CN218854253U - A automatic synthesizer of radiopharmaceutical for 68Ga marks - Google Patents
A automatic synthesizer of radiopharmaceutical for 68Ga marks Download PDFInfo
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- CN218854253U CN218854253U CN202222820350.5U CN202222820350U CN218854253U CN 218854253 U CN218854253 U CN 218854253U CN 202222820350 U CN202222820350 U CN 202222820350U CN 218854253 U CN218854253 U CN 218854253U
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Abstract
The utility model provides an automatic synthesizer of radiopharmaceutical for 68Ga mark, each system of by control system automatic control carries out work, control each valve and syringe pump and switch, make liquid pass through the syringe pump as liquid way drive power, realize the transfer of liquid with the help of each valve and corresponding pipeline, make 68Ga mark water-soluble polypeptide and micromolecule positron medicine quick, high-efficient automatic mark, the purification, aseptic injection liquid of final preparation is in order to use, both realized the automatic preparation of 68Ga mark positron medicine, remove the cost of disposing large-scale medical cyclotron again; the fully-automatic preparation process can effectively reduce the exposure time of workers under radioactive substances, save mechanical repetitive manual operation, greatly improve the reproducibility and reliability of radiopharmaceutical production, and facilitate the realization of standard production of 68 Ga-labeled positron medicines.
Description
Technical Field
The utility model relates to a nuclear medicine and molecular imaging field especially relate to an automatic synthesizer of radiopharmaceutical for 68Ga marks.
Background
With the development of nuclear physics and nuclear chemistry related technologies becoming more mature, some novel radionuclide drugs such as 68Ga can be respectively realized by 68Ge/68Ga nuclide generators, the generators occupy smaller space, the nuclide acquisition way is convenient and easy to obtain, and the dependence on large-scale medical cyclotrons can be eliminated to a great extent. For the commonly used 18F nuclear species, the half-life of the 68Ga nuclear species is short, so that the 68 Ga-labeled radiopharmaceutical is not suitable for long-distance distribution, and the 68Ga positron medicine production center must perform the production and quality control activities of the medicine in real time and on the spot. Most of the existing production units label the radioactive drugs in a manual synthesis mode, no commercial automatic synthesis module is used for preparing the drugs, and compared with the automatic module synthesis, the manual preparation of the drugs has poor reproducibility and low synthesis efficiency due to the difference of proficiency of operators; and is affected by radiation during the manual preparation of the drug, causing damage to the health of the operator.
SUMMERY OF THE UTILITY MODEL
In order to solve the above problems, the present technical solution provides an automated synthesis apparatus for 68 Ga-labeled radiopharmaceuticals.
In order to realize the purpose, the technical scheme is as follows: an automatic synthesis device for 68 Ga-labeled radiopharmaceuticals comprises a 68Ge-68Ga generator, a generator leaching system, a heating reaction system, a synthesis purification system and a control system; the 68Ge-68Ga generator is connected with the generator leaching system through a pipeline, the generator leaching system and the synthesis and purification system are respectively connected with the heating reaction system through pipelines, and the control system is respectively electrically connected with the generator leaching system, the synthesis and purification system and the heating reaction system.
In some embodiments, the control system is any one of a microcomputer software control system or a human-computer interaction interface touch screen control system.
In some embodiments, the generator leaching system includes a first injection pump, a first one-way six-way distribution valve, a first two-position four-way electric valve, a two-position three-way electromagnetic valve, and a 68Ga waste liquid recovery bottle, the first injection pump is connected to the first one-way six-way distribution valve through a pipeline, one of the channels of the first one-way six-way distribution valve is connected to the first two-position four-way electric valve through a pipeline, the first two-position four-way electric valve is respectively connected to the 68Ge-68Ga generator and the two-position three-way electromagnetic valve through pipelines, and the two-position three-way electromagnetic valve is connected to the 68Ga waste liquid recovery bottle through a pipeline.
In some embodiments, the pressure-resistant range of the first one-way six-way distribution valve and the first two-position four-way electric valve is 1.0-1.2MPa, and the pressure-resistant range of the two-position three-way electromagnetic valve is 0.2-0.3MPa.
In some embodiments, the heating reaction system includes a moving unit, a temperature control heating unit, a reaction tube, and a two-position two-way solenoid valve, the two-position two-way solenoid valve is connected to the reaction tube through a pipeline, the two-position three-way solenoid valve is connected to the reaction tube through a pipeline, and the moving unit is configured to drive the temperature control heating unit to move up and down, so as to heat the reaction tube.
In some embodiments, the moving unit includes a stepping motor, a ball screw is connected to an output end of the stepping motor, and a lifting sliding table is connected to the ball screw, and the lifting sliding table is connected to the temperature control heating unit.
In some embodiments, the synthesis and purification system includes a second syringe pump, a second first-through sixth-branch distribution valve, a solid-phase extraction and purification column, a second two-position four-way electric valve, a two-position three-way electric valve, a product collection bottle, a sterile filtration membrane and a waste liquid bottle, the second syringe pump is connected to the second first-through sixth-branch distribution valve through a pipeline, one channel of the second first-through sixth-branch distribution valve is connected to the reaction tube through a pipeline, the other channel of the second first-through sixth-branch distribution valve is connected to the second two-position four-way electric valve through a pipeline, the second two-position four-way electric valve is connected to the solid-phase extraction and purification column and the two-position three-way electric valve through a pipeline, the two-position three-way electric valve is connected to the sterile filtration membrane and the waste liquid bottle through a pipeline, and the sterile filtration membrane is connected to the product collection bottle.
In some embodiments, the second one-way six-way distributing valve, the second two-position four-way electric valve and the two-position three-way electric valve have a pressure resistance range of 1.0-1.2MPa.
In some embodiments, the solid phase extraction purification column is any one of a C18 solid phase extraction column or an HLB solid phase extraction column.
The beneficial effect of this application does:
1. the large medical cyclotron does not need to be configured, the acquisition cost is saved, and more use space is liberated.
2. The automatic preparation of 68 Ga-labeled positron medicine is realized, the mechanical repetitive manual operation can be omitted, the reproducibility and reliability of radiopharmaceutical production are greatly improved, and the standardized production of 68 Ga-labeled positron medicine is convenient to realize.
3. The fully-automatic preparation process can effectively reduce the exposure time of workers under radioactive substances, and greatly reduce the health influence of the radioactive substances on the workers.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below.
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the switching states of first and second two-position, four-way electrically operated valves (one position on the left and two position on the right);
FIG. 3 is a schematic diagram showing the switching states of a two-position three-way solenoid valve (the left is a one-position state, and the right is a two-position state);
FIG. 4 is a schematic diagram of the switching states of the two-position three-way electric valve (the left is the one-position state, and the right is the two-position state);
FIG. 5 is a schematic diagram showing the switching states of the two-position two-way solenoid valve (the left is the one-position state, and the right is the two-position state);
FIG. 6 is a radioactive HPLC chromatogram of the positron emission tomography reaction system prepared by the present invention;
FIG. 7 is a radioactive HPLC chromatogram of the sterile product liquid after purification of the positron emission drug prepared by the utility model.
Reference numerals:
1. a 68Ge-68Ga generator; 2. the generator leaching system comprises a generator leaching system 21, a first injection pump 22, a first one-to-six distribution valve 23, a first two-position four-way electric valve 24, a two-position three-way electromagnetic valve, and 25 and 68Ga waste liquid recovery bottles; 3. a heating reaction system 31, a temperature control heating unit 32, a reaction tube 33, a two-position two-way electromagnetic valve, 34, a stepping motor, 35, a ball screw, 36 and a lifting sliding table; 4. a synthesis purification system, 41, a second injection pump, 42, a second first-pass six-minute distribution valve, 43, a solid-phase extraction purification column, 44, a second two-position four-way electric valve, 45, a two-position three-way electric valve, 46, a product collection bottle, 47, a sterile filter membrane, 48 and a waste liquid bottle; 5. a control system; 6. line a,61, line B,62, line C,63, line D,64, line E,65, line F,66, line G.
Detailed Description
In order to make the technical problem, technical solution and advantageous effects solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to further explain the present invention in detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1, an automated synthesis apparatus for 68 Ga-labeled radiopharmaceuticals comprises a 68Ge-68Ga generator 1, a generator leaching system 2, a heating reaction system 3, a synthesis purification system 4 and a control system 5; the 68Ge-68Ga generator 1 is connected with the generator leaching system 2 through a pipeline, the generator leaching system 2 and the synthesis and purification system 4 are respectively connected with the heating reaction system 3 through pipelines, and the control system 5 is respectively electrically connected with the generator leaching system 2, the synthesis and purification system 4 and the heating reaction system 3. The automatic synthesis device automatically controls all systems to work by a control system 5, so that a generator leaching system 2 leaches a 68Ge-68Ga generator 1 and collects 68Ga ion solution into a heating reaction system 3; then the control system 5 automatically controls the heating reaction system 3 to carry out heating reaction on the 68Ga ion solution and then convey the solution to the synthesis and purification system 4, and finally the control system 5 automatically controls the synthesis and purification system 4 to carry out adsorption purification and collection on the reacted 68Ga ion solution, so that the 68 Ga-labeled radiopharmaceutical is obtained.
In this embodiment, the control system 5 is any one of a microcomputer software control system 5 or a human-computer interaction interface touch screen control system 5.
In this embodiment, the generator leaching system 2 includes a first injection pump 21, a first one-to-one six-way distribution valve 22, a first two-position four-way electric valve 23, a two-position three-way solenoid valve 24, and a 68Ga waste liquid recovery bottle 25, the first injection pump 21 is connected with the first one-to-one six-way distribution valve 22 through a pipeline, one of the channels of the first one-to-one six-way distribution valve 22 is connected with the first two-position four-way electric valve 23 through a pipeline, the first two-position four-way electric valve 23 is connected with the 68Ge-68Ga generator 1 and the two-position three-way solenoid valve 24 through pipelines, and the two-position three-way solenoid valve 24 is connected with the 68Ga waste liquid recovery bottle 25 through a pipeline.
In the present embodiment, the pressure-resistant range of the first one-way six-way distributing valve 22 and the first two-position four-way electric valve 23 is 1.0-1.2MPa, and the pressure-resistant range of the two-position three-way electromagnetic valve 24 is 0.2-0.3MPa.
In this embodiment, the heating reaction system 3 includes a moving unit, a temperature control heating unit 31, a reaction tube 32 and a two-position two-way solenoid valve 33, the two-position two-way solenoid valve 33 is connected to the reaction tube 32 through a pipeline, the two-position three-way solenoid valve 24 is connected to the reaction tube 32 through a pipeline, and the moving unit is configured to drive the temperature control heating unit 31 to move up and down, so as to heat the reaction tube 32.
In this practical example, the moving unit includes a stepping motor 34, a ball screw 35 is connected to an output end of the stepping motor 34, a lifting slide table 36 is connected to the ball screw 35, and the lifting slide table 36 is connected to the temperature control heating unit 31.
In this embodiment, the synthesis and purification system 4 includes a second injection pump 41, a second first-pass six-way distribution valve 42, a solid-phase extraction and purification column 43, a second two-position four-way electric valve 44, a two-position three-way electric valve 45, a product collection bottle 46, an aseptic filter membrane 47 and a waste liquid bottle 48, the second injection pump 41 is connected to the second first-pass six-way distribution valve 42 through a pipeline, one of the channels of the second first-pass six-way distribution valve 42 is connected to the reaction tube 32 through a pipeline, the other channel thereof is connected to the second two-position four-way electric valve 44 through a pipeline, the second two-position four-way electric valve 44 is connected to the solid-phase extraction and purification column 43 and the two-way three-way electric valve 45 through a pipeline, the two-position three-way electric valve 45 is connected to the aseptic filter membrane 47 and the waste liquid bottle 48 through a pipeline, and the aseptic filter membrane 47 is connected to the product collection bottle 46.
In the present embodiment, the pressure-resistant ranges of the second one-way six-way distributing valve 42, the second two-position four-way electric valve 44 and the two-position three-way electric valve 45 are 1.0 to 1.2MPa.
In this embodiment, the solid-phase extraction and purification column 43 is either a C18 solid-phase extraction column or an HLB solid-phase extraction column.
The following description of the operation of preparing a radiopharmaceutical using the above-described automated synthesis apparatus is given, for example, in the synthesis of 68 Ga-DOTA-RGD:
the line A6, the line B61, the line C62, the line E64, the line F65, and the line G66 are respectively communicated with a specific reagent solution, and the line D63 is a line communicated with the atmosphere.
Before synthesis, a pipeline A6 is required to be connected with 100mL of sterile water for injection, a reagent bottle connected with a pipeline B61 is placed in 10mL of physiological saline, a reagent bottle connected with a pipeline C62 is placed in 50mL of 80% ethanol aqueous solution, a reagent bottle connected with a pipeline E64 is placed in 20mL of 68Ga leacheate (high-purity hydrochloric acid aqueous solution 0.05M), a reagent bottle connected with a pipeline F65 is placed in 50mL of 80% ethanol aqueous solution, a pipeline G66 is used for standby connection and is placed in 5mL of stock solution (the component is acetic acid-sodium acetate aqueous solution containing precursors) containing labeled precursors DOTA-RGD, and a pipeline D63 is communicated with the atmosphere; in example 68Ga-DOTA-RGD drug, the solid phase extraction purification column 43 is a C18 solid phase extraction column, which needs to be activated before use, and the method comprises: the column was rinsed with 10mL of ethanol, then 20mL of ultra pure water, and finally blown dry for use.
Leaching 68Ga ions to the reaction tube 32: first, the reaction precursor and the buffer salt solution were previously added to the reaction tube 32, 4mL of the eluent was eluted into the reaction tube 32, and then the procedure for preparing 68 Ga-labeled radiopharmaceutical was started in the control system 5, as follows:
1. adding materials: the precursor solution DOTA-RGD and the acetic acid-sodium acetate buffer salt solution are sequentially added into the cleaned reaction tube 32 in advance, and the reaction tube 32 is well covered after being uniformly mixed.
2. Leaching 68Ga ions: the first one-way six-way distribution valve 22 is switched to the second channel connecting pipeline E64 to 68Ga leacheate, the first injection pump 21 sucks 4mL of 68Ga leacheate at the speed of 20mL/min, then the first one-way six-way distribution valve 22 is switched to the first position, the first two-position four-way electric valve 23 is placed in the two-position state, and the two-position two-way electromagnetic valve 33 is placed in the two-position state. The first syringe pump 21 pumps the 68Ga eluate through the 68Ge-68Ga generator 1 at a rate of 5mL/min, and the control system 5 is set to a one-position state by controlling the two-position three-way solenoid valve 24, so that part or all of the 68Ga solution can be selectively collected into the reaction tube 32. Finally, the first one-to-six distribution valve 22 is switched to the channel six connecting pipeline E64 to the atmosphere, at this time, the first injection pump 21 sucks 5mL of air at the speed of 20mL/min, then the first one-to-six distribution valve 22 is switched to the first position, meanwhile, the first two-position four-way electric valve 23 is placed in the one-position state, the two-position two-way electromagnetic valve 33 is placed in the two-position state, the two-position three-way electromagnetic valve 24 is placed in the two-position state, and residual liquid in the pipeline is blown into the 68Ga waste liquid recovery bottle 25.
3. Heating and marking 68Ga ions and a precursor DOTA-RGD: the control system 5 controls the temperature control heating unit 31 to be heated to a preset temperature (95 ℃) in advance, the temperature control of the temperature control heating unit 31 is controlled accurately through a PID algorithm, and the control accuracy is less than or equal to +/-1 oC; then the ball screw 35 at the output end of the stepping motor 34 is controlled to drive the lifting sliding table 36, so as to drive the temperature control heating unit 31 to ascend to the reaction tube 32, the two-position two-way electromagnetic valve 33 is placed in a one-position state, the tube is sealed for heating for 10min, after the heating is finished, the temperature control heating unit 31 descends, the reaction tube 32 is cooled for 3min, and finally the two-position two-way electromagnetic valve 33 is placed in a two-position state.
4. And (3) completing purification and extraction of the product: firstly, the product diluent is adsorbed by a solid phase extraction column, then the product is injected into a product collecting bottle 46, then a reaction bottle is cleaned to wash the C18 solid phase extraction column, the unreacted 68Ga is ensured to be cleaned, and finally the column is dried by blowing, and the specific flow is as follows:
the first process, hanging the column by the product: the second first-through sixth-minute distribution valve 42 is switched to the first-channel connecting pipeline A6 to the ultrapure water bottle, the second injection pump 41 sucks 5mL of ultrapure water at the speed of 20mL/min, then the second first-through sixth-minute distribution valve 42 is switched to the second position, the second injection pump 41 sucks all the cooled reaction system diluent into the injector, then the second first-through sixth-minute distribution valve 42 is switched to the third position, meanwhile, the second two-position four-way electric valve 44 is placed in the two-position state, the two-position three-way electric valve 45 is placed in the two-position state, and the second injection pump 41 sucks the reaction system diluent onto the column through the C18 solid phase extraction column at the speed of 5mL/min to adsorb the product onto the column.
And (2) washing the C18 solid phase extraction column: and switching the second first-pass six-minute distribution valve 42 to the first-pass connecting pipeline A6 to an ultrapure water bottle, sucking 5mL of ultrapure water, cleaning the reaction tube 32, passing the product leacheate through the C18 solid-phase extraction column in an operation mode of a flow four to obtain the target medicament, and repeating the operation twice.
And (3) drying the C18 solid-phase extraction column: and switching the second first-pass six-way distribution valve 42 to a sixth channel to be communicated with atmosphere to suck air, then switching to a third channel, keeping the states of the second two-position four-way electric valve 44 and the two-position three-way electric valve 45 unchanged, blowing the C18 solid-phase extraction column and the corresponding pipeline to dry, and enabling the redundant waste liquid to flow into a waste liquid bottle 48, and repeating the operation twice.
5. Rinsing the product to a product collection bottle 46: firstly, the product is leached from the C18 solid phase extraction column into the product collecting bottle 46 through the sterile filter membrane 47, then 1mL of physiological saline is pumped to wash the C18 solid phase extraction column and the pipeline thereof, and the product on the column and in the pipeline is completely leached into the product collecting bottle 46, and the specific flow is as follows:
and step four, leaching the product: the second first-pass sixth-branch distribution valve 42 is switched to a fourth channel connecting pipeline C62 to a product leacheate bottle, the second injection pump 41 sucks 400uL of product leacheate at the speed of 20mL/min, then the second first-pass sixth-branch distribution valve 42 is switched to a third position, meanwhile, the second two-position four-way electric valve 44 is placed in a two-position state, the two-position three-way electric valve 45 is placed in a one-position state, and then the second injection pump 41 pushes the product leacheate into the product collection bottle 46 through the sterile filter membrane 47 at the speed of 5mL/min to obtain the 68 Ga-labeled radiopharmaceutical. Finally, the second first six-way distribution valve 42 is switched to the sixth position, the second injection pump 41 pumps 10mL of air, and then the second six-way distribution valve 42 is switched to the third channel to blow the whole pipeline dry.
A fifth flow path, flushing the pipeline: the second first-through sixth distribution valve 42 is switched to the fifth channel to connect the pipeline B61 to a physiological saline bottle, the second injection pump 41 sucks 1mL of physiological saline at the speed of 20mL/min, then the second first-through sixth distribution valve 42 is switched to the third position, meanwhile, the second two-position four-way electric valve 44 is placed in the two-position state, the two-position three-way electric valve 45 is placed in the one-position state, then the second injection pump 41 injects the physiological saline into the product collection bottle 46 through the sterile filter membrane 47 at the speed of 10mL/min, finally the second first-through sixth distribution valve 42 is switched to the sixth channel, the second injection pump 41 sucks 10mL of air, and the whole pipeline is dried through the third channel of the second first-through sixth distribution valve 42.
6. Preparing injection with appropriate concentration:
depending on the amount of radiopharmaceutical to be prepared, the product collection bottle 46 may be diluted with a suitable saline solution, as follows:
and a sixth process, namely, switching the second first-through sixth-minute distribution valve 42 to a fifth channel to connect the pipeline B61 to a physiological saline bottle, sucking a proper amount of physiological saline (according to the concentration requirement of the radiopharmaceutical) at a speed of 20mL/min by the second injection pump 41, switching the second first-through sixth-minute distribution valve 42 to a third position, simultaneously placing the second two-position four-way electric valve 44 in a one-position state, placing the two-position three-way electric valve 45 in a one-position state, then enabling the second injection pump 41 to inject the physiological saline into the product collection bottle 46 through the sterile filter membrane 47 at a speed of 10mL/min, finally switching the second first-through sixth-minute distribution valve 42 to a sixth channel, pumping 10mL of air by the second injection pump 41, and drying the whole pipeline through the third channel of the second first-through sixth-minute distribution valve 42.
The utility model provides an automatic synthesizer of radiopharmaceutical for 68Ga mark, each system of 5 automatic control of control system carries out work, control each valve and syringe pump and switch, make liquid pass through the syringe pump as liquid way drive power, realize the transfer of liquid with the help of each valve and corresponding pipeline, make 68Ga mark water-soluble polypeptide and micromolecule positron medicine quick, high-efficient automatic mark, the purification, prepare aseptic injection finally for future use, both realized the automatic preparation of 68Ga mark positron medicine, remove the cost of disposing large-scale medical cyclotron again; the fully-automatic preparation process can effectively reduce the exposure time of workers under radioactive substances, save mechanical repetitive manual operation, greatly improve the reproducibility and reliability of radiopharmaceutical production, and facilitate the realization of standard production of 68 Ga-labeled positron medicines.
The above description is only for the purpose of illustrating the preferred embodiments of the present application and is not intended to limit the scope of the present application, which is within the scope of the present application, except that the same or similar principles and basic structures as the present application may be used.
Claims (9)
1. An automatic synthesis device for 68 Ga-marked radiopharmaceuticals is characterized by comprising a 68Ge-68Ga generator (1), a generator leaching system (2), a heating reaction system (3), a synthesis and purification system (4) and a control system (5); the 68Ge-68Ga generator (1) is connected with the generator leaching system (2) through a pipeline, the generator leaching system (2) and the synthesis and purification system (4) are respectively connected with the heating reaction system (3) through pipelines, and the control system (5) is respectively and electrically connected with the generator leaching system (2), the synthesis and purification system (4) and the heating reaction system (3).
2. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 1, characterized in that: the control system (5) is any one of a microcomputer software control system (5) or a man-machine interaction interface touch screen control system (5).
3. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 1, characterized in that: the generator leaching system (2) comprises a first injection pump (21), a first one-way six-way distribution valve (22), a first two-position four-way electric valve (23), a two-position three-way electromagnetic valve (24) and a 68Ga waste liquid recovery bottle (25), wherein the first injection pump (21) is connected with the first one-way six-way distribution valve (22) through a pipeline, one channel of the first one-way six-way distribution valve (22) is connected with the first two-position four-way electric valve (23) through a pipeline, the first two-position four-way electric valve (23) is respectively connected with a 68Ge-68Ga generator (1) and the two-position three-way electromagnetic valve (24) through pipelines, and the two-position three-way electromagnetic valve (24) is connected with the 68Ga waste liquid recovery bottle (25) through a pipeline.
4. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 3, wherein: the pressure-resistant range of the first one-way six-distribution valve (22) and the first two-position four-way electric valve (23) is 1.0-1.2MPa, and the pressure-resistant range of the two-position three-way electromagnetic valve (24) is 0.2-0.3MPa.
5. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 3, wherein: heating reaction system (3) are including mobile unit, control by temperature change heating element (31), reaction tube (32) and two solenoid valve (33), two solenoid valve (33) that lead to pass through the pipeline with reaction tube (32) are connected, above-mentioned two three solenoid valve (24) pass through the pipeline with reaction tube (32) are connected, the mobile unit is used for the drive control by temperature change heating element (31) carry out displacement from top to bottom to heat reaction tube (32).
6. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 5, wherein: the moving unit comprises a stepping motor (34), the output end of the stepping motor (34) is connected with a ball screw (35), a lifting sliding table (36) is connected onto the ball screw (35), and the lifting sliding table (36) is connected with the temperature control heating unit (31).
7. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 5, wherein: synthetic purification system (4) include second syringe pump (41), the first six minute distribution valve (42) that leads to of second, solid-phase extraction purification post (43), second two-position four-way motorised valve (44), two three-position three way motorised valve (45), product receiving flask (46), aseptic filter membrane (47) and waste liquid bottle (48), second syringe pump (41) through the pipeline with the second leads to six minute distribution valve (42) and connects, the first one of them passageway that leads to six minute distribution valve (42) of second pass through the pipeline with reaction tube (32) are connected, its another passageway pass through the pipeline with the second two-position four-way motorised valve (44) are connected, second two-position four-way motorised valve (44) pass through the pipeline respectively with solid-phase extraction purification post (43) with two three-position three way motorised valve (45) are connected, two three-position three way motorised valve (45) pass through the pipeline respectively with aseptic filter membrane (47) and waste liquid bottle (48) are connected, aseptic filter membrane (47) with product receiving flask (46) are connected.
8. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 7, wherein: the pressure-resistant ranges of the second first-pass sixth-branch distribution valve (42), the second two-position four-way electric valve (44) and the two-position three-way electric valve (45) are 1.0-1.2MPa.
9. An automated synthesis apparatus for 68 Ga-labelled radiopharmaceuticals according to claim 7, wherein: the solid phase extraction and purification column (43) is any one of a C18 solid phase extraction column or an HLB solid phase extraction column.
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| CN202222820350.5U CN218854253U (en) | 2022-10-25 | 2022-10-25 | A automatic synthesizer of radiopharmaceutical for 68Ga marks |
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| CN202222820350.5U CN218854253U (en) | 2022-10-25 | 2022-10-25 | A automatic synthesizer of radiopharmaceutical for 68Ga marks |
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