CN218546602U - Expiration analysis device - Google Patents
Expiration analysis device Download PDFInfo
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- CN218546602U CN218546602U CN202222783437.XU CN202222783437U CN218546602U CN 218546602 U CN218546602 U CN 218546602U CN 202222783437 U CN202222783437 U CN 202222783437U CN 218546602 U CN218546602 U CN 218546602U
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- gas
- air
- flow controller
- pipe
- humidity
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- 238000004458 analytical method Methods 0.000 title claims description 7
- 239000007789 gas Substances 0.000 claims description 58
- 238000012360 testing method Methods 0.000 claims description 35
- 239000011521 glass Substances 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 6
- -1 polytetrafluoroethylene Polymers 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 6
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical class [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000011540 sensing material Substances 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229910021389 graphene Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000002073 nanorod Substances 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 14
- 238000001514 detection method Methods 0.000 abstract description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 8
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 description 1
- 238000005085 air analysis Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 239000010340 shenyuan Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229960000744 vinpocetine Drugs 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to an expiration analytical equipment can be used to the expiration analytical equipment who does not have the wound detection diabetes mellitus patient's state of an illness belongs to medical instrument technical field. The device comprises two parts, namely a human body breath collecting/transmitting part; a gas sensing responsive section. The device can be used for detecting the acetone concentration in human breath, and then judging whether the breath owner has diabetes by comparing the acetone concentrations in different breathes.
Description
Technical Field
The utility model relates to an expiration analytical equipment, it is specific that can be used to not have the expiration analytical equipment who has the wound detection diabetes patient's state of an illness, belong to medical instrument technical field.
Background
At present, the diagnosis means of diabetes mainly comprises blood component detection and urine component detection. Both of these detection methods usually require a certain analysis time and the related instruments are expensive. In addition, blood drawing can cause some damage to the patient's body. The method can preliminarily diagnose the illness state of the diabetic by detecting the concentration of the diabetes markers such as acetone and the like in the breath of the patient, and has the advantages of short time consumption, no wound, lower equipment cost and the like.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is: an exhalation analysis apparatus is provided. The utility model discloses an expiration analytical equipment can be used to the noninvasive detection diabetes patient and state of an illness, can judge whether the owner of this sample has the diabetes through the sensor response difference of comparison sensor to the expiration of different samples. Compared with the traditional diagnosis method, the method is quicker, more convenient and lower in cost, and can realize noninvasive examination.
The utility model discloses a solve the technical scheme that above-mentioned technical problem provided and be: an expired air analysis device for non-invasive detection of diabetes patients comprises two parts, wherein the part 1 is a human expired air collection/transmission part which mainly comprises an air collection bag, an air pump, an air flow rate controller and a humidity controller; wherein the volume of the air collecting bag is 500mL, and the air collecting bag is purchased from Shanghai Shenyuan scientific instruments GmbH; the air pump is a miniature air pump purchased from Chengdu Hailin technology limited, the working voltage is 5V, the peak flow is more than or equal to 0.4L/min, and the size is as follows: the length is 50mm, the width is 29mm and the height is 36mm. The gas flow rate controller can control the flow rate of gas during transmission, the diameter of a gas inlet interface of the gas flow rate controller is 4mm, the diameter of a gas outlet interface of the gas flow rate controller is 4mm, the flow rate of the gas can be controlled at 0.4-1L/min, and the gas flow rate controller is purchased from Chengdu Hailin technology limited company. The humidity controller consists of a closed 500mL glass bottle and two glass air delivery pipes, and 300mL of saturated magnesium nitrate solution is put into the glass bottle. The glass gas pipe has a pore size of 4mm and is inserted into the sealed glass bottle in a long and short way. The long pipe is a gas pipe and is inserted to the position 1cm above the liquid level of the saline solution, and the short pipe is a gas outlet pipe and is inserted to the position 2cm away from the sealing buckle.
Section 2 is the gas test section. The part 2 mainly comprises a test cavity, a gas sensor and a data acquisition unit. The testing cavity is composed of a polytetrafluoroethylene cylinder with the radius of 15cm and the height of 5cm, a rectangular groove with the length of 10cm, the width of 7cm and the depth of 4cm is dug in the center of the polytetrafluoroethylene cylinder and used for placing a gas sensor, and in order to achieve a sealing effect, the testing cavity is additionally provided with a gasket with the inner diameter of 12cm and the outer diameter of 12.2cm and a sealing cover with the radius of 15cm and the height of 0.5 cm. Through holes with the diameter of 4mm are drilled outwards at the two sides of the test cavity and 1cm away from the bottom of the groove respectively to serve as an air outlet and an air inlet. The gas sensor consists of gold interdigital electrodes purchased from vinpocetine Fenbory technologies, inc. and a gas sensing material (multiple hydrogen bond organic supramolecular nanorod/graphene oxide compound). The electrode is arranged in the groove of the test cavity, two ends of the electrode are welded with the two wires, and the other end of the wire penetrates through the through hole to be connected with the data acquisition unit.
The peak output flow of the air pump is more than 0.4L/min, a humidity controller is used for adopting a saturated magnesium nitrate solution, the output port of the air transmission port is positioned at the upper end 1cm of the liquid level of the saline solution, and the size of the test chamber is 10 multiplied by 7 multiplied by 4cm 3 The gas sensing material is a multiple hydrogen bond organic supermolecule nanorod/graphene oxide compound.
All the parts are connected by a soft air pipe with the aperture of 4 mm.
Has the advantages that:
when the device is used, the air collecting bag filled with sample expiration is connected with the air inlet of the air pump, and the air outlet of the air pump is connected with the air inlet of the flow controller. The air outlet of the flow controller is connected with the air inlet pipe of the humidity controller, and the air outlet of the humidity controller is connected with the air inlet of the test cavity.
The flow rate (0.4-1L/min) can be adjusted appropriately according to the difference of atmospheric humidity.
Since the humidity of the human breath is RH =100%, which is much higher than the ambient humidity, the humidity in the test chamber will rise significantly after ventilation. In order to solve the influence of humidity change to gas sensitive response around ventilating, the utility model discloses use the expiration humidity that humidity controller will let in to drop to about 50%, show the humidity change of test intracavity around ventilating. The humidity change of the test chamber before and after ventilation is 45% → 90% before and after the humidity controller is provided, and the humidity change of the test chamber before and after ventilation is 45% → 50% after and after the humidity controller is provided (taking the case that the ambient humidity is 45%).
Unlike other similar products that remove moisture from the breath directly prior to breath testing to eliminate the effect of humidity on the sensor, some of the moisture in the breath is retained in this example. This is because disease markers such as acetone and the like exhaled by the diabetic patient are very soluble in water, and direct removal of water will affect the detection result of the sensor on the water-soluble disease markers. This embodiment retains a part of moisture in the exhaled breath by the humidity control device, contributing to the improvement of the detection performance of the device.
The invention is not limited to the specific technical solutions described in the above embodiments, and all technical solutions formed by equivalent substitutions are within the scope of the invention as claimed.
Drawings
The present invention will be further explained with reference to the accompanying drawings.
Fig. 1 is a schematic structural diagram of embodiment 1 of the present invention.
Fig. 2 is a schematic view of the structure of the humidity controller.
FIG. 3 is a schematic diagram of a test chamber.
Figure 4 is a graph comparing the response of the test device to three normal persons and three diabetic patients exhaling.
Detailed Description
Example 1
The simple schematic diagram of this embodiment is shown in fig. 1, and includes a gas collecting bag, a gas pump, a gas flow controller, a humidity control device, and a gas sensitive test chamber.
As shown in figure 2, the humidity control device consists of a closed 500mL glass bottle and two glass air delivery pipes, and 300mL of saturated magnesium nitrate solution is put into the glass bottle. The glass gas pipe has a pore size of 4mm and is inserted into the sealed glass bottle in a long and short way. The long pipe is a gas pipe and is inserted to the position 1cm above the liquid level of the saline solution, and the short pipe is a gas outlet pipe and is inserted to the position 2cm away from the sealing buckle.
As shown in FIG. 3, the test chamber is composed of a polytetrafluoroethylene cylinder with a radius of 10cm and a height of 2cm, a rectangular groove with a length of 12cm, a width of 8cm and a depth of 1.2cm is dug in the center of the polytetrafluoroethylene cylinder for placing the gas sensor, and a gasket with an inner diameter of 8cm and an outer diameter of 8.2cm and a sealing cover with a radius of 15cm and a height of 0.5cm are additionally arranged for achieving a sealing effect. Through holes with the diameter of 4mm are drilled outwards at the two sides of the test cavity and the position with the center 0.4cm away from the bottom of the groove respectively to serve as an air outlet and an air inlet. To tightly connect the sealing cap and the cylindrical vessel, six screw holes were drilled equally at 0.9cm from the center by M4 tapping.
When the device is used, the air collecting bag filled with sample expiration is connected with the air inlet of the air pump, and the air outlet of the air pump is connected with the air inlet of the flow controller. The air outlet of the flow controller is connected with the air inlet pipe of the humidity controller, and the air outlet of the humidity controller is connected with the air inlet of the testing cavity provided with the gas sensor. And when the environmental humidity RH is less than or equal to 50%, recording the current environmental humidity, then opening the pump, opening all the air valves, opening the data acquisition unit, and adjusting the flow controller to be 0.5L/min. And after 1min, closing the air pump, removing the air collecting bag, closing all air valves, and standing the test chamber. After waiting for 1h, the test chamber is opened, the air pump is opened, all the air valves are opened, and the air is ventilated for 2min. The exhalation test may be performed again when the ambient humidity again coincides with the humidity at the time of the last test.
The resistance of the gas sensor when the pump is not on is recorded as R 0 The real-time resistance of the gas sensor at the time of the test is recorded as R, and the gas sensitive response of the gas sensor is recorded as Δ R = (R-R) 0 )/R 0 *100 percent. As shown in fig. 4, the test was performed using the expired air of three normal persons and three diabetic persons as a sample (the ambient humidity at the time of the test was RH = 45%). After testing, the sensor was found to respond approximately ar = -45% to normal exhalation and at least 50% to patient exhalation. Three patients had expiratory responses of-50%, -5%, respectively7%, -60%. From the response results, it can be found that the expiratory response of the patient is significantly larger than that of a normal person. The device can accurately distinguish the expired air of a diabetic patient and a normal person by measuring the gas-sensitive response of the gas sensor, and assists a doctor in diagnosing and treating diabetes.
The present invention is not limited to the above embodiments. All technical solutions formed by equivalent substitutions fall within the protection scope of the present invention.
Claims (3)
1. The breath analysis device is characterized by comprising two parts, wherein the part 1 is a human breath collection/transmission part and mainly comprises a gas collection bag, a gas pump, a gas flow controller and a humidity control device; wherein the volume of the air collecting bag is 500mL, the air pump is a micro air pump, the working voltage is 5V, the peak flow is more than or equal to 0.4L/min, and the size is as follows: the length is 50mm, the width is 29mm, and the height is 36 mm; the gas flow controller can control the flow rate of gas during transmission, the diameter of a gas inlet interface of the gas flow controller is 4mm, the diameter of a gas outlet interface of the gas flow controller is 4mm, and the gas flow can be controlled to be 0.4-1L/min; the humidity control device consists of a closed 500mL glass bottle and two glass gas conveying pipes, wherein 300mL of saturated magnesium nitrate solution is put into the glass bottle, the aperture size of the glass gas conveying pipes is 4mm, the glass gas conveying pipes are inserted into the closed glass bottle in a long and short way, the long pipe is a gas conveying pipe and is inserted to the position 1cm away from the upper end of the liquid level of the saline solution, and the short pipe is a gas outlet pipe and is inserted to the position 2cm away from the sealing buckle; part 2 is a gas test part;
the part 2 mainly comprises a testing cavity, a gas sensor and a data acquisition unit, wherein the testing cavity consists of a polytetrafluoroethylene cylinder with the radius of 15cm and the height of 5cm, a rectangular groove with the length of 10cm, the width of 7cm and the depth of 4cm is dug in the center of the polytetrafluoroethylene cylinder for placing the gas sensor, and in order to achieve the sealing effect, the testing cavity is provided with a gasket with the inner diameter of 12cm and the outer diameter of 12.2cm and a sealing cover with the radius of 15cm and the height of 0.5 cm; through holes with the diameter of 4mm are drilled outwards at the positions, 1cm away from the bottom of the groove, of the two sides of the test cavity respectively to serve as an air outlet and an air inlet, and the gas sensor is composed of a gold interdigital electrode and a gas sensing material; the gold interdigital electrode is arranged in the groove of the test cavity, two ends of the gold interdigital electrode are welded with the two wires, and the other end of the wire penetrates through the through hole to be connected with the data collector;
the air collecting bag is connected with an air inlet of the air pump, and an air outlet of the air pump is connected with an air inlet of the flow controller; the gas outlet of the flow controller is connected with the gas inlet pipe of the humidity control device, and the gas outlet of the humidity control device is connected with the gas inlet of the test cavity.
2. The breath analysis apparatus of claim 1, wherein: the gas sensing material is a multiple hydrogen bond organic supermolecule nanorod/graphene oxide compound.
3. The breath analysis apparatus of claim 1, wherein: the peak output flow of the air pump is more than 0.4L/min, a humidity controller is used for adopting a saturated magnesium nitrate solution, the output port of the air transmission port is positioned at the upper end 1cm of the liquid level of the saline solution, and the size of the test chamber is 10 multiplied by 7 multiplied by 4cm 3 。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202222783437.XU CN218546602U (en) | 2022-10-21 | 2022-10-21 | Expiration analysis device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN202222783437.XU CN218546602U (en) | 2022-10-21 | 2022-10-21 | Expiration analysis device |
Publications (1)
Publication Number | Publication Date |
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CN218546602U true CN218546602U (en) | 2023-02-28 |
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Family Applications (1)
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CN202222783437.XU Active CN218546602U (en) | 2022-10-21 | 2022-10-21 | Expiration analysis device |
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2022
- 2022-10-21 CN CN202222783437.XU patent/CN218546602U/en active Active
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