CN109847199A - Anoxic cell irradiation devices - Google Patents
Anoxic cell irradiation devices Download PDFInfo
- Publication number
- CN109847199A CN109847199A CN201910079432.9A CN201910079432A CN109847199A CN 109847199 A CN109847199 A CN 109847199A CN 201910079432 A CN201910079432 A CN 201910079432A CN 109847199 A CN109847199 A CN 109847199A
- Authority
- CN
- China
- Prior art keywords
- irradiation
- irradiation capsule
- capsule
- gas
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Present disclose provides a kind of anoxic cell irradiation devices, comprising: irradiation capsule, gas control unit and dosage monitoring unit；Box like structure made of irradiation capsule is spliced and combined as six irradiation capsule sidings is provided with air inlet, gas outlet, multiple sockets on irradiation capsule side wall；Gas control unit is connect by socket with the irradiation capsule, the control for gas in irradiation capsule；Dosage monitoring unit is connect by socket with the irradiation capsule, for detecting the exposure dose in the irradiation capsule.The dosage of different location can be carried out relative biological effectiveness measurement for the anoxic cell in different location and be provided accurate physical dosage data in disclosure irradiation capsule with accurate measurements and measurement.
Description
Technical field
This disclosure relates to radiological measuring field more particularly to a kind of anoxic cell irradiation devices.
Background technique
Cancer is the common frdquently encountered disease for seriously endangering human life and health, and the situation is tense for China's pathogenesis of cancer, disease incidence
It is in continue ascendant trend with the death rate, annual neopathy number of cases is more than 4,300,000 people, and death number has been more than 2,800,000 people, is had become
For the first killer of China's national health, it have become the maximum public health problem in China (W.Chen, R.Zheng,
P.D.Baade, et al.Cancer Statistics in China, 2015, CA Cancer J Clin., 2016.；66
(2): 115-32).Radiotherapy is three big conventional means of current treatment of cancer with chemotherapy together with performing the operation, and is suffered from existing cancer
In person's treatment, need to carry out different degrees of radiotherapy more than 70% patient.
Compared with gamma-rays, X-ray and electron beam, its kinetic energy rejection when the charged particles such as carbon ion/proton pass through substance
The narrow peak (bragg peak) sharply enhanced can be presented in the end of range, i.e. charged particle and energy when matter interaction is main
Loss is in the range of end-of-range millimeter magnitude.Tune can be passed through using the radiotherapy that this characteristic of charged particle carries out
Section charged particle energy falls in the position of bragg peak in lesion, to guarantee to tumor-killing maximum, and damages to health tissues
Hurt small.Therefore, the advantage that there are charged-particle therapy cancer other radiation therapy methods to hardly match: 1. energy is mainly deposited on
End-of-range Bragg peak region, positioning accuracy is high, damages to health tissues small；2. heavy ion/proton charging property is utilized, it can
To be oriented to line by sweeping magnet, it is irradiated it accurately by the shape of tumour tomography, realization is conformal to be controlled by force with tune
It treats；3. the positron annihilation radiation of nuclear reaction products can be monitored in conjunction with positron emission tomography, online prison is realized
The dynamic of control irradiation line, realizes the accurate monitoring of position；4. linear energy transfer is high, relative biological effectiveness is high；Oxygen enhancement ratio connects
It is bordering on 1, the radiosensitivity of anoxic cell in tumour can be improved, can effectively kill hypoxic tumor cells；5. treatment cycle is short,
The course for the treatment of 4-20 times (day), cure rate is high, also highly effective particular against the tumour recurred after conventional ray and treatment.6. without bright
Aobvious toxic side effect.Since charged particle has these advantages, thus charged particle is known as being that Twenty-First Century is most ideal
Radiotherapy ray, there is heavy ion/proton precessional magnetometer country all to have poured into a large amount of man power and material in the world and carry out band
The construction of electrochondria beamlet cancer-curing apparatus and basis for cancer and clinical application research, so that charged particle research for cancer becomes radiation and controls
The frontier nature research hotspot in treatment field.
Radiotherapy accounts for critically important position in cancer treatment, to the contribution rate and surgical operation phase of the treatment rate of cancer
When.Clinically often there is the phenomenon that recurring after treating, is primarily due to exist in tumor therapeutic procedure and conventional ray is resisted
Influence factor, such as tumor hypoxia.Weary oxygen is a feature of most of tumours, is the key regulator of tumour growth,
Its incidence and severity are also different in patients.(drug resistance, anti-radiation), blood because of weary oxygen confrontation cell death factors
Pipe generation, angiogenesis, invasion transfer, metabolism change and genomic instability etc. influence, it reduces ionising radiation to swollen
The damage of tumor has seriously affected the prognosis and treatment of radiotherapy.Weary the anti-radiation of oxygen induction is considered as tumor in radiotherapy control
Key constraints.Therefore clinically would generally by oxygenation treat or give the means such as weary oxygen selective drug come into
Row hypoxic tumor radiotherapy.
During charged-particle therapy, tumor target is given in the setting for generalling use theoretical calculation data progress treatment plan
The certain biological effective dose in area.Since the relative biological effect of tumour is influenced by oxygen concentration in its environment, normal oxygen situation
Lower oxygen concentration is 21%, therefore our obtained relative biological effectiveness are all under 21% oxygen partial pressure under normal conditions
Numerical value.The oxygen concentration of normal tissue may only exist 3%~7.4% in the oxygen concentration of tumor area under physiological environment
Between 0.3%~4%.Using relative biological effectiveness data obtained in the case of normal oxygen cannot be equal in the case of weary oxygen, because
We need the relative biological effectiveness for tumour cell under different oxygen concentrations to carry out accurate evaluation for this, obtain different oxygens
The oxygen enhancement ratio data of tumour cell are depressed, to be modified to the Rapid Dose Calculation for being directed to weary oxygen target area in treatment plan, to protect
Accurate dosage is given in card treatment.
But it is merely able to keep the stabilization of partial pressure of oxygen in irradiation process, oxygen as usual or fixed partial pressure of oxygen in currently available technology
The hypoxemia or anoxia state of concentration；Since physical dosage of the charged particle in irradiated volume is uneven, need to different location
Physical dosage carry out real-time tracking, while also needing the case where simulating inside tumor different location, realize that different location is low weary
The dosage of oxygen cell monitors irradiation in real time.
Summary of the invention
(1) technical problems to be solved
Present disclose provides a kind of anoxic cell irradiation devices, at least partly to solve technical problem set forth above.
(2) technical solution
According to one aspect of the disclosure, provide a kind of controllable different partial, different location irradiation dose it is real
When the anoxic cell irradiation devices that monitor, comprising: irradiation capsule, including six irradiation capsule sidings, six irradiation capsule sidings are spelled
It connects and is combined into box like structure；Air inlet, gas outlet, multiple sockets are provided on the irradiation capsule siding；Gas control unit leads to
It crosses socket to connect with the irradiation capsule, the control for gas in irradiation capsule；Dosage monitoring unit passes through socket and the irradiation
Box connection, for detecting the exposure dose in the irradiation capsule.
In some embodiments of the present disclosure, the gas control unit includes: gas mixing controller, with the air inlet
Mouth is connected by air inlet pipe；The mixed proportion of gas mixing controller the control nitrogen and carbon dioxide, obtained gaseous mixture
Body is entered in the irradiation capsule by air inlet pipe by the air inlet；Gas control valve is mounted in the air inlet pipe, and control is logical
Cross the gas flow that air inlet enters the irradiation capsule；Partial pressure of oxygen monitor is placed in the irradiation capsule inner cavity, the partial pressure of oxygen
Oxygen partial pressure value is transferred to the gas control valve by feedback signal data line by monitor, and control oxygen partial pressure value reaches pre-
Definite value；The partial pressure of oxygen monitor is used to monitor the partial pressure of oxygen numerical value of irradiation capsule inner cavity.
In some embodiments of the present disclosure, the dosage monitoring unit includes: dosemeter, for detecting the irradiation capsule
The real-time ray of different location or particle dose in inner cavity；Pen shape ionisation chamber, the pen shape ionisation chamber first end are connected by data
Wiring is connected with the dosemeter；The pen shape ionisation chamber second end is connected with multiple sockets on the irradiation capsule；For surveying
Measure the intensity of ionising radiation；Dose detector is connected with the socket on irradiation capsule；For detecting the ray of the irradiation capsule inner cavity
Or particle irradiation dosage.
In some embodiments of the present disclosure, what is be connected on the irradiation capsule with the pen shape ionisation chamber second end is multiple slotting
Mouthful, in dislocation arrangement, 1-2cm is divided between adjacent sockets；It is blocked for preventing from existing in same direction.
In some embodiments of the present disclosure, the multiple sockets being connected with ionisation chamber are arranged along the diagonal line of irradiation capsule siding
Cloth.
In some embodiments of the present disclosure, further includes: gasket is set to adjacent irradiation capsule siding in the irradiation capsule
Junction.
In some embodiments of the present disclosure, further includes: multiple Tissue Culture Dish are plugged in side by side in the irradiation capsule.
In some embodiments of the present disclosure, the material of the irradiation capsule siding is polyethylene, polystyrene, organic glass
It is any in glass, polyether-ether-ketone.
In some embodiments of the present disclosure, partial pressure of oxygen is 0.1-20% in the irradiation capsule.
In some embodiments of the present disclosure, a length of 120-400mm of the irradiation capsule, width 60-200mm, a height of 80-
200mm。
(3) beneficial effect
It can be seen from the above technical proposal that disclosure anoxic cell irradiation devices at least have the advantages that wherein
One of or in which a part:
(1) dosage of different location can be with accurate measurements and measurement, in the weary of different location in disclosure irradiation capsule
Oxygen cell carries out relative biological effectiveness measurement and provides accurate physical dosage data.
(2) gas control unit of the disclosure and dosage monitoring unit, can carry out to oxygen concentration in irradiation capsule can control
Section and monitoring, to meet the irradiation of different cultivation conditions anoxic cells.
(3) disclosure is compact-sized, is readily cleaned, practicability and high reliablity.
Detailed description of the invention
Fig. 1 is the schematic diagram of the embodiment of the present disclosure.
Fig. 2 is the structural schematic diagram of embodiment of the present disclosure anoxic cell irradiation devices.
Fig. 3 a, Fig. 3 b are the arrangement schematic diagram of the socket of the multiple pen shape ionisation chambers of the embodiment of the present disclosure.
[embodiment of the present disclosure main element symbol description in attached drawing]
1- beam direction；2- fixture nut；
3- irradiation capsule；4- gasket；
5- Tissue Culture Dish；6- partial pressure of oxygen monitor；
7- dosemeter；8- gas control valve；
9- air inlet pipe；10- air inlet；
11- socket；12- pen shape ionisation chamber；
The gas outlet 13- feedback signal data line 14-；
15- data connecting line.
Specific embodiment
Present disclose provides a kind of anoxic cell irradiation devices, comprising: irradiation capsule, gas control unit and dosage monitoring list
Member；Box like structure made of irradiation capsule is spliced and combined as six irradiation capsule sidings is provided with air inlet on irradiation capsule side wall, goes out
Port, multiple sockets；Gas control unit is connect by socket with the irradiation capsule, the control for gas in irradiation capsule；Agent
Amount monitoring unit is connect by socket with the irradiation capsule, for detecting the exposure dose in the irradiation capsule.Disclosure irradiation
The dosage of different location can carry out Relative Biological effect with accurate measurements and measurement for the anoxic cell in different location in box
It should measure and accurate physical dosage data are provided.
For the purposes, technical schemes and advantages of the disclosure are more clearly understood, below in conjunction with specific embodiment, and reference
The disclosure is further described in attached drawing.
Disclosure some embodiments will be done referring to appended attached drawing in rear and more comprehensively describe to property, some of but not complete
The embodiment in portion will be shown.In fact, the various embodiments of the disclosure can be realized in many different forms, and should not be construed
To be limited to this several illustrated embodiment；Relatively, these embodiments are provided so that the disclosure meets applicable legal requirement.
In first exemplary embodiment of the disclosure, a kind of anoxic cell irradiation devices are provided.Fig. 1 is the disclosure
The weary oxygen irradiation devices schematic diagram of embodiment.Disclosure anoxic cell irradiation devices as shown in Figure 1 include gas control unit, irradiation
Box, partial pressure of oxygen monitor and online dose measurement unit.The oxygen density value of partial pressure of oxygen monitor feeds back to gas control unit
To guarantee that stablizing for gas partial pressure of oxygen in irradiation capsule is adjustable.Fig. 2 is the structure of embodiment of the present disclosure anoxic cell irradiation devices
Schematic diagram.Shown in Fig. 2, irradiation capsule 3 be spliced and combined as six irradiation capsule sidings made of box like structure, irradiation capsule side wall it is upper
It is provided with air inlet 10, gas outlet 14, multiple sockets.Wherein, irradiation capsule siding is connected with each other by fixture nut 2.Wherein, spoke
Further include gasket 4 according to box 3, is set in irradiation capsule 3, the junction of adjacent 3 siding of irradiation capsule.It is selectable, irradiation capsule 3
A length of 120-400mm, width 60-200mm, a height of 80-200mm.Selectable, the material of 3 siding of irradiation capsule is polyethylene, gathers
It is styrene, organic glass, any in polyether-ether-ketone.
Gas control unit is connect by socket with the irradiation capsule 3, the control for gas in irradiation capsule 3.Specifically
, gas control unit includes: that gas mixing controller, gas control valve 8, partial pressure of oxygen monitor 6 and feedback signal data pass
Defeated line 13.Gas mixing controller and air inlet 10 are connected by air inlet pipe 9, gas mixing controller control air, nitrogen and
The mixed proportion of carbon dioxide, the mixed gas made enter the irradiation capsule 3 by the air inlet 10 by air inlet pipe 9
It is interior.Gas control valve 8 is mounted in the air inlet pipe 9, and control enters the mixed gas of the irradiation capsule 3 by air inlet 10
Flow.Partial pressure of oxygen monitor 6 is placed in 3 inner cavity of irradiation capsule, and the partial pressure of oxygen monitor passes through feedback signal data line
Oxygen partial pressure value is transferred to the gas control valve, control oxygen partial pressure value reaches predetermined value, realizes the oxygen of monitoring 3 inner cavity of irradiation capsule
Divide the effect of numerical value.
Dosage monitoring unit is connect, for detecting the irradiation agent in the irradiation capsule 3 with the irradiation capsule 3 by socket
Amount.Specifically, dosage monitoring unit includes: Multi-channel dosimeter 7, pen shape ionisation chamber 12 and data connecting line 15.Pen shape ionization
12 first end of room is connected by data connecting line 15 with dosemeter 7；12 second end of pen shape ionisation chamber is corresponding on irradiation capsule 3 to insert
Mouth is connected；For measuring the intensity of ray or particle radiation.Multi-channel dosimeter, for measuring the physics agent of multiple positions simultaneously
Amount.Further, the corresponding socket being connected on irradiation capsule 3 with 12 second end of pen shape ionisation chamber is adjacent to insert in dislocation arrangement
1-2cm is divided between mouthful；It is blocked for preventing from existing in same direction.Optionally, the multiple sockets being connected with ionisation chamber are along spoke
According to the diagonal line arrangement of 3 siding of box.Further, when carrying out dose monitoring to different beam directions 1, on irradiation capsule 3 with institute
It is also different to state the connected multiple socket arrangement modes of 12 second end of pen shape ionisation chamber.As shown in Figure 3a, for along beam direction 1
The multiple socket arrangement modes being connected when carrying out dose monitoring, on irradiation capsule 3 with 12 second end of pen shape ionisation chamber.Such as Fig. 3 b
It is shown, when carrying out dose monitoring for the transverse direction to beam direction 1, it is connected on irradiation capsule 3 with 12 second end of pen shape ionisation chamber
Multiple socket arrangement modes.
Different sockets correspond to different irradiation positions, the object of different location anoxic cell irradiation on irradiation capsule 3 in the disclosure
Reason dosage can be detected by the multiple pen shape ionisation chambers 12 being connected with Multi-channel dosimeter 7, and be read from Multi-channel dosimeter 7.
Cell used in the disclosure can be the anoxic cell of fixed culture, and partial pressure of oxygen is between 0.1-20%.Specific training
The form of supporting is that formula culture is fixed by the multiple Tissue Culture Dish 5 being plugged in the irradiation capsule side by side.
So far, attached drawing is had been combined the embodiment of the present disclosure is described in detail.It should be noted that in attached drawing or saying
In bright book text, the implementation for not being painted or describing is form known to a person of ordinary skill in the art in technical field, and
It is not described in detail.In addition, the above-mentioned definition to each element and method be not limited in mentioning in embodiment it is various specific
Structure, shape or mode, those of ordinary skill in the art simply can be changed or be replaced to it.
According to above description, those skilled in the art, which should have disclosure anoxic cell irradiation devices, clearly to be recognized
Know.
In conclusion the dosage that the disclosure provides different location in a kind of pair of irradiation capsule can be with accurate measurements and measurement
Anoxic cell in different location carries out relative biological effectiveness measurement and provides the anoxic cell of accurate physical dosage data
Irradiation devices.
It should also be noted that, the direction term mentioned in embodiment, for example, "upper", "lower", "front", "rear", " left side ",
" right side " etc. is only the direction with reference to attached drawing, not is used to limit the protection scope of the disclosure.Through attached drawing, identical element by
Same or similar appended drawing reference indicates.When may cause understanding of this disclosure and cause to obscure, conventional structure will be omitted
Or construction.
And the shape and size of each component do not reflect actual size and ratio in figure, and only illustrate the embodiment of the present disclosure
Content.In addition, in the claims, any reference symbol between parentheses should not be configured to the limit to claim
System.
It unless there are known entitled phase otherwise anticipates, the numerical parameter in this specification and appended claims is approximation, energy
Enough bases pass through the resulting required characteristic changing of content of this disclosure.Specifically, all be used in specification and claim
The middle content for indicating composition, the number of reaction condition etc., it is thus understood that repaired by the term of " about " in all situations
Decorations.Under normal circumstances, the meaning expressed refers to include by specific quantity ± 10% variation in some embodiments, some
± 5% variation in embodiment, ± 1% variation in some embodiments, in some embodiments ± 0.5% variation.
Furthermore word "comprising" does not exclude the presence of element or step not listed in the claims.It is located in front of the element
Word "a" or "an" does not exclude the presence of multiple such elements.
Similarly, it should be understood that in order to simplify the disclosure and help to understand one or more of each open aspect,
Above in the description of the exemplary embodiment of the disclosure, each feature of the disclosure is grouped together into single implementation sometimes
In example, figure or descriptions thereof.However, the disclosed method should not be interpreted as reflecting the following intention: i.e. required to protect
The disclosure of shield requires features more more than feature expressly recited in each claim.More precisely, as following
Claims reflect as, open aspect is all features less than single embodiment disclosed above.Therefore,
Thus the claims for following specific embodiment are expressly incorporated in the specific embodiment, wherein each claim itself
All as the separate embodiments of the disclosure.
Particular embodiments described above has carried out further in detail the purpose of the disclosure, technical scheme and beneficial effects
Describe in detail it is bright, it is all it should be understood that be not limited to the disclosure the foregoing is merely the specific embodiment of the disclosure
Within the spirit and principle of the disclosure, any modification, equivalent substitution, improvement and etc. done should be included in the guarantor of the disclosure
Within the scope of shield.
Claims (10)
1. a kind of anoxic cell irradiation devices, comprising:
Irradiation capsule, including six irradiation capsule sidings, six irradiation capsule sidings splice and combine into box like structure；The irradiation capsule
Air inlet, gas outlet, multiple sockets are provided on siding；
Gas control unit is connect by socket with the irradiation capsule, the control for gas in irradiation capsule；
Dosage monitoring unit is connect, for detecting the exposure dose in the irradiation capsule with the irradiation capsule by socket.
2. anoxic cell irradiation devices according to claim 1, wherein the gas control unit includes:
Gas mixing controller is connected with the air inlet by air inlet pipe；The gas mixing controller controls nitrogen and two
The mixed proportion of carbonoxide, obtained mixed gas are entered in the irradiation capsule by air inlet pipe by the air inlet；
Gas control valve is mounted in the air inlet pipe, and control enters the gas flow of the irradiation capsule by air inlet；
Partial pressure of oxygen monitor, is placed in the irradiation capsule inner cavity, and the partial pressure of oxygen monitor will by feedback signal data line
Oxygen partial pressure value is transferred to the gas control valve, and control oxygen partial pressure value reaches predetermined value；The partial pressure of oxygen monitor is for monitoring
The partial pressure of oxygen numerical value of irradiation capsule inner cavity.
3. anoxic cell irradiation devices according to claim 1, wherein the dosage monitoring unit includes:
Dosemeter, for detecting the real-time ray of different location or particle dose in the irradiation capsule inner cavity；
Pen shape ionisation chamber, the pen shape ionisation chamber first end are connected by data connecting line with the dosemeter；The pen shape electricity
It is connected from room second end with multiple sockets on the irradiation capsule；For measuring the intensity of ionising radiation；
Dose detector is connected with the socket on irradiation capsule；For detecting ray or the particle irradiation agent of the irradiation capsule inner cavity
Amount.
4. anoxic cell irradiation devices according to claim 3, wherein on the irradiation capsule with the pen shape ionisation chamber
The connected multiple sockets in two ends are divided into 1-2cm between adjacent sockets in dislocation arrangement；It is hidden for preventing from existing in same direction
Gear.
5. anoxic cell irradiation devices according to claim 4, wherein the multiple sockets being connected with ionisation chamber are along irradiation capsule
The diagonal line of siding is arranged.
6. anoxic cell irradiation devices according to claim 1, wherein further include:
Gasket is set to the junction of adjacent irradiation capsule siding in the irradiation capsule.
7. anoxic cell irradiation devices according to claim 1, wherein further include:
Multiple Tissue Culture Dish are plugged in side by side in the irradiation capsule.
8. anoxic cell irradiation devices according to claim 1, wherein the material of the irradiation capsule siding be polyethylene,
It is polystyrene, organic glass, any in polyether-ether-ketone.
9. anoxic cell irradiation devices according to claim 1, wherein partial pressure of oxygen is 0.1-20% in the irradiation capsule.
10. anoxic cell irradiation devices according to claim 1, wherein a length of 120-400mm of the irradiation capsule, it is wide
For 60-200mm, a height of 80-200mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910079432.9A CN109847199B (en) | 2019-01-28 | 2019-01-28 | Oxygen lack cell irradiation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910079432.9A CN109847199B (en) | 2019-01-28 | 2019-01-28 | Oxygen lack cell irradiation device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109847199A true CN109847199A (en) | 2019-06-07 |
| CN109847199B CN109847199B (en) | 2020-10-02 |
Family
ID=66896428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910079432.9A Active CN109847199B (en) | 2019-01-28 | 2019-01-28 | Oxygen lack cell irradiation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109847199B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110967721A (en) * | 2019-12-24 | 2020-04-07 | 中国人民解放军63919部队 | Combined type radiation detector and radiation dose measurement system |
| CN113447976A (en) * | 2021-06-29 | 2021-09-28 | 中国科学院高能物理研究所 | Method and device for measuring morphology of high-resolution slow positron beam |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201713521U (en) * | 2010-04-27 | 2011-01-19 | 重庆医科大学附属儿童医院 | Experimental device used for building oxidizing cell model |
| CN101987229A (en) * | 2010-11-11 | 2011-03-23 | 天津滨海华医光电技术有限公司 | Photodynamic system for treating tumors |
| CN102488974A (en) * | 2011-12-15 | 2012-06-13 | 广州市美锐美容健康设备实业有限公司 | Pure oxygen- photodynamic composite skin therapeutic instrument |
| CN104225806A (en) * | 2014-08-28 | 2014-12-24 | 高献书 | Radiotherapy plan design method and system based on biologically effective dose |
| WO2017053283A1 (en) * | 2015-09-21 | 2017-03-30 | Bayer Healthcare Llc | Power-optimizing ionizing radiation dosimeter |
-
2019
- 2019-01-28 CN CN201910079432.9A patent/CN109847199B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201713521U (en) * | 2010-04-27 | 2011-01-19 | 重庆医科大学附属儿童医院 | Experimental device used for building oxidizing cell model |
| CN101987229A (en) * | 2010-11-11 | 2011-03-23 | 天津滨海华医光电技术有限公司 | Photodynamic system for treating tumors |
| CN102488974A (en) * | 2011-12-15 | 2012-06-13 | 广州市美锐美容健康设备实业有限公司 | Pure oxygen- photodynamic composite skin therapeutic instrument |
| CN104225806A (en) * | 2014-08-28 | 2014-12-24 | 高献书 | Radiotherapy plan design method and system based on biologically effective dose |
| WO2017053283A1 (en) * | 2015-09-21 | 2017-03-30 | Bayer Healthcare Llc | Power-optimizing ionizing radiation dosimeter |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110967721A (en) * | 2019-12-24 | 2020-04-07 | 中国人民解放军63919部队 | Combined type radiation detector and radiation dose measurement system |
| CN113447976A (en) * | 2021-06-29 | 2021-09-28 | 中国科学院高能物理研究所 | Method and device for measuring morphology of high-resolution slow positron beam |
| CN113447976B (en) * | 2021-06-29 | 2024-04-02 | 中国科学院高能物理研究所 | Method and device for measuring morphology of high-resolution slow positron beam |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109847199B (en) | 2020-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Polf et al. | Measurement and calculation of characteristic prompt gamma ray spectra emitted during proton irradiation | |
| Peschke et al. | Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat | |
| CN103222009B (en) | Positron emitter irradiation system | |
| WO2017054556A1 (en) | Radiation detection system and radiation detection method for neutron capture therapy system | |
| Riley et al. | Performance characteristics of the MIT fission converter based epithermal neutron beam | |
| CN109847199A (en) | Anoxic cell irradiation devices | |
| US20220409925A1 (en) | Surgically positioned neutron flux activated high energy therapeutic charged particle generation system | |
| Vatnitsky et al. | Proton dosimetry intercomparison based on the ICRU report 59 protocol | |
| Vedelago et al. | Integration of Fricke gel dosimetry with Ag nanoparticles for experimental dose enhancement determination in theranostics | |
| Huang et al. | Hollow gold nanoparticals as biocompatible radiosensitizer: an in vitro proof of concept study | |
| Badry et al. | A Monte Carlo investigation of the dose distribution for 60Co high dose rate brachytherapy source in water and in different media | |
| Sánchez-Doblado et al. | Micro ionization chamber dosimetry in IMRT verification: Clinical implications of dosimetric errors in the PTV | |
| Didi et al. | Calculate primary and secondary dose in proton therapy using 200 and 250 MeV proton beam energy | |
| Ready | Development of a multi-knife-edge slit collimator for prompt gamma ray imaging during proton beam cancer therapy | |
| Schuff et al. | Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells | |
| Zheng et al. | Photon dose calculation method based on Monte Carlo finite-size pencil beam model in accurate radiotherapy | |
| Rucinski et al. | Plastic scintillator based PET detector technique for proton therapy range monitoring: A Monte Carlo study | |
| Di Ruzza | Proton and x-ray irradiation of silicon devices at the TIFPA-INFN facilities in Trento | |
| Barnett et al. | IMRT point dose measurements with a diamond detector | |
| Binns et al. | Improved dose targeting for a clinical epithermal neutron capture beam using optional 6Li filtration | |
| Wallace et al. | Monte Carlo calculations of epithermal boron neutron capture therapy with heavy water | |
| Djam | Nanoparticles for Simultaneous Assessment of ROS and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes | |
| Mattei et al. | Scintillating fiber devices for particle therapy applications | |
| Verhaegen et al. | Developing technologies for small animal radiotherapy | |
| Lühr et al. | Strategies to overcome hypoxia–a roadmap to LET optimized treatment planning for ion therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |