CN219071576U

CN219071576U - Closed-loop system for diabetes

Info

Publication number: CN219071576U
Application number: CN202223499937.7U
Authority: CN
Inventors: 崔悦
Original assignee: Peking University
Current assignee: Peking University
Priority date: 2022-12-27
Filing date: 2022-12-27
Publication date: 2023-05-26
Anticipated expiration: 2032-12-27

Abstract

The application belongs to the technical field of medical equipment, and discloses a diabetes closed-loop system which comprises an insulin pump, a hose sensor and a control unit; the insulin pump comprises a pump body, wherein the pump body is internally used for storing insulin, a film with a conical hole is arranged in the pump body, a piezoelectric ring is arranged on the film, and the film and the piezoelectric ring are connected with an external alternating current power supply through a wire; the hose sensor comprises a tubular matrix and electrodes circumferentially distributed on the outer wall of the matrix; the control unit receives the electric signal of the hose biosensor and then controls the insulin pump to be started and stopped. The insulin pump, the hose sensor and the control unit are integrated to form a closed loop, the hose sensor detects glucose concentration signals in tissue fluid of a patient, the work of the insulin pump is controlled, the cavity in the tubular substrate is used as an insulin injection channel, automatic detection of blood sugar and automatic insulin supply of a diabetic patient are realized, the detection and treatment functions are integrated, the size is small, the portable is convenient, and the manufacturing cost is low.

Description

Closed-loop system for diabetes

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a diabetes closed-loop system.

Background

Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. Diabetes is a long-standing symptom of hyperglycemia that can lead to chronic damage, dysfunction of various tissues, especially eyes, kidneys, heart, blood vessels, nerves.

In order to better and more portable control blood sugar and improve the life quality of diabetics, a diabetes closed-loop system is developed on the market, and the human pancreas function is simulated to realize the automatic insulin supplementation, but the diabetes closed-loop system in the current business has large volume and high price, can not be carried about by diabetics, is difficult to popularize and use, and the diabetes closed-loop system with small volume, convenient carrying and low price is developed, so that the diabetics can keep blood sugar balance for a long time and improve the life quality.

Disclosure of Invention

In order to solve the problems, the utility model provides a diabetes closed-loop system.

The technical aim of the utility model is realized by the following technical scheme: a diabetes closed loop system comprising an insulin pump, a hose sensor and a control unit;

the insulin pump comprises a pump body, wherein insulin is stored in the pump body, a film with a conical hole is arranged in the pump body, a piezoelectric ring is arranged on the film, and the film and the piezoelectric ring are connected with an external alternating current power supply through a wire;

the hose sensor comprises a tubular matrix and electrodes circumferentially distributed on the outer wall of the matrix;

the input end of the control unit is connected with the output end of the hose sensor, and the output end of the control unit is connected with the input end of the insulin pump; the control unit receives the electric signal of the hose biosensor and then controls the insulin pump to be started and stopped.

Through adopting above-mentioned technical scheme, with insulin pump and hose sensor integration together, form the closed loop through the control unit connection control, electrode collection through on the hose sensor detects the glucose concentration in the patient's tissue fluid, thereby control the work of insulin pump, the cavity in the reuse hose is as insulin injection passageway, realize the automated inspection of diabetes patient's blood sugar and the automatic supply of insulin, collect detection and treatment function in an organic whole, small, portable, the cost is low, can satisfy the automated inspection of diabetes patient's blood sugar in daily life and the automatic supply of insulin, improve quality of life.

Further, the film is a hard film material or a flexible film material.

By adopting the technical scheme, the film is made of hard or flexible film materials, and can be stretched and bent under the vibration condition.

Further, the piezoelectric ring is integrally connected with the film.

Through adopting above-mentioned technical scheme, connect piezoelectricity ring and film as an organic whole for piezoelectricity ring vibration directly drives the film vibration, has avoided the energy loss.

Further, the cross section of the tubular matrix is circular or polygonal, and the length of the tubular matrix is 1mm-15mm.

By adopting the technical scheme, when the cross section of the tubular matrix is circular, the electrodes are arranged on the outer wall of the tubular matrix, and when the cross section of the tubular matrix is polygonal, the electrodes can be arranged on all sides of the polygonal shape of the tubular matrix.

Further, the electrodes include a working electrode and a working electrode.

By adopting the technical scheme, two electrodes are arranged to form a loop, and the action electrode can simultaneously play roles of communicating a circuit and stabilizing voltage.

Further, the electrodes include a working electrode, a counter electrode, and a reference electrode.

By adopting the technical scheme, three electrodes are arranged, the counter electrode plays a role of communicating a circuit, and the reference electrode plays a role of stabilizing voltage.

Further, the control unit comprises a signal acquisition module, a control module and an execution module, wherein the signal acquisition module is used for receiving and converting an electric signal of the hose sensor; the control module analyzes the electric signals acquired by the signal acquisition module and issues instructions to the execution module; the execution module controls the start and stop of the insulin pump according to the instruction sent by the control module.

By adopting the technical scheme, the signal acquisition module, the control module and the execution module are arranged, and the closed loop of the control system is formed from acquisition to analysis to execution.

In summary, the utility model has the following beneficial effects:

1. in the application, the insulin pump and the hose sensor are integrated together, the control unit is connected and controlled to form a closed loop, the electrode on the hose sensor is used for collecting and detecting the glucose concentration in tissue fluid of a patient, so that the work of the insulin pump is controlled, and then the cavity in the hose is used as an insulin injection channel, so that the automatic detection of blood sugar and the automatic replenishment of insulin of a diabetic patient are realized, the functions of detection and treatment are integrated, the volume is small, the carrying is convenient, the manufacturing cost is low, the automatic detection of blood sugar and the automatic replenishment of insulin of the diabetic patient in daily life can be satisfied, and the life quality is improved;

2. in this application, through setting up the hose sensor, the hose sensor sets up circular or polygon tubulose to set up the electrode at the tubulose base member outer wall, the electrode is arranged in as sensor collection patient's tissue in-liquid glucose concentration signal and transmission, and the cavity in the tubulose base member is used for doing insulin injection passageway and injects insulin, and hose sensor has integrated the two megafunctions of detection and injection promptly, makes whole function more concentrated, is convenient for miniaturized.

Drawings

FIG. 1 is a schematic flow chart of an embodiment of the present utility model;

FIG. 2 is a schematic diagram of an embodiment of the present utility model;

FIG. 3 is a schematic view of a hose sensor according to an embodiment of the present utility model in a bent state of a tubular base body;

FIG. 4 is a schematic diagram of the structure of an insulin pump according to an embodiment of the present utility model;

FIG. 5 is a schematic view of a circular tubular hose sensor with two electrodes according to an embodiment of the present utility model;

FIG. 6 is a schematic view of a three electrode circular tubular hose sensor according to an embodiment of the present utility model;

FIG. 7 is a cross-sectional view of a two-electrode rectangular tubular hose sensor according to an embodiment of the present utility model;

fig. 8 is a cross-sectional view of a three-electrode regular hexagonal tubular hose sensor according to an embodiment of the present utility model.

In the figure: 10. an insulin pump; 11. a pump body; 12. a film; 13. a tapered bore; 14. a piezoelectric ring; 20. a hose sensor; 21. a tubular base; 22. an electrode; 221. a working electrode; 222. an active electrode; 223. a counter electrode; 224. a reference electrode; 30. a control unit; 31. a signal acquisition module; 32. a control module; 33 execute the module.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application; it is apparent that the described embodiments are only a part of the embodiments of the present application, not all of the embodiments, and all other embodiments obtained by a person having ordinary skill in the art without making creative efforts based on the embodiments in the present application are within the scope of protection of the present application.

As shown in fig. 1-8, embodiments of the present application disclose a diabetes closed loop system comprising an insulin pump 10, a hose sensor 20, and a control unit 30.

Insulin pump 10 includes a pump body 11, a film 12 is provided in pump body 11, film 12 is made of hard film material or flexible film material, such as stainless steel, gold, copper, zinc, platinum, silver, tungsten, aluminum alloy, natural rubber, isoprene rubber, polybutadiene rubber, styrene-butadiene rubber, butadiene nitrile rubber, chloroprene rubber, butyl rubber, halogenated butyl rubber, ethylene propylene diene rubber, epichlorohydrin rubber, polyacrylate rubber, silicone rubber, fluorosilicone rubber, fluororubber, chlorosulfonated polyethylene, hydrogenated butadiene nitrile rubber, thermoplastic polyolefin elastomer, thermoplastic styrene elastomer, polyurethane thermoplastic elastomer, polyester thermoplastic elastomer, polyamide thermoplastic elastomer, halogen-containing thermoplastic elastomer, ionic thermoplastic elastomer, ethylene copolymer thermoplastic elastomer, 1,2 polybutadiene thermoplastic elastomer, trans-polyisoprene thermoplastic elastomer, melt-processed thermoplastic elastomer, thermoplastic vulcanized rubber, polydimethylsiloxane, and the like.

The film 12 is provided with a plurality of conical holes 13, the conical holes 13 are arranged on the film 12 in a laser etching or ion selective etching mode, the large-caliber end of the conical holes 13 is positioned on one side of the cavity for storing insulin, namely, the large-caliber end of the conical holes 13 is a liquid inlet end, and the small-caliber end is a liquid outlet end.

The membrane 12 is also provided with a piezoelectric ring 14, the piezoelectric ring 14 is arranged on one side of the small caliber end of the conical hole 13, the piezoelectric ring 14 is made of piezoelectric materials such as piezoelectric crystals, piezoelectric ceramics or piezoelectric polymers, and when the membrane 12 is manufactured, a layer of piezoelectric materials can be deposited by sputtering through holes of a mask plate at the outer edge of the membrane 12 to form the piezoelectric ring 14, so that the piezoelectric ring 14 and the membrane 12 are integrated.

The membrane 12 and the piezoelectric ring 14 are connected with an external alternating current power supply through a lead, and specifically, the external alternating current power supply adopts alternating current with the voltage of 10V-100V, and can also be externally connected with direct current with the voltage of 1-10V, and the alternating current is converted into alternating current with the voltage of 10V-100V through a circuit.

When the insulin pump works specifically, the film 12 and the piezoelectric circular ring 14 are electrified, the piezoelectric circular ring 14 is driven to vibrate after being electrified with alternating current, the film 12 is stretched or bent, the conical hole 13 is continuously stretched or contracted under the stretching or bending action of the film 12, and the caliber is alternately changed, so that insulin stored in the pump body 11 is extruded.

The hose sensor 20 comprises a tubular base 21, the tubular base 21 being tubular in shape as a whole, and having a cavity along its length for the passage of insulin injection. Specifically, the flexible tube sensor 20 is connected to the insulin pump 10, and the liquid inlet end of the tubular base 21 is engaged with the liquid outlet end of the pump body 11 for injecting insulin from the insulin pump 10 into the human body through the flexible tube sensor 20.

An electrode 22 is provided on the outer wall of the tubular base 21, and the electrode 22 includes a working electrode 221 and a power electrode 222. Wherein the active electrode 222 serves as a communication circuit and a stabilizing voltage for the hose sensor 20. When the hose sensor 20 detects the glucose concentration of the patient, the reagent enzyme on the working electrode 221 reacts with the corresponding component in the body fluid of the patient to generate a product, so that the working electrode 221 generates an electric signal. Specifically, glutaraldehyde, chitosan, or other immobilized glucose oxidase may be used as a reagent enzyme, and when the concentration of glucose in the subcutaneous tissue fluid changes, glucose reacts with the glucose oxidase to generate hydrogen peroxide, which is oxidized or reduced on the working electrode 211 to generate a current change, so that the sensor 2 outputs an electrical signal.

In this embodiment, the working electrode 221 may use carbon paste, gold, platinum, or a carbon composite, or a gold composite or a platinum composite as an electrode material; the active electrode 222 may be silver/silver chloride as the electrode material. The working electrode 221 and the working electrode 222 may be processed by a processing method such as screen printing, ink jet printing, micro-nano processing evaporation or sputtering, and formed on the tubular substrate 21.

Electrode 22 may also include a working electrode 221, a counter electrode 223, and a reference electrode 224. At this time, the counter electrode 223 serves as a communication circuit for the hose sensor 20, and the reference electrode 224 serves as a stabilizing voltage for the hose sensor 20. Specifically, the working electrode 221 may employ carbon paste, or gold, or platinum, or carbon composite, or gold composite, or platinum composite as an electrode material; the counter electrode 223 may employ carbon paste, or gold, or platinum, or carbon composite, or gold composite, or platinum composite as an electrode material; the reference electrode 224 may be silver/silver chloride as the electrode material. The working electrode 221, the counter electrode 223, and the reference electrode 224 may be processed by a processing method such as screen printing, ink-jet printing, micro-nano processing evaporation or sputtering, and formed on the tubular substrate 21.

The cross section of the tubular base 21 is circular or polygonal, wherein the polygonal shape may be rectangular, regular pentagonal, regular hexagonal, etc. The material of the tubular substrate 21 may be Polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), polyvinyl chloride (PVC), glass fiber (FR 4), polyurethane silk fibroin, chitosan, polylactic acid, polycarbonate, polyurethane (PU), polyester, polypropylene (PP), polyethylene (PE), polyimide thermoplastic polyurethane elastomer (TPU), silicone, rubber, latex, thermoplastic elastomer (TPE), or perfluoroethylene propylene copolymer (FEP), etc. The tubular substrate 21 has a length of lmm-10mm, such as lmm, 2mm, 5mm, 8mm, l0mm, 12mm, or 15mm, and the inner diameter of the substrate 21 is 100 μm-1000 μm, such as 100 μm, 200 μm, 300 μm, 500m, 1000 μm.

The control unit 30 comprises a signal acquisition module 31, a control module 32 and an execution module 33, wherein the input end of the signal acquisition module 31 is connected with the output end of the hose sensor 20, the output end of the signal acquisition module 31 is connected with the input end of the control module 32, the input end of the control module 32 is connected with the input end of the execution module 33, and the output end of the execution module 33 is connected with the input end of the insulin pump 10. The signal acquisition module 31 is configured to receive and convert an electrical signal of the flexible tube sensor 20, transmit the electrical signal detected by the flexible tube sensor 20 to the control module 32, analyze and determine the electrical signal acquired by the signal acquisition module 31 by the control module 32, and then send an instruction to the execution module 33, where the execution module 33 controls the on-off of the insulin pump 10 according to the instruction sent by the control module 32 to execute the instruction.

The use principle of the diabetes closed-loop system in the embodiment is as follows: after the tubular substrate 21 of the hose sensor 20 penetrates into the skin, electrochemical reaction occurs on the working electrode 221, the change of the electric signal is transmitted to the signal acquisition module 31, the signal acquisition module 31 transmits the electric signal to the control module 32, and the control module 32 analyzes the glucose concentration in the tissue fluid so as to judge whether insulin is to be injected; if the glucose concentration in the tissue fluid increases, the control module 32 sends an instruction of insulin injection to the execution module 33, the execution module 33 instructs the insulin pump 10 to be electrified, the piezoelectric ceramic ring 14 generates radial vibration to drive the membrane 12 to vibrate synchronously and radially, so that the conical hole 13 on the membrane 12 extends and bends repeatedly, the insulin is continuously fed into the injection channel in the tubular matrix 21 of the hose sensor 20 on the basis of the insulin, and then fed into the skin, the blood glucose concentration of a diabetic patient is detected, the insulin is automatically fed, manual intervention is not needed in the using process, the use is convenient, the functions of measurement and treatment are realized, and the integration level is higher. And the insulin pump 10 and the hose sensor 20 are small in size, convenient to carry and low in manufacturing cost.

The above description is only a preferred embodiment of the present utility model, and the protection scope of the present utility model is not limited to the above examples, and all technical solutions belonging to the concept of the present utility model belong to the protection scope of the present utility model. It should be noted that modifications and adaptations to the present utility model may occur to one skilled in the art without departing from the principles of the present utility model and are intended to be within the scope of the present utility model.

Claims

1. A closed-loop system for diabetes mellitus, characterized by:

comprises an insulin pump, a hose sensor and a control unit;

the input end of the control unit is connected with the output end of the hose sensor, and the output end of the control unit is connected with the input end of the insulin pump; the control unit receives the electric signal of the hose sensor and then controls the insulin pump to be started and stopped.

2. A closed-loop system for diabetes according to claim 1, characterized in that: the film is a hard film material or a flexible film material.

3. A closed-loop system for diabetes according to claim 1, characterized in that: the piezoelectric ring is integrally connected with the film.

4. A closed-loop system for diabetes according to claim 1, characterized in that: the cross section of the tubular matrix is circular or polygonal, and the length of the tubular matrix is 1mm-15mm.

5. A closed-loop system for diabetes according to claim 1, characterized in that: the electrodes include a working electrode and a working electrode.

6. A closed-loop system for diabetes according to claim 1, characterized in that: the electrodes include a working electrode, a counter electrode, and a reference electrode.

7. A closed-loop system for diabetes according to claim 1, characterized in that: the control unit comprises a signal acquisition module, a control module and an execution module, wherein the signal acquisition module is used for receiving and converting an electric signal of the hose sensor; the control module analyzes the electric signals acquired by the signal acquisition module and issues instructions to the execution module; the execution module controls the start and stop of the insulin pump according to the instruction sent by the control module.