CN218842162U - Tee bend subassembly, reagent extraction distributor and gene sequencer - Google Patents
Tee bend subassembly, reagent extraction distributor and gene sequencer Download PDFInfo
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- CN218842162U CN218842162U CN202223487867.3U CN202223487867U CN218842162U CN 218842162 U CN218842162 U CN 218842162U CN 202223487867 U CN202223487867 U CN 202223487867U CN 218842162 U CN218842162 U CN 218842162U
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 58
- 238000000605 extraction Methods 0.000 title claims abstract description 31
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 11
- 239000010902 straw Substances 0.000 claims abstract description 4
- 238000012423 maintenance Methods 0.000 abstract description 10
- 230000008859 change Effects 0.000 abstract description 6
- 238000012163 sequencing technique Methods 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The disclosure relates to the technical field of gene sequencing, in particular to a three-way component for reagent extraction and distribution, a reagent extraction and distribution device and a gene sequencer. The three-way assembly for extracting and distributing the reagent comprises a three-way fixing plate and a plurality of three-way structures, wherein the three-way structures are detachably connected with the three-way fixing plate; every tee bend structure includes the valve body, be provided with first interface, second interface and third interface on the valve body, the first interface and the first connecting pipe of every tee bend structure are connected, and the second interface is connected with the second connecting pipe, and the third interface passes the tee bend fixed plate for be connected with the reagent straw. The utility model provides a tee bend subassembly for reagent extraction distribution adopts tee bend fixed plate and a plurality of tee bend structures can dismantle the mode of connecting, and cost of maintenance is far less than and needs to change the tee bend subassembly is whole or tee bend and distribution valve are whole.
Description
Technical Field
The disclosure relates to the technical field of gene sequencing, in particular to a three-way component for reagent extraction and distribution, a reagent extraction and distribution device and a gene sequencer.
Background
The related art provides a fluidic system for delivering reagents from a cartridge to a flow cell, including a three-way structure and a dispensing valve and associated connections, using a one-piece structure, all integrated together, with high manufacturing costs on the one hand and high post-maintenance costs on the other hand. If a problem occurs at a certain position, the whole fluid system needs to be replaced integrally, so that the cost is high, and the use convenience and reliability are poor.
SUMMERY OF THE UTILITY MODEL
The embodiment of the disclosure at least provides a tee assembly for reagent extraction and distribution, a reagent extraction and distribution device and a gene sequencer.
According to one aspect of the present disclosure, a three-way assembly for reagent extraction and distribution is provided, which includes a three-way fixing plate and a plurality of three-way structures, wherein the plurality of three-way structures are detachably connected with the three-way fixing plate; every tee bend structure includes the valve body, be provided with first interface, second interface and third interface on the valve body, the first interface and the first connecting pipe of every tee bend structure are connected, and the second interface is connected with the second connecting pipe, and the third interface passes the tee bend fixed plate for be connected with the reagent straw.
In an optional embodiment, the first connection pipe is detachably connected to the first interface of the three-way structure, and the second connection pipe is detachably connected to the second interface.
In an optional implementation manner, two sides of the valve body of the three-way structure are provided with connecting lugs, and the connecting lugs are connected with the three-way fixing plate in a threaded connection manner.
In an alternative embodiment, an avoiding structure is arranged at the joint of the upper part of the valve body and the first connecting pipe and the second connecting pipe, so as to avoid the interference of the connecting pipes on the two adjacent tee structures.
In an alternative embodiment, the avoidance structure is an avoidance ramp.
In an alternative embodiment, the escape ramp is arranged symmetrically with respect to the axial direction of the reagent pipette.
In an alternative embodiment, two of the escape ramps are arranged at 60 ° to the horizontal.
According to a second aspect of the present disclosure, there is provided a reagent extraction and dispensing device comprising a dispensing valve assembly and a three-way assembly according to the present disclosure for reagent extraction and dispensing, the dispensing valve assembly comprising a first dispensing valve and a second dispensing valve, a first interface of the three-way structure being connected to the first dispensing valve by a first connecting pipe, and a second interface of the three-way structure being connected to the second dispensing valve by a second connecting pipe.
In an alternative embodiment, the tee assembly and the distributor valve assembly are provided in a split arrangement.
In an alternative embodiment, the first connecting pipe is detachably connected to the first distribution valve, and the second connecting pipe is detachably connected to the second distribution valve.
In an alternative embodiment, the dispensing valve assembly includes a dispensing valve mount, the first and second dispensing valves being mounted on the dispensing valve mount.
According to a third aspect of the present disclosure, there is provided a gene sequencer comprising the reagent extraction and distribution device according to the present disclosure as described above.
The utility model provides a tee bend subassembly for reagent extraction distribution adopts tee bend fixed plate and a plurality of tee bend structure can dismantle the mode of connecting, when certain tee bend structure goes wrong wherein, only need change the single tee bend structure that breaks down can, other tee bend structures can continue to use, consequently, cost of maintenance is far less than and needs to change the whole tee bend subassembly or tee bend and distribution valve are whole.
In order to make the aforementioned objects, features and advantages of the present disclosure more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings required for use in the embodiments will be briefly described below, and the drawings herein incorporated in and forming a part of the specification illustrate embodiments consistent with the present disclosure and, together with the description, serve to explain the technical solutions of the present disclosure. It is appreciated that the following drawings depict only certain embodiments of the disclosure and are therefore not to be considered limiting of its scope, for those skilled in the art will be able to derive additional related drawings therefrom without the benefit of the inventive faculty.
Fig. 1 shows a schematic structural view of a reagent extraction and dispensing device provided by some embodiments of the present disclosure; there is shown a three-way assembly for reagent draw dispensing of the present disclosure;
FIG. 2 illustrates a schematic diagram of the connection of a single tee structure to a dispensing assembly provided by some embodiments of the present disclosure;
FIG. 3 illustrates a schematic diagram of a three-way structure and reagent pipette connection provided by some embodiments of the present disclosure;
FIG. 4 shows a cross-sectional view of the structure shown in FIG. 3;
FIG. 5 illustrates a cross-sectional view of a tee structure provided by some embodiments of the present disclosure;
figure 6 illustrates a perspective view of a tee structure provided by some embodiments of the present disclosure.
Illustration of the drawings:
1-a tee assembly; 11-a three-way fixing plate; 12-a three-way structure; 13-a first connection pipe; 14-a second connecting tube; 15-reagent pipette; 120-a valve body; 121 — a first interface; 122 — a second interface; 123-a third interface; 124-attachment lugs; 124 a-threaded hole; 120 a-avoiding inclined plane;
2-a dispensing valve assembly; 21-a first dispensing valve; 22-a second dispensing valve; 23-dispensing valve fixing.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure more clear, the technical solutions of the embodiments of the present disclosure will be described clearly and completely with reference to the drawings in the embodiments of the present disclosure, and it is obvious that the described embodiments are only a part of the embodiments of the present disclosure, not all of the embodiments. The components of embodiments of the present disclosure, as generally described and illustrated herein, may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present disclosure is not intended to limit the scope of the disclosure, as claimed, but is merely representative of selected embodiments of the disclosure. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the disclosure without making creative efforts, shall fall within the protection scope of the disclosure.
Fig. 1 shows a schematic structural view of a reagent extraction and dispensing device provided by some embodiments of the present disclosure; there is shown a three-way assembly for reagent draw dispensing of the present disclosure; FIG. 2 illustrates a schematic diagram of the connection of a single tee structure to a dispensing assembly provided by some embodiments of the present disclosure; FIG. 3 illustrates a schematic diagram of a three-way structure and reagent pipette connection provided by some embodiments of the present disclosure; FIG. 4 shows a cross-sectional view of the structure shown in FIG. 3; FIG. 5 illustrates a cross-sectional view of a tee structure provided by some embodiments of the present disclosure; figure 6 illustrates a perspective view of a tee structure provided by some embodiments of the present disclosure.
As shown in fig. 1 to 6, according to one aspect of the present disclosure, a three-way assembly 1 for reagent extraction and distribution is provided, the three-way assembly 1 for reagent extraction and distribution includes a three-way fixing plate 11 and a plurality of three-way structures 12, and each of the plurality of three-way structures 12 and the three-way fixing plate 11 is detachably connected; each three-way structure 12 comprises a valve body 120, a first connector 121, a second connector 122 and a third connector 123 are arranged on the valve body 120, the first connector 121 of each three-way structure 12 is connected with the first connecting pipe 13, the second connector 122 is connected with the second connecting pipe 14, and the third connector 123 penetrates through the three-way fixing plate 11 and is used for being connected with the reagent pipette 15.
The utility model provides a tee bend subassembly 1 for reagent extraction distribution adopts tee bend fixed plate 11 and a plurality of tee bend structure 12 can dismantle the mode of connecting, when wherein certain tee bend structure 12 goes wrong, only need to change the single tee bend structure 12 that breaks down can, other tee bend structures 12 can continue to use, consequently, cost of maintenance is far less than the whole change that perhaps tee bend and distribution valve are whole to tee bend subassembly 1.
Specifically, as shown in fig. 1 and fig. 2, the first connection pipe 13 and the first interface 121 of the three-way structure 12 may be connected by a screw thread, or may be plugged by a quick-plugging port or the like. Similarly, the second connection pipe 14 and the second interface 122 of the three-way structure 12 may be connected by a screw thread, or may be connected by a plug-in manner such as a quick-plug socket.
In an alternative embodiment, the first connection pipe 13 is in threaded connection with the first interface 121 of the three-way structure 12, and when the first connection pipe 13 fails, the first connection pipe 13 only needs to be detached from the first interface 121 and replaced with a new connection pipe, so that the maintenance cost is low.
In an alternative embodiment, the second connection pipe 14 is screwed to the second interface 122. When the second connection pipe 14 fails, the second connection pipe 14 is simply detached from the second port 122. The new connecting pipe can be replaced, and the maintenance cost is low.
In an alternative embodiment, as shown in fig. 3 and 4, the reagent pipette 15 is connected to the third port 123 of the three-way structure 12 by a screw thread.
In an alternative embodiment, the first connecting tube 13 and the second connecting tube 14 are flexible tubes.
In an alternative embodiment, the reagent pipette 15 is of peek material.
Specifically, the three-way structure 12 and the three-way fixing plate 11 may be detachably connected in various suitable manners, such as a quick-release connection manner, a clamping connection manner, and a threaded connection manner.
In an alternative embodiment, referring to fig. 6, the valve body 120 of the three-way structure 12 is provided with connecting lugs 124 on both sides, and the connecting lugs 124 are connected with the three-way fixing plate 11 in a threaded manner. Specifically, be equipped with the spliced eye on the tee bend fixed plate 11, the both sides of spliced eye are equipped with the screw hole, be equipped with screw hole 124a on the connection lug 124, during the installation, this spliced eye is inserted to the valve body 120 bottom of tee bend structure 12, connect lug 124 and the laminating of tee bend fixed plate 11, adopt bolt or screw to pass the screw hole 124a and the tee bend fixed plate 11 of connection lug 124 and can get up tee bend structure 12 and tee bend mounting panel fixed connection, the third interface 123 and the reagent straw 15 of tee bend fixed plate 11 below of bottom are connected. When the three-way structure is disassembled, the separation of the three-way structure 12 and the three-way fixing plate 11 can be realized by unscrewing the bolts, and the quick replacement is convenient. Meanwhile, since the connection lugs 124 are outwardly convex, a sufficient space is provided for the connection pipes to avoid interference between the adjacent two connection pipes.
In an alternative embodiment, referring to fig. 6, the connection between the upper portion of the valve body 120 and the first connecting pipe 13 and the second connecting pipe 14 is provided with an avoiding structure to avoid the interference between the connecting pipes of the two adjacent three-way structures 12. Due to the existence of the avoiding structure, even in the situation that a plurality of tee joint structures 12 are closely and adjacently installed, the interference of connecting pipes on the adjacent tee joint structures 12 can still be avoided, and the connecting pipes occupy the space above the tee joint structures 12 but not the space between the two adjacent tee joint structures 12 (in the horizontal direction).
In an alternative embodiment, the three-way structure 12 may be groove-shaped for accommodating the first connection pipe 13 or the second connection pipe 14.
In an alternative embodiment, referring to fig. 5 and 6, the avoidance structure is an avoidance ramp 120a. That is, two corners of the square valve body 120 are cut off to provide a space for the first and second connection pipes 13 and 14.
The escape ramp 120a can be at any suitable angle from the horizontal. In an alternative embodiment, the escape ramp 120a is disposed at an angle of 20 ° to 80 °, preferably 30 ° to 60 °, to the horizontal plane.
In the embodiment shown in fig. 5, referring to fig. 5, two of the escape ramps 120a are disposed at 60 ° from the horizontal. The first port 121 and the second port 122 are respectively perpendicular to the avoidance slope 120a, every two of the axial direction of the first port 121, the axial direction of the second port 122 and the axial direction of the reagent pipette 15 are arranged at 120 degrees, and the first port 121, the second port 122 and the third port 123 are uniformly arranged along the circumferential direction.
In an alternative embodiment, referring to fig. 4 and 5, the escape ramp 120a is arranged symmetrically with respect to the axial direction of the reagent pipette 15. In this way, the avoidance spaces on both sides of the valve body 120 are equal, the whole body is uniform, and the symmetrical installation of the first connecting pipe 13 and the second connecting pipe 14 can be maintained.
The first port 121 and the second port 122 are respectively arranged on an avoidance inclined surface 120a, and the avoidance inclined surface 120a is arranged axially symmetrically with respect to the reagent pipette 15, so that the first port 121 and the second port 122 can be arranged axially symmetrically with respect to the reagent pipette 15.
According to a second aspect of the present disclosure, a reagent extraction dispensing device is provided, see fig. 1, comprising a dispensing valve assembly 2 and a three-way assembly 1 for reagent extraction dispensing according to the present disclosure, said dispensing valve assembly 2 comprising a first dispensing valve 21 and a second dispensing valve 22, said first interface 121 of said three-way structure 12 being connected with said first dispensing valve 21 by a first connecting tube 13, said second interface 122 of said three-way structure 12 being connected with said second dispensing valve 22 by a second connecting tube 14. This embodiment can reduce reagent extraction dispensing device's cost of maintenance, when the part goes wrong, only need change problematic part can.
In an alternative embodiment, see fig. 2, each tee structure 12 requires the installation of one reagent pipette 15 and two connecting tubes. The two connecting pipes are respectively connected with different distribution valves. The reagent drawn by each tee structure 12 flows to two dispensing valves (only one dispensing valve is fed with reagent per draw, and there is no simultaneous feeding of reagents to both dispensing valves). Each tee structure 12 corresponds to a single reagent during the sequencing process.
In an alternative embodiment, referring to fig. 1, the tee assembly 1 and the distributor valve assembly 2 are provided in a split arrangement. When one of the distribution valve assembly 2 and the three-way assembly 1 has a problem, only the component with the problem needs to be replaced, and the whole distribution valve assembly does not need to be replaced completely. Compared with the mode that the three-way component 1 and the distribution valve component 2 are fixedly and integrally connected, the mode of the embodiment can save large maintenance cost.
In an alternative embodiment, the first connecting pipe 13 is detachably connected to the first distributing valve 21, and the second connecting pipe 14 is detachably connected to the second distributing valve 22. Specifically, the detachable connection manner in this embodiment may be a quick-release connection manner, a clamping connection manner, a threaded connection manner, or any other suitable detachable connection manner.
In an alternative embodiment, referring to fig. 1, the dispensing valve assembly 2 comprises a dispensing valve fixture 23, the first dispensing valve 21 and the second dispensing valve 22 being mounted on the dispensing valve fixture 23. The distribution valve fixing member 23 may be a sheet metal member. The middle portions of the first and second distribution valves 21 and 22 are fixed to a distribution valve fixing member 23. The distribution valve fixing member 23 functions to fix the first distribution valve 21 and the second distribution valve 22. The distribution valve fixing member 23 may be detachably coupled to the first distribution valve 21 and the second distribution valve 22, thereby facilitating maintenance. The dispensing valve fixing member 12 may be a sheet metal member.
According to a third aspect of the present disclosure, there is provided a gene sequencer comprising the reagent extraction and distribution device according to the present disclosure as described above. The embodiment can reduce the maintenance cost of the gene sequencer.
The above drawbacks are the results of the inventor after practical and careful study, and therefore, the discovery process of the above problems and the solutions proposed by the present disclosure in the following description should be the contribution of the inventor to the present disclosure in the course of the present disclosure.
Finally, it should be noted that: the above-mentioned embodiments are merely specific embodiments of the present disclosure, which are used for illustrating the technical solutions of the present disclosure and not for limiting the same, and the scope of the present disclosure is not limited thereto, and although the present disclosure is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive of the technical solutions described in the foregoing embodiments or equivalent technical features thereof within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present disclosure, and should be construed as being included therein. Therefore, the protection scope of the present disclosure shall be subject to the protection scope of the claims.
Claims (10)
1. The three-way component for extracting and distributing the reagent is characterized by comprising a three-way fixing plate and a plurality of three-way structures, wherein the three-way structures are detachably connected with the three-way fixing plate; every tee bend structure includes the valve body, be provided with first interface, second interface and third interface on the valve body, the first interface and the first connecting pipe of every tee bend structure are connected, and the second interface is connected with the second connecting pipe, and the third interface passes the tee bend fixed plate for be connected with the reagent straw.
2. The tee assembly for reagent draw dispensing of claim 1, wherein said first connection tube is removably connected to a first interface of a tee structure and said second connection tube is removably connected to said second interface.
3. The three-way assembly for reagent extraction and distribution of claim 1, wherein two sides of the valve body of the three-way structure are provided with connecting lugs, and the connecting lugs are connected with the three-way fixing plate in a threaded manner.
4. The tee assembly for reagent draw dispensing of any one of claims 1-3, wherein the junction of the upper portion of the valve body with the first connecting tube and the second connecting tube is provided with an avoiding structure to avoid interference of the connecting tubes on two adjacent tee structures.
5. The tee assembly for reagent extraction and dispensing of claim 4, wherein said avoidance structure is an avoidance ramp.
6. A reagent extraction dispensing device comprising a dispensing valve assembly and a three-way assembly for reagent extraction dispensing according to any of claims 1-5, the dispensing valve assembly comprising a first dispensing valve and a second dispensing valve, the first interface of the three-way structure being connected to the first dispensing valve by a first connecting tube and the second interface of the three-way structure being connected to the second dispensing valve by a second connecting tube.
7. The reagent extraction dispensing device of claim 6, wherein the three-way assembly and the dispensing valve assembly are provided in a split arrangement.
8. The reagent extraction and dispensing device of claim 6 or 7, wherein the first connecting tube is removably connected to the first dispensing valve and the second connecting tube is removably connected to the second dispensing valve.
9. The reagent extraction dispensing device of claim 6, wherein the dispensing valve assembly includes a dispensing valve mount, the first dispensing valve and the second dispensing valve being mounted on the dispensing valve mount.
10. A gene sequencer comprising a reagent extraction and dispensing apparatus according to any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223487867.3U CN218842162U (en) | 2022-12-26 | 2022-12-26 | Tee bend subassembly, reagent extraction distributor and gene sequencer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223487867.3U CN218842162U (en) | 2022-12-26 | 2022-12-26 | Tee bend subassembly, reagent extraction distributor and gene sequencer |
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| Publication Number | Publication Date |
|---|---|
| CN218842162U true CN218842162U (en) | 2023-04-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223487867.3U Active CN218842162U (en) | 2022-12-26 | 2022-12-26 | Tee bend subassembly, reagent extraction distributor and gene sequencer |
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| Country | Link |
|---|---|
| CN (1) | CN218842162U (en) |
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- 2022-12-26 CN CN202223487867.3U patent/CN218842162U/en active Active
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