CN218907704U - Sterile transmission consumable for bio-pharmaceuticals - Google Patents
Sterile transmission consumable for bio-pharmaceuticals Download PDFInfo
- Publication number
- CN218907704U CN218907704U CN202320046551.6U CN202320046551U CN218907704U CN 218907704 U CN218907704 U CN 218907704U CN 202320046551 U CN202320046551 U CN 202320046551U CN 218907704 U CN218907704 U CN 218907704U
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- Prior art keywords
- filling needle
- filling
- pipeline
- sealing
- liquid
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- 229960000074 biopharmaceutical Drugs 0.000 title claims description 13
- 230000005540 biological transmission Effects 0.000 title abstract description 11
- 238000007789 sealing Methods 0.000 claims abstract description 70
- 239000007788 liquid Substances 0.000 claims abstract description 61
- 238000005086 pumping Methods 0.000 claims abstract description 20
- 239000011550 stock solution Substances 0.000 claims abstract description 13
- 230000001681 protective effect Effects 0.000 claims description 26
- 238000005452 bending Methods 0.000 claims description 7
- 230000002572 peristaltic effect Effects 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 239000013013 elastic material Substances 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 9
- 239000000463 material Substances 0.000 description 5
- 238000009434 installation Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000012864 cross contamination Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model relates to the technical field of liquid medicine filling, in particular to an aseptic transmission consumable which can be used for biological pharmacy, comprising a buffer bag, wherein three groups of pipeline connectors are arranged at the bottom of the buffer bag, one group of pipeline connectors are connected with a stock solution bin connecting pipeline, the other end of the stock solution bin connecting pipeline penetrates through the other side of a first sealing gasket to be fixedly connected with a stock solution bin connector, the other two groups of pipeline connectors are respectively connected with a liquid pumping pipeline, the other end of the liquid pumping pipeline penetrates through the other side of a second sealing gasket to be connected with a filling needle assembly.
Description
Technical Field
The utility model relates to the technical field of liquid medicine filling, in particular to a sterile transmission consumable material for bio-pharmaceuticals.
Background
The liquid medicine filling is to extract the stock solution from stock solution bag/bucket and pass through pipeline and filling needle to in the filling package material such as xilin bottle or prefilling needle, how to guarantee reagent or liquid medicine is not polluted and partial shipment measurement accuracy is the one step of vital in the filling process, traditional filling system is the stainless steel system that uses repeatedly, connect stock solution bucket, aseptic joint, pump, filling needle as an organic whole through the pipeline, all need to disinfect and sterilize to filling system before the liquid medicine filling at every turn, the washing operation before every operation, consuming time and effort, there is cross contamination risk between batches, and traditional filling line is mostly special for special line, the cost is higher, pump liquid precision is lower relatively, unable 100% weighing, the compatibility is low and different batch cross contamination's risk etc..
In summary, the present utility model solves the problems by designing a sterile transfer consumable that can be used in biopharmaceuticals.
Disclosure of Invention
The present utility model is directed to a sterile transfer consumable for biopharmaceuticals, which solves the problems set forth in the background art.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
the utility model provides a sterile transmission consumable that can be used to bio-pharmaceuticals, includes the buffer bag, the bottom of buffer bag is provided with three sets of pipeline connectors, and wherein a set of pipeline connector is connected with stoste storehouse connecting tube, and wherein the other end of stoste storehouse connecting tube runs through to the opposite side fixedly connected with stoste storehouse connector of sealed pad one, and two other sets of pipeline connectors are connected with pump liquid pipeline respectively, and wherein the other end of pump liquid pipeline runs through to the opposite side of sealed pad two and is connected at the filling needle subassembly;
the filling needle assembly comprises a filling needle mounting clamping jaw, a filling needle fixing piece is arranged on the filling needle mounting clamping jaw, the filling needle fixing piece is sleeved with a filling needle, the needle head of the filling needle is sleeved with a protective cover, the protective cover is provided with a filling needle inlet corresponding to the filling needle, a sealing ring mounting position is arranged at the port of the filling needle inlet and at the joint of the filling needle inlet and the filling needle, a sealing ring is assembled on the sealing ring mounting position, elastic locking belts are correspondingly arranged at the left side and the right side of the protective cover, the end part of each elastic locking belt is fixedly provided with a manipulator clamping hole position, one side of manipulator clamp hole site is provided with locking buckle, and wherein locking buckle joint is in the inside of the protection casing draw-in groove that sets up on the filling needle mounting, the filling needle clamping jaw clamp that is located on the terminal surface of filling needle mounting is put and is provided with filling needle clamping jaw clamp and is put, and wherein filling needle clamping jaw clamp is put the left and right sides and be provided with the filling needle mounting hole on the filling needle mounting, the bottom of filling needle mounting and with filling needle mounting hole one-to-one be provided with elastic filling needle anticreep buckle, the inside plug of filling needle mounting hole is connected with the filling needle erection column, and wherein the outer wall of filling needle erection column passes through filling needle anticreep buckle joint.
As a preferable scheme of the utility model, the pipeline of the liquid pumping pipeline after the liquid pumping pipeline comes out of the buffer bag is a double-pump pipeline, and the protective cover is made of elastic materials.
As a preferable scheme of the utility model, the liquid inlet of the filling needle is fixedly connected with the end part of the liquid pumping pipeline, wherein the liquid inlet of the filling needle is sleeved with a bending spring which is positioned on the outer wall of the liquid pumping pipeline.
As a preferable scheme of the utility model, the first sealing gasket and the second sealing gasket are sealing gaskets with the same structure, wherein the sealing gaskets are arranged on a flange plate on a sealing panel, the sealing gaskets are locked on the sealing panel by anchor clamps, the sealing panel is arranged between a filling cabin and a liquid storage cabin, and the sealing gaskets are sealed with the flange plate through sealing rings.
As a preferable scheme of the utility model, the buffer bag is hung on the weighing sensor, and the pump liquid pipeline is arranged at a corresponding working position of the peristaltic pump.
Compared with the prior art, the utility model has the beneficial effects that:
1. according to the utility model, by designing the sterile transmission consumable which can be used for bio-pharmaceuticals, the sterile transmission consumable can be sealed in all chambers after being installed in place, the key parts of the sterile transmission consumable are not polluted during secondary sterilization of the filling chambers, meanwhile, convenience in the installation and replacement of the sterile transmission consumable is also realized, and the multi-channel disposable consumable is used, each channel is independently pumped, the high-throughput production efficiency is guaranteed, and the filling high precision of each channel is guaranteed, so that safer, more economical and faster filling disposable consumable products can be provided in a bio-pharmaceutical filling system, the product quality is guaranteed, the equipment utilization rate is improved, and the comprehensive production cost is reduced.
Drawings
FIG. 1 is a schematic diagram of an axial measurement structure of a sterile transmission consumable of the present utility model;
FIG. 2 is a schematic illustration of an axial structure of a filling needle assembly of the present utility model;
FIG. 3 is a schematic cross-sectional view of a filling needle assembly of the present utility model;
FIG. 4 is a schematic view of the axial measurement structure of the filling needle protection cover of the present utility model;
FIG. 5 is a schematic view of the axial structure of the filling needle part of the present utility model;
FIG. 6 is a schematic view of a seal axial measurement structure of the gasket of the present utility model;
FIG. 7 is a schematic diagram of a cross-sectional structure of a gasket and seal ring of the present utility model.
In the figure: 1. a cache bag; 2. the stock solution bin is connected with a pipeline; 3. a first sealing gasket; 4. a liquid pumping pipeline; 5. a second sealing gasket; 6. a filling needle assembly; 7. a bending spring; 8. a sealing gasket; 9. a sealing panel; 10. a flange plate; 11. a seal ring; 12. a hoop; 601. the filling needle is provided with clamping jaws; 602. a filling needle mount; 603. a filling needle; 604. a protective cover; 605. a filling needle inlet; 606. a sealing ring installation position; 607. a seal ring; 608. an elastic locking belt; 609. the mechanical arm clamps the hole site; 610. locking buckle; 611. a protective cover clamping groove; 612. clamping and positioning clamping jaws of a filling needle; 613. a filling needle mounting hole; 614. the filling needle is prevented from falling off the buckle; 615. a filling needle mounting column; 101. a stock solution bin connector.
Detailed Description
The technical solutions of the embodiments of the present utility model will be clearly and completely described below in conjunction with the embodiments of the present utility model, and it is apparent that the described embodiments are only some embodiments of the present utility model, but not all embodiments, and all other embodiments obtained by those skilled in the art without making any inventive effort based on the embodiments of the present utility model are within the scope of protection of the present utility model.
In order that the utility model may be readily understood, several embodiments of the utility model will be described more fully hereinafter with reference to the accompanying drawings, in which, however, the utility model may be embodied in many different forms and is not limited to the embodiments described herein, but instead is provided for the purpose of providing a more thorough and complete disclosure of the utility model.
It will be understood that when an element is referred to as being "mounted" on another element, it can be directly on the other element or intervening elements may also be present, and when an element is referred to as being "connected" to the other element, it may be directly connected to the other element or intervening elements may also be present, the terms "vertical", "horizontal", "left", "right" and the like are used herein for the purpose of illustration only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs, and the terms used herein in this description of the utility model are for the purpose of describing particular embodiments only and are not intended to be limiting of the utility model, with the term "and/or" as used herein including any and all combinations of one or more of the associated listed items.
Referring to fig. 1-7, the present utility model provides a technical solution:
the sterile transmission consumable capable of being used for biological pharmacy comprises a buffer bag 1, wherein three groups of pipeline connectors are arranged at the bottom of the buffer bag 1, one group of pipeline connectors are connected with a raw liquid bin connecting pipeline 2, the other end of the raw liquid bin connecting pipeline 2 penetrates through the other side of a sealing gasket I3 and is fixedly connected with a raw liquid bin connector 101, the other two groups of pipeline connectors are respectively connected with a liquid pumping pipeline 4, and the other end of the liquid pumping pipeline 4 penetrates through the other side of the sealing gasket II 5 and is connected with a filling needle assembly 6;
the filling needle assembly 6 comprises a filling needle mounting clamping jaw 601, a filling needle fixing piece 602 is mounted on the filling needle mounting clamping jaw 601, a filling needle 603 is sleeved on the filling needle fixing piece 602, a protective cover 604 is sleeved on a needle head of the filling needle 603, a filling needle inlet 605 is correspondingly arranged on the protective cover 604, a sealing ring mounting position 606 is arranged at a port of the filling needle inlet 605 and at a joint of the filling needle inlet 605 and the filling needle 603, a sealing ring 607 is assembled on the sealing ring mounting position 606, elastic locking belts 608 are correspondingly arranged on the left side and the right side of the protective cover 604, a mechanical hand clamp taking hole 609 is fixedly arranged at the end part of the elastic locking belts 608, a locking buckle 610 is arranged on one side of the mechanical hand clamp taking hole 609, a protective cover clamping groove 611 is arranged on the filling needle fixing piece 602, a sealing ring taking position 612 is arranged on the end face of the filling needle fixing piece 602 and at the rear side of the filling needle 603, an anti-falling-out pin mounting hole 614 is correspondingly arranged on the left side and the right side of the filling needle clamping jaw 612, and the sealing ring mounting hole is correspondingly connected with the filling needle mounting hole 613, and the elastic locking clamp mounting hole 613 is arranged on the outer wall of the filling needle mounting clamping jaw 613.
As a preferable scheme of the utility model, the pipeline of the liquid pumping pipeline 4 after the liquid pumping pipeline is discharged from the buffer bag 1 is a double-pump pipeline, so that the pulse influence is reduced, the optimal precision is achieved, the protective cover 604 is made of elastic materials, after the cabin for installing consumable materials is sterilized and disabled, the robot clamping jaw is inserted into the robot clamping hole, the robot clamping jaw is opened, and the elastic material protective cover is separated from the protected liquid pumping needle.
As a preferred solution of the present utility model, the liquid inlet of the filling needle 603 is fixedly connected to the end of the liquid pumping pipeline 4, wherein the bending spring 7 is sleeved on the liquid inlet of the filling needle 603 and positioned on the outer wall of the liquid pumping pipeline 4.
As a preferred scheme of the utility model, the first sealing gasket 3 and the second sealing gasket 5 are sealing gaskets 8 with the same structure, wherein the sealing gaskets 8 are arranged on a flange plate 10 on a sealing panel 9, the sealing gaskets 8 are locked on the sealing panel 9 by anchor bolts, the sealing panel 9 is arranged between a filling cabin and a liquid storage cabin, and the sealing gaskets 8 and the flange plate 10 are sealed by a sealing ring 11.
As the preferable scheme of the utility model, the buffer bag 1 is hung on the weighing sensor, and the peristaltic pump of the stock solution bin can be controlled according to feedback to maintain the liquid level to the liquid level and ensure the liquid inlet pressure; the pump liquid pipeline 4 is arranged at the corresponding working position of the peristaltic pump.
Wherein,,
the buffer bag 1 is used for storing reagent or liquid medicine pumped by a primary liquid cabin, so that continuous liquid supplementing is realized, the same liquid level height and liquid inlet pressure are kept, and good filling precision is ensured;
the primary liquid cabin connector 101 is used for guaranteeing sterile connection of pipelines, and can effectively guarantee clean environment in the liquid pumping pipeline 4;
the first sealing gasket 3 and the second sealing gasket 5 are used for isolating the buffer cabin from the filling cabin and the stock solution cabin, and have a sealing effect on the buffer cabin;
the pump liquid pipelines 4 are designed to be double pump pipelines after the pump liquid pipelines 4 come out of the buffer bags 1, so that the pulse influence can be reduced, and the optimal precision is achieved;
the bending-resistant spring 7 is used for guaranteeing that a reasonable bending radius is maintained after the pump liquid pipeline 4 enters the filling cabin, and avoiding influencing the accuracy of the pump liquid amount due to the fact that the bending radius is too small;
the filling needle 603 accurately controls the flow direction of the liquid medicine, and ensures that the liquid medicine is completely led into the container;
the protection cover 604 is matched with the filling needle fixing piece 602 and the sealing ring 607 to form a closed environment, so that leakage is prevented under a certain pressure environment; on the other hand, the filling needle is protected from being damaged in the process of transportation, installation and transportation, and H is prevented in the process of cabin sterilization 2 O 2 The sterilizing gas permeates into the needle;
the sealing ring 603 enables the filling needle assembly to form a sealing structure, so that the air tightness of the filling needle assembly is ensured;
filling needle mounting clamping jaw 601 clamps a filling needle part in a cache cabin through a glove box by using the filling needle mounting clamping jaw, and takes and places the filling needle part to a mounting position;
the filling needle assembly 6 is formed by compressing and sealing the sealing ring through a shaft shoulder fixedly positioned by the sealing ring and the shaft end face of a filling needle fixing piece, and then fixing the relative positions of the two parts by utilizing a protective cover locking buckle and a protective cover clamping groove of the filling needle fixing piece; the protective cover is also provided with a manipulator clamping hole, and the protective cover can be taken off and secondarily installed through a manipulator, so that manual protective cover removal operation can be avoided, and the influence of leakage of personnel protective equipment on the filling environment is effectively prevented;
the sealing gasket 8 uses the pressing force of the hoop 12 on the flange plate 10 and the sealing gasket 8 to deform the sealing ring 11 of the sealing gasket 8 to achieve the sealing effect.
The working flow of the utility model is as follows:
step 4, placing the pump liquid pipeline 4 at a corresponding working position of the peristaltic pump;
1) The sterility safety of the whole process is ensured;
2) Cross contamination among different batches and different liquid medicines is effectively prevented;
3) As disposable filling system consumable, this patent filling consumable possesses the convenience of installation change. Simultaneously realizing the automatic operation of the filling needle head part in a sterile closed environment;
4) The disposable consumable material is provided with a plurality of channels, and the channels improve the parallel use efficiency. Each channel is provided with an independent pump body, so that the flux is improved, and meanwhile, the weighing accuracy of each channel is ensured;
5) The interlayer of consumptive material passes through mounting structure, ensures mounting structure's leakproofness and the security of use.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. Sterile transfer consumables for biopharmaceuticals, comprising a buffer pouch (1), characterized in that: three groups of pipeline connectors are arranged at the bottom of the buffer bag (1), one group of pipeline connectors are connected with a stock solution bin connecting pipeline (2), the other end of the stock solution bin connecting pipeline (2) penetrates through the other side of the first sealing gasket (3) and is fixedly connected with a stock solution bin connector (101), the other two groups of pipeline connectors are respectively connected with a pump liquid pipeline (4), and the other end of the pump liquid pipeline (4) penetrates through the other side of the second sealing gasket (5) and is connected with a filling needle assembly (6);
the filling needle assembly (6) comprises a filling needle mounting clamping jaw (601), a filling needle fixing piece (602) is mounted on the filling needle mounting clamping jaw (601), the filling needles (603) are sleeved on the filling needle fixing piece (602), a protective cover (604) is sleeved on the needle heads of the filling needles (603), a filling needle inlet (605) is correspondingly arranged on the protective cover (604), a sealing ring mounting position (606) is arranged at the port of the filling needle inlet (605) and at the joint of the filling needle inlet (605) and the filling needles (603), a sealing ring (607) is mounted on the sealing ring mounting position (606), an elastic locking belt (608) is correspondingly arranged at the left side and the right side of the protective cover (604), a mechanical arm clamping hole position (609) is fixedly arranged at the end part of the elastic locking belt (608), a locking buckle (610) is arranged at one side of the mechanical arm clamping hole position (609), the locking buckle (610) is clamped on the inner part 611 of the protective cover fixing piece (602) and is arranged at the end face of the filling needle fixing piece (602), the filling needle clamping jaw clamping device comprises a filling needle clamping jaw clamping position (612) and is characterized in that filling needle mounting holes (613) are formed in the left side and the right side of the filling needle clamping jaw clamping position (612) and in a filling needle fixing piece (602), elastic filling needle anti-falling buckles (614) are arranged at the bottom of the filling needle fixing piece (602) in one-to-one correspondence with the filling needle mounting holes (613), filling needle mounting columns (615) are connected in a plug-in mode, and the outer walls of the filling needle mounting columns (615) are connected in a clamping mode through the filling needle anti-falling buckles (614).
2. A sterile transfer consumable for biopharmaceutical use according to claim 1, wherein: the pipeline of the liquid pumping pipeline (4) after the liquid pumping pipeline (4) comes out of the buffer bag (1) is a double-pump pipeline, and the protective cover (604) is made of elastic materials.
3. A sterile transfer consumable for biopharmaceutical use according to claim 1, wherein: the liquid inlet of the filling needle (603) is fixedly connected to the end part of the liquid pumping pipeline (4), wherein a bending spring (7) is sleeved on the liquid inlet of the filling needle (603) and positioned on the outer wall of the liquid pumping pipeline (4).
4. A sterile transfer consumable for biopharmaceutical use according to claim 1, wherein: the sealing gasket I (3) and the sealing gasket II (5) are sealing gaskets (8) with the same structure, wherein the sealing gaskets (8) are arranged on a flange plate (10) on a sealing panel (9), the sealing gaskets (8) are locked on the sealing panel (9) by anchor clamps (12), the sealing panel (9) is arranged between a filling cabin and a liquid storage cabin, and the sealing gaskets (8) and the flange plate (10) are sealed by sealing rings (11).
5. A sterile transfer consumable for biopharmaceutical use according to claim 1, wherein: the buffer bag (1) is hung on the weighing sensor, and the liquid pumping pipeline (4) is arranged at a corresponding working position of the peristaltic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320046551.6U CN218907704U (en) | 2023-01-09 | 2023-01-09 | Sterile transmission consumable for bio-pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320046551.6U CN218907704U (en) | 2023-01-09 | 2023-01-09 | Sterile transmission consumable for bio-pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218907704U true CN218907704U (en) | 2023-04-25 |
Family
ID=86045021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320046551.6U Active CN218907704U (en) | 2023-01-09 | 2023-01-09 | Sterile transmission consumable for bio-pharmaceuticals |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218907704U (en) |
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2023
- 2023-01-09 CN CN202320046551.6U patent/CN218907704U/en active Active
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