CN218854154U - NK cell culture medium preparation device - Google Patents
NK cell culture medium preparation device Download PDFInfo
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- CN218854154U CN218854154U CN202122378342.5U CN202122378342U CN218854154U CN 218854154 U CN218854154 U CN 218854154U CN 202122378342 U CN202122378342 U CN 202122378342U CN 218854154 U CN218854154 U CN 218854154U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
The application discloses NK cell culture medium preparation facilities includes: biological safety cabinet, compounding jar, stirring subassembly, auxiliary material storage tank, its characterized in that includes: an injection pump assembly; the mixing tank, the stirring assembly, the auxiliary material storage tank and the injection pump assembly are accommodated in the operation cavity of the biological safety cabinet; one end of the stirring component is inserted into the mixing tank, the mixing tank is arranged on the bottom surface of the operation cavity, and the stirring component is arranged on the top surface of the mixing tank; the device realizes quantitative unloading, prepares required auxiliary material and carries out the unloading stirring in the biological safety cabinet, can effectively reduce the pollution of impurity such as microorganism to this culture medium, reduces impurity content, improves product quality.
Description
Technical Field
The application relates to the technical field of cell culture, in particular to a NK cell culture medium preparation device.
Background
Natural Killer (NK) cells are differentiated from myeloid lymphoid stem cells and distributed in nasal cavities, intestinal tracts, mucous membranes, skin and the like. The differentiation from T lymphocytes is difficult only by morphology, and can be shown by differentiation after labeling with CD3, CD56, CD 16. After being activated, the recombinant DNA can secrete TIA-1, perforin and granzyme B cytotoxics to destroy and kill target cells. It can kill some tumor cells or virus-infected cells without the presence of antibody or antigen sensitization. NK cell casts are a hot spot for research in the field of tumor immunotherapy. In order to meet the experimental requirements, in-vitro amplification culture is mostly required to be carried out on NK cells.
The prior NK cell culture medium is mostly prepared by taking a LONZA X-VIVO culture medium or a VIVO-15 culture medium as a base in the preparation process and adding other biological proteins, aldesleukin, interleukin 15 or cytokine components according to needs. In the existing preparation process, because all materials are easily decomposed by heat, sterilization treatment cannot be carried out by adopting conventional means after preparation is finished, the product quality is not ensured, the possibility of infecting exogenous microorganisms or impurities needs to be reduced in the preparation process, and preparation operation is mostly carried out in a biological safety cabinet. The operating efficiency is easily influenced by the cabinet body, and the manual operation difficulty is higher.
SUMMERY OF THE UTILITY MODEL
The present application provides an NK cell medium preparing apparatus for solving the above technical problems.
The application provides an NK cell culture medium preparation device, includes: biological safety cabinet, compounding jar, stirring subassembly, auxiliary material storage tank, its characterized in that includes: an injection pump assembly; the mixing tank, the stirring assembly, the auxiliary material storage tank and the injection pump assembly are accommodated in the operation cavity of the biological safety cabinet;
one end of the stirring component is inserted into the mixing tank, the mixing tank is arranged on the bottom surface of the operation cavity, and the stirring component is arranged on the top surface of the mixing tank;
the auxiliary material storage tank is arranged on the inner side wall of the operation cavity and is communicated with a liquid inlet pipeline of the injection pump assembly;
the syringe pump assembly comprises: the device comprises a base, an injection tube, a piston rod, a screw rod driving assembly, a mounting plate, a driving motor and a remote controller; the base is arranged on the bottom surface of the operation cavity; the screw rod driving assembly is arranged on the base, and the mounting plate is arranged on the top surface of the screw rod driving assembly; the injection tube is arranged on the top surface of the mounting plate; one end of the piston rod is inserted into the injection tube, and the other end of the piston rod extends out of the injection tube and is in driving connection with the screw rod driving assembly; the driving motor is in driving connection with the screw rod driving assembly; the remote controller is connected with the driving motor in a control way;
the liquid outlet of the auxiliary material storage tank is communicated with the liquid inlet pipeline of the injection tube; the liquid outlet of injection tube and compounding jar inlet pipeline intercommunication.
Preferably, the stirring assembly comprises: the stirring motor, the flange cover and the stirring paddle; the top surface of the mixing tank is provided with an opening; the flange cover is arranged on the top surface of the opening; the stirring motor is arranged at the center of the top surface of the flange cover; the stirring paddle is in driving connection with the stirring motor through a rotating shaft.
Preferably, the auxiliary material storage tank includes: the auxiliary material storage device comprises a first auxiliary material storage tank, a second auxiliary material storage tank and a plurality of valves; the first auxiliary material storage tank is arranged on the inner side wall of the upper part of the operation cavity, a liquid outlet is formed in the bottom surface of the first auxiliary material storage tank, the liquid outlet is communicated with a liquid inlet pipeline of the injection tube, and a valve is arranged on the communicating pipeline; the second auxiliary material storage tank sets up on the lower part inside wall in operation chamber, and the liquid outlet is seted up to second auxiliary material storage tank bottom surface, liquid outlet and injection tube inlet pipeline intercommunication set up the valve on communicating pipe.
Preferably, the syringe pump assembly comprises: a first metering syringe pump and a second metering syringe pump; a liquid outlet of the first auxiliary material storage tank is communicated with a liquid inlet pipeline of the first metering injection pump; and the liquid outlet of the second auxiliary material storage tank is communicated with the liquid inlet pipeline of the second metering injection pump.
Preferably, the method comprises the following steps: a valve; the first metering injection pump and the second metering injection pump are respectively communicated with a liquid inlet pipeline of the mixing tank, and a valve is arranged on the communicating pipeline.
Preferably, the lead screw driving assembly includes: the device comprises a base, a plurality of bearing seats and a screw rod; the screw rods are inserted into the bearing blocks and are rotatably arranged in the bearing blocks; the mounting plate is erected on the top surface of the bearing seat; the bearing seat is arranged on the top surface of the base; the movable plate is sleeved on the screw rod and is in threaded connection with the screw rod; one end of the screw rod is in driving connection with the driving motor.
Preferably, the syringe pump assembly comprises: the paired barrel racks and the paired clamping plates are arranged; the barrel frames are symmetrically arranged on the mounting plate; the injection tube is clamped in the tube frame; the clamping plates are symmetrically arranged on the top surface of the movable plate; the extending end of the piston rod is clamped between the clamping plates.
Preferably, the cartridge holder comprises: a friction material layer, a clamping plate; the top surface of the barrel frame is open; the clamping plate is covered on the opening and is connected with the barrel frame through a bolt; the friction material layer is arranged on the inner side wall of the barrel frame.
The beneficial effects that this application can produce include:
1) The application provides an NK cell culture medium preparation facilities, through operation intracavity installation compounding agitator tank and a plurality of auxiliary material storage tanks at biosafety cabinet, each auxiliary material storage tank communicates with injection pump subassembly pipeline respectively, the piston of injection syringe is under lead screw drive assembly's drive, the play liquid end and the agitator tank pipeline intercommunication of injection syringe, realize quantitative unloading, it carries out the unloading stirring to prepare required auxiliary material in biosafety cabinet, can effectively reduce the pollution of impurity such as microorganism to this culture medium, reduce impurity content, and the product quality is improved.
Drawings
FIG. 1 is a schematic view of an NK cell culture medium preparation apparatus provided herein;
FIG. 2 is a schematic view of a point A in FIG. 1;
fig. 3 is a schematic top view of a metering pump provided in the present application;
illustration of the drawings:
11. an air exhaust pipe; 10. an air filtration assembly; 12. an operating chamber; 13. a movable frame; 131. a support rail; 132. a roller; 211. a first auxiliary material storage tank; 213. a second auxiliary material storage tank; 212. a support plate; 215. a valve; 221. a stirring motor; 222. a flange cover; 223. a mixing tank; 224. a stirring paddle; 251. a first metering syringe pump; 252. a second metering syringe pump; 231. a base; 233. a bearing seat; 232. a drive motor; 234. a screw rod; 235. a movable plate; 241. a piston rod; 242. an injection tube; 237. a barrel frame; 238. mounting a plate; 239. a feed pipe; 262. a clamping plate; 261. a clamping plate; 244. a layer of friction material.
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the drawings of the embodiments of the present invention are combined to clearly and completely describe the technical solutions of the embodiments of the present invention, and obviously, the described embodiments are some embodiments of the present invention, not all embodiments. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the present invention, the embodiments and the features of the embodiments may be combined with each other without conflict.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate the directions or positional relationships based on the directions or positional relationships shown in the drawings, or the directions or positional relationships that the products of the present invention are usually placed when used, or the directions or positional relationships that the skilled person usually understand, and are only for the convenience of describing the present invention and simplifying the description, but not for indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Technical means which are not described in detail in the present application and are not used for solving the technical problems of the present application are all arranged according to common knowledge in the field, and various common knowledge arrangement modes can be realized.
Referring to fig. 1~3, the present application provides an NK cell medium preparation device comprising: the biological safety cabinet, the mixing tank 223, the stirring component, the auxiliary material storage tank and the injection pump component; the mixing tank 223, the stirring assembly, the auxiliary material storage tank and the injection pump assembly are accommodated in the operation cavity 12 of the biological safety cabinet;
one end of the stirring component is inserted into the material mixing tank 223, the material mixing tank 223 is arranged on the bottom surface of the operation cavity 12, and the stirring component is arranged on the top surface of the material mixing tank 223;
the auxiliary material storage tank is arranged on the inner side wall of the operation cavity 12 and is communicated with a liquid inlet pipeline of the injection pump assembly;
the syringe pump assembly comprises: the device comprises a base 231, an injection cylinder 242, a piston rod 241, a screw rod 234 driving assembly, a mounting plate 238, a driving motor 232 and a remote controller; the base 231 is installed on the bottom surface of the operation chamber 12; the screw 234 driving component is arranged on the base 231, and the mounting plate 238 is arranged on the top surface of the screw 234 driving component; a barrel 242 is mounted on the top surface of the mounting plate 238; one end of the piston rod 241 is inserted into the syringe 242, and the other end of the piston rod 241 extends out of the syringe 242 and is in driving connection with the screw 234 driving component; the driving motor 232 is in driving connection with the driving component of the screw rod 234; the remote controller is connected with the driving motor 232 in a control way;
the liquid outlet of the auxiliary material storage tank is communicated with the liquid inlet pipeline of the injection tube 242; the liquid outlet of the injection cylinder 242 is communicated with the liquid inlet pipeline of the mixing tank 223.
Set up accessible lead screw 234 drive assembly drive piston rod 241 according to this and stretch into or take out, realize the ration interpolation to the auxiliary material, and whole set of device is in operation chamber 12, and operation chamber 12 is in the aseptic environment of negative pressure, can effectively avoid the pollution of batching in-process pollutant to the culture medium, reduces the bacterial content of culture medium, improves product quality.
When the device is used, after a pipeline for communicating the auxiliary material storage tank with the injection tube 242 is connected, after the pipeline for communicating the injection tube 242 with the mixing tank 223 is closed, the piston is drawn out, the auxiliary material enters the injection tube under the action of air pressure, an operator can drive the screw rod 234 to rotate after starting the driving motor 232 through remote control, the piston rod 241 extends into the injection tube 242 through the movable plate 235, the operator observes the addition amount of the auxiliary material through the protective window made of transparent material and the injection tube 242 outside the operation cavity 12, and after the requirement of the addition amount is met, the driving motor 232 is closed to finish feeding. The process can be automatically completed in the operation cavity 12, the operation is simple and convenient, and the preparation efficiency of the culture medium is improved.
The biosafety cabinet, drive motor 232 used in this application are arranged in the usual manner in the prior art and will not be described herein. The drive motor 232 used may be a conventional motor with a receiving module and can be connected to a remote control.
This application regards as the measuring pump with the injection syringe, and used injection syringe is mostly disposable injection syringe, and the disinfection can reach medical aseptic requirement, can effectively avoid the batching material to receive the pollution.
In one embodiment, a biosafety cabinet comprises: a movable frame 13, a plurality of rollers 132, an air filter assembly 10 and an exhaust pipe 11; the air exhaust pipe 11 is arranged on an air inlet and an air outlet of the air filter component 10; the air filter assembly 10 is housed on the top surface of the operation chamber 12 and communicates with the operation chamber 12. According to the arrangement, microorganisms contained in the gas entering or discharging can be effectively filtered and removed, and the culture medium is prevented from being polluted by microorganism impurities. The operation cavity 12 is erected on the top surface of the movable frame 13; a plurality of rollers 132 are arranged on the bottom surface of the movable frame 13 at intervals; the movable frame 13 is transversely provided with a support cross bar 131, and rollers 132 are arranged at two ends of the bottom surface of the cross bar. Is convenient for moving the biological safety cabinet.
Preferably, the stirring assembly comprises: a stirring motor 221, a flange cover 222 and a stirring paddle 224; the top surface of the material mixing tank 223 is provided with an opening; the flange cover 222 covers the top surface of the opening; the stirring motor 221 is installed at the center of the top surface of the flange cover 222; the stirring paddle 224 is in driving connection with the stirring motor 221 through a rotating shaft.
Preferably, the auxiliary material storage tank includes: a first auxiliary material tank 211, a second auxiliary material tank 213, a plurality of valves 215; the first auxiliary material storage tank 211 is arranged on the inner side wall of the upper part of the operation cavity 12, a liquid outlet is formed in the bottom surface of the first auxiliary material storage tank 211, the liquid outlet is communicated with a liquid inlet pipeline of the injection tube 242, and a valve 215 is arranged on the communication pipeline; the second auxiliary material storage tank 213 is arranged on the inner side wall of the lower part of the operation cavity 12, a liquid outlet is arranged on the bottom surface of the second auxiliary material storage tank 213, the liquid outlet is communicated with a liquid inlet pipeline of the injection tube 242, and a valve 215 is arranged on the communicating pipeline. According to the arrangement, synchronous addition of multiple auxiliary materials can be realized, and the preparation efficiency is improved.
In one embodiment, each of the auxiliary material reservoirs may be mounted on the top surface of a support plate 212 mounted on the inner side wall of the process chamber 12.
Preferably, the syringe pump assembly comprises: a first metering syringe pump 251 and a second metering syringe pump 252; the liquid outlet of the first auxiliary material storage tank 211 is communicated with the liquid inlet pipeline of the first metering injection pump 251; the liquid outlet of the second auxiliary material storage tank 213 is communicated with the liquid inlet pipeline of the second metering injection pump 252.
According to the device, materials can be fed independently, and feeding accuracy is improved.
Preferably, a first metering syringe pump 251 and a second metering syringe pump 252 are spaced apart from each other on the top surface of the mounting plate 238.
Preferably, the method comprises the following steps: a valve 215; the first metering injection pump 251 and the second metering injection pump 252 are respectively communicated with a liquid inlet pipeline of the mixing tank 223, and a valve 215 is arranged on the communicating pipeline. According to the arrangement, when feeding is needed, feed liquid can be prevented from flowing back into the injection tube 242.
Preferably, the screw 234 drive assembly includes: a base 231, a plurality of bearing seats 233, a screw 234; the screw rods 234 are inserted into the bearing seats 233 and rotatably mounted in the bearing seats 233; the mounting plate 238 is erected on the top surface of the bearing seat 233; the bearing housing 233 is mounted on the top surface of the base 231; the movable plate 235 is sleeved on the screw rod 234 and is in threaded connection with the screw rod 234; one end of the screw rod 234 is drivingly connected with the driving motor 232. The rotation of the screw 234 thus set causes the movable plate 235 to move linearly, thereby driving the piston rod 241 to be inserted into or withdrawn from the syringe 242.
Preferably, the syringe pump assembly comprises: a pair of arranged barrel frames 237, a pair of arranged clamp plates 261; the cylinder frame 237 is symmetrically arranged on the mounting plate 238; the injection tube 242 is clamped in the tube frame 237; the clamping plates 261 are symmetrically disposed on the top surface of the movable plate 235; the extending end of the piston rod 241 is engaged between the clamping plates 261. Relative movement is thereby achieved at a relative position that effectively fixes the syringe 242 and piston rod 241.
Preferably, the cartridge frame 237 includes: friction material layer 244, clamping plate 262; the top surface of the barrel frame 237 is open; the clamping plate 262 covers the opening and is connected with the barrel frame 237 through a bolt; a layer 244 of friction material is disposed on the inside walls of cartridge holder 237. This arrangement enables strong clamping of the syringe 242, and improves reliability of the relative movement.
In one embodiment, the method comprises the following steps: a feeding pipe 239, the feeding pipe 239 is inserted on the side wall of the injection tube 242 near the discharge end, and the liquid outlet of each auxiliary material storage tank is communicated with the feeding pipe 239 pipeline. This arrangement enables efficient feeding of the injection tube.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (8)
1. An NK cell medium formulation device comprising: biological safety cabinet, compounding jar (223), stirring subassembly, auxiliary material storage tank, its characterized in that includes: an injection pump assembly; the mixing tank (223), the stirring component, the auxiliary material storage tank and the injection pump component are accommodated and arranged in the operation cavity (12) of the biological safety cabinet;
one end of the stirring component is inserted into the mixing tank (223), the mixing tank (223) is arranged on the bottom surface of the operation cavity (12), and the stirring component is arranged on the top surface of the mixing tank (223);
the auxiliary material storage tank is arranged on the inner side wall of the operation cavity (12) and is communicated with a liquid inlet pipeline of the injection pump assembly;
the syringe pump assembly comprises: the device comprises a base (231), an injection cylinder (242), a piston rod (241), a lead screw (234) driving assembly, a mounting plate (238), a driving motor (232) and a remote controller; the base (231) is arranged on the bottom surface of the operation cavity (12); the screw rod (234) driving component is arranged on the base (231), and the mounting plate (238) is arranged on the top surface of the screw rod (234) driving component; the syringe (242) is mounted on the top surface of the mounting plate (238); one end of the piston rod (241) is inserted into the syringe (242), and the other end of the piston rod (241) extends out of the syringe (242) and is in driving connection with the screw rod (234) driving component; the driving motor (232) is in driving connection with the screw rod (234) driving assembly; the remote controller is connected with the driving motor (232) in a control way;
the liquid outlet of the auxiliary material storage tank is communicated with the liquid inlet pipeline of the injection tube (242); the liquid outlet of the injection cylinder (242) is communicated with the liquid inlet pipeline of the mixing tank (223).
2. The NK cell medium formulation device of claim 1, wherein the agitation assembly comprises: a stirring motor (221), a flange cover (222) and a stirring paddle (224); the top surface of the material mixing tank (223) is provided with an opening; the flange cover (222) is arranged on the top surface of the opening in a covering manner; the stirring motor (221) is arranged at the center of the top surface of the flange cover (222); the stirring paddle (224) is in driving connection with the stirring motor (221) through a rotating shaft.
3. The NK cell medium formulation device of claim 1, wherein the adjuvant reservoir comprises: a first auxiliary material storage tank (211), a second auxiliary material storage tank (213) and a plurality of valves (215); a first auxiliary material storage tank (211) is arranged on the inner side wall of the upper part of the operation cavity (12), a liquid outlet is formed in the bottom surface of the first auxiliary material storage tank (211), the liquid outlet is communicated with a liquid inlet pipeline of the injection tube (242), and a valve (215) is arranged on the communicating pipeline; second auxiliary material storage tank (213) set up on the lower part inside wall of operation chamber (12), and the liquid outlet is seted up to second auxiliary material storage tank (213) bottom surface, and the liquid outlet communicates with injection tube (242) inlet pipeline, sets up valve (215) on communicating pipeline.
4. The NK cell culture medium formulation device of claim 3, wherein the injection pump assembly comprises: a first metering syringe pump (251) and a second metering syringe pump (252); a liquid outlet of the first auxiliary material storage tank (211) is communicated with a liquid inlet pipeline of the first metering injection pump (251); the liquid outlet of the second auxiliary material storage tank (213) is communicated with the liquid inlet pipeline of the second metering injection pump (252).
5. The NK cell culture medium formulation device of claim 4, comprising: a valve (215); the first metering injection pump (251) and the second metering injection pump (252) are respectively communicated with a liquid inlet pipeline of the material mixing tank (223), and a valve (215) is arranged on the communicating pipeline.
6. The NK cell medium formulation device of claim 1, wherein the screw (234) drive assembly comprises: a base (231), a plurality of bearing seats (233), and a screw rod (234); the screw rods (234) are inserted into the bearing blocks (233) and are rotatably arranged in the bearing blocks (233); the mounting plate (238) is erected on the top surface of the bearing seat (233); the bearing seat (233) is arranged on the top surface of the base (231); the movable plate (235) is sleeved on the screw rod (234) and is in threaded connection with the screw rod (234); one end of the screw rod (234) is in driving connection with the driving motor (232).
7. The NK cell culture medium formulation device of claim 6, wherein the injection pump assembly comprises: a pair of barrel frames (237) and a pair of clamping plates (261); the cylinder frames (237) are symmetrically arranged on the mounting plate (238); the injection tube (242) is clamped in the tube frame (237); the clamping plates (261) are symmetrically arranged on the top surface of the movable plate (235); the extending end of the piston rod (241) is clamped between the clamping plates (261).
8. The NK cell culture medium preparation device according to claim 7, wherein the cartridge (237) comprises: a friction material layer (244), a clamping plate (262); the top surface of the cylinder frame (237) is open; the clamping plate (262) is covered on the opening and is connected with the barrel frame (237) through a bolt; a layer of friction material (244) is disposed on the inside wall of the cartridge holder (237).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122378342.5U CN218854154U (en) | 2021-09-29 | 2021-09-29 | NK cell culture medium preparation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122378342.5U CN218854154U (en) | 2021-09-29 | 2021-09-29 | NK cell culture medium preparation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218854154U true CN218854154U (en) | 2023-04-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122378342.5U Active CN218854154U (en) | 2021-09-29 | 2021-09-29 | NK cell culture medium preparation device |
Country Status (1)
| Country | Link |
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| CN (1) | CN218854154U (en) |
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2021
- 2021-09-29 CN CN202122378342.5U patent/CN218854154U/en active Active
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