CN219001641U - Intravesical drug infusion device - Google Patents

Intravesical drug infusion device Download PDF

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Publication number
CN219001641U
CN219001641U CN202320784163.8U CN202320784163U CN219001641U CN 219001641 U CN219001641 U CN 219001641U CN 202320784163 U CN202320784163 U CN 202320784163U CN 219001641 U CN219001641 U CN 219001641U
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China
Prior art keywords
drug infusion
drug
intravesical
infusion body
catheter
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CN202320784163.8U
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Chinese (zh)
Inventor
张崔建
贯华
杨梦云
林健
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Peking University First Hospital
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Peking University First Hospital
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Priority to CN202320784163.8U priority Critical patent/CN219001641U/en
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Abstract

The utility model relates to an intravesical drug infusion device, which comprises a drug infusion body, wherein the initial state of the drug infusion body is in an expandable curled shape, the drug infusion body is a catheter, a cylindrical tube cavity is arranged in the drug infusion body, a slow release hole is arranged outside the tube cavity of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the medicine in the lumen is slowly released through the osmotic pressure gradient between the inside and the outside of the device and through the slow release hole in the device under the action of the osmotic pressure, repeated transurethral catheter insertion treatment is not needed, and the phenomenon of overflowing can not occur when the medicine is infused.

Description

Intravesical drug infusion device
Technical Field
The utility model belongs to the technical field of medical appliances, and particularly relates to an intravesical drug infusion device.
Background
At present, a patient after bladder cancer operation carries out chemotherapy drug infusion treatment, generally, an indwelling catheter is given to the patient under aseptic operation, and the chemotherapy drug is infused into the bladder through the catheter, so that the purposes of treatment and prevention are achieved. The infusion treatment course lasts for 1-3 years according to the illness state of the patient, the patient needs to be infused and treated once every week before the patient carries out chemotherapy medicine for 8 weeks, and as the urinary catheter is inserted through the urethra repeatedly for a plurality of times in the whole bladder infusion treatment course, the adverse reactions such as bladder irritation symptom, hematuria, difficult urination, fever, urethral opening relaxation and the like are easily caused, and the pain caused by repeated intubation and a plurality of inconveniences frequently going to a hospital are added, so that the patient is easy to fear and reject the infusion therapy. In addition, the chemical treatment medicine is easy to overflow in the medicine filling process, so that medicine waste and environmental pollution are caused, and the risk of infecting medical staff is increased.
The present utility model addresses the above-described problems by providing an intravesical drug infusion device.
Disclosure of Invention
In order to overcome the problems in the background art, the utility model adopts the following technical scheme:
an intravesical drug infusion device comprises a drug infusion body, wherein the initial state of the drug infusion body is in an expandable curled shape, the drug infusion body is a catheter, a cylindrical lumen is arranged in the drug infusion body, a slow release hole is arranged outside the lumen of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the medicine in the lumen is slowly released through the osmotic pressure gradient between the inside and the outside of the device and through the slow release hole in the device under the action of the osmotic pressure, so that the medicine can be released in the bladder for a long time, repeated urethral catheter insertion treatment is not needed, and the overflow phenomenon of the poured medicine can not occur.
Further, the drug infusion body is a catheter made of an elastic, biocompatible polymer material, which arrangement ensures that the device will naturally return to an initially distensible coiled shape within the bladder after placement within the bladder, preventing expulsion from the body during urination.
Further, at least one slow release hole is arranged on the outer side of the drug infusion body; the medicine can slowly permeate out through the slow release holes to achieve the effect of sustained release.
Further, the slow release holes are round through holes, and the inside and the outside of the catheter are communicated.
Further, at least one of the drug storage cavities is provided; the medicine storage cavity is used for storing medicines.
Further, the medicine storage cavity is a cylindrical groove on the inner side of the catheter, and medicine can be fixed inside the cylindrical groove.
Further, a fixed net is arranged outside the medicine storage cavity, and medicines can be placed in the medicine storage cavity to fall out.
Further, the bladder chemotherapeutic drug is disposed in the drug storage cavity, and the bladder chemotherapeutic drug is in a non-liquid form (such as solid, semi-solid).
Further, the surface of the catheter is provided with a coating of an adhesive formula, and when the catheter stretches into the bladder and the drug permeates to the outer surface of the catheter, the drug can adhere to the bladder wall through the coating substance on the surface of the catheter, so that the drug is kept at each corner of the bladder wall and can be released continuously.
Further, the diameter of the drug infusion body is 3-8mm; the above arrangement ensures that the drug infusion body can be conveniently placed in the urethra, and has good treatment effect.
The utility model has the beneficial effects that: the utility model has reasonable structure; the medicine can be fixed in the medicine storage cavity by arranging the medicine storage cavity; by arranging the slow release holes, the medicine in the lumen is released through the slow release holes in the device under the action of osmotic pressure through the osmotic pressure gradient between the inside and the outside of the device; by arranging the coating of the adhesive formula on the outer surface of the drug infusion body, the drug can be adhered to the bladder wall through the coating substance on the surface of the catheter when penetrating to the outer surface of the catheter, so that the drug is kept at each corner of the bladder wall and the sustained release effect is achieved.
Drawings
FIG. 1 is a schematic view of the overall structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of the present utility model without a fixation net;
FIG. 3 is a schematic cross-sectional view of the present utility model after installation of a fixation net;
FIG. 4 is a schematic cross-sectional view of the cylindrical recess and the fixing mesh of the present utility model;
in the figure, 1, a catheter; 2. a slow release hole; 3. a cylindrical recess; 4. and (5) fixing the net.
Detailed Description
The following detailed description of the embodiments of the present utility model will be made more apparent to those skilled in the art from the following detailed description, in which the utility model is embodied in several, but not all, embodiments of the utility model. The utility model may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the utility model.
Example 1
Referring to fig. 1-4, an intravesical drug infusion device in this embodiment includes a drug infusion body, wherein the drug infusion body is in an expandable curled shape in an initial state, the drug infusion body is a catheter 1, a cylindrical lumen is arranged in the drug infusion body, a slow release hole 2 is arranged outside the lumen of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the drug within the lumen is released by osmotic pressure gradient between the inside and outside of the device through a sustained release orifice 2 in the device under the influence of osmotic pressure.
The drug infusion body is a catheter 1 made of an elastic, biocompatible polymer material, which arrangement ensures that the device will naturally return to an initially distensible curled shape within the bladder after placement in the bladder, preventing expulsion from the body during urination.
Example 2
Referring to fig. 1-3, the present embodiment adds the following technical features: (the structure of the sustained release hole 2 is specifically set as follows): an intravesical drug infusion device comprises a drug infusion body, wherein the initial state of the drug infusion body is in an expandable curled shape, the drug infusion body is a catheter 1, a cylindrical lumen is arranged in the drug infusion body, a slow release hole 2 is arranged outside the lumen of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the drug within the lumen is released by osmotic pressure gradient between the inside and outside of the device through a sustained release orifice 2 in the device under the influence of osmotic pressure.
The drug infusion body is a catheter 1 made of an elastic, biocompatible polymer material, which arrangement ensures that the device will naturally return to an initially distensible curled shape within the bladder after placement in the bladder, preventing expulsion from the body during urination.
At least one slow release hole 2 is arranged on the outer side of the drug infusion body; the medicine can slowly permeate out through the slow release holes 2 to achieve the effect of sustained release.
The slow release hole 2 is a circular through hole which communicates the inside and the outside of the catheter 1.
Example 3
Referring to fig. 2-4, the following technical features (the following specific arrangement is performed on the structure of the drug storage cavity) are added in this embodiment: an intravesical drug infusion device comprises a drug infusion body, wherein the initial state of the drug infusion body is in an expandable curled shape, the drug infusion body is a catheter 1, a cylindrical lumen is arranged in the drug infusion body, a slow release hole 2 is arranged outside the lumen of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the drug within the lumen is released by osmotic pressure gradient between the inside and outside of the device through a sustained release orifice 2 in the device under the influence of osmotic pressure.
The drug infusion body is a catheter 1 made of an elastic, biocompatible polymer material, which arrangement ensures that the device will naturally return to an initially distensible curled shape within the bladder after placement in the bladder, preventing expulsion from the body during urination.
At least one slow release hole 2 is arranged on the outer side of the drug infusion body; the medicine can slowly permeate out through the slow release holes 2 to achieve the effect of sustained release.
The slow release hole 2 is a circular through hole which communicates the inside and the outside of the catheter 1.
At least one drug storage cavity is arranged; the medicine storage cavity is used for storing medicines.
The medicine storage cavity is a cylindrical groove 3 on the inner side of the catheter 1, and medicine can be fixed inside the cylindrical groove 3.
The outside of the medicine storage cavity is provided with a fixed net 4 which can be used for placing medicines to drop out of the medicine storage cavity.
The bladder chemotherapeutic medicine is arranged in the medicine storage cavity and is in a non-liquid form (such as solid and semisolid).
Example 4
Referring to fig. 1, the following technical features (the following specific arrangement is performed on the structure of the adhesive coating on the outer side of the catheter 1) are added in this embodiment: an intravesical drug infusion device comprises a drug infusion body, wherein the initial state of the drug infusion body is in an expandable curled shape, the drug infusion body is a catheter 1, a cylindrical lumen is arranged in the drug infusion body, a slow release hole 2 is arranged outside the lumen of the drug infusion body, and a drug storage cavity is arranged in the drug infusion body; after the device is implanted, the drug within the lumen is released by osmotic pressure gradient between the inside and outside of the device through a sustained release orifice 2 in the device under the influence of osmotic pressure.
The drug infusion body is a catheter 1 made of an elastic, biocompatible polymer material, which arrangement ensures that the device will naturally return to an initially distensible curled shape within the bladder after placement in the bladder, preventing expulsion from the body during urination.
At least one slow release hole 2 is arranged on the outer side of the drug infusion body; the medicine can slowly permeate out through the slow release holes 2 to achieve the effect of sustained release.
The slow release hole 2 is a circular through hole which communicates the inside and the outside of the catheter 1.
At least one drug storage cavity is arranged; the medicine storage cavity is used for storing medicines.
The medicine storage cavity is a cylindrical groove 3 on the inner side of the catheter 1, and medicine can be fixed inside the cylindrical groove 3.
The outside of the medicine storage cavity is provided with a fixed net 4 which can be used for placing medicines to drop out of the medicine storage cavity.
The bladder chemotherapeutic medicine is arranged in the medicine storage cavity and is in a non-liquid form (such as solid and semisolid).
The surface of the catheter 1 is provided with a coating of an adhesive formula, and when the catheter 1 stretches into the bladder and the medicine permeates to the outer surface of the catheter 1, the medicine can adhere to the bladder wall through the coating substance on the surface of the catheter 1, so that the medicine is kept at each corner of the bladder wall and can be released continuously.
The diameter of the drug infusion body is 3-8mm; the above arrangement ensures that the drug infusion body can be conveniently placed in the urethra, and has good treatment effect.
The above description of embodiments is only for the understanding of the present utility model. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present utility model without departing from the principles of the utility model, and such modifications will fall within the scope of the claims.

Claims (10)

1. The utility model provides an intravesical drug infusion device, its includes drug infusion body, its characterized in that, drug infusion body initial state is the curling shape that can enlarge, drug infusion body is a pipe, be a cylinder lumen in the drug infusion body, drug infusion body extraluminal is equipped with the sustained release hole, drug infusion body internal setting up the medicine and storing the chamber.
2. The intravesical drug infusion device of claim 1, wherein the drug infusion body is a catheter made of an elastic, biocompatible polymeric material.
3. An intravesical drug infusion device as claimed in claim 2, in which at least one slow release aperture is provided on the outside of the drug infusion body.
4. An intravesical drug infusion device as claimed in claim 3, in which the slow release aperture is provided as a circular through aperture.
5. An intravesical drug infusion device as claimed in claim 1, in which at least one drug storage chamber is provided.
6. The intravesical drug infusion device of claim 5, wherein the drug storage lumen is a cylindrical recess inside a catheter.
7. The intravesical drug infusion device of claim 6, wherein a fixation mesh is disposed outside the drug storage lumen.
8. The intravesical drug infusion device of claim 1, wherein the drug storage chamber is provided with a bladder chemotherapeutic drug in a non-liquid form.
9. The intravesical drug infusion device of claim 1, wherein the catheter surface is provided with a coating of an adhesive formulation.
10. An intravesical drug infusion device as claimed in any one of claims 1 to 9, in which the drug infusion body is 3 to 8mm in diameter.
CN202320784163.8U 2023-04-11 2023-04-11 Intravesical drug infusion device Active CN219001641U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202320784163.8U CN219001641U (en) 2023-04-11 2023-04-11 Intravesical drug infusion device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202320784163.8U CN219001641U (en) 2023-04-11 2023-04-11 Intravesical drug infusion device

Publications (1)

Publication Number Publication Date
CN219001641U true CN219001641U (en) 2023-05-12

Family

ID=86232787

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202320784163.8U Active CN219001641U (en) 2023-04-11 2023-04-11 Intravesical drug infusion device

Country Status (1)

Country Link
CN (1) CN219001641U (en)

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