CN219001785U

CN219001785U - Novel animal irradiation fixing device

Info

Publication number: CN219001785U
Application number: CN202222846417.2U
Authority: CN
Inventors: 请求不公布姓名
Original assignee: Neutron High Tech Industry Development Chongqing Co ltd
Current assignee: Guozhong Medical Technology Chongqing Co ltd
Priority date: 2022-10-27
Filing date: 2022-10-27
Publication date: 2023-05-12
Anticipated expiration: 2032-10-27

Abstract

The utility model relates to a novel animal irradiation fixing device, which relates to the field of animal experiment research equipment, wherein a fixing disc is rotationally connected with a bracket and positioned, the fixing disc comprises a disc body, a plurality of partition boards and a central rod, one end of the disc body is provided with a regular polygon or round containing groove, the partition boards are uniformly distributed along the circumferential direction of the disc body and are fixed in the containing groove, the radial outer area of the containing groove is divided into a plurality of containing areas, the central rod is arranged in the radial inner area of the containing groove, a shielding cover is annular, and the shielding cover is detachably connected with one end of the disc body and seals all the containing areas. The beneficial effects of the utility model are as follows: the experimental animal can be firmly fixed, and the part to be irradiated is irradiated. Can realize the irradiation at any angle and has simple operation. And a plurality of animals are irradiated at one time, so that the irradiation dose is consistent, the experimental efficiency is improved, and the cost is reduced. The shielding cover reduces the irradiation of normal tissues except the part to be irradiated, and experimental data are more reliable.

Description

Novel animal irradiation fixing device

Technical Field

The utility model relates to the field of animal experiment research equipment, in particular to a novel animal irradiation fixing device.

Background

Malignant tumors (cancers) are seriously threatening human life and health, and radiation therapy is one of the main means of cancer treatment, and more than 70% of tumor patients need radiation therapy to different degrees. Radiation or radiation biology is a discipline that studies the effects of radiation on living organisms and plays an important role in the theoretical research of radiotherapy. Radiation therapy theory research often requires further verification of safety and effectiveness by establishing animal tumor models for animal testing prior to entering human clinical trials. The effect of radiation on living organism tissue is known through animal radiation experiments, and the biological effect generated by different types of radiation and the influence of different internal and external factors on the biological effect are observed.

In experiments, small animals are mostly adopted as experimental objects, such as mice and rats, and particularly nude mice. Because small animals are small in size, easy to move and not matched, when the experiment is carried out, the experimental animals are subjected to anesthesia, full fixation, exposure of an irradiation part and the like, and then transported to a ray generating device such as a deep X-ray machine, a linear accelerator or a heavy ion accelerator for irradiation, and meanwhile, the environment with ventilation and sufficient oxygen supply under the irradiation condition is ensured.

At present, most of radiation treatment experiment animal irradiation fixing devices can be used for single animal experiments, and fewer fixing devices can be used for batch animal experiments. Some devices place experimental animals side by side, the distance between the animals and the radiation source is not equal, and the uniformity and flatness of the received radiation dose are not ideal. The irradiation angle of the part of the fixing device is fixed single-field irradiation, the horizontal irradiation is mostly used, and the irradiation angle cannot be adjusted.

Disclosure of Invention

The utility model aims to solve the technical problem of fixing a plurality of experimental objects at the same time and adjusting the irradiation angle.

The technical scheme for solving the technical problems is as follows: the utility model provides a novel animal irradiation fixing device, includes support, shielding lid and fixed disk, the fixed disk with the support rotates to be connected and fixes a position, the fixed disk includes disk body, baffle and well core rod, the one end of disk body has regular polygon or circular shape holding tank, the baffle is a plurality of, and is a plurality of the baffle is followed disk body circumference evenly distributed just is fixed in the holding tank, and will the radial external area of holding tank divide into a plurality of holding sections, well core rod install in the radial internal area of holding tank, the shielding lid is annular, the shielding lid with the one end of disk body can be dismantled and be connected and seal all the holding section.

The beneficial effects of the utility model are as follows: the experimental animal is placed in the accommodating area, the part to be irradiated extends out of the accommodating area and is fixed on the central rod, and the part to be irradiated is exposed out of the shielding cover, so that the experimental animal can be firmly fixed, and the part to be irradiated is irradiated. The fixed disk can rotate relative to the bracket, so that irradiation at any angle is realized. The vertical, horizontal or other angle irradiation can be realized without other auxiliary equipment, and the operation is simple. And a plurality of animals are irradiated at one time, so that the irradiation dose is consistent, the experimental efficiency is improved, and the cost is reduced. The shielding cover protects the animals from radiation, reduces the irradiation of normal tissues except the part to be irradiated, and has less damage to the animals, so that experimental data are more reliable. Simple structure, easy disassembly and convenient cleaning.

On the basis of the technical scheme, the utility model can be improved as follows.

Further, the device also comprises a rotating rod, wherein one end of the rotating rod is fixedly connected with the side wall of the fixed disc; the other end of the rotary rod is in threaded connection with the support, or the other end of the rotary rod is in rotary connection with the support, a limit screw is further in threaded connection with the support, and the end of the limit screw is in butt joint with the rotary rod to limit or separate.

The beneficial effects of adopting the further scheme are as follows: the rotating rod is rotationally adjusted and positioned relative to the bracket, so that the rotation and the positioning of the fixed disc are realized.

Further, the support includes base and dead lever, the dead lever is vertical to be set up, its lower extreme with base fixed connection, the other end of rotary rod with the dead lever is connected.

Further, the adjustable bolt comprises an adjusting bolt, the end wall of the other end of the disc body is provided with a strip-shaped adjusting hole which is arranged along the radial direction, the adjusting bolt comprises a bolt head and a bolt screw rod, one end of the bolt screw rod is fixedly connected with the bolt head, and the other end of the bolt screw rod penetrates through the adjusting hole and is in threaded connection with the end part of the central rod.

The beneficial effects of adopting the further scheme are as follows: the lengths of the parts to be irradiated of different experimental animals extending out of the accommodating area can be different, and the positions of the central rod along the radial direction of the tray body can be adjusted, so that the experimental animals can adapt to different conditions.

Further, the center rod is provided with at least two along the circumferential direction of the disc body, and the adjusting hole and the adjusting bolt are correspondingly provided with at least two.

The beneficial effects of adopting the further scheme are as follows: at least two center poles can provide more locations for holding laboratory animals for ease of handling.

Further, the fixed disk further comprises a separation plate, the separation plate is cylindrical, one end of the separation plate is fixedly connected with the bottom wall of the accommodating groove, the separation plate is located on the outer side of the center rod, and the separation plate is provided with arched door holes corresponding to each accommodating area.

The beneficial effects of adopting the further scheme are as follows: the isolation plate and the isolation plate are used for limiting the position of the experimental animal, and the arched door hole is arranged to facilitate pulling out the part to be irradiated of the experimental animal from the accommodating area.

Further, the isolation plate is made of transparent organic glass.

Further, the other end wall of the tray body is provided with a ventilation through hole corresponding to each accommodating area.

The beneficial effects of adopting the further scheme are as follows: the ventilation through holes are convenient for the breath of experimental animals, and can carry out irradiation experiments in living bodies or in anesthesia states.

Further, the bracket is made of aluminum alloy or carbon fiber; the material of the fixed disk is transparent organic glass.

The beneficial effects of adopting the further scheme are as follows: the transparent organic glass has certain strength, the half-life period of the radioactive isotope generated after the transparent organic glass is activated by neutrons is short, the radiation dose of the non-irradiated part of the experimental animal is reduced, and the transparent organic glass is convenient for observing the state of the experimental animal.

Further, the shielding cover is made of lead, lithium-containing polyethylene, boron-containing polyethylene or gadolinium-containing compound; the thickness of the shielding cover is 2cm to 3cm.

The beneficial effects of adopting the further scheme are as follows: the shielding cover can furthest reduce non-selective dose deposition of normal tissues, reduce irradiation dose caused to non-irradiation parts of an irradiated body, and enable experimental results to be more accurate.

Drawings

FIG. 1 is a three-dimensional view of the novel animal irradiation fixture of the present utility model at one of its viewing angles;

FIG. 2 is a three-dimensional view of the novel animal irradiation fixture of the present utility model at another perspective;

FIG. 3 is an internal structural view of the fixing plate of the present utility model;

fig. 4 is a schematic view of the fixing plate of the present utility model when a mouse is fixed.

In the drawings, the list of components represented by the various numbers is as follows:

1. a bracket; 1-1, a base; 1-2, fixing rods;

2. a shielding cover;

3. a fixed plate; 3-1, a separator; 3-2, a separation plate; 3-3, a central rod;

4. and (5) rotating the rod.

Detailed Description

The principles and features of the present utility model are described below with reference to the drawings, the examples are illustrated for the purpose of illustrating the utility model and are not to be construed as limiting the scope of the utility model.

As shown in fig. 1 to 4, this embodiment provides a novel animal irradiation fixing device, including support 1, shielding lid 2 and fixed disk 3, fixed disk 3 with support 1 rotates to be connected and fix a position, fixed disk 3 includes disk body, baffle 3-1 and central pole 3-3, the one end of disk body has regular polygon or circular holding tank, baffle 3-1 is a plurality of baffle 3-1 is followed disk body circumference evenly distributed just is fixed in the holding tank, and will the radial outer region of holding tank is divided into a plurality of holding sections, central pole 3-3 install in the radial inner region of holding tank, shielding lid 2 is annular, shielding lid 2 with the one end detachably of disk body is connected and is sealed all holding sections.

The experimental animal is placed in the accommodating area (an experimental animal is placed between the adjacent partition boards 3-1), the part to be irradiated extends out of the accommodating area and is fixed on the central rod 3-3, and the part to be irradiated is exposed out of the shielding cover 2, so that the experimental animal can be firmly fixed, and the part to be irradiated is irradiated. The fixed disk 3 can rotate relative to the bracket 1, so that irradiation at any angle is realized, and the fixed disk 3 can be adjusted and positioned according to different angles of irradiation sources. The vertical, horizontal or other angle irradiation can be realized without other auxiliary equipment, and the operation is simple. And a plurality of animals are irradiated at one time, so that the irradiation dose is consistent, the experimental efficiency is improved, and the cost is reduced. The shielding cover 2 protects the animals from radiation, reduces the irradiation of normal tissues except the part to be irradiated, and has less damage to the animals, so that experimental data are more reliable. Simple structure, easy disassembly and convenient cleaning.

Wherein the axis of the central rod 3-3 is parallel to the axis of the receiving groove.

Wherein the partition plate 3-1 is disposed along the radial direction of the receiving groove.

The outer contour shape of the shield cover 2 is the same as the shape of the accommodating groove, for example, when the cross section of the accommodating groove is circular, the outer contour of the shield cover 2 is also circular.

In one particular embodiment, the receiving groove is circular in cross-section and has a diameter of about 22 to 24cm.

On the basis of the technical scheme, the rotary rod device further comprises a rotary rod 4, wherein one end of the rotary rod 4 is fixedly connected with the side wall of the fixed disc 3; the other end of the rotary rod 4 is in threaded connection with the support 1, or the other end of the rotary rod 4 is in rotary connection with the support 1, a limit screw is further in threaded connection with the support 1, and the end of the limit screw is in butt joint with the rotary rod 4 to limit or separate.

The rotary rod 4 is rotationally adjusted and positioned relative to the bracket 1, thereby realizing the rotation and positioning of the fixed disc 3.

Wherein the axis of the rotating rod 4 is perpendicular to the axis of the accommodating groove.

Specifically, the other end of rotary rod 4 passes through the through-hole on the support 1, and can rotate in the through-hole, and stop screw's one end threaded connection stretches into this through-hole after passing support 1 lateral wall, and rotary rod 4 tip and rotary rod 4 lateral wall butt rely on frictional force to realize spacing to rotary rod 4.

Preferably, the other end of the rotating rod 4 penetrates the bracket 1 and is fixed with a handle.

On the basis of the technical scheme, the bracket 1 comprises a base 1-1 and a fixing rod 1-2, the fixing rod 1-2 is vertically arranged, the lower end of the fixing rod is fixedly connected with the base 1-1, and the other end of the rotating rod 4 is connected with the fixing rod 1-2.

On the basis of the technical scheme, the novel adjustable screw bolt further comprises an adjusting bolt, the end wall of the other end of the disc body is provided with a strip-shaped adjusting hole which is arranged along the radial direction, the adjusting bolt comprises a bolt head and a bolt screw rod, one end of the bolt screw rod is fixedly connected with the bolt head, and the other end of the bolt screw rod penetrates through the adjusting hole and is in threaded connection with the end part of the central rod 3-3.

The lengths of the parts to be irradiated of different experimental animals extending out of the accommodating area can be different, and the positions of the central rod 3-3 along the radial direction of the tray body can be adjusted, so that the experimental animals can adapt to different situations.

Specifically, when the position of the center rod 3-3 needs to be adjusted, the adjusting bolt is unscrewed, the center rod 3-3 is moved along the strip-shaped hole, and after the adjustment is completed, the adjusting bolt is screwed.

On the basis of the technical scheme, the center rod 3-3 is provided with at least two along the circumferential direction of the disc body, and the adjusting holes and the adjusting bolts are correspondingly provided with at least two.

At least two center poles 3-3 can provide more locations for holding laboratory animals for ease of handling.

On the basis of the technical scheme, the fixed disc 3 further comprises a separation plate 3-2, the separation plate 3-2 is cylindrical, one end of the separation plate 3-2 is fixedly connected with the bottom wall of the accommodating groove, the separation plate 3-2 is located on the outer side of the central rod 3-3, and an arched door hole is formed in the position, corresponding to each accommodating area, of the separation plate 3-2.

The partition plate 3-2 and the partition plate 3-1 are used together to limit the position of the experimental animal, and the arched door holes are arranged so as to facilitate the drawing of the part to be irradiated of the experimental animal out of the accommodating area.

Specifically, the diameter of the through hole in the center of the shield cover 2 is the same as the inner diameter of the partition plate 3-2. The other end of the partition plate 3-2 abuts against the shield cover 2.

Specifically, when the experiment is carried out on the mice, the size of the arch door hole is larger than the diameter of the rear thigh of the mice, and the tails of the mice can also pass through the arch door hole, thereby providing convenience for tail intravenous injection and blood drawing.

On the basis of the technical scheme, the isolation plate 3-2 is made of transparent organic glass.

On the basis of the technical scheme, the other end wall of the tray body is provided with ventilation through holes corresponding to each accommodating area.

The ventilation through holes are convenient for the breath of experimental animals, and can carry out irradiation experiments in living bodies or in anesthesia states.

Wherein each accommodation area may be provided with a plurality of ventilation through holes. Preferably, the plurality of ventilation through holes of each accommodation area are distributed at intervals in the radial direction, and the plurality of ventilation through holes sequentially increase in area from inside to outside in the radial direction.

Specifically, the ventilation through hole penetrates the tray body along the axial direction of the accommodating groove.

On the basis of the technical scheme, the bracket 1 is made of aluminum alloy or carbon fiber; the material of the fixed disc 3 is transparent organic glass.

The transparent organic glass has certain strength, the half-life period of the radioactive isotope generated after the transparent organic glass is activated by neutrons is short, the radiation dose of the non-irradiated part of the experimental animal is reduced, and the transparent organic glass is convenient for observing the state of the experimental animal.

On the basis of the technical scheme, the shielding cover 2 is made of lead, lithium-containing polyethylene, boron-containing polyethylene or gadolinium-containing compound; the thickness of the shielding cover 2 is 2cm to 3cm.

The shielding cover 2 can furthest reduce non-selective dose deposition of normal tissues, reduce irradiation dose caused to non-irradiation parts of an irradiated body, and enable experimental results to be more accurate.

It should be noted that: the lead, the lithium-containing polyethylene, the boron-containing polyethylene or the gadolinium-containing compound are all selected from the existing materials.

When the novel animal irradiation fixing device of the embodiment is adopted for irradiation experiments, the specific operation is as follows:

1. the shielding cover 2 is opened, and the anesthetized animals are placed in different accommodation areas.

2. The tumor-bearing hind legs of the animals were pulled out of the arched door openings of the spacer plate 3-2 with forceps to expose the tumor. And the tail of the animal is pulled out from the arched door hole of the isolation plate 3-2, thereby facilitating tail vein injection and blood collection.

3. One end of the string is tied on the shank with tumor, and the other end is tied on the central rod 3-3. After all animals are fixed, the shielding cover 2 is used to cover all the accommodation areas of the fixed tray 3.

4. According to experimental requirements, the angle of the fixed disc 3 is adjusted and fixed through the rotary rod 4, so that the center of the fixed disc 3 is aligned with the center of the machine head of the radiotherapy apparatus, and the animal tumor receives specified dose irradiation.

5. After the irradiation, the shielding cover 2 is opened, the experimental animals are taken out, and the shielding cover 2 and the fixed disk 3 are cleaned and sterilized.

In the description of the present utility model, it should be noted that the terms "center," "vertical," "horizontal," "inner," "outer," "axial," "radial," "circumferential," and the like indicate an orientation or a positional relationship based on that shown in the drawings, and are merely for convenience of description and to simplify the description, and do not indicate or imply that the apparatus or element in question must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.

In the description of the present utility model, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present utility model, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

In the description of the present specification, a description referring to the terms "one embodiment," "example," "specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

The foregoing description of the preferred embodiments of the utility model is not intended to limit the utility model to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the utility model are intended to be included within the scope of the utility model.

Claims

1. The utility model provides a novel animal irradiation fixing device, its characterized in that, including support (1), shielding lid (2) and fixed disk (3), fixed disk (3) with support (1) rotate and are connected and fix a position, fixed disk (3) are including disk body, baffle (3-1) and well core rod (3-3), the one end of disk body has regular polygon or circular shape holding tank, baffle (3-1) are a plurality of, and is a plurality of baffle (3-1) are followed disk body circumference evenly distributed just is fixed in the holding tank, and will the radial external area of holding tank divide into a plurality of holding sections, well core rod (3-3) install in the radial internal area of holding tank, shielding lid (2) are annular, shielding lid (2) with the one end of disk body can be dismantled and be connected and seal all holding section.

2. The novel animal irradiation fixing device according to claim 1, further comprising a rotating rod (4), wherein one end of the rotating rod (4) is fixedly connected with the side wall of the fixing disc (3); the other end of the rotary rod (4) is in threaded connection with the support (1), or the other end of the rotary rod (4) is in rotary connection with the support (1), a limit screw is further in threaded connection with the support (1), and the end of the limit screw is in butt joint with the rotary rod (4) to limit or separate.

3. A novel animal irradiation fixing device according to claim 2, wherein the bracket (1) comprises a base (1-1) and a fixing rod (1-2), the fixing rod (1-2) is vertically arranged, the lower end of the fixing rod is fixedly connected with the base (1-1), and the other end of the rotating rod (4) is connected with the fixing rod (1-2).

4. A new animal irradiation fixture as claimed in claim 1, further comprising an adjusting bolt, the other end wall of the disc having a radially arranged bar-shaped adjusting hole, the adjusting bolt comprising a bolt head and a bolt screw, one end of the bolt screw being fixedly connected to the bolt head, the other end passing through the adjusting hole and being threadedly connected to the end of the central rod (3-3).

5. The novel animal irradiation fixing device according to claim 4, wherein the central rod (3-3) is provided with at least two along the circumference of the tray body, and the adjusting hole and the adjusting bolt are correspondingly provided with at least two.

6. The novel animal irradiation fixing device according to claim 1, wherein the fixing disc (3) further comprises a separation plate (3-2), the separation plate (3-2) is cylindrical, one end of the separation plate (3-2) is fixedly connected with the bottom wall of the containing groove, the separation plate (3-2) is located on the outer side of the central rod (3-3), and an arch door hole is formed in the position, corresponding to each containing area, of the separation plate (3-2).

7. The novel animal irradiation fixing device according to claim 6, wherein the isolation plate (3-2) is made of transparent organic glass.

8. A novel animal irradiation fixture as set forth in any one of claims 1-7 wherein said tray body has a vent opening at the end wall at the other end thereof corresponding to each of said receiving areas.

9. A novel animal irradiation fixing device according to any one of claims 1-7, wherein the bracket (1) is made of aluminum alloy or carbon fiber; the material of the fixed disc (3) is transparent organic glass.

10. A novel animal irradiation fixture according to any one of claims 1-7, wherein the shielding cover (2) is made of lead, lithium-containing polyethylene, boron-containing polyethylene or gadolinium-containing compound; the thickness of the shielding cover (2) is 2cm to 3cm.