CN218834267U

CN218834267U - Extraction device is used in production of monabilivir

Info

Publication number: CN218834267U
Application number: CN202222845068.2U
Authority: CN
Inventors: 侯鹏翼
Original assignee: Fujian Weijia Biomedical Co ltd
Current assignee: Fujian Weijia Biomedical Co ltd
Priority date: 2022-10-27
Filing date: 2022-10-27
Publication date: 2023-04-11
Anticipated expiration: 2032-10-27

Abstract

The utility model relates to the technical field of medicine preparation, in particular to an extraction device for producing monatiravir; the stirring device comprises a tank body, the top of the tank body is provided with a driving device through a bolt fixed mounting, the inside of the tank body is provided with a stirring mechanism, and the stirring mechanism comprises a stirring shaft, an upper stirring ring frame, a lower stirring ring frame, an upper connecting rod, a lower connecting rod, a supporting frame, stirring blades, a first scraper blade and a second scraper blade. By arranging the supporting frames and the stirring blades, the supporting frames are uniformly distributed on the inner side of the tank body, and the stirring blades are matched, so that a sufficient material mixing effect can be realized; through setting up first scraper blade and second scraper blade, can realize scraping and sweep jar body jar wall and bottom for the ritonavir midbody of jar body jar wall and bottom separates with jar body jar wall and bottom under the effect of first scraper blade and second scraper blade, can prevent effectively that solid sodium bicarbonate from adhering to jar body jar wall and bottom, avoids causing the condition emergence that compounding jar volume reduces, thereby has improved production efficiency.

Description

Extraction device is used in production of monabilivir

Technical Field

The utility model relates to a medicine preparation technical field, in particular to extraction device is used in production of monailavir.

Background

Lopinavir ritonavir tablets are a drug suitable for use in combination with other antiretroviral drugs for the treatment of HIV infection in adults and children over 2 years of age. Experience with lopinavir ritonavir has been largely attributed to patients who have not received antiretroviral drug therapy.

The company provides a preparation method of the monatiravir in 2021, 9 and 23 days, and the company is an extraction device designed based on the extraction steps in the method. See the patent for the preparation of the finished monatin bilar product, "stirred filtration, mother liquor vacuum distillation of isopropanol. To the remaining residue was added water (5 mL), and the mixture was dissolved with stirring and extracted with ethyl acetate ". That is, in the extraction requirement of the method step, the extraction reagent should be stirred twice before and after being added, so that the extraction reagent can be more uniformly diffused, and a more extraction effect can be achieved. However, the extraction equipment of the existing manufacturers cannot realize the process, and usually only a static extraction box can be adopted for extraction; while a small part of the solid sodium bicarbonate is provided with a stirring component, the solid sodium bicarbonate needs to be added before extraction, and the solid sodium bicarbonate is distilled to finally enter an extraction process, and in the process, once the solid sodium bicarbonate is not completely dissolved, the solid sodium bicarbonate is easily adhered to an easy wall, so that the dissolving quality of the solid sodium bicarbonate is reduced, and the quality of a final finished product is influenced.

Therefore, an extraction device for producing the monatiravir is provided.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the extraction device for producing the monatiravir is provided, and the technical scheme solves the problem that although the ritonavir intermediate can be uniformly stirred by the mixing tank provided in the background art, the volume of the mixing tank is reduced due to the fact that a large amount of solid sodium bicarbonate is adhered to the wall and the bottom of the mixing tank due to the limited stirring range, and the production efficiency is affected.

In order to achieve the above purpose, the technical solution of the present invention is as follows:

the utility model provides an extraction device is used in moani Lawei production, includes a jar body, there is drive arrangement at the top of jar body through bolt fixed mounting, the inside of jar body is equipped with rabbling mechanism, rabbling mechanism includes (mixing) shaft, goes up stirring ring frame, lower stirring ring frame, goes up the connecting rod, lower connecting rod, support frame, stirring vane, first scraper blade and second scraper blade, the top fixed connection of jar body and (mixing) shaft is worn to establish by drive arrangement's output, the (mixing) shaft is from last to setting gradually stirring ring frame and stirring ring frame down, it welds with the (mixing) shaft through a plurality of last connecting rods to go up stirring ring frame, stirring ring frame is through a plurality of lower connecting rods and (mixing) shaft welding down, the support frame is through a plurality of stirring vane and (mixing) shaft welding, the one side that stirring vane was kept away from to the support frame is equipped with first standing groove, install first scraper blade in the first standing groove, one side that the support frame was kept away from to the first standing groove is connected with the jar wall looks butt of jar body, the bottom surface of the connecting rod is equipped with the second standing groove down, the bottom surface butt of the jar body of the scraper blade.

As a preferred technical scheme of the utility model, drive arrangement includes positive reverse motor and pivot, positive reverse motor passes through the bolt fastening in the top of the jar body, the upper end of pivot is connected with the output of positive reverse motor, the top fixed connection of jar body and (mixing) shaft is worn to establish by the lower extreme of pivot.

As a preferred technical scheme of the utility model, the bottom surface of second scraper blade inclines towards the direction of motion of second scraper blade.

As an optimal technical scheme of the utility model, the quantity of going up connecting rod and lower connecting rod is 3, 3 go up the connecting rod and be interval 120 evenly lay between last stirring ring frame and (mixing) shaft, 3 the connecting rod is interval 120 evenly lays down between stirring ring frame and the (mixing) shaft.

As an optimized technical scheme of the utility model, a plurality of through-holes have been seted up on the stirring vane.

As the utility model discloses a preferred technical scheme, the feed inlet has been seted up at the top of the jar body, the bottom of the jar body is equipped with the bin outlet, the bottom fixed mounting of the jar body has the support.

The utility model provides a pair of extraction device is used in production of monatibaravir, its beneficial effect is:

by arranging the supporting frames and the stirring blades, the supporting frames are uniformly distributed on the inner side of the tank body, and the stirring blades are matched, so that a sufficient material mixing effect can be realized; through setting up first scraper blade and second scraper blade, can realize scraping and sweep jar body jar wall and bottom for the ritonavir midbody of jar body jar wall and bottom separates with jar body jar wall and bottom under the effect of first scraper blade and second scraper blade, can prevent effectively that solid sodium bicarbonate from adhering to jar body jar wall and bottom, avoids causing the condition emergence that compounding jar volume reduces, thereby has improved production efficiency. Meanwhile, the dissolution degree of an extraction reagent (ethyl acetate) can be improved, and the extraction quality is improved.

Drawings

Fig. 1 is a schematic structural diagram of an embodiment of the present invention.

Fig. 2 is a schematic structural diagram of an agitation mechanism according to an embodiment of the present invention.

Fig. 3 is a top view of the upper stirring ring frame according to the embodiment of the present invention.

Reference numerals are as follows: jar body 1, positive reverse motor 2, feed inlet 3, bin outlet 4, support 5, pivot 6, (mixing) shaft 7, go up stirring ring frame 8, stir down ring frame 9, first standing groove 10, first scraper blade 11, stirring vane 12, through-hole 13, second scraper blade 14, last connecting rod 15.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to the attached drawings 1-3, an extraction device for producing moania bilavir comprises a tank body 1, a driving device is fixedly mounted at the top of the tank body 1 through bolts, a stirring mechanism is arranged inside the tank body 1 and comprises a stirring shaft 7, an upper stirring ring frame 8, a lower stirring ring frame 9, an upper connecting rod 15, a lower connecting rod, a support frame, stirring blades 12, a first scraping blade 11 and a second scraping blade 14, the output end of the driving device penetrates through the tank body 1 and is fixedly connected with the top end of the stirring shaft 7, the stirring shaft 7 is sequentially provided with the upper stirring ring frame 8 and the lower stirring ring frame 9 from top to bottom, the upper stirring ring frame 8 is welded with the stirring shaft 7 through a plurality of upper connecting rods 15, the lower stirring ring frame 9 is welded with the stirring shaft 7 through a plurality of lower connecting rods, a plurality of support frames are uniformly and fixedly connected between the upper stirring ring frame 8 and the lower stirring ring frame 9, the support frames are welded with the stirring shaft 7 through a plurality of stirring blades 12, a first placing groove 10 is arranged at one side of the support frame far away from the stirring blades 12, a first scraping blade 11 is arranged in the first placing groove 10, one side of the first scraping blade 11 far away from the support frame is abutted against the tank wall of the tank 1, a second scraping blade 14 is arranged at the bottom surface of the second placing groove in the second scraping blade, and the second placing groove 14 in the second placing groove.

In this embodiment, the upper stirring ring frame 8 and the lower stirring ring frame 9 serve as the main structure of the stirring mechanism support, and meanwhile, the upper stirring ring frame 8 and the stirring shaft 7 are fixed through the upper connecting rod 15, and the lower stirring ring frame 9 and the stirring shaft 7 are fixed through the lower connecting rod, so that the requirement for high strength is high, and the stirring mechanism is not easy to deform.

In this embodiment, the number of the upper connecting rods 15 and the lower connecting rods is 3, the 3 upper connecting rods 15 are uniformly distributed between the upper stirring ring frame 8 and the stirring shaft 7 at intervals of 120 °, and the 3 lower connecting rods are uniformly distributed between the lower stirring ring frame 9 and the stirring shaft 7 at intervals of 120 °. Through setting up 3 upper connecting rods 15 that are interval 120 evenly distributed and 3 lower connecting rods that are interval 120 evenly distributed, can further improve the support intensity of going up stirring ring frame 8 and stirring ring frame 9 down.

In this embodiment, the even rigid coupling of support frame is in last stirring ring frame 8 and stirring ring frame 9 down between, and cooperation stirring vane 12 can realize abundant compounding effect.

In this embodiment, drive arrangement includes just reversing motor 2 and pivot 6, and just reversing motor 2 passes through the bolt fastening in jar top of body 1, and the upper end of pivot 6 is connected with just reversing motor 2's output, and jar body 1 and the top fixed connection of (mixing) shaft 7 are worn to establish to the lower extreme of pivot 6. Through setting up just reversing motor 2, can drive rabbling mechanism and carry out the positive and negative stirring, simultaneously, can also guarantee that the reversal cooperation second scraper blade 14 of just reversing motor 2 makes the ritonavir midbody of jar body 1 bottom convey upwards at the stirring in-process, cooperation stirring vane 12, and then to ritonavir midbody intensive mixing.

In the present embodiment, the bottom surface of the second squeegee 14 is inclined toward the moving direction of the second squeegee 14. Through setting up inclined second scraper blade 14, can reduce the resistance of scraping the in-process on the one hand for second scraper blade 14 can upwards shovel the ritonavir midbody that adheres in jar body 1 bottom, and on the other hand can move to the rear of second scraper blade 14 to the ritonavir midbody that is shoveled, and then avoids the ritonavir midbody that shovels to move along with second scraper blade 14 and increased the resistance that second scraper blade 14 scraped.

In this embodiment, the stirring blade 12 is provided with a plurality of through holes 13. The through holes 13 are formed in the stirring blades 12, so that the resistance of the stirring blades 12 in the stirring process can be effectively reduced; in addition, the bottom surface of the stirring blade 12 may be inclined toward the moving direction of the stirring blade 12, further reducing the resistance of the stirring blade 12 during the stirring process.

In this embodiment, feed inlet 3 has been seted up at the top of jar body 1, and the bottom of jar body 1 is equipped with bin outlet 4, and the bottom fixed mounting of jar body 1 has support 5. The raw materials are put into the tank body 1 from the feed inlet 3, the stirring mechanism is driven by the driving device to be fully mixed, the well mixed ritonavir intermediate is discharged from the discharge outlet 4, and the support 5 is used for supporting the tank body 1.

The utility model discloses a work flow: during material mixing, firstly, raw materials are put into the tank body 1 from the feeding hole 3, the forward and reverse rotation motor 2 is used for driving the stirring mechanism to perform forward and reverse rotation stirring through the rotating shaft 6, wherein the tank wall and the bottom of the tank body 1 can be swept through the first scraper blade 11 and the second scraper blade 14, so that ritonavir intermediates on the tank wall and the bottom of the tank body 1 are separated from the tank wall and the bottom of the tank body 1 under the action of the first scraper blade 11 and the second scraper blade 14, the ritonavir intermediates can be effectively prevented from being adhered to the tank wall and the bottom of the tank body 1, the situation that the volume of the material mixing tank is reduced is avoided, and the production efficiency is improved; by using the stirring blades 12, the raw materials can be fully mixed, and the well-mixed ritonavir intermediate can be discharged from the discharge port 4.

Finally, although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the present invention can be modified or replaced by other means without departing from the spirit and scope of the present invention, which should be construed as limited only by the appended claims.

Claims

1. The utility model provides an extraction device is used in moani Lawei production, includes the jar body, its characterized in that, there is drive arrangement at the top of the jar body through bolt fixed mounting, the inside of the jar body is equipped with rabbling mechanism, rabbling mechanism includes (mixing) shaft, last stirring ring frame, lower stirring ring frame, goes up connecting rod, lower connecting rod, support frame, stirring vane, first scraper blade and second scraper blade, the top fixed connection of jar body and (mixing) shaft is worn to establish by drive arrangement's output, the (mixing) shaft sets gradually from last stirring ring frame and stirring ring frame down, it welds with the (mixing) shaft through a plurality of last connecting rods to go up the stirring ring frame, the stirring ring frame is from last to setting gradually, it is equipped with first standing groove to go up stirring ring frame, install first scraper blade in the first standing groove, one side that the support frame was kept away from to first scraper blade connects with the jar wall looks butt of the jar body, the bottom surface counterbalance of lower connecting rod is equipped with the second standing groove, the installation of second scraper blade butt in the second standing groove.

2. The extraction device for producing the monatiravir is characterized in that the driving device comprises a forward and reverse rotating motor and a rotating shaft, the forward and reverse rotating motor is fixed to the top of the tank body through a bolt, the upper end of the rotating shaft is connected with the output end of the forward and reverse rotating motor, and the lower end of the rotating shaft penetrates through the tank body and is fixedly connected with the top end of the stirring shaft.

3. The apparatus according to claim 1, wherein the bottom surface of the second scraper is inclined toward the direction of movement of the second scraper.

4. The extraction device for producing the monatiravir according to claim 1, wherein the number of the upper connecting rods and the number of the lower connecting rods are 3, the 3 upper connecting rods are uniformly arranged between the upper stirring ring frame and the stirring shaft at intervals of 120 degrees, and the 3 lower connecting rods are uniformly arranged between the lower stirring ring frame and the stirring shaft at intervals of 120 degrees.

5. The extraction device for producing the monatiravir according to claim 1, wherein the stirring blade is provided with a plurality of through holes.

6. The extraction device for producing the monatiravir, according to claim 1, wherein the top of the tank body is provided with a feed inlet, the bottom of the tank body is provided with a discharge outlet, and the bottom of the tank body is fixedly provided with a support.