CN218567381U

CN218567381U - Dry type fluorescence immunoassay instrument

Info

Publication number: CN218567381U
Application number: CN202222591601.7U
Authority: CN
Inventors: 谭大喜; 李青峰; 林文祥; 齐岳; 雷宇
Original assignee: MGI Tech Co Ltd
Current assignee: MGI Tech Co Ltd
Priority date: 2022-09-29
Filing date: 2022-09-29
Publication date: 2023-03-03
Anticipated expiration: 2032-09-29

Abstract

The utility model discloses a dry type fluorescence immunoassay analyzer, which belongs to the technical field of immunoassay, and comprises a shell, a display screen, a driving mechanism and a fluorescence detector, wherein the shell is provided with a socket; the display screen is arranged on the shell; the driving mechanism is arranged in the shell and comprises a driving component and a clamping block, a detection channel capable of receiving a reagent card is formed on the clamping block, an inlet of the detection channel is arranged opposite to the socket, an opening is formed in one side of the detection channel, and the driving component can drive the clamping block to move linearly; the fluorescence detector is disposed within the housing and directly opposite the opening of the detection channel. The detection result is displayed by the display screen, so that the operator can observe the detection result visually, and the time is saved. The whole machine has small volume, is convenient to carry and has low cost. The reagent card is received through the clamping block so as to limit the reagent card, and the accuracy of a detection result is ensured.

Description

Dry type fluorescence immunoassay instrument

Technical Field

The utility model relates to an immunoassay technical field especially relates to a dry-type fluorescence immunoassay appearance.

Background

The fluorescence effect refers to that when high-energy short-wavelength light rays are emitted into certain substances, electrons in the substances absorb energy and transition from a ground state to a high energy level; because the electrons are unstable at a high energy level, the electrons transit from the high energy level to a low energy level, and release energy to emit fluorescence, which is a fluorescence effect. In an immune response, two basic concepts are antigen and antibody. Antigens are substances that stimulate the immune system of the animal body, induce an immune response, produce antibodies to humoral immunity and/or effector lymphocytes to cellular immunity, and react with them in vitro. Antibodies are glycoproteins produced by B lymphocytes in the body in an immune response to antigen stimulation. Immunoassay technology has been developed rapidly due to its characteristics of rapidness, simplicity, economy, single-person detection, etc., and has been widely used in medical detection, food quality monitoring, drug detection, and environmental monitoring.

A fluorescence analyzer is an apparatus for detecting fluorescence using a fluorescent substance. The immunochromatographic test strip is provided with fluorescein, after the immunochromatographic test strip is irradiated by an excitation light source and absorbs incident light with a certain wavelength, the fluorescence which is slightly longer than the wavelength of the incident light can be emitted, when the light source stops irradiation, the emitted light disappears, the fluorescein is used as a marker and is combined with a known antibody, but the immunological characteristics of the antibody are not influenced, then the fluorescein-marked antibody is used as a standard reagent for detecting and identifying unknown antigen, after the antigen and the antibody carry out immunoreaction, the fluorescein combined with the antibody is released, the more the antigen which is immunoreactive with the antibody is, the more the released fluorescein is, the more fluorescence is generated by the fluorescence effect, and conversely, the generated fluorescence is less, the content of the corresponding antigen in a detected object can be known by converting the fluorescence intensity into an electric signal and analyzing the electric signal.

The current dry type fluorescence immunoassay analyzer has large volume, is inconvenient to carry and is inconvenient for outdoor operation; and the data automation degree is low, the data needs to be transmitted to another device for analysis after being acquired, the detection result cannot be accurately obtained within the specified time, and time and labor are wasted.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a dry-type fluorescence immunoassay appearance to solve the technical problem that portable, data transmission wastes time and energy that exist among the prior art.

As the above conception, the utility model discloses the technical scheme who adopts is:

a dry fluoroimmunoassay analyzer comprising:

the shell is provided with a socket;

the display screen is arranged on the shell;

the driving mechanism is arranged in the shell and comprises a driving assembly and a clamping block, a detection channel capable of receiving a reagent card is formed on the clamping block, an inlet of the detection channel is arranged opposite to the socket, an opening is formed in one side of the detection channel, and the driving assembly can drive the clamping block to move linearly;

a fluorescence detector disposed within the housing and directly opposite the opening of the detection channel.

The inner wall of the detection channel is provided with an elastic clamping protrusion, and the elastic clamping protrusion can clamp the reagent card.

One end of the elastic clamping protrusion is connected with the inner wall of the detection channel, and the other end of the elastic clamping protrusion is a free end.

The fixture block is of a split structure and comprises two clamping plates which are arranged at intervals, the clamping plates are L-shaped, and the detection channel is formed between the two clamping plates; or the clamping block is of an integrally formed structure.

The driving assembly comprises a motor and a screw rod, the motor can drive the screw rod to rotate, a sliding block is connected to the screw rod through threads, and the sliding block is connected with the clamping block.

Wherein, be provided with the fixed plate in the shell, the motor with fluorescence detector all with fixed plate fixed connection.

The shell comprises an upper shell, a lower shell and a cover plate, the upper shell and the lower shell are buckled to form a containing cavity, the driving mechanism and the fluorescence detector are located in the containing cavity, and the cover plate is arranged at an opening of the containing cavity.

Wherein, the entrance of the detection channel is provided with a guide inclined plane.

One end of the fluorescence detector, which is close to the socket, is provided with a scanning piece, and the scanning piece can scan a bar code on the reagent card.

Wherein, the socket is provided with at least two, is provided with a set of actuating mechanism and one fluorescence detector corresponding to each socket.

The utility model has the advantages that:

the utility model provides a dry-type fluorescence immunoassay appearance, when using, open through display screen control test process and stop, after the start, insert the reagent card in the socket of shell, because form the sense passage that can receive the reagent card on the fixture block, and sense passage's entry is just to the socket setting, therefore the reagent card can insert in the sense passage and be spacing by the sense passage, when testing, drive assembly drives the fixture block and removes, it removes to drive the reagent card promptly, make fluorescence detector detect reagent card comprehensively, the opening that one side of sense passage formed is convenient for fluorescence detector and is detected the reagent card, the testing result is shown by the display screen, the operator of being convenient for is directly perceived to be observed, need not frequent transmission data, save time. Because each part is integrated in the shell, the whole machine has small volume, is convenient to carry and has low cost. The reagent card is limited through the detection channel on the clamping block, so that the reagent card is stable in position, relative displacement cannot occur, and the accuracy of a detection result is ensured.

Drawings

Fig. 1 is a schematic structural diagram of a dry type fluorescence immunoassay analyzer provided by an embodiment of the present invention;

FIG. 2 is a schematic structural diagram II of a dry fluoroimmunoassay analyzer according to an embodiment of the present invention;

fig. 3 is a front view of a dry type fluorescence immunoassay analyzer according to an embodiment of the present invention;

FIG. 4 is a schematic view showing an exploded structure of a dry fluoroimmunoassay analyzer according to an embodiment of the present invention;

fig. 5 is a schematic view of an exploded structure of a dry type fluorescence immunoassay analyzer according to an embodiment of the present invention;

FIG. 6 is a schematic view of a part of a dry fluoroimmunoassay analyzer according to an embodiment of the present invention;

FIG. 7 is a side view of FIG. 6;

fig. 8 is a partial structural schematic view of fig. 6.

In the figure:

100. a reagent card;

11. a housing; 110. a socket; 111. an upper shell; 112. a lower case; 113. a cover plate; 114. a rubber plug; 115. a switch key;

21. a display screen; 22. a main control board; 23. a cushion pad;

31. a drive assembly; 311. a motor; 312. a screw rod; 32. a clamping block; 321. a detection channel; 3210. a guide slope; 322. elastic clamping protrusions; 323. clamping a plate; 33. an adapter plate; 34. a microswitch; 35. a signal plate;

41. a fluorescence detector;

51. a battery; 52. a power panel;

61. and (5) fixing the plate.

Detailed Description

Reference will now be made in detail to the embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, unless otherwise explicitly specified or limited, the terms "connected", "connected" and "fixed" are to be construed broadly, e.g., as being fixedly connected, detachably connected, or integrated; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In the present disclosure, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise direct contact between the first and second features, or may comprise contact between the first and second features not directly. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

The technical solution of the present invention is further explained by the following embodiments with reference to the accompanying drawings.

Referring to fig. 1 to 8, the embodiment of the present invention provides a dry-type fluorescence immunoassay analyzer, which includes a housing 11 and a display screen 21, wherein the display screen 21 is disposed on the housing 11, which may be specifically a front surface of the housing 11, the housing 11 is provided with a socket 110, and the socket 110 can be inserted into a reagent card 100. All the parts are integrated in the shell 11, so that the whole machine has small volume and complete functions and is convenient to carry.

The housing 11 is internally provided with a driving mechanism, a fluorescence detector 41 and a storage battery 51, the driving mechanism is used for driving the reagent card 100 to move, the fluorescence detector 41 detects the reagent card 100, and the storage battery 51 supplies power to the display screen 21, the driving mechanism and the fluorescence detector 41.

Specifically, the housing 11 includes an upper shell 111, a lower shell 112 and a cover plate 113, the upper shell 111 and the lower shell 112 are fastened to form a containing cavity, the driving mechanism, the fluorescence detector 41 and the battery 51 are located in the containing cavity, and the cover plate 113 is disposed at an opening of the containing cavity. The cover plate 113 is clamped between the upper shell 111 and the lower shell 112, the upper end and the lower end of the cover plate 113 are both provided with a limiting groove, limiting protrusions are arranged on the upper shell 111 and the lower shell 112, the limiting protrusions are inserted into the limiting grooves to limit the cover plate 113, and the upper shell 111 and the lower shell 112 are connected through screws.

The front surface of the upper shell 111 is provided with an opening, and the display screen 21 is located at the opening, wherein the display screen 21 is a touch screen. Be provided with main control board 22 in the shell 11, display screen 21 is connected with main control board 22 electricity, presss from both sides between display screen 21 and the main control board 22 and is equipped with blotter 23 to protect display screen 21. The back of the lower case 112 is provided with a label and a counter bore for the screw to pass through.

The driving mechanism comprises a driving component 31 and a clamping block 32, a detection channel 321 capable of receiving the reagent card 100 is formed on the clamping block 32, an inlet of the detection channel 321 is arranged opposite to the socket 110, an opening is formed on one side of the detection channel 321, and the driving component 31 can drive the clamping block 32 to move linearly; the fluorescence detector 41 faces the opening of the detection channel 321. During the movement of the card block 32, the reagent card 100 moves, and the fluorescence detector 41 detects the reagent card 100.

In this embodiment, the latch 32 is capable of engaging the reagent card 100. The inner wall of the detection channel 321 is provided with an elastic clamping protrusion 322, and the elastic clamping protrusion 322 can clamp the reagent card 100, so that relative displacement between the reagent card 100 and the clamping block 32 is avoided, the position stability of the reagent card 100 is ensured, and the detection result is accurate. In this embodiment, the bottom wall and the side wall of the detecting channel 321 are provided with elastic protrusions 322.

One end of the elastic clamping protrusion 322 is connected with the inner wall of the detection channel 321, and the other end of the elastic clamping protrusion 322 is a free end. Specifically, a notch is formed in the inner wall of the detection channel 321, the elastic clamping protrusion 322 is located at the notch, and one end of the elastic clamping protrusion 322 is connected with the inner wall of the notch. When the reagent card 100 enters the detection channel 321, the reagent card 100 presses the elastic protrusions 322, so that the elastic protrusions 322 are elastically deformed to clamp the reagent card 100.

The entrance of the detecting channel 321 is provided with a guiding inclined plane 3210, and when the reagent card 100 is inserted, the reagent card 100 can smoothly slide into the detecting channel 321 along the guiding inclined plane 3210. Specifically, the guiding slope 3210 is configured such that the entrance of the detecting channel 321 is flared to facilitate receiving the reagent card 100.

The latch 32 may be formed integrally or may be formed separately. In this embodiment, the fixture block 32 is a split structure, the fixture block 32 includes two clamping plates 323 arranged at intervals, the clamping plates 323 are L-shaped, and a detection channel 321 is formed between the two clamping plates 323. Through the split arrangement, the distance between the two clamping plates 323 can be conveniently adjusted to change the size of the detection channel 321, so that the reagent card 100 with different sizes can be adapted.

In this embodiment, the driving assembly 31 includes a motor 311 and a lead screw 312, the motor 311 can drive the lead screw 312 to rotate, a slider is screwed on the lead screw 312, and the slider is connected with the fixture block 32. Specifically, the slider is connected to the fixture block 32 through the adapter plate 33, and when the screw 312 rotates, the slider moves linearly along the screw 312, so as to drive the adapter plate 33 and the fixture block 32 to move linearly. The screw rod 312 and the sliding block are adopted for matching transmission, so that the occupied space is small, and the transmission precision is high. In other embodiments, the driving assembly 31 may be a motor 311, a gear and a rack, the motor 311 can drive the gear to rotate, the gear can drive the rack to move linearly, and the latch 32 is connected to the rack. Specifically, the rack is disposed on one side of the latch 32 and extends along the moving direction of the latch 32, and the latch 32 is fixedly connected to the side surface of the rack, which may be locked by a bolt. The rack and the shell 11 can be in sliding fit through a sliding rail.

The adapter plate 33 is used for connecting the slider and the latch 32. In this embodiment, the adapter plate 33 is bent in a zigzag shape, and the fixture block 32 and the adapter plate 33 are connected by bolts, so that the installation and the disassembly are convenient. Specifically, a plurality of bolt holes may be provided on the adapter plate 33, which facilitates adjusting the position of the clamp plate 323.

The fluorescence detector 41 is opposite to the opening of the detection channel 321, so as to facilitate the detection of the reagent card 100. In order to ensure the relative position accuracy, a fixing plate 61 is disposed in the housing 11, the motor 311 and the fluorescence detector 41 are both fixedly connected to the fixing plate 61, the motor 311 is disposed on the fixing plate 61, the fixture block 32 can move relative to the fixing plate 61, and the fluorescence detector 41 is disposed on the fixing plate 61 for facilitating the detection. In this embodiment, the fixing plate 61 is a U-shaped plate, and the motor 311 is mounted on one side arm of the fixing plate 61, and the fluorescence detector 41 is mounted on the other side arm.

Further, a scanning member is provided in the housing 11, and the scanning member can scan a bar code on the reagent card 100. Specifically, a scanning element may be coupled to the end of fluorescence detector 41 near socket 110, and may be scanned when reagent card 100 is inserted.

The socket 110 is disposed on the cover plate 113, the detecting channel 321 extends along a first straight line, and an included angle between the cover plate 113 and the first straight line is an acute angle. That is, the cover plate 113 is disposed obliquely with respect to the upper case 111 and the lower case 112, as shown in fig. 3, the oblique disposition of the cover plate 113 facilitates the operator to view the insertion opening 110, and facilitates the smooth insertion of the reagent card 100.

In this embodiment, the receptacles 110 are provided one at a time to allow for the detection of one reagent card 100 at a time. In other embodiments, at least two sockets 110 may be provided, and a set of driving mechanism and a fluorescence detector 41 are provided corresponding to each socket 110, so that at least two reagent cards 100 can be detected at a time, thereby improving the detection efficiency. The wavelength bands of the two fluorescence detectors 41 on the same machine may be different to extend the range of use.

A microswitch 34 is further arranged in the housing 11, the microswitch 34 is used for controlling the moving stroke of the fixture block 32, and when the adapter plate 33 touches the signal switch, the adapter plate 33 is moved in place. A signal plate 35 is further arranged in the shell 11, and the micro switch 34 is electrically connected with the signal plate 35. A buzzer is also arranged in the housing 11 for emitting a prompt sound to prompt an operator.

Be provided with a plurality of interface on the shell 11, including USB interface, type-C interface and Dp interface, the kneck is provided with rubber buffer 114, plays dustproof effect. The storage battery 51 can be charged through the type-C interface, and the complete machine can be connected with other equipment through the USB interface to complete data transmission.

The housing 11 is further provided with a switch key 115, and the power-on or power-off can be realized by pressing the switch key 115. Specifically, a power supply board 52 is arranged in the housing 11, and the storage battery 51, the main control board 22, the signal board 35 and the switch key 115 are all electrically connected with the power supply board 52. A bluetooth module may be disposed in the housing 11 for connecting with an external bluetooth module to complete data transmission.

When the device is used, the switch key 115 controls the whole device to be started, the reagent card 100 is inserted into the socket 110 of the shell 11, the detection channel 321 capable of clamping the reagent card 100 is formed on the fixture block 32, and the inlet of the detection channel 321 is opposite to the socket 110, so that the reagent card 100 can be inserted into the detection channel 321 and clamped by the detection channel 321; control the testing process through display screen 21 and begin, drive assembly 31 drives fixture block 32 and removes, drives reagent card 100 and removes promptly for fluorescence detector 41 detects reagent card 100 comprehensively, and the opening that the top of detecting channel 321 formed is convenient for fluorescence detector 41 to detect reagent card 100, and the testing result is shown by display screen 21, and the operator of being convenient for is directly perceived to be observed, saves time. After the test is finished, the display screen 21 controls the test process to be finished, the driving assembly 31 drives the clamping block 32 to move reversely, when the adapter plate 33 triggers the micro switch 34, the motor 311 stops, and at this time, the reagent card 100 can be drawn out. The next detection or shutdown may be performed.

The above embodiments have only been explained the basic principle and characteristics of the present invention, the present invention is not limited by the above embodiments, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these changes and modifications all fall into the scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A dry-type fluoroimmunoassay analyzer, comprising:

the shell (11), wherein a socket (110) is arranged on the shell (11);

a display screen (21) disposed on the housing (11);

the driving mechanism is arranged in the shell (11) and comprises a driving component (31) and a clamping block (32), a detection channel (321) capable of receiving a reagent card (100) is formed on the clamping block (32), an inlet of the detection channel (321) is arranged right opposite to the socket (110), an opening is formed in one side of the detection channel (321), and the driving component (31) can drive the clamping block (32) to move linearly;

a fluorescence detector (41) disposed within the housing (11) and facing the opening of the detection channel (321).

2. The dry fluoroimmunoassay analyzer of claim 1, wherein the inner wall of the detection channel (321) is provided with an elastic protrusion (322), and the elastic protrusion (322) can clamp the reagent card (100).

3. The dry fluoroimmunoassay analyzer of claim 2, wherein one end of the elastic protrusion (322) is connected to an inner wall of the detection channel (321), and the other end of the elastic protrusion (322) is a free end.

4. The dry fluoroimmunoassay analyzer as set forth in claim 1, wherein the fixture block (32) is a split structure, the fixture block (32) comprises two clamping plates (323) arranged at intervals, the clamping plates (323) are L-shaped, and the detection channel (321) is formed between the two clamping plates (323); or the fixture block (32) is of an integrally molded structure.

5. The dry fluoroimmunoassay analyzer as set forth in claim 1, wherein the driving assembly (31) comprises a motor (311) and a lead screw (312), the motor (311) can drive the lead screw (312) to rotate, a slider is screwed on the lead screw (312), and the slider is connected with the fixture block (32).

6. The dry fluoroimmunoassay analyzer as set forth in claim 5, wherein a fixing plate (61) is provided in the housing (11), and both the motor (311) and the fluorescence detector (41) are fixedly connected to the fixing plate (61).

7. The dry fluoroimmunoassay analyzer as set forth in claim 1, wherein the housing (11) comprises an upper case (111), a lower case (112) and a cover plate (113), the upper case (111) and the lower case (112) are fastened to form a receiving chamber, the driving mechanism and the fluorescence detector (41) are both located in the receiving chamber, and the cover plate (113) is disposed at an opening of the receiving chamber.

8. The dry fluoroimmunoassay analyzer of claim 1, wherein an entrance of the detection channel (321) is provided with a guide slope (3210).

9. The dry fluoroimmunoassay analyzer of claim 1, wherein an end of the fluorescence detector (41) near the socket (110) is provided with a scanning member capable of scanning a bar code on the reagent card (100).

10. The dry fluoroimmunoassay analyzer as set forth in claim 1, wherein the sockets (110) are provided in at least two, and a set of the drive mechanism and one of the fluorescence detectors (41) are provided for each of the sockets (110).