CN218774189U - Phototherapy instrument - Google Patents
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- CN218774189U CN218774189U CN202221855967.4U CN202221855967U CN218774189U CN 218774189 U CN218774189 U CN 218774189U CN 202221855967 U CN202221855967 U CN 202221855967U CN 218774189 U CN218774189 U CN 218774189U
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Abstract
The utility model discloses a phototherapy instrument relates to recovered physiotherapy instrument technical field, include: the irradiation device, the temperature control overload protector and the base; the irradiation device comprises a plurality of laser modules with different optical powers, is arranged on the upper surface of the base and is used for emitting lasers with different optical powers; the temperature control overload protector is arranged on the irradiation device and used for powering off the irradiation device when the temperature of an object to be irradiated, which is placed on the irradiation device, exceeds a set temperature. The utility model discloses a laser that irradiation arrangement produced pierces through the skull of rat and mouse, depolymerizes the fibrous body that amyloid formed, reduces the quantity and the area of senile plaque, reduces the A beta oligomer, strengthens the production of adenosine triphosphate to improve neuron vitality, reach the purpose that improves APP PS1 mouse memory.
Description
Technical Field
The utility model relates to a rehabilitation physiotherapy instrument technical field especially relates to a phototherapy instrument.
Background
Senile dementia (Alzheimer's disease) has unclear pathogenesis and no clinical medicine capable of reversing AD is available. And clinical imaging finds that: brain tissues of dementia patients including hippocampus, temporal lobe, frontal lobe, occipital lobe and the like are aggregated with spatiotemporal amyloid-beta (Α β) to form a large number of Senile Plaques (SP), and accompanied with dysfunction of cognition, memory, emotion and the like of the patients. Similarly, the pathological features and behavior disorders of APP/PS1 transgenic dementia mice are similar to those of AD patients. Endogenous formaldehyde in mouse, rat, human brain accumulates rapidly with age; the accumulated formaldehyde can induce the cross-linking of A beta monomer to form A beta oligomer and fiber body, and tau protein over-phosphorylation, which leads to the occurrence of neuron death and dementia.
Currently, there is no drug that can reverse dementia clinically, and therefore, there is a strong need for a physical therapy for dementia that can reduce neurotoxicity of a β oligomers.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a phototherapy instrument which can reduce the neurotoxicity of the Abeta oligomer.
In order to achieve the above object, the utility model provides a following scheme:
a phototherapy instrument comprising: the irradiation device, the temperature control overload protector and the base;
the irradiation device comprises a plurality of Diode (DL) laser modules with different optical powers, and is arranged on the upper surface of the base and used for emitting lasers with different optical powers;
the temperature control overload protector is arranged on the irradiation device and used for powering off the irradiation device when the temperature of an object to be irradiated, placed on the irradiation device, exceeds a set temperature.
Optionally, the phototherapy apparatus further comprises: a power adjustment knob and a controller;
the power adjusting knob is arranged on the side surface of the base, is connected with the controller, and is used for selecting the optical power and sending a gear signal corresponding to the optical power to the controller;
the controller is arranged in the base, connected with the irradiation device and used for controlling the switch of the power supply of the corresponding laser module according to the gear signal.
Optionally, the phototherapy instrument further comprises a light power display screen; the optical power display screen is arranged on the side face of the base, connected with the controller and used for displaying the optical power.
Optionally, the phototherapy instrument further comprises a time adjustment knob; the time adjusting knob is arranged on the side surface of the base, is connected with the controller, and is used for selecting the duration of laser irradiation of the object to be irradiated and sending a signal of the duration to the controller; and the controller controls the working time of the irradiation device according to the duration.
Optionally, the phototherapy instrument further comprises a time display screen; the time display screen is arranged on the side face of the base, connected with the controller and used for displaying the duration.
Optionally, the laser module comprises a plurality of diode lasers and a plurality of resistors; one end of the diode laser is connected with one end of the power supply; the other end of the diode laser is connected with one end of the resistor; the other end of the resistor is connected with the other end of the power supply.
Optionally, the diode laser emits laser light with a wavelength of 630-680 nanometers.
Optionally, the illumination device comprises a first laser module, a second laser module, and a third laser module;
the above-mentionedThe optical power of the laser emitted by the first laser module is 5mW/cm 2 ；
The optical power of the laser emitted by the second laser module is 20mW/cm 2 ；
The optical power of the laser emitted by the third laser module is 50mW/cm 2 。
Optionally, when the power adjusting knob is rotated to a first gear, the first laser module works;
when the power adjusting knob is turned to a second gear, the second laser module works;
when the power adjusting knob is turned to a third gear, the third laser module works;
when the power adjusting knob is turned to a fourth gear, the first laser module, the second laser module and the third laser module work simultaneously.
Optionally, the phototherapy instrument further comprises a three-grid glass cover; the three-grid glass cover covers the irradiation device; and three lattices of the three-lattice glass cover correspond to the first laser module, the second laser module and the third laser module one to one respectively.
According to the utility model provides a concrete embodiment, the utility model discloses a following technological effect:
the utility model provides a pair of phototherapy instrument, include: the irradiation device, the temperature control overload protector and the base; the irradiation device comprises a plurality of laser modules with different optical powers, is arranged on the upper surface of the base and is used for emitting lasers with different optical powers; the temperature control overload protector is arranged on the irradiation device and used for powering off the irradiation device when the temperature of an object to be irradiated placed on the irradiation device exceeds a set temperature. The utility model discloses a laser that irradiation device produced pierces through the skull of rat and mouse, depolymerizes the corpus fibrosum that amyloid formed, reduces the quantity and the area of age pigment, reduces the Abeta oligomer, strengthens the production of Adenosine Triphosphate (ATP) to improve neuron vigor, reach the purpose that improves APP PS1 mouse memory.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive labor.
Fig. 1 is a schematic structural view of the phototherapy apparatus of the present invention;
fig. 2 is a circuit diagram of a diode laser driving circuit according to the present invention;
fig. 3 is a test chart of the present invention for the DL diode laser light source;
FIG. 4 is a graph of the control time and light power inside the pulse laser therapeutic apparatus of the present invention;
fig. 5 is a schematic diagram of the phototherapy apparatus of the present invention using a FLA4000+ spectrometer to detect laser irradiation;
FIG. 6 is a schematic view of the phototherapy apparatus of the present invention using mouse ATP kit to detect neurons;
fig. 7 is a schematic view of the phototherapy apparatus of the present invention using a transmission electron microscope to detect abeta corpus fibrosum;
fig. 8 is a schematic view of the phototherapy apparatus of the present invention using an FS5 fluorescence spectrophotometer to detect a β structure;
fig. 9 is a schematic diagram of a phototherapy apparatus according to the present invention for detecting a11 antibody by confocal laser;
fig. 10 is a schematic view of the phototherapy apparatus of the present invention using confocal laser detection to detect 4G8 antibody;
FIG. 11 is a schematic diagram of a phototherapy apparatus according to the present invention for detecting p-tau181 antibody by confocal laser;
fig. 12 is a schematic diagram of the phototherapy apparatus of the present invention using Morris water maze to detect memory.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The utility model aims at providing a phototherapy instrument can reduce the neurotoxicity of the Abeta oligomer to easy operation, economy are suitable for, are a low-intensity laser therapeutic instrument, can supply research, use, the popularization of Alzheimer's disease animal model.
In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention is described in detail with reference to the accompanying drawings and the detailed description.
As shown in fig. 1 and 2, the utility model provides a phototherapy apparatus, which comprises: irradiation device, control by temperature change overload protection ware and base.
The irradiation device comprises a plurality of laser modules with different optical powers, is arranged on the upper surface of the base and is used for emitting lasers with different optical powers.
The temperature control overload protector is arranged on the irradiation device and used for powering off the irradiation device when the temperature of an object to be irradiated, placed on the irradiation device, exceeds a set temperature. The temperature control overload protector is a 38-DEG C temperature control overload protector. When the temperature detected by the temperature sensor is 38 ℃, the irradiation device is automatically powered off, and the laser heating is prevented from burning the skin of the mouse. Specifically, a 38-DEG C temperature-sensitive electronic element in the temperature control overload protector is connected with a power supply, is arranged on the back of the laser module and is used for detecting temperature change, and when the temperature of an irradiated object exceeds 38℃, the power supply of the irradiation device is automatically cut off, so that the continuous temperature rise caused by laser irradiation is avoided.
As a specific embodiment, the phototherapy apparatus further comprises: a power adjustment knob and a controller.
The power adjusting knob is arranged on the side face of the base, is connected with the controller and is used for selecting the optical power and sending a gear signal corresponding to the optical power to the controller.
The controller is arranged in the base, connected with the irradiation device and used for controlling the switch of the power supply of the corresponding laser module according to the gear signal.
Furthermore, the phototherapy apparatus further comprises a light power display screen; the optical power display screen is arranged on the side face of the base, connected with the controller and used for displaying the optical power.
As a specific embodiment, the phototherapy apparatus further comprises a time adjusting knob; the time adjusting knob is arranged on the side surface of the base, is connected with the controller, and is used for selecting the duration of laser irradiation of the object to be irradiated and sending a signal of the duration to the controller; and the controller controls the working time of the irradiation device according to the duration. Specifically, the continuous time can be adjusted to 0-60 minutes by rotating the time adjustment knob.
Furthermore, the phototherapy instrument also comprises a time display screen; the time display screen is arranged on the side face of the base, connected with the controller and used for displaying the duration.
Wherein the laser module comprises a plurality of diode lasers and a plurality of resistors; one end of the diode laser is connected with one end of the power supply; the other end of the diode laser is connected with one end of the resistor; the other end of the resistor is connected with the other end of the power supply. Specifically, as shown in fig. 3, the diode laser emits laser light having a wavelength of 630 to 680 nanometers.
The irradiation device comprises a first laser module, a second laser module and a third laser module; power of diode laser of different laser modules (5-50 mW/cm) 2 Error of + -1 mW/cm 2 ) The combination of (a) provides the measurement of the regulation and control parameters, and the optical power can be regulated and controlled into three different levels through regulating the resistance: the three different optical powers are respectively: 5. 20, 50mW/cm 2 . The optical power of the laser emitted by the first laser module is 5mW/cm 2 (ii) a The optical power of the laser emitted by the second laser module is 20mW/cm 2 (ii) a The third laserThe optical power of the laser emitted by the optical module is 50mW/cm 2 . Specifically, the first laser module, the second laser module and the third laser module are independent of each other. The laser module can generate diode laser-630-680 nanometer low-intensity laser which can penetrate through the skull of rats and mice. In vitro experiments show that the laser with the wavelength can obviously depolymerize fibrous bodies formed by amyloid; in vivo experiments show that the number and the area of senile plaques are reduced, and the A beta oligomer is reduced. Meanwhile, the production of Adenosine Triphosphate (ATP) which is an energy substance can be enhanced, the activity of neurons can be improved, and the damaged spatial memory of APP/PS1 mice can be saved.
Specifically, the utility model provides a diode laser's of three laser module's luminous power parameter is shown as table 1:
TABLE 1 parameters of diode lasers of three laser modules
| Model number | Voltage of | Electric current | Power of | Luminous flux | Light efficiency | Optical radiation power |
| Single particle (Bright) | 1.89V | 0.0099A | 0.018W | 775mlm | 43072mlm/W | 5.8mW |
| Single particle (Bright) | 1.95V | 0.0150A | 0.029W | 1137mlm | 39194mlm/W | 8.6mW |
| Single particle (Bright) | 1.99V | 0.0200A | 0.039W | 1480mlm | 37947mlm/W | 11.4mW |
| Single particle (Bright) | 2.03V | 0.0250A | 0.050W | 1794mlm | 35883mlm/W | 14.0mW |
| Single particle (Bright) | 2.06V | 0.0300A | 0.061W | 2075mlm | 34022mlm/W | 16.6mW |
| Single particle (super bright) | 1.88V | 0.0099A | 0.018W | 1013mlm | 56253mlm/W | 5.5mW |
| Single particle (super bright) | 1.92V | 0.0149A | 0.028W | 1498mlm | 53503mlm/W | 8.2mW |
| Single particle (super bright) | 1.96V | 0.0200A | 0.039W | 1950mlm | 49993mlm/W | 10.7mW |
| Single particle (super bright) | 2.00V | 0.0250A | 0.050W | 2391mlm | 47824mlm/W | 13.1mW |
| Single particle (super bright) | 2.06V | 0.0300A | 0.061W | 2099mlm | 34408mlm/W | 16.7mW |
| Model number | Voltage of | Electric current | Power of | Luminous flux | Light efficiency | Radiant flux |
| Big head | 4.999V | 1.564A | 7.820W | 88.608lm | 11.33lm/W | 690.28mW |
| Big head | 4.000V | 1.107A | 4.429W | 68.298lm | 15.42lm/W | 496.47mW |
| Big head | 3.000V | 0.6112A | 1.833W | 37.305lm | 20.35lm/W | 265.58mW |
| Big head | 2.000V | 0.1383A | 0.2765W | 7.1463lm | 25.84lm/W | 50.226mW |
| Small head | 4.999V | 0.5582A | 2.791W | 23.719lm | 8.50lm/W | 187.95mW |
| Small head | 4.000V | 0.3866A | 1.546W | 15.336lm | 9.92lm/W | 119.99mW |
| Small head | 3.000V | 0.2153A | 0.6458W | 7.5027lm | 11.62lm/W | 57.317mW |
According to the parameters of the diode laser, the maximum light radiation power of a single lamp bead is 16.7mW. Three lamp beads with power of 16.7mW are evenly distributed in each square centimeter of PCB circuit, so that the total light radiation power is 16.7 multiplied by 3=50.1mW, namely 50.1mW/cm 2 The current is 30mA, and the loss of energy in propagation is subtracted, so that the condition of 40mW/cm is met 2 The requirements of (2).
Three lamp beads with power of 16.7mW are used per square centimeter, the current flowing through each light bead is 20mA, and the energy loss in propagation is reduced, so that the condition of 20mW/cm is met 2 The requirements of (1).
Three lamp beads with power of 16.7mW are used per square centimeter, the current flowing through each light bead is 10mA, and the energy loss in propagation is reduced, so that the condition of 5mW/cm is met 2 The requirements of (1).
Therefore, the PCB size and the layout of the laser module are the same.
The method for calculating the current-limiting resistance takes the current flowing through a lamp bead as 30mA for example, the resistance and the light bead are connected in series, the total voltage is 5V, the resistance is x, x is multiplied by 0.03A, then 2 is added to be equal to 5, therefore, x =100 omega, and 40mW/cm 2 The current limiting resistor is 100 omega, the power is 0.09W,20mW/cm 2 The current limiting resistance is 150 omega, the power is 0.06W,5mW/cm 2 The current limiting resistance is 300 omega, and the power is 0.03W.
As a specific embodiment, when the power adjusting knob is rotated to a first gear, the first laser module works; when the power adjusting knob is turned to the second gear, the second laser module works; when the power adjusting knob is turned to a third gear, the third laser module works; when the power adjusting knob is turned to a fourth gear, the first laser module, the second laser module and the third laser module work simultaneously.
Specifically, the power adjusting screw consists of four-gear adjustment, wherein the first gear, the second gear and the third gear respectively correspond to 5mW/cm, 20mW/cm and 50mW/cm 2 Respectively irradiating; and 4, simultaneously irradiating the three laser modules.
In addition, the phototherapy instrument also comprises a three-grid glass cover; the three-grid glass cover covers the irradiation device; and three lattices of the three-lattice glass cover correspond to the first laser module, the second laser module and the third laser module one to one respectively.
Specifically, three glass covers in the three-grid glass cover for the mouse correspond to three laser irradiation modules with different light powers respectively; that is, no. 1 corresponds to 5mW/cm 2 (ii) a No. 2 corresponds to 20mW/cm 2 (ii) a No. 3 corresponds to 50mW/cm 2 。
As a specific embodiment, the optical power adjusting knob is adjusted to 1 gear corresponding to 5mW/cm in the No. 1 glass cover 2 A laser module; the optical power adjusting knob is adjusted to 2 gears corresponding to 20mW/cm in the No. 2 glass cover 2 A laser module; the optical power adjusting knob is adjusted to 3 gears corresponding to 50mW/cm in the No. 3 glass cover 2 A laser module; the optical power adjusting knob is adjusted to 4 gears corresponding to 5, 20 and 50mW/cm in No. 1, no. 2 and No. 3 glass covers 2 The laser modules illuminate simultaneously.
The phototherapy instrument provided by the utility model has the following effects:
as shown in fig. 4 and 5, the internal control time and optical power of the pulsed laser therapeutic apparatus are tested, a diode laser with 630-680nm is used to irradiate the whole body of the mouse, the laser with the wavelength can penetrate through the whole head of the mouse, and the detection apparatus: FLA4000 and spectrometer (Hangzhou crystal fly), DL diode laser penetrated the skull of mice by 47.5%.
As shown in FIG. 6, the phototherapy apparatus provided by the present invention can activate hippocampal neurons by using 630-680nm low-intensity laser, improve mitochondrial metabolism in neurons, and synthesize cell energy substance Adenosine Triphosphate (ATP), which is beneficial to improving neuron functions. The detection kit comprises: the results of the mouse ATP kit (Isogen Life Science, netherlands) showed that the ATP content in hippocampal neurons was significantly increased after laser treatment.
As shown in fig. 7, in vitro experiments show that the therapeutic apparatus can prevent the aggregation of the A beta and reduce the formation of the A beta fibrous body by adopting 630-680 nanometer low-intensity diode laser. And (3) detecting an instrument: transmission electron microscope (JEOL JEM-100CX electron microscope); in the figure, a represents a Diode Laser (DL) pulse pattern; in the figure, B represents the cross-linking of amyloid protein (A beta) induced by formaldehyde irradiation with diode laser; in the figure, C represents the diode laser pulse to depolymerize formaldehyde induced amyloid (A β) cross-linking; d is the detection of amyloid (Abeta 42) aggregation by a Transmission Electron Microscope (TEM); e is formaldehyde to intensify (Abeta 42) aggregation; f is the laser pulse depolymerization effect.
As shown in fig. 8, the phototherapy apparatus provided by the present invention uses 630-680nm laser to irradiate abeta, which induces sharp quenching of abeta fluorescence, indicating that abeta structure is destroyed, and diode laser pulse has different degrees of influence on different amyloid structures. A detection instrument: the model is as follows: FS5 spectrofluorometer, manufacturer: edinburgh instruments, UK.
As shown in fig. 9, fig. 10 and fig. 11, in vivo experiments show that the treatment device adopts a low-intensity diode laser with 630-680 nanometers to reduce A beta oligomer, phosphorylate the formation of tau and reduce the number and the area of senile plaques. And (3) detecting the medicine: a11 antibody (# AHB0052, thermo Fisher Scientific), 4G8 antibody (# MAB1561, chemicon and Upstate ore Millipore), p-tau181 antibody (# KHO0631, thermo Fisher Scientific). And (3) detecting an instrument: laser confocal (A1R + N-SIM + N-STORM Nikon, japan); as can be obtained from fig. 9, the results of the histochemical structure of the amyloid oligomer (a β O) antibody showed a significant reduction of the expression of a β -pair in hippocampal neurons after laser treatment; as can be obtained from fig. 10, the results of the formation of senile plaque (4G 8) antibody showed that the number of hippocampal senile plaques was significantly reduced after laser treatment; as can be taken from fig. 11, the results of the histochemical formation of phosphorylated tau protein (p-tau) antibodies show that hyperphosphorylation of tau within hippocampal neurons is significantly reduced after laser treatment.
As shown in fig. 12, in vivo experiments show that the therapy apparatus can save the damaged spatial memory of the mice by irradiating APP/PS1 mice with 630-680 nanometer low-intensity diode laser. A detection instrument: the Morris water maze (hardware: hikvision camera; software: ANY-maze; grobel, suzhou, china). As can be seen from fig. 12, the diode laser pulses significantly reduced the escape latency of the demented mice and increased the time in the target platform quadrant, changing the target platform search pattern from edge-to-trend.
In conclusion, the laser generated by the irradiation device of the present invention penetrates the skull of the rat and the mouse, depolymerizes the fibrous body formed by amyloid, reduces the number and area of senile plaques, reduces the Α β oligomers, and enhances the production of Adenosine Triphosphate (ATP), thereby improving the vitality of neurons and achieving the purpose of improving the memory of APP/PS1 mice.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principle and the implementation of the present invention are explained herein by using specific examples, and the above description of the embodiments is only used to help understand the method and the core idea of the present invention; meanwhile, for the general technical personnel in the field, according to the idea of the present invention, there are changes in the concrete implementation and the application scope. In summary, the content of the present specification should not be construed as a limitation of the present invention.
Claims (10)
1. A phototherapy apparatus, comprising: the irradiation device, the temperature control overload protector and the base;
the irradiation device comprises a plurality of laser modules with different optical powers, is arranged on the upper surface of the base and is used for emitting lasers with different optical powers;
the temperature control overload protector is arranged on the irradiation device and used for powering off the irradiation device when the temperature of an object to be irradiated placed on the irradiation device exceeds a set temperature.
2. The phototherapy instrument according to claim 1, further comprising: a power adjustment knob and a controller;
the power adjusting knob is arranged on the side surface of the base, is connected with the controller, and is used for selecting the optical power and sending a gear signal corresponding to the optical power to the controller;
the controller is arranged in the base, connected with the irradiation device and used for controlling the switch of the power supply of the corresponding laser module according to the gear signal.
3. The phototherapy instrument of claim 2 further comprising an optical power display screen; the optical power display screen is arranged on the side face of the base, connected with the controller and used for displaying the optical power.
4. The phototherapy instrument of claim 2 further comprising a time adjustment knob; the time adjusting knob is arranged on the side surface of the base, is connected with the controller, and is used for selecting the duration of laser irradiation of the object to be irradiated and sending a signal of the duration to the controller; and the controller controls the working time of the irradiation device according to the time length.
5. The phototherapy instrument of claim 4 further comprising a time display screen; the time display screen is arranged on the side face of the base, connected with the controller and used for displaying the duration.
6. The phototherapy instrument of claim 1 wherein the laser module comprises a plurality of diode lasers and a plurality of resistors; one end of the diode laser is connected with one end of the power supply; the other end of the diode laser is connected with one end of the resistor; the other end of the resistor is connected with the other end of the power supply.
7. A phototherapy instrument according to claim 6, characterized in that the diode laser emits laser light at a wavelength of 630-680 nm.
8. The phototherapy instrument of claim 2 wherein the irradiation device comprises a first laser module, a second laser module, and a third laser module;
the first laser modeThe optical power of the block-emitted laser light was 5mW/cm 2 ；
The optical power of the laser emitted by the second laser module is 20mW/cm 2 ；
The optical power of the laser emitted by the third laser module is 50mW/cm 2 。
9. The phototherapy instrument of claim 8 wherein the first laser module operates when the power adjustment knob is rotated to a first gear;
when the power adjusting knob is turned to the second gear, the second laser module works;
when the power adjusting knob is turned to a third gear, the third laser module works;
when the power adjusting knob is turned to a fourth gear, the first laser module, the second laser module and the third laser module work simultaneously.
10. The phototherapy instrument of claim 8 further comprising a three-pane glass cover; the three-grid glass cover covers the irradiation device; three lattices of the three-lattice glass cover correspond to the first laser module, the second laser module and the third laser module one to one respectively.
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| CN202221855967.4U CN218774189U (en) | 2022-07-07 | 2022-07-07 | Phototherapy instrument |
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| CN202221855967.4U CN218774189U (en) | 2022-07-07 | 2022-07-07 | Phototherapy instrument |
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