CN218740343U

CN218740343U - Multi-channel protein purification appearance chromatography column support

Info

Publication number: CN218740343U
Application number: CN202223047027.5U
Authority: CN
Inventors: 沙晓姣; 方利; 吴蝶
Original assignee: Changzhou Smart Lifesciences Co ltd
Current assignee: Changzhou Smart Lifesciences Co ltd
Priority date: 2022-11-16
Filing date: 2022-11-16
Publication date: 2023-03-28
Anticipated expiration: 2032-11-16

Abstract

The utility model belongs to the technical field of biological assay equipment technique and specifically relates to a multichannel protein purification appearance chromatography column holder, including support body, movable block, pull rod and spring, be equipped with counter bore and guiding hole on the support body, counter bore and the coaxial setting of guiding hole, pull rod slidable mounting just is equipped with the column cap in the guiding hole, spring suit is on the pull rod, and the hole bottom of its one end butt counter bore, the shoulder face of its other end butt column cap, the column cap is located the counter bore, and the other end and the movable block fixed connection of pull rod are equipped with the second constant head tank that is used for pressing from both sides the dress chromatography column with adjacent one side of support body on the movable block, and this support structure is simple, and loading and unloading chromatography column time is convenient and fast, and the chromatography column installation is stable, and difficult not hard up, and the chromatography column of applicable different diameters is provided with a multiunit mounting structure on the same support body, and overall structure is compact, can fix a plurality of chromatography columns simultaneously, satisfies the chromatography column installation requirement of multichannel protein purification appearance, realizes a set of chromatography column synchronous motion.

Description

Multi-channel protein purification appearance chromatography column support

Technical Field

The utility model belongs to the technical field of biological assay equipment technique and specifically relates to a multichannel protein purification appearance chromatography column support.

Background

When the protein to experimental sample purifies, generally carry out the protein purification through the protein purification appearance, current purification appearance can satisfy the demand of daily a small amount of samples basically, to a large amount of samples or need purify multiple samples simultaneously, many people guard, make mistakes easily moreover, waste time and energy. The multi-channel protein purifier can purify a plurality of chromatographic columns simultaneously, the chromatographic columns are required to be assembled and disassembled more conveniently and rapidly, the treatment efficiency is improved, the installation of the chromatographic columns is required to be compact, more chromatographic columns are arranged, the overall dimension of the purifier is optimized, corresponding chromatographic column supports are required to be designed, and the synchronous movement of the plurality of chromatographic columns is realized, so that component collecting pipes, sample pipes and the like below the chromatographic columns are aligned.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the prior problems, the utility model provides a chromatographic column bracket of a multi-channel protein purifier.

The utility model provides a technical scheme that its technical problem adopted is: the utility model provides a multichannel protein purification appearance chromatography column support, includes support body, movable block, pull rod and spring, be equipped with counter bore and guiding hole on the support body, counter bore and the coaxial setting of guiding hole, pull rod slidable mounting just is equipped with the column cap in the guiding hole, spring suit is on the pull rod, and the hole bottom of its one end butt counter bore, the shoulder face of its other end butt column cap, the column cap is located the counter bore, the other end and the movable block fixed connection of pull rod, be equipped with the second constant head tank that is used for pressing from both sides the dress chromatography column with the adjacent one side of support body on the movable block.

According to the utility model discloses a further embodiment, further include, be equipped with first constant head tank on the support body with the second constant head tank is relative.

According to the utility model discloses a further embodiment, further include, first constant head tank and second constant head tank are circular arc groove or V type groove.

According to the utility model discloses a further embodiment, further include, the outside of movable block is equipped with the handle of Y shape, the outside of handle is equipped with curved first recess, the both sides of handle are formed with the second recess.

According to the utility model discloses a further embodiment, further include, be equipped with on the support body and the adjacent one side lateral wall of movable block and dodge the groove, the thickness of movable block is less than the width of dodging the groove.

According to the utility model discloses a further embodiment, further include, the equipartition is equipped with a plurality of counter bores and guiding hole on the support body, and corresponding a plurality of movable blocks of group, pull rod and the spring of installing.

The beneficial effects of the utility model are that, this supporting structure is simple, and convenient and fast when loading and unloading chromatography post, the chromatography post installation is stable, and is difficult not hard up, and the chromatography post of applicable different diameters is provided with a multiunit mounting structure on the same support body, and overall structure is compact, can fix a plurality of chromatography posts simultaneously, satisfies multichannel protein purification appearance's chromatography post installation requirement, realizes a set of chromatography post synchronous motion.

Drawings

The present invention will be further explained with reference to the drawings and examples.

Fig. 1 is a schematic structural diagram of the present invention;

fig. 2 is a schematic partial top view of the present invention;

fig. 3 is a schematic perspective cross-sectional view of the present invention;

fig. 4 is a schematic cross-sectional view of the present invention;

in the figure, a frame body 1, a first positioning groove 11, a counter bore 12, a guide hole 13, an avoiding groove 14, a movable block 2, a second positioning groove 21, a handle 22, a first groove 23, a second groove 24, a pull rod 3, a column head 31, a spring 4 and a chromatographic column 5.

Detailed Description

Fig. 1-4 are the utility model discloses a structural schematic diagram, a multichannel protein purification appearance chromatography column support, including support body 1, movable block 2, pull rod 3 and spring 4, be equipped with counter bore 12 and guiding hole 13 on the support body 1, counter bore 12 and the coaxial setting of guiding

hole

13, 3 slidable mounting of pull rod are in guiding hole 13, and are equipped with

column cap

31, 4 suits of spring are on pull rod 3, and the hole bottom of its one end butt counter bore 12, the shoulder face of its other end butt column cap 31, column cap 31 is located counter bore 12, the other end and the 2 fixed connection of movable block of pull rod 3, be equipped with the second constant head tank 21 that is used for pressing from both sides dress chromatography column 5 with the adjacent one side of support body 1 on the movable block 2.

The other end of the pull rod 3 is connected with the movable block 2 through screw threads.

The pull rod 3 pulls the movable block 2 to approach the frame body 1 under the action of the spring 4, so that clamping force for clamping the chromatographic column 5 is formed. The chromatographic column 5 is clamped between the second positioning groove 21 and the frame body 1, and is stably installed. When the chromatographic column 5 is assembled and disassembled, only the movable block 2 needs to be pulled out outwards, and the operation is convenient. The outer circle step of the chromatographic column 5 can be abutted against the upper surface of the frame body 1 for axial positioning, so that the accuracy of the installation position of the chromatographic column 5 is ensured.

Preferably, the frame body 1 is provided with a first positioning groove 11 opposite to the second positioning groove 21. Further improve the stability of chromatographic column 5 installation, chromatographic column 5 non-deformable.

Preferably, the first positioning groove 11 and the second positioning groove 21 are arc grooves or V-shaped grooves. The V-shaped groove can adapt to the chromatographic columns 5 with different diameters, and the chromatographic columns 5 are stably installed.

Preferably, a Y-shaped handle 22 is arranged on the outer side of the movable block 2, an arc-shaped first groove 23 is arranged on the outer side of the handle 22, and second grooves 24 are formed on two sides of the handle 22. Through the handle 22 that sets up the Y shape, conveniently stimulate the movable block 2, the movable block 2 atress is even, is difficult for leading to the movable block 2 at the junction fracture with pull rod 3, and makes conveniently, and in forefinger and middle finger stretched into second recess 24 from the below respectively during the use, the thumb was put in first recess 23, conveniently controls the position of movable block 2 under the condition that the movable block 2 closely arranged. The handle may also be a conventional mushroom shaped handle.

Preferably, the side wall of the frame body 1 adjacent to the side wall of the movable block 2 is provided with an avoiding groove 14, and the thickness of the movable block 2 is smaller than the width of the avoiding groove 14. When the small chromatographic column 5 is clamped, one side of the second positioning groove 21 of the movable block 2 can extend into the avoiding groove 14, so that the clamping range of the bracket is improved.

Preferably, the frame body 1 is uniformly provided with a plurality of counter bores 12 and guide holes 13, and a plurality of groups of movable blocks 2, pull rods 3 and springs 4 are correspondingly arranged. Groups of chromatography columns 5 may be held.

The edges of all parts of the bracket are provided with chamfers or fillets, so that the chromatographic column 5 is prevented from being scratched.

The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.

Claims

1. The utility model provides a multichannel protein purification appearance chromatographic column support, characterized by, includes support body (1), movable block (2), pull rod (3) and spring (4), be equipped with counter bore (12) and guiding hole (13) on support body (1), counter bore (12) and guiding hole (13) coaxial setting, pull rod (3) slidable mounting is in guiding hole (13), and is equipped with column cap (31), spring (4) suit is on pull rod (3), and the hole bottom of its one end butt counter bore (12), the shoulder face of its other end butt column cap (31), column cap (31) are located counter bore (12), the other end and movable block (2) fixed connection of pull rod (3), be equipped with second constant head tank (21) that are used for pressing from both sides dress chromatographic column (5) with support body (1) adjacent one side on movable block (2).

2. The chromatography column support of a multi-channel protein purifier as claimed in claim 1, wherein the support body (1) is provided with a first positioning groove (11) opposite to the second positioning groove (21).

3. The chromatography column support of a multi-channel protein purifier as recited in claim 2, wherein the first positioning groove (11) and the second positioning groove (21) are arc grooves or V-shaped grooves.

4. The chromatography column bracket of the multi-channel protein purifier as claimed in claim 1, wherein a Y-shaped handle (22) is arranged on the outer side of the movable block (2), an arc-shaped first groove (23) is arranged on the outer side of the handle (22), and second grooves (24) are formed on two sides of the handle (22).

5. The chromatography column bracket of the multi-channel protein purifier as claimed in claim 1, wherein an avoiding groove (14) is formed in the side wall of the bracket body (1) adjacent to the movable block (2), and the thickness of the movable block (2) is smaller than the width of the avoiding groove (14).

6. The chromatography column support of the multi-channel protein purifier according to claim 1, wherein the support body (1) is uniformly provided with a plurality of counter bores (12) and guide holes (13), and is correspondingly provided with a plurality of groups of movable blocks (2), pull rods (3) and springs (4).