bump is higher than the top of the support base.
Through adopting above-mentioned technical scheme, the lug that is higher than that array subassembly top set up supports the base top can facilitate the use through pushing the mode of lug with array subassembly will support the base and demolish, has further simplified the dismantlement process of this application.
Optionally, the bump is slidingly connected to the array assembly along a direction perpendicular to the ground.
Through adopting above-mentioned technical scheme, lug and array subassembly along perpendicular ground direction sliding connection's structural design makes the lug when functioning, can not cause the influence to subsequent detection operation.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the supporting base plays a role in supporting and limiting other part structures, the side plate arranged on the supporting base plays a role in supporting and limiting the lighting assembly, the lighting assembly arranged on the side plate can generate light rays to illuminate the bottom of the array assembly, so that whether bubbles exist at the binding points of the protein chip or not to enable the protein chip to be observed more easily, a liquid storage hole in the array assembly can be used for containing biological sample solution, the problem of reflection of light on the surface of the biological sample solution is avoided due to the light incidence angle of the lighting assembly, the bubble observation work of the binding points of the protein chip is simplified, the purpose of reducing the operation difficulty of the matrix-assisted laser desorption ionization time-of-flight mass spectrometer is achieved, and meanwhile, the subsequent detection operation cannot be influenced;
2. the picture peg in the lighting assembly in this application provides the mounted position for the installation of lamp pearl, and a plurality of lamp pearls of installing on the picture peg can produce the light beam after the circular telegram and illuminate the bottom of array subassembly, and picture peg and curb plate joint's structural design can simplify the installation and the dismantlement process of this application;
3. limiting slide block structures symmetrically arranged on two sides of the array assembly play a limiting role on a sliding connection structure between the array assembly and the supporting base, and the gesture stability of the array assembly when relative sliding occurs between the array assembly and the supporting base is improved.
Drawings
Fig. 1 is a schematic structural diagram of a light guiding device suitable for a protein chip processor according to an embodiment of the present application.
Fig. 2 is a schematic structural view of a side plate in an embodiment of the present application.
Fig. 3 is a schematic structural view of an illumination assembly in an embodiment of the present application.
FIG. 4 is a schematic diagram of an array assembly according to an embodiment of the present application.
Reference numerals illustrate: 1. a support base; 2. a side plate; 21. a light hole; 22. a yielding chute; 3. a lighting assembly; 31. inserting plate; 32. a lamp bead; 4. an array assembly; 41. a liquid storage hole; 42. a limit sliding block; 43. and a bump.
Detailed Description
The present application is described in further detail below in conjunction with fig. 1-4.
The matrix-assisted laser desorption ionization time-of-flight mass spectrometer is a novel soft ionization biological mass spectrometer which is developed in recent years, and is an analytical instrument widely used in the fields of chemistry, biology and pharmacy. In detecting biological samples using matrix-assisted laser desorption ionization time-of-flight mass spectrometers, protein extraction of the biological samples is required first using a protein chip processor. The method specifically comprises the steps of respectively adding a protein chip and a processed biological sample into a protein chip processor, and combining the biological sample with the protein chip after full mixing. In order to ensure the accuracy of the subsequent detection, after the biological sample solution is added into the protein chip processor, the binding points of the protein chip are also required to be observed, and whether bubbles exist on the surfaces of the binding points is observed. Because the hole site of the protein chip processor of the matrix assisted laser desorption ionization time-of-flight mass spectrometer is deeper, the work of observing bubbles is usually carried out with the aid of the lamp light of an illuminating lamp. In addition, the solution surface can generate light reflection, which further increases the difficulty of bubble observation and increases the requirement for operators. In order to simplify the bubble observation work of the bonding point of the protein chip and reduce the operation difficulty of the matrix-assisted laser desorption ionization time-of-flight mass spectrometer, the application provides a light guide device suitable for a protein chip processor.
The embodiment of the application discloses a light guide device suitable for a protein chip processor. Referring to fig. 1, a light guide device suitable for a protein chip handler includes a support base 1, a side plate 2, an illumination assembly 3, and an array assembly 4. Wherein, curb plate 2 installs perpendicularly in the one end of supporting base 1, and lighting assembly 3 installs on curb plate 2, and array assembly 4 installs on supporting base 1.
Referring to fig. 1, a support base 1 may be a base formed by vertically splicing plates made of polymer materials and provided with a chute along a length direction. The sliding groove on the supporting base 1 is matched with the appearance of the array assembly 4 to form a sliding connection structure.
Referring to fig. 1 and 2, the side plate 2 may be a rectangular plate having a slot formed along a direction perpendicular to the ground, and a light hole 21 is formed in a middle position of the side plate 2. The light transmission hole 21 may be a circular through hole. The side plate 2 is provided with a yielding chute 22 perpendicular to the ground, and the yielding chute 22 is communicated with the light hole 21.
Referring to fig. 1 and 3, the lighting assembly 3 includes a shutter and a plurality of lamp beads 32. The lamp beads 32 are mounted on the insert plate 31, and the number of the lamp beads 32 may be 2. The 2 lamp beads 32 are arranged up and down in parallel and are consistent with the vertical height of the light holes 21 on the side plate 2. The plugboard 31 is clamped in a clamping groove on the side plate 2, and the thickness of the lamp beads 32 is not greater than the depth of the yielding chute 22.
Referring to fig. 1 and 4, the array assembly 4 may be a transparent solid polymer block, and the array assembly 4 is provided with a plurality of liquid storage holes 41 along the length direction, and the liquid storage holes 41 may be cylindrical blind holes, and the plurality of liquid storage holes 41 are uniformly arranged along the length direction of the array assembly 4. Limiting sliding blocks 42 are symmetrically arranged on the left side and the right side of the array assembly 4, and the top of the array assembly 4 is connected with a protruding block 43 in a sliding mode along the direction perpendicular to the ground. The height of the bump 43 is higher than the top of the support base 1.
The implementation principle of the light guide device suitable for the protein chip processor in the embodiment of the application is as follows: the operator firstly inserts the array component 4 containing the protein chip and the biological sample solution into the supporting base 1, then inserts the lighting component 3 into the side plate 2, turns on the power supply of the lighting component 3, observes the bubble condition of the binding point of the protein chip in the array component 4, marks the sample meeting the requirement and removes the sample from the supporting base 1 for further detection operation.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (8)
1. A light guide device suitable for a protein chip processor, characterized in that: the device comprises a support base (1), a side plate (2) perpendicular to the ground and arranged at one end of the support base (1), an illumination assembly (3) arranged on the side plate (2) and an array assembly (4) connected to the support base (1) in a sliding manner; the array assembly (4) is provided with a plurality of liquid storage holes (41), and the liquid storage holes (41) are uniformly formed along the length direction of the array assembly (4).
2. A light guide device for a protein chip processor as defined in claim 1, wherein: the lighting assembly (3) comprises a plugboard (31) clamped on the side plate (2) and a plurality of lamp beads (32) arranged on the plugboard (31).
3. A light guide device for a protein chip processor as defined in claim 2, wherein: the side plates (2) are provided with light holes (21), and the vertical heights of the light holes (21) correspond to the vertical heights of the lamp beads (32).
4. A light guide device for a protein chip processor as defined in claim 3, wherein: a yielding chute (22) is formed in the side plate (2); the depth of the yielding chute (22) is consistent with the thickness of the lamp beads (32), and the yielding chute (22) is communicated with the light hole (21).
5. A light guide device for a protein chip processor as defined in claim 1, wherein: the side plates (2) are detachably connected with the support base (1).
6. A light guide device for a protein chip processor as defined in claim 1, wherein: limiting sliding blocks (42) are symmetrically arranged on two sides of the array assembly (4).
7. A light guide device for a protein chip processor as defined in claim 1, wherein: the top of the array component (4) is provided with a bump (43); the protruding block (43) is higher than the top of the supporting base (1).
8. A light guide apparatus for a protein chip processor as defined in claim 7, wherein: the bump (43) is slidingly connected with the array assembly (4) along a direction perpendicular to the ground.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223470139.1U CN219163322U (en) | 2022-12-24 | 2022-12-24 | Light guide device suitable for protein chip processor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223470139.1U CN219163322U (en) | 2022-12-24 | 2022-12-24 | Light guide device suitable for protein chip processor |
Publications (1)
| Publication Number | Publication Date |
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| CN219163322U true CN219163322U (en) | 2023-06-09 |
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| CN202223470139.1U Active CN219163322U (en) | 2022-12-24 | 2022-12-24 | Light guide device suitable for protein chip processor |
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