CN218995396U

CN218995396U - Nanometer membrane microfluidic colloidal gold detection device

Info

Publication number: CN218995396U
Application number: CN202223475916.1U
Authority: CN
Inventors: 王家祥; 郑佳; 刘宝; 张鑫
Original assignee: Jiangsu Zhizhun Testing Technology Service Co ltd
Current assignee: Jiangsu Zhizhun Testing Technology Service Co ltd
Priority date: 2022-12-26
Filing date: 2022-12-26
Publication date: 2023-05-09
Anticipated expiration: 2032-12-26

Abstract

The utility model discloses a nano-film microfluidic colloidal gold detection device which comprises a detection box, a feeding pipe, a floating plate, a convex plate, a first adjusting plate, a second adjusting plate, a third adjusting plate and a discharging mechanism, wherein the feeding box is arranged at the upper end of the detection box, the feeding pipe is fixedly arranged at one side of the feeding box, a sealing unit is arranged at the top end of the feeding pipe, the floating plate is slidably arranged in the feeding box, the convex plate is elastically supported at the upper end of the floating plate and is in three-phase linkage with the first adjusting plate, the second adjusting plate and the third adjusting plate, the floating plate slidably drives the convex plate to slide left and right under the action of the first adjusting plate, the second adjusting plate and the third adjusting plate, the first adjusting plate and the third adjusting plate are fixedly arranged on the feeding box, and the discharging mechanism guides materials. According to the utility model, through controlling the adding amount of the detection liquid in the feeding box, the problem that the error rate of the detection result is increased due to the fact that the adding amount of the detection liquid in the feeding box is too large or too small is avoided, and the convenience of using the device is improved.

Description

Nanometer membrane microfluidic colloidal gold detection device

Technical Field

The utility model relates to the technical field of nano-film microfluidic colloidal gold detection, in particular to a nano-film microfluidic colloidal gold detection device.

Background

The nano film microfluidic colloid Jin Youchen gold sol is gold sol with a disperse phase particle diameter of l-150nm, belongs to a multiphase heterogeneous system, and has orange-red to purplish-red color. Colloidal gold can be used as a marker for immunohistochemistry, and colloidal gold labeling has been developed as an important immunolabeling technique for more than 10 years. Colloidal gold immunoassays have been developed in many fields such as drug detection and biomedical science, and are increasingly being paid attention to the related fields of research.

In the technology for detecting colloidal gold, the colloidal gold is taken as a chromogenic medium, the reaction is completed in the chromatography process by utilizing the principle of specific binding of antigen and antibody in immunology, so that the detection purpose is achieved, the colloidal gold is a group of gold particles suspended in aqueous solution in a colloidal state with the particle size below the micron level, and a non-radioactive tracer which is more commonly used in the immunolabeling technology, namely, the gold-labeled antibody is an antibody combined with the colloidal gold, which is equivalent to the antibody which is dyed with color, so that the antibody which is not seen by naked eyes originally can be seen by people because of the color.

In the prior art, the detection solution is added into the detection box for detecting the colloidal gold, then the judgment of the detection result of the colloidal gold is completed by observing the color change degree of the test paper, but the addition amount of the detection solution is difficult to control in the technology, and the addition amount or the addition amount is too much or too little to influence the detection result of the colloidal gold finally, so that the detection needs to be carried out again, the time and the labor are wasted, the test paper needs to be replaced frequently, and the error of the detection result is possibly caused by the change of the test paper.

Disclosure of Invention

The utility model aims to provide a nano-film microfluidic colloidal gold detection device for solving the problems in the background technology.

In order to solve the technical problems, the utility model provides the following technical scheme: the utility model provides a nanometer membrane micro-fluidic colloidal gold detection device, including detecting the box, the feeding box, the inlet pipe, the kickboard, the flange, regulating plate one, regulating plate two, regulating plate three and discharge mechanism, the feeding box is located and is detected the box upper end, one side of locating the feeding box is fixed to the inlet pipe, and the inlet pipe top is equipped with sealing unit, the kickboard slides and locates in the feeding box, flange elastic support is in the kickboard upper end, and with regulating plate one, regulating plate two and regulating plate three-phase linkage, the kickboard slides and drives the flange and slide about under regulating plate one, regulating plate two and regulating plate three effect, regulating plate one is fixed to be located on the feeding box, regulating plate two and regulating plate three all seal slide on the feeding box, discharge mechanism derives the material.

In a preferred embodiment: the sealing unit comprises a feed inlet, a first sealing plate and a handle, wherein the feed inlet is fixedly arranged at the upper end of the feed pipe and communicated with the material reducing pipe, the first sealing plate is rotatably arranged at the upper end of the feed inlet, and the handle is fixedly arranged on the first sealing plate.

In a preferred embodiment: the convex plate horizontally slides on the floating plate through an elastic structure with a limiting plate, and the materials of the convex plate and the limiting plate are the same as the floating plate.

In a preferred embodiment: the elastic structure comprises a limiting plate, a first spring and a limiting groove, wherein the left side of the limiting plate is fixedly connected with the convex plate, the limiting groove is formed in the upper end of the floating plate, the lower end of the limiting plate slides in the limiting groove, one end of the first spring is fixedly connected with the limiting plate, and the other end of the first spring is fixedly arranged on the floating plate.

In a preferred embodiment: two extension blocks are respectively arranged on the inner wall of the feeding box, and the two extension blocks are distributed in a staggered manner.

In a preferred embodiment: the discharging mechanism comprises a second sealing plate, a supporting plate, a discharging hole and a second spring, wherein the second sealing plate is slidably arranged in the feeding box, the discharging hole is formed in the bottom end wall body of the feeding box, the supporting plate is slidably connected with the lower end wall body of the feeding box, the second lower end of the sealing plate is arranged, the upper end of the second spring is fixedly connected with the second sealing plate, and the lower end of the second spring is fixedly connected with the bottom end of the feeding box.

In a preferred embodiment: sealing rubber I is arranged on the outer walls of the first sealing plate, the second sealing plate, the first adjusting plate, the second adjusting plate, the third adjusting plate and the supporting plate, sealing rubber II is arranged on the inner wall of the feeding box, and clamping grooves matched with one side of the supporting plate are formed in two side wall bodies of the second sealing plate.

Compared with the prior art, the utility model has the following beneficial effects:

1. according to the utility model, the rising position of the floating plate is controlled by changing the positions of the second adjusting plate and the third adjusting plate, so that the addition of the detection liquid in the feeding box is controlled, the increase of the error rate of the detection result caused by the excessive or insufficient addition of the detection liquid in the feeding box is avoided, the waste of test paper can be reduced by controlling the addition of the detection liquid, and the convenience of using the device is improved.

2. According to the utility model, through the arrangement of the discharging mechanism, liquid in the feeding box can be conveniently led into the detection box when needed, and the arrangement of the second sealing plate further increases the sealing effect in the feeding box, and the tightness in the feeding box is increased through the arrangement of the first sealing rubber and the sealing rubber.

Drawings

The accompanying drawings are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the embodiments of the utility model, serve to explain the utility model. In the drawings:

FIG. 1 is a schematic view of the overall structure of the present utility model;

FIG. 2 is a schematic view of a front cross-sectional structure of the feed box of the present utility model;

FIG. 3 is a schematic side cross-sectional view of the feed box of the present utility model;

FIG. 4 is a schematic view of the connection structure of the floating plate, the convex plate and the limiting plate of the present utility model;

FIG. 5 is a schematic top cross-sectional view of the feed cassette of the present utility model;

in the figure: 1. a detection box; 2. a feed box; 3. a feed pipe; 4. a floating plate; 5. a convex plate; 6. an adjusting plate I; 7. an adjusting plate II; 8. an adjusting plate III; 9. a feed inlet; 10. a first sealing plate; 11. a limiting plate; 12. a first spring; 13. an extension block; 14. a second sealing plate; 15. a support plate; 16. and a discharge port.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-5, the present utility model provides the following technical solutions: a nano-film microfluidic colloidal gold detection device comprises a detection box 1, a feeding box 2, a feeding pipe 3, a floating plate 4, a convex plate 5, a first adjusting plate 6, a second adjusting plate 7, a third adjusting plate 8 and a discharging mechanism, wherein the feeding box 2 is arranged at the upper end of the detection box 1, the feeding pipe 3 is fixedly arranged at one side of the feeding box 2, a sealing unit is arranged at the top end of the feeding pipe 3, the floating plate 4 is slidingly arranged in the feeding box 2, the convex plate 5 is elastically supported at the upper end of the floating plate 4 and is interlocked with the first adjusting plate 6, the second adjusting plate 7 and the third adjusting plate 8, the floating plate 4 slidingly drives the convex plate 5 to slide left and right under the actions of the first adjusting plate 6, the second adjusting plate 7 and the third adjusting plate 8, the first adjusting plate 6 is fixedly arranged on the feeding box 2, the second adjusting plate 7 and the third adjusting plate 8 are hermetically slidingly arranged on the feeding box 2, the discharge mechanism derives the material, during the use, open the closing plate one 10 in the sealing unit, with the detection liquid in leading-in feeding box 2 of inlet pipe 3, along with the continuous increase of test liquid, thereby can drive floating plate 4 to rise in the liquid in the feeding box 2 constantly, when floating plate 4 risen to regulating plate two 7, floating plate 4 receives the power and no longer moves, take out regulating plate two 7 left this moment, afterwards can make floating plate 4 continue upwards moving under the increase of detection liquid, through the upward shift position of controlling floating plate 4 with regulating plate one 6, regulating plate two 7 and regulating plate three 8 positions, and then the quantity of detection liquid in the steerable entering feeding box 2, thereby can avoid making the phenomenon emergence of the quantity too much or too little that detects liquid and get into feeding box 2.

The sealing unit comprises a feed inlet 9, a sealing plate one 10 and a handle, wherein the feed inlet 9 is fixedly arranged at the upper end of the feed pipe 3 and communicated with the material reducing pipe, the sealing plate one 10 is rotationally arranged at the upper end of the feed inlet 9, the handle is fixedly arranged on the sealing plate one 10, and the sealing unit is arranged, so that the feeding box 2 is convenient for adding detection liquid at any time, and dust is prevented from falling into the feed pipe 3 when the detection is not performed.

The convex plate 5 horizontally slides on the floating plate 4 through an elastic structure with the limiting plate 11, materials of the convex plate 5 and the limiting plate 11 are the same as those of the floating plate 4, and the limiting plate 11 and the limiting groove can play a certain role in limiting and guiding the left and right movement of the convex plate 5

The elastic structure comprises a limiting plate 11, a first spring 12 and a limiting groove, wherein the left side of the limiting plate 11 is fixedly connected with the first convex plate 5, the limiting groove is formed in the upper end of the floating plate 4, the lower end of the limiting plate 11 slides in the limiting groove, one end of the first spring 12 is fixedly connected with the limiting plate 11, the other end of the first spring is fixedly arranged on the floating plate 4, when the elastic structure is used, the first adjusting plate 6 enables the convex plate 5 to move rightwards under the action of an inclined plane along with the movement of the first convex plate 5 to the lower end of the first adjusting plate 6 until the convex plate 5 is separated from the first adjusting plate 6, the convex plate 5 is reset under the action of the first spring 12, when the convex plate 5 moves to the lower end of the second adjusting plate 7, the second adjusting plate 7 enables the convex plate 5 to be unable to move, and then the floating plate 4 stops sliding upwards, at the moment, the detection liquid can not be added into the detection box 1, when the second adjusting plate 7 moves rightwards to be leveled with the first adjusting plate 6, the first adjusting plate 5 and the first adjusting plate 4 can move upwards, the third adjusting plate 8 and the second adjusting plate 7 can realize the detection of the detection liquid, and the detection of the detection liquid can be added at least or the detection liquid can be prevented from being excessively

Two extension blocks 13 are respectively arranged on the inner wall of the feeding box 2, the two extension blocks 13 are distributed in a staggered manner, and the floating plate 4 can be supported by the arrangement of the extension blocks 13

The discharging mechanism comprises a second sealing plate 14, a supporting plate 15, a discharging hole 16 and a second spring, wherein the second sealing plate 14 is slidably arranged in the feeding box 2, the discharging hole 16 is arranged on the bottom end wall body of the feeding box 2, the supporting plate 15 is slidably connected with the lower end wall body of the feeding box 2 and is arranged at the lower end of the second sealing plate 14, the upper end of the second spring is fixedly connected with the second sealing plate 14, the lower end of the second spring is fixedly connected with the bottom end of the feeding box 2, when a proper amount of detection liquid is added in the detection box 1, the two supporting plates 15 are pulled out towards two sides, the second sealing plate 14 slides downwards under the action of the detection liquid until the upper end of the second sealing plate 14 is lower than the upper end of the discharging hole 16, the detection box 1 is communicated with the inside of the feeding box 2 through the discharging hole 16, and the detection liquid flows into the detection box 1 through the discharging hole 16, so that the detection work of colloidal gold is completed

Sealing rubber I is arranged on the outer walls of the first sealing plate 10, the second sealing plate 14, the first adjusting plate 6, the second adjusting plate 7, the third adjusting plate 8 and the supporting plate 15, sealing rubber II is arranged on the inner wall of the feeding box 2, clamping grooves matched with one side of the supporting plate 15 are formed in two side wall bodies of the second sealing plate 14, and sealing rubber I and sealing rubber are arranged, so that the sealing performance of the inside of the feeding box 2 is improved.

Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present utility model, and the present utility model is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present utility model has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.

Claims

1. A nano-film microfluidic colloidal gold detection device is characterized in that: including detecting box (1), feeding box (2), inlet pipe (3), kickboard (4), flange (5), regulating plate one (6), regulating plate two (7), regulating plate three (8) and discharge mechanism, detecting box (1) upper end is located to feeding box (2), one side of feeding box (2) is located to inlet pipe (3), and inlet pipe (3) top is equipped with sealing unit, in feeding box (2) is located in kickboard (4) slip, flange (5) elastic support is in kickboard (4) upper end, and link with regulating plate one (6), regulating plate two (7) and regulating plate three (8), kickboard (4) slip drive flange (5) are in regulating plate one (6), regulating plate two (7) and regulating plate three (8) effect down horizontal slip, on feeding box (2) is located to regulating plate one (6) is fixed, regulating plate two (7) and regulating plate three (8) all seal and slide on feeding box (2), discharge mechanism derives the material.

2. The nano-film microfluidic colloidal gold detection device according to claim 1, wherein: the sealing unit comprises a feed inlet (9), a first sealing plate (10) and a handle, wherein the feed inlet (9) is fixedly arranged at the upper end of the feed pipe (3) and is communicated with the feed pipe (3), the first sealing plate (10) is rotationally arranged at the upper end of the feed inlet (9), and the handle is fixedly arranged on the first sealing plate (10).

3. The nano-film microfluidic colloidal gold detection device according to claim 1, wherein: the convex plate (5) horizontally slides on the floating plate (4) through an elastic structure with a limiting plate (11), and the materials of the convex plate (5) and the limiting plate (11) are the same as those of the floating plate (4).

4. A nanomembrane microfluidic colloidal gold detection device according to claim 3, wherein: the elastic structure comprises a limiting plate (11), a first spring (12) and a limiting groove, wherein the left side of the limiting plate (11) is fixedly connected with the convex plate (5), the limiting groove is formed in the upper end of the floating plate (4), the lower end of the limiting plate (11) slides in the limiting groove, one end of the first spring (12) is fixedly connected with the limiting plate (11), and the other end of the first spring is fixedly arranged on the floating plate (4).

5. The nano-film microfluidic colloidal gold detection device according to claim 1, wherein: two extension blocks (13) are respectively arranged on the inner wall of the feeding box (2), and the two extension blocks (13) are distributed in a staggered manner.

6. The nano-film microfluidic colloidal gold detection device according to claim 2, wherein: the discharging mechanism comprises a second sealing plate (14), a supporting plate (15), a discharging hole (16) and a second spring, wherein the second sealing plate (14) is slidably arranged in the feeding box (2), the discharging hole (16) is arranged on the bottom end wall body of the feeding box (2), the supporting plate (15) is slidably connected with the lower end wall body of the feeding box (2), the lower end of the second sealing plate (14) is arranged, the upper end of the second spring is fixedly connected with the second sealing plate (14), and the lower end of the second spring is fixedly connected with the bottom end of the feeding box (2).

7. The nano-film microfluidic colloidal gold detection device according to claim 6, wherein: sealing rubber I is arranged on the outer walls of the first sealing plate (10), the second sealing plate (14), the first adjusting plate (6), the second adjusting plate (7), the third adjusting plate (8) and the supporting plate (15), sealing rubber II is arranged on the inner walls of the feeding box (2) and the feeding hole (9), and clamping grooves matched with one side of the supporting plate (15) are formed in the two side wall bodies of the second sealing plate (14).