CN218739248U - Drug delivery device for intracranial ultramicro injection of mouse - Google Patents

Abstract

The utility model provides a device of dosing for intracranial super microinjection of mouse, including trace injector and glass microelectrode, on the syringe needle of trace injector was located to glass microelectrode cover, it is fixed through the colloid between glass microelectrode and the syringe needle. After the glass microelectrode and the microsyringe are fixed to form the administration device for mouse intracranial ultramicro injection, the glass microelectrode can be fixed to a brain stereotaxic instrument to administer medicine to the intracranial or the vertebral column, and can also administer the micro-medicine to internal organs such as colorectal wall, gastric wall and the like, and the administration part and the metering are accurate. The utility model also has the advantages of repeated use, easy cleaning, convenient hand-hold during drug administration, etc.

Description

Drug delivery device for intracranial ultramicro injection of mice

Technical Field

The utility model relates to the field of medical equipment, in particular to a drug delivery device for intracranial ultramicro injection of mice.

Background

The method is very important for the brain and the vertebra of a human or an animal, has very high requirements on the precision of the administration part and the precision of metering when positioning administration is needed when abnormality occurs in the brain or the vertebra, and can cause unpredictable influence on the brain or the vertebra if the administration position or the administration amount is inaccurate.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a device of dosing that is used for the intracranial super microinjection of mouse, solve one or more among the above-mentioned prior art problem.

The utility model provides a device of dosing for intracranial super microinjection of mouse, including trace injector and glass microelectrode, glass microelectrode cover is located on the syringe needle of trace injector, it is fixed through the colloid between glass microelectrode and the syringe needle.

In some embodiments, the tip of the injection needle is embedded in the glass microelectrode, and the distance between the tip of the glass microelectrode and the tip of the injection needle is 2-3 mm.

In some embodiments, the microsyringe is coupled to a brain stereotaxic apparatus.

In some embodiments, the microsyringe includes barrel and push rod subassembly, the barrel is transparent glass system barrel, the barrel with the syringe needle is connected, be equipped with the appearance chamber with the syringe needle intercommunication in the barrel, it sets up the scale mark to correspond to hold the chamber on the barrel, push rod subassembly includes the push rod, the one end of push rod is inserted hold the intracavity, and this end is equipped with red head, is convenient for carry out the observation of dosage, provides the guarantee for accurate dosing.

In some embodiments, the cavity between the push rod and the injection needle, the injection needle and the glass microelectrode are filled with paraffin.

In some embodiments, a limiting plate is arranged on the other side of the barrel, a square surface is arranged on at least one side of the limiting plate, a through hole is formed in the limiting plate corresponding to the containing cavity and communicated with the containing cavity, the through hole, the containing cavity and the injection needle are coaxially arranged, and the push rod penetrates through the through hole.

In some embodiments, the other end of the push rod penetrates through the limit plate to be connected with the push handle.

In some embodiments, the push handle is cylindrical, the end surface of one side of the push handle, which is in contact with the finger, is flat, and the outer surface of the limit plate is smooth and flat.

In some embodiments, the upper side and the lower side of the limiting plate are both provided with square surfaces, and the left side and the right side of the limiting plate are provided with convex arc surfaces.

In some embodiments, when the light source of the orthographic cylinder body is arranged in the direction perpendicular to the square face, the shadow generated by the scale mark intersects with the shadow generated by the push rod, and the shadow generated by the scale mark intersects with the shadow generated by the accommodating cavity.

The utility model discloses an advantage of a device of dosing for intracranial super little injection of mouse be:

1. the device has a simple structure, is convenient to carry, and can carry out administration operation by holding a microsyringe of an administration device for intracranial ultramicro injection of a mouse;

2. the micro-sample injector and the glass microelectrode can be disassembled to be respectively replaced and cleaned, and the cleaning is easy;

3. the administration device for intracranial ultramicro injection of the mouse is convenient for realizing the accurate positioning of the administration part and the accurate control of the dosage during micro administration;

4. the drug delivery device for intracranial ultramicro injection of mice has small wound surface and is not easy to infect when in drug delivery.

Drawings

Fig. 1 is a schematic structural diagram of a drug delivery device for intracranial microinjection in mice according to some embodiments of the present invention;

fig. 2 is an enlarged view of a portion a-a in fig. 1.

Detailed Description

In conjunction with the contents shown in fig. 1 and fig. 2, the present embodiment provides a drug delivery device for mouse intracranial ultramicro injection, which comprises a microsyringe and a glass microelectrode 4, wherein the glass microelectrode 4 is sleeved on an injection needle 5 of the microsyringe, and the glass microelectrode 4 and the injection needle 5 are fixed by a colloid 3. When the micro-sampler and the glass microelectrode 4 need to be detached, the colloid 3 is stripped, and then the glass microelectrode 4 is pulled out from the injection needle 5.

The tip of the injection needle 5 is embedded in the glass microelectrode 4, and the distance between the tip of the glass microelectrode 4 and the tip of the injection needle 5 is 2-3 mm.

The microsyringe comprises a barrel body 1 and a push rod assembly, wherein the barrel body 1 is made of transparent glass, the barrel body 1 is connected with a syringe needle 5, a containing cavity 102 communicated with the syringe needle 5 is arranged in the barrel body 1, a scale mark 103 is arranged on the barrel body 1 corresponding to the containing cavity 102, the push rod assembly comprises a push rod 202, one end of the push rod 202 is inserted into the containing cavity 102, a red head 203 is arranged at the end of the push rod 202, the red head 203 is striking in color, the change of the amount of liquid medicine in the containing cavity 102 can be better observed while the liquid medicine is pushed out, and the accurate control of the dosage during the micro-dosage is facilitated; the other end of the push rod 202 penetrates through the limit plate 101 to be connected with the push handle 201.

Paraffin is filled in the cavity 102 between the push rod 202 and the injection needle 5, the injection needle 5 and the glass microelectrode 4.

The other side of barrel 1 is equipped with limiting plate 101, and limiting plate 101 is last to have at least one side to set up square surface 1011, is convenient for be used for the device of dosing of the intracranial ultramicro injection of mouse to put on the instrument dish, and limiting plate 101 is last to correspond to holding chamber 102 and to set up the through-hole, through-hole and holding chamber 102 intercommunication, and through-hole, holding chamber 102 and syringe needle 5 coaxial setting, and push rod 202 passes the through-hole.

Push handle 201 is cylindrical, and pushes away the terminal surface surfacing of one side of handle 201 with finger contact, and the surface of limiting plate 101 is smooth and flat, and the travelling comfort that pushes away the finger of handle 201 when guaranteeing to push away handle 201 and use.

In some specific implementation manners, the upper and lower both sides of limiting plate 101 all are provided with square face 1011, and the left and right sides of limiting plate sets up convex arcwall face, and setting up of the convex arcwall face through the left and right sides provides the point of application of force for stabilizing barrel 1, guarantees the stability of the process of dosing.

In some specific implementation manners, when the light source of the orthocylinder 1 is arranged in the direction perpendicular to the square surface 1011, the shadow generated by the scale line 103 intersects with the shadow generated by the push rod 202, and the shadow generated by the scale line 103 intersects with the shadow generated by the cavity 102, so that when the administration device for mouse intracranial ultramicro injection is used, a user can observe the liquid medicine in the cavity 102 and the scale line 103 at the same time, and can intuitively sense the change of the liquid medicine amount in the cavity 102.

The microsampler can be selected from microsamplers of various specifications, such as: 10ul microsampler or 25ul microsampler are commonly used.

When the micro-injector is used for intracranial ultramicro injection of a mouse, the micro-injector is connected with a brain stereotaxic apparatus, so that the accurate positioning of the administration part is convenient.

Taking a commonly used 10ul microsampler as an example, the working principle of the administration device for intracranial microinjection of mice is as follows:

selecting a glass microelectrode with the outer diameter of 1.5 mm, the inner diameter of 0.86 mm and the length of 10 cm, drawing by using a drawing machine (the drawing process of the drawing machine is the prior art and is not described herein in detail), setting drawing parameters (the drawing parameters can be set on the drawing machine according to requirements and are not described herein in detail), dividing the glass microelectrode into two parts to form two glass microelectrodes, cutting off the tip part of the glass microelectrode formed by drawing by using scissors, and filling paraffin into the cut glass microelectrode;

taking out the push rod 202 of the microsyringe, filling paraffin into the cavity 102, then reinserting the push rod 202, and pushing to the position of 6-7ul, at the moment, filling paraffin into the injection needle 5;

the glass microelectrode filled with paraffin is sleeved on the injection needle 5, the distance between one end of the glass microelectrode, which is far away from the microsyringe, and one end of the injection needle 5, which is far away from the cylinder 1, is kept at 2-3 mm, a glue gun is utilized to glue and fix the joint of the other end of the glass microelectrode and the injection needle 5 (the glue is solidified into a glue body 3, and the glue can be glass glue, so that a drug delivery device for intracranial ultramicro injection of a mouse is formed, can be used for drug delivery to the intracranial or spinal cord of the mouse, and can also be used for ultramicro drug delivery to viscera such as the colorectal wall, the stomach wall and other parts, the site accuracy can be achieved, the dosage is accurate, the window of animal tissues is small, the infection is not easy, and the drug delivery amount is accurately monitored.

The administration device for mouse intracranial ultramicro injection is characterized in that after a medicine to be injected is absorbed by a glass microelectrode, the administration device for mouse intracranial ultramicro injection which absorbs the medicine is placed on a brain stereotaxic apparatus and fixed, and the injection is started after the fixation. The medicine can be completely squeezed into the position needing to be administered during injection, a little paraffin can be pushed away at the same time, so that the whole injection cavity (the cavity consisting of the containing cavity 102 between the red head 203 and the tip of the glass microelectrode 4, the channel in the injection needle 5 and the channel in the glass microelectrode 4) is ensured to be free of air and filled with paraffin, then the medicine can be directly sucked again, injection is carried out according to the flow, after paraffin is pushed to the end (namely, paraffin in the administration device for intracranial ultramicro injection of a mouse is used up), the glass microelectrode is detached and discarded, the micro-injector can be reused by installing a new glass microelectrode on the micro-injector again, and the resource utilization rate is effectively improved.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, many similar modifications and improvements can be made without departing from the inventive concept, and these should also be considered as the protection scope of the present invention.

Claims (10)

1. The drug delivery device for intracranial ultramicro injection of the mouse is characterized by comprising a microsyringe and a glass microelectrode (4), wherein the glass microelectrode (4) is sleeved on an injection needle (5) of the microsyringe, and the glass microelectrode (4) and the injection needle (5) are fixed through a colloid (3).

2. The drug delivery device for intracranial microinjection into a mouse according to claim 1, wherein the tip of the injection needle (5) is embedded in the glass microelectrode (4), and the distance between the tip of the glass microelectrode (4) and the tip of the injection needle (5) is 2-3 mm.

3. The device of claim 1, wherein the microsyringe is coupled to a brain stereotaxic apparatus.

4. The drug delivery device for intracranial ultramicro injection in mice as claimed in claim 1, wherein the microsyringe comprises a barrel (1) and a push rod assembly, the barrel (1) is made of transparent glass, the barrel (1) is connected with the injection needle (5), a cavity (102) communicated with the injection needle (5) is arranged in the barrel (1), the barrel (1) is provided with scale marks (103) corresponding to the cavity (102), the push rod assembly comprises a push rod (202), one end of the push rod (202) is inserted into the cavity (102), and the end is provided with a red head (203).

5. The device for the intracranial ultramicro injection of a mouse according to claim 4, wherein the cavity (102) between the push rod (202) and the injection needle (5), the injection needle (5) and the glass microelectrode (4) are filled with paraffin.

6. The drug delivery device for intracranial ultramicro injection in mice as claimed in claim 4, wherein the other side of the barrel (1) is provided with a limiting plate (101), at least one side of the limiting plate (101) is provided with a square surface (1011), the limiting plate (101) is provided with a through hole corresponding to the cavity (102), the through hole is communicated with the cavity (102), the through hole, the cavity (102) and the injection needle (5) are coaxially arranged, and the push rod (202) passes through the through hole.

7. The device for intracranial and ultramicro-injection in mice as claimed in claim 6, wherein the other end of the push rod (202) passes through the limiting plate (101) and is connected with the push handle (201).

8. The device for the intracranial microinjection of a mouse according to claim 7, wherein the push handle (201) is cylindrical, and the end surface of the push handle (201) that contacts with the finger is flat, and the outer surface of the limiting plate (101) is smooth.

9. The drug delivery device for intracranial ultramicro injection in mice as claimed in claim 6, wherein the upper and lower sides of the limiting plate (101) are both provided with square surfaces (1011), and the left and right sides of the limiting plate are provided with convex arc surfaces.

10. The administration device for intracranial ultramicro injection in mice according to claim 6 or 9, wherein when the light source of the orthographic cylinder (1) is arranged in the direction perpendicular to the square face (1011), the shadow generated by the scale line (103) intersects with the shadow generated by the push rod (202), and the shadow generated by the scale line (103) intersects with the shadow generated by the cavity (102).

Images