CN218617243U - Oral solid agent production line - Google Patents

Abstract

The utility model discloses an oral solid agent production line, including crushing apparatus, pelletization equipment, hard capsule filling machine, tablet press, capsule machine, blister pack machine and bottle filling equipment, crushing apparatus connects pelletization equipment to carry the preliminary treatment raw materials after smashing extremely pelletization equipment, pelletization equipment connects respectively hard capsule filling machine, tablet press to send the granule that obtains with the preparation into to hard capsule filling machine, tablet press, hard capsule filling machine connects blister pack machine and bottle filling machine, the tablet press is connected the capsule machine, the capsule machine is connected bottle filling equipment or blister pack machine. The utility model discloses with the medicine granule of a pelletization production line production, process hard gelatin capsule and tablet respectively to carry out blister package and medicine bottle packing respectively, accomplish the production of two kinds of products on a production line, can promote the space utilization of factory building, reduce the human cost, promote production efficiency.

Description

Oral solid agent production line

Technical Field

The utility model relates to a medicine production manufacturing installation technical field especially relates to an oral solid agent production line.

Background

The common solid dosage forms comprise powder, granules, tablets, capsules and the like, and the solid dosage forms account for about 70 percent of the pharmaceutical preparation. The solid preparation has the common characteristics of good physical and chemical stability, lower production and manufacturing cost and convenient taking and carrying compared with the liquid preparation; the pretreatment of the preparation process is carried out by the same unit operation, so as to ensure the uniform mixing and accurate dosage of the medicine, and the dosage forms are closely related; the drug can penetrate physiological membranes and be absorbed into the blood circulation after being dissolved in vivo.

In the prior art, for example, patent No. CN108160001B, it specifically discloses a wet mixing granulator and a solid preparation production line using the same, including a material cylinder, a rotating shaft, a granulating blade, and a stirring paddle, the stirring paddle is fixed on the rotating shaft, the rotating shaft is driven by a power device to rotate, the granulating blade is driven to rotate by a power device, a first connecting rod is fixedly sleeved on the rotating shaft, one end of the first connecting rod is fixed with a first powder scraping blade abutted against the inner wall of the material cylinder, a second connecting rod capable of moving along the axial direction of the rotating shaft is arranged on the rotating shaft, one end of the second connecting rod is fixed with a second powder scraping blade abutted against the inner wall of the material cylinder, the first powder scraping blade is located at the upper end of the granulating blade, the second powder scraping blade is located at the same height as the granulating blade, the first powder scraping blade and the second powder scraping blade are staggered, a guide strip is arranged at one side of the material cylinder close to the granulating blade, the guide strip is located at the outer side of the granulating blade, the rotating shaft rotates to drive the first powder scraping blade and the second powder scraping blade to extend along the guide strip along the circumferential direction when the outer side of the granulating blade. It further discloses a solid preparation production line, which comprises a pulverizer, a mixer, a mixing granulator and a coating machine which are connected in sequence. That is, the production line disclosed in this patent can achieve the preparation of tablets.

Generally, oral solid dosage forms comprising tablets and capsules are usually prepared separately using two production lines, occupying a large space. Therefore, there is a need to design an oral solid dosage production line that can simultaneously prepare tablets and capsules to reduce the occupied space and improve the production efficiency.

SUMMERY OF THE UTILITY MODEL

In view of the above-mentioned shortcomings of the prior art, it is an object of the present invention to provide an oral solid dosage form production line, which can simultaneously prepare tablets and capsules on one production line.

The technical scheme of the utility model is that:

the utility model provides an oral solid agent production line, includes crushing apparatus, pelletization equipment, hard capsule filling machine, tablet press, capsule machine, blister packaging machine and bottling equipment, crushing apparatus connects pelletization equipment to carry the preliminary treatment raw materials after will smashing to pelletization equipment, pelletization equipment connects respectively hard capsule filling machine, tablet press are sent into to granule that obtains with preparing hard capsule filling machine, tablet press, hard capsule filling machine connects blister packaging machine or bottling equipment to send into the capsule midbody that obtains filling to blister packaging machine carries out blister packaging or sends into bottling equipment and mould the bottle packing, the tablet press is connected the capsule machine to send into the plain piece that obtains with the preforming processing to the capsule machine, the capsule machine connect blister packaging machine or bottling equipment the bottling equipment is sent into with the capsule piece after the capsule to blister packaging machine carries out blister packaging or bottling equipment and bottles. Preferably, the granulation equipment comprises one of a whole-grain wet mixing granulator, a boiling granulator and a combination thereof.

Preferably, the bottling equipment comprises a high-speed intelligent bottle arranging machine, a tablet counting machine, a high-speed intelligent linear cap screwing machine and an electromagnetic sealing machine, the high-speed intelligent bottle arranging machine is connected with the bottle feeding end of the tablet counting machine, the coating machine is connected with the medicine feeding end of the tablet counting machine, the discharge end of the tablet counting machine is connected with the bottle feeding end of the high-speed intelligent linear cap screwing machine, and the high-speed intelligent linear cap screwing machine is connected with the feed end of the electromagnetic sealing machine.

Preferably, the packaging machine further comprises an outer packaging system, and the discharge ends of the blister packaging machine and the bottling equipment are connected with the outer packaging system.

Preferably, the external packing system comprises a labeling machine, an automatic boxing machine, an online weighing machine, a domino laser machine, a full-automatic film bundling machine, a full-automatic opening, packaging and sealing integrated machine, an instant labeling and labeling machine and an unmanned packing machine which are sequentially connected, the blister packing machine is connected with the automatic boxing machine, and the bottling equipment is connected with the labeling machine.

Preferably, the discharge end of the unmanned packer is connected with a lifter.

Preferably, the overwrap system is disposed in a general production area.

Preferably, the crushing equipment, the granulating equipment, the hard capsule filling machine, the tablet pressing machine, the coating machine, the blister packaging machine and the bottling equipment are arranged in a D-grade clean area.

Compared with the prior art, the beneficial effects of the utility model reside in that:

according to the utility model discloses an oral solid agent production line, with the medicine granule of a pelletization production line production, process hard gelatin capsule and tablet respectively to carry out blister package and medicine bottle packing respectively, accomplish the production of two kinds of products on a production line, can promote the space utilization of factory building, reduce the human cost, promote production efficiency.

Drawings

In the drawings, which are not necessarily drawn to scale, like reference numerals may describe similar components in different views. Like reference numerals having letter suffixes or different letter suffixes may represent different instances of similar components. The drawings illustrate various embodiments generally by way of example and not by way of limitation, and together with the description and claims serve to explain the disclosed embodiments. The same reference numbers will be used throughout the drawings to refer to the same or like parts, where appropriate. Such embodiments are illustrative, and are not intended to be exhaustive or exclusive embodiments of the present apparatus or method.

Fig. 1 shows a schematic structural diagram of an oral solid agent production line according to an embodiment of the present invention.

Fig. 2 shows a structure diagram of a bottle filling equipment of an oral solid agent production line according to an embodiment of the present invention.

Fig. 3 shows a schematic view of a partition structure of an oral solid agent production line according to an embodiment of the present invention.

Fig. 4 shows a schematic structural diagram of an oral solid dosage production line with an outer packaging system according to an embodiment of the present invention.

Fig. 5 shows a block diagram of an outer packaging system of an oral solid dosage production line according to an embodiment of the present invention.

In the figure, 1-the comminution apparatus; 2-granulating equipment; 3-hard capsule filling machine; 4-tabletting machine; 5-a coating machine; 6-blister packaging machine; 7-bottling equipment; 701-a high-speed intelligent bottle arranging machine; 702-a pellet counter; 703-high speed intelligent linear cap screwing machine; 704-an electromagnetic sealing machine; a class 8-D clean zone; 9-an overwrap system; 901-labeling machine; 902-automatic cartoning machine; 903-an online weighing machine; 904-domino laser; 905-full automatic film bundler; 906-full automatic unpacking and sealing integrated machine; 907-printing and labeling machine; 908-unmanned baler; 909-hoist; 10-general production zone.

Detailed Description

The following examples are given for the purpose of better illustrating the present invention, but the present invention is not limited to the examples. It is within the scope of the present invention that those skilled in the art may make insubstantial modifications and adaptations to the embodiments described above and other embodiments.

The invention will now be further described with reference to the accompanying drawings.

Fig. 1 shows a schematic structural diagram of an oral solid agent production line according to an embodiment of the present invention. The embodiment of the utility model provides an oral solid agent production line. As shown in fig. 1, arrows indicate the conveying direction of materials, the production line for oral solid dosage comprises a crushing device 1, a granulating device 2, a hard capsule filling machine 3, a tablet press 4, a coating machine 5, a blister packaging machine 6 and a bottling device 7, wherein the crushing device 1 is connected with the granulating device 2 to convey the crushed pre-processing raw materials to the granulating device 2, the granulating device 2 is respectively connected with the hard capsule filling machine 3 and the tablet press 4 to convey the prepared granules to the hard capsule filling machine 3 and the tablet press 4, the hard capsule machine 3 is connected with the blister packaging machine 6 or the bottling device 7 to convey the filled capsule intermediates to the blister packaging machine 6 for blister packaging or the bottling device 7 for plastic bottle packaging, the tablet press 4 is connected with the coating machine 5 to convey the tablet-pressed plain tablets to the coating machine 5, and the coating machine 5 is connected with the blister packaging machine 6 or the bottling device 7 to convey the coated tablets to the coating machine 6 for blister packaging or the blister packaging device 7 for plastic bottle packaging.

In specific implementation, the raw and auxiliary materials are crushed by the crushing equipment 1 to obtain a pretreated material, and the pretreated material is sent to the granulating equipment 2 for preparation. The raw materials and auxiliary materials are determined according to components of different oral solid agents, for example, various components corresponding to the oral solid agents can be added into a mixer to be mixed to obtain the raw materials and auxiliary materials, or the components are directly added into a crushing device 1 according to a ratio to be crushed, and the raw materials and auxiliary materials can be mixed in the crushing process to obtain the pretreated material. If the raw auxiliary materials (such as liquid auxiliary materials) which do not need to be crushed are available, the raw auxiliary materials can be directly added into the granulating equipment 2. The granules prepared by the granulating device 2 are respectively fed into a hard capsule filling machine 3 and a tablet press machine 4, wherein the hard capsule filling machine 3 fills corresponding quantity of granules into empty capsules to obtain capsule intermediates, and the tablet press machine 4 correspondingly presses the granules into plain tablets. The capsule intermediate is sent to a blister packaging machine 6 or a bottling device 7 to obtain the corresponding capsule. The plain tablets are coated by a coating machine 5 to obtain coated tablets, and the coated tablets are sent to a blister packaging machine 6 or a bottling device 7 to obtain corresponding tablets. Thus, this example allows the preparation of tablets and capsules on one production line.

It should be noted that, the transportation modes of the above-mentioned raw and auxiliary materials, pretreated materials, granules, capsule intermediates, plain tablets, coated tablets and the like may be a pipeline or container transfer mode, that is, the devices may be connected by a pipeline or a container transfer mode, and certainly, other common material transportation modes such as a conveyor belt, a conveyor drum or a hopper may also be used, which is not limited in this embodiment.

In addition, the embodiment can prepare the tablets and the capsules at the same time, and in the specific production, the production line can be used for only producing the tablets and the capsules according to different order requirements.

In some embodiments, the granulation equipment comprises one of a whole-grain wet-mix granulator, an ebullient granulator, and combinations thereof. In particular, the granulation equipment may select corresponding process equipment according to different granulation processes of different oral solid dosage, such as a whole particle wet mixing granulator, a boiling granulator, and the like. The two granulation devices can be simultaneously equipped or one granulation device can be selected on one production line.

In some embodiments, fig. 2 shows a block diagram of a bottling plant of an oral solid dose production line according to an embodiment of the invention. As shown in fig. 2, the bottling equipment 7 includes a high-speed intelligent bottle straightening machine 701, a counting machine 702, a high-speed intelligent linear cap screwing machine 703 and an electromagnetic sealing machine 704, the high-speed intelligent bottle straightening machine 701 is connected with a bottle feeding end of the counting machine 702, the coating machine 5 is connected with a medicine feeding end of the counting machine 702, a discharging end of the counting machine 702 is connected with a feeding end of the high-speed intelligent linear cap screwing machine 703, and the high-speed intelligent linear cap screwing machine 703 is connected with a feeding end of the electromagnetic sealing machine 704.

The specific work flow of the bottling plant 7 is: the high-speed intelligent bottle arranging machine 701 sends the medicine bottles into the tablet counting machine 702 through the conveying belt, the tablet counting machine 702 receives the coated tablets from the coating machine 5 and pours the coated tablets into the medicine bottles according to a preset number, and the filled medicine bottles are continuously conveyed to the high-speed intelligent linear cap screwing machine 703 through the conveying belt to be capped and screwed. The capped vials are fed into an electromagnetic sealer 704 via a conveyor belt to seal the vials to obtain packaged tablets.

In some embodiments, fig. 3 shows a schematic view of a zoned structure of an oral solid dose production line according to embodiments of the present invention. As shown in fig. 3, the pulverizing apparatus 1, the granulating apparatus 2, the hard capsule filling machine 3, the tablet press machine 4, the coating machine 5, the blister packaging machine 6 and the bottling apparatus 7 are all disposed in a class D clean area 8. Wherein the class D clean zone 8 refers specifically to a clean operating zone divided according to GMP standards. The method can be realized as an independent production room in a specific production workshop, and the production room can be formed by partition in a factory or constructed by adopting brick wall construction and is provided with corresponding equipment so as to ensure that the corresponding area reaches the clean standard. The utility model discloses a to each equipment place regional combination GMP standard and carry out rational arrangement, when guaranteeing production quality, controlled manufacturing cost effectively. The equipment not specifically described in this embodiment in the clean operation zone is defaulted to be disposed in the general production zone.

In some embodiments, fig. 4 illustrates a schematic diagram of an oral solid dosage production line with an overwrap system, according to an embodiment of the invention. As shown in fig. 4, the oral solid dose production line further comprises an outer packaging system 9, and the discharge ends of the blister packaging machine 6 and the bottling device 7 are connected to the outer packaging system 9. The oral solid dosage form is already internally packaged before entering the packaging system 9, so that the entire packaging system 9 can be located in the general production area 10.

In some embodiments, fig. 5 shows a block diagram of an outer packaging system of an oral solid dose production line, in accordance with an embodiment of the present invention. As shown in fig. 5, the external packaging system 9 includes a labeling machine 901, an automatic boxing machine 902, an online weighing machine 903, a domino laser 904, a full-automatic film bundler 905, a full-automatic unpacking and sealing all-in-one machine 906, a labeling machine 907 and an unmanned packer 908, which are connected in sequence, the blister packing machine 6 is connected with the automatic boxing machine 902, and the bottling device 7 is connected with the labeling machine 901.

The overwrap system 9 is used to package tablets and capsules. The product after bottling needs to be labeled correspondingly, so the bottling equipment 7 is connected with the labeling machine 901 to label the medicine bottles. The blister packaged product may then be directed to an automatic cartoning machine 902 for cartoning. Wherein the outer packaging system 9 can be provided with one outer packaging line or a plurality of outer packaging lines for respectively carrying out outer packaging on the tablets and the capsules. Specifically, the bottled products are first labeled in a labeling machine 901, and the blister products can be directly loaded by an automatic loader 902. The processing procedures after boxing are basically consistent, weighing detection is carried out through an online weighing machine 903 to check whether neglected loading (such as medicine shortage, specification shortage and the like) exists, after the neglected loading is qualified, the domino laser 904 is fed into a box body for coding, then a full-automatic film bundler 905 is used for covering film and bundling, then the boxing is carried out through a full-automatic unpacking and packaging integrated machine 906, after the boxing, a corresponding label is pasted on the outer side of the box body through a labeling machine 907, and finally the box body is packed through unmanned 908 to obtain a final product.

In some embodiments, with continued reference to FIG. 5, the discharge end of the unmanned baler 908 is attached to a hoist 909. The elevator 909 is used for lifting and conveying the finished product to a warehouse. Of course, also can adopt other various mode of unloading to the storehouse such as artifical transportation, rail robot transportation, the transportation mode of lifting machine 21 more is applicable to the design of multilayer factory building, and for example the lower floor is the workshop, and the upper strata is the storehouse, then uses lifting machine 18 can promote the transfer efficiency greatly. Also can set up the frame of keeping in and come to keep in the product, perhaps set up the transfer equipment and transport, the transfer equipment includes fork truck, transfer robot and so on.

The crushing device 1, the granulating device 2, the hard capsule filling machine 3, the tablet press 4, the coating machine 5, the blister packaging machine 6, the bottling device 7, the labeling machine 901, the automatic boxing machine 902, the online weighing machine 903, the domino laser 904, the full-automatic film bundling machine 905, the full-automatic unpacking and sealing integrated machine 906, the labeling machine 907 and the unmanned packing machine 908 are all conventional devices, and are all commercially available.

For example only, the device and corresponding inter-function information that may be used in the specific use of the present embodiment is shown in table 1:

TABLE 1 Main device and corresponding inter-function information sheet

With reference to table 1, in this embodiment, when each device is specifically arranged, a plurality of rooms are arranged in a plant, each room correspondingly realizes its corresponding function, the function is represented by a room name, and the room number is used to distinguish each room. Wherein the equipment connections between the various rooms include pipe connections and container transfers, e.g. for the transfer of liquids using pipes and for the transfer of solids using conveyor belts. Each room may be arranged on the same floor, or may adopt a layout design of a multi-floor factory building, which is not particularly limited in this embodiment.

The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the scope of the embodiments of the present invention, and are intended to be covered by the claims and the specification.

Claims (8)

1. The utility model provides an oral solid agent production line, its characterized in that, includes crushing apparatus, pelletization equipment, hard capsule filling machine, tablet press, capsule machine, blister packaging machine and bottling equipment, crushing apparatus connects pelletization equipment to carry the preliminary treatment raw materials after will smashing to pelletization equipment, pelletization equipment connects respectively hard capsule filling machine, tablet press are sent into with the granule that obtains to hard capsule filling machine, tablet press, hard capsule filling machine connects blister packaging machine or bottling equipment to send the capsule midbody that obtains into blister packaging machine carries out the blister packaging or send into bottling equipment and mould the bottle packing, the tablet press is connected the capsule machine is sent into with the plain piece that the preforming was handled to the capsule machine, the capsule machine is connected blister packaging machine or bottling equipment are sent into with the coated tablet piece behind the capsule packaging machine carries out blister packaging or bottling equipment and bottles.

2. The oral solids manufacturing line of claim 1, wherein the granulation equipment comprises one of a whole grain wet mix granulator, a boiling granulator, and combinations thereof.

3. The oral solid dose production line of claim 1, wherein the bottling equipment comprises a high-speed intelligent bottle straightening machine, a tablet counting machine, a high-speed intelligent linear cap screwing machine and an electromagnetic sealing machine, the high-speed intelligent bottle straightening machine is connected with a bottle feeding end of the tablet counting machine, the coating machine is connected with a medicine feeding end of the tablet counting machine, a discharge end of the tablet counting machine is connected with a bottle feeding end of the high-speed intelligent linear cap screwing machine, and the high-speed intelligent linear cap screwing machine is connected with a feed end of the electromagnetic sealing machine.

4. The oral solid dose production line of claim 1 further comprising an overwrapping system to which both the blister pack machine and the discharge end of the bottling equipment are connected.

5. The production line of claim 4, wherein the external packing system comprises a labeling machine, an automatic boxing machine, an online weighing machine, a domino laser machine, a full-automatic film bundling machine, a full-automatic unpacking and sealing all-in-one machine, an instant labeling machine and an unmanned packing machine which are connected in sequence, the blister packing machine is connected with the automatic boxing machine, and the bottling device is connected with the labeling machine.

6. The oral solid dosage production line of claim 5, wherein the discharge end of the unmanned baler is connected to a hoist.

7. The oral solid dose manufacturing line of claim 4, wherein the overwrap system is disposed in a general manufacturing area.

8. The oral solid dose production line of claim 1, wherein the comminuting equipment, the granulating equipment, the hard capsule filling machine, the tablet press, the enrobing machine, the blister packaging machine, and the bottling equipment are all located in a class D clean zone.

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