CN218516219U - Telmisartan intermediate filter-pressing and drying integrated machine - Google Patents
Telmisartan intermediate filter-pressing and drying integrated machine Download PDFInfo
- Publication number
- CN218516219U CN218516219U CN202222680205.1U CN202222680205U CN218516219U CN 218516219 U CN218516219 U CN 218516219U CN 202222680205 U CN202222680205 U CN 202222680205U CN 218516219 U CN218516219 U CN 218516219U
- Authority
- CN
- China
- Prior art keywords
- filter
- pressing
- tank body
- tank
- lower cover
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The utility model relates to a telmisartan intermediate filter-pressing and drying integrated machine, which comprises a bracket and a filter-pressing tank, wherein the filter-pressing tank comprises a tank body, an upper cover and a lower cover, a rotary supporting shaft is arranged in the middle of the tank body, and the upper cover is provided with a mixed liquid inlet, a first nitrogen inlet and outlet and a discharge hole; the lower cover is provided with a mother liquor outlet and a second nitrogen inlet and outlet; a filter plate is also arranged between the tank body and the lower cover; the outer side of the tank body is also provided with a jacket, an annular cavity is formed between the jacket and the outer wall of the tank body, the jacket is provided with a first connector and a second connector which are communicated with the annular cavity, and cold water or hot water is injected into the annular cavity to cool or heat the tank body; the nitrogen is used as the driving force for filter pressing, so that the tank is simple in structure, good in filter pressing reliability and high in nitrogen filter pressing safety coefficient, the nitrogen is used as the common protective gas in the drug production process, the existing nitrogen supply equipment in a factory can be utilized, and the nitrogen filter pressing device is convenient to popularize and use; can carry out drying operation after the filter pressing, and has high production efficiency.
Description
Technical Field
The utility model relates to a pharmaceutical equipment, especially a telmisartan midbody filter-pressing drying machine.
Background
The crystallization process of the intermediate methyl 4 '-bromomethylbiphenyl-2-carboxylate produced by telmisartan requires the use of petroleum ether as a crystallization solvent, and then the crystallization liquid of the methyl 4' -bromomethylbiphenyl-2-carboxylate is subjected to pressure filtration through a pressure filtration tank to separate crystals from mother liquor.
For example, in the Chinese patent document CN211462271U, "a filter-press tank for producing pharmaceutical intermediates, which is convenient for taking materials after filtration", the filter-press tank is provided with a pull plate with a mounting hole, so that the partition plate is convenient to replace, and the material guide mechanism and the material taking assembly are arranged, so that after filter pressing is completed, an upper tank and a lower tank do not need to be separated and then filter materials are taken out, the risk coefficient of the operation process is reduced, the materials can be conveniently taken by operators, the practicability is high, and the working efficiency of the filter-press tank is improved. In the disclosed technical scheme, materials to be subjected to filter pressing are added into a tank body through a feed hopper, fall onto a partition plate through a feed pipe, a lifting electric cylinder is started, a pressure plate is driven by a lifting driving mechanism to carry out filter pressing on the materials along the tank body, and separated liquid enters a discharge hopper through a liquid outlet hole in the partition plate and a baffle plate in a material guide mechanism; the filter pressing mode is complex in structure and poor in reliability, drying equipment is required to be used for drying after filter pressing, production efficiency is low, and improvement is needed urgently.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a telmisartan midbody filter-pressing drying machine for solve the problem that current filter-pressing equipment structure is complicated, the reliability is poor, can not carry out the stoving operation.
In order to solve the problems, the utility model provides a telmisartan intermediate filter-pressing and drying integrated machine, which comprises a bracket and a filter-pressing tank, wherein the filter-pressing tank comprises a tank body, an upper cover and a lower cover, a rotary supporting shaft is arranged in the middle of the tank body, and the tank body is rotatably arranged on the bracket through the rotary supporting shaft; the upper cover is provided with a mixed liquid inlet, a first nitrogen inlet and outlet and a discharge hole, and the discharge hole is positioned at the top of the upper cover; a mother liquor outlet and a second nitrogen inlet and outlet are formed in the lower cover, and the mother liquor outlet is positioned at the bottom of the lower cover; a filter plate is also arranged between the tank body and the lower cover; the outer side of the tank body is further provided with a jacket, an annular cavity is formed between the jacket and the outer wall of the tank body, the jacket is provided with a first connector and a second connector which are communicated with the annular cavity, the tank body can be cooled by injecting cold water into the annular cavity, and the tank body can be heated by injecting hot water into the annular cavity.
The utility model provides a telmisartan midbody filter-pressing drying machine still has following technical characteristic:
furthermore, one end of the rotating support shaft is also provided with a turntable.
Furthermore, a positioning disc is further arranged on the rotary supporting shaft, positioning holes are formed in the positioning disc, positioning blocks corresponding to the positioning disc are arranged on the support, and positioning pins capable of being inserted into the positioning holes are arranged on the positioning blocks.
Further, the filter plate is circular and outer along being equipped with annular mounting panel, be equipped with on the lower cover with the filter plate constant head tank of mounting panel adaptation, jar be equipped with on the body with the filter plate constant head tank of mounting panel adaptation, the lower cover with when the jar body passes through bolt fastening and links to each other the mounting panel clamp is established the lower cover with between the jar body.
Furthermore, an annular upper partition plate and an annular lower partition plate are further arranged in the jacket, and a plurality of through holes which are uniformly distributed are formed in the upper partition plate and the lower partition plate.
Furthermore, a plurality of vertical partition plates which are uniformly arranged are arranged between the upper partition plate and the lower partition plate.
Further, the inner side of the outer wall of the jacket is also provided with a heat insulation layer.
The utility model discloses following beneficial effect has: by adopting nitrogen as the driving force for filter pressing, the tank body has simple structure, good filter pressing reliability and high safety coefficient of the nitrogen filter pressing, and the nitrogen is used as the commonly used protective gas in the production process of the medicament, can utilize the existing nitrogen supply equipment in a factory and is convenient to popularize and use; can carry out drying operation after the filter pressing, and has high production efficiency.
Drawings
Fig. 1 is a schematic structural diagram of a telmisartan intermediate filter-pressing and drying integrated machine according to an embodiment of the present invention;
FIG. 2 is another view structure diagram of the integrated filter-press drying machine for telmisartan intermediates in FIG. 1;
fig. 3 is a schematic structural diagram of a tank body in an embodiment of the present invention;
FIG. 4 is a cross-sectional view of the can body of FIG. 3;
FIG. 5 is an enlarged view of a portion of FIG. 4 at A;
fig. 6 is a schematic structural view of a jacket according to an embodiment of the present invention;
fig. 7 is a schematic view of the inner structure of the jacket of fig. 6.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments. It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.
In the embodiment of the telmisartan intermediate filter-pressing and drying integrated machine of the present invention as shown in fig. 1 to 7, the telmisartan intermediate filter-pressing and drying integrated machine includes a support 10 and a filter-pressing tank, and is characterized in that the filter-pressing tank includes a tank body 20, an upper cover 30 and a lower cover 40, a rotating support shaft 21 is disposed in the middle of the tank body 20, and the tank body 10 is rotatably mounted on the support 10 through the rotating support shaft 21; the upper cover 30 is provided with a mixed liquid inlet 31, a first nitrogen inlet and outlet 32 and a discharge port 33, and the discharge port 33 is positioned at the top of the upper cover 30; a mother liquor outlet 41 and a second nitrogen inlet and outlet 42 are arranged on the lower cover 40, and the mother liquor outlet 41 is positioned at the bottom of the lower cover 40; a filter plate 50 is also arranged between the tank body 20 and the lower cover 40; the outer side of the tank body 20 is further provided with a jacket 60, an annular cavity is formed between the jacket 60 and the outer wall of the tank body 20, the jacket 60 is provided with a first connector 61 and a second connector 62 which are communicated with the annular cavity, the tank body 20 can be cooled by injecting cold water into the annular cavity, and the tank body 20 can be heated by injecting hot water into the annular cavity.
When the crystallization liquid of 4' -bromomethyl biphenyl-2-carboxylic acid methyl ester is subjected to filter pressing, firstly, the posture of a tank body is adjusted, the tank body is kept vertical, an upper cover is positioned above the tank body, a first nitrogen inlet and outlet 32 and a second nitrogen inlet and outlet 42 are closed, the crystallization liquid of 4' -bromomethyl biphenyl-2-carboxylic acid methyl ester is injected into the tank body through a mixed liquid inlet 31, then, the mixed liquid inlet 31 is closed, the first nitrogen inlet and outlet 32 is opened, nitrogen is injected into the tank body through the first nitrogen inlet and outlet 32, the mixed liquid in the tank body is subjected to filter pressing through nitrogen, mother liquid is discharged out of the tank body from a mother liquid outlet 41 at the bottom of a lower cover downwards through the filter plate, until no mother liquid is discharged from the mother liquid outlet 41, then, the first nitrogen inlet and outlet 32 is closed, the mixed liquid inlet 31 is opened, the crystallization liquid of 4' -bromomethyl biphenyl-2-carboxylic acid methyl ester is injected into the tank body through the mixed liquid inlet 31, the filter plate process is repeated until crystal particles on the upper side are accumulated to 1/2-2/3 position of a middle cylinder, filter pressing operation is finished, and each inlet and each outlet on the tank body is closed; and in the filter pressing process, low-temperature brine is continuously pumped into the jacket 60 through the first connector 61 or the second connector 62, so that the interior of the tank body is kept at low temperature all the time.
In the telmisartan intermediate filter-pressing and drying integrated machine, after filter pressing is finished, the tank body is rotated to enable the upper cover to be positioned at the lower side of the tank body and keep the tank body vertical, at the moment, the discharge hole 33 in the upper cover 30 is positioned at the bottommost end of the tank body, and hot water is continuously pumped into the jacket 60 through the first connector 61 or the second connector 62 to heat the tank body; open second nitrogen gas access & exit 42, first nitrogen gas access & exit 32, inject nitrogen gas through second nitrogen gas access & exit 42 to jar internal injection and sweep the filter plate, make the crystal granule that bonds on the filter plate break away from and fall to the bottom, after sweeping finishes, through pressing from both sides the cover and carrying out the blast to the internal crystal granule of jar through first nitrogen gas access & exit 32 to jar internal injection nitrogen gas of jar when heating the jar body, consequently, can dry the crystal granule in the jar body fast, after the stoving, close first nitrogen gas access & exit 32, open discharge gate 33, through second nitrogen gas access & exit 42 to jar internal injection nitrogen gas can make the internal crystal granule of jar discharge gate 33 discharge jar body.
In the application, when the upper cover is positioned above the middle cylinder in the filter pressing process, nitrogen can be injected into the tank body through the second nitrogen inlet and outlet 32 on the lower side to perform back flushing on the filter plates from the lower sides of the filter plates, so that the filter plates can be prevented from being blocked.
According to the telmisartan intermediate filter-pressing and drying integrated machine, nitrogen is used as the driving force of filter pressing, so that the structure in the tank body is simple, the filter-pressing reliability is good, the safety coefficient of the nitrogen filter-pressing is high, the nitrogen is used as a commonly used protective gas in the drug production process, the existing nitrogen supply equipment in a factory can be utilized, and the telmisartan intermediate filter-pressing and drying integrated machine is convenient to popularize and use; can carry out the stoving operation after the filter-pressing, production efficiency is high.
In one embodiment of the present application, preferably, the filter plates 50 are circular, the outer edges of the filter plates are provided with annular mounting plates 51, filter plate positioning grooves adapted to the mounting plates 51 are formed in the lower cover 40, filter plate positioning grooves adapted to the mounting plates 51 are formed in the tank body 20, and when the lower cover 40 is fixedly connected to the tank body 20 through bolts, the mounting plates 51 are clamped between the lower cover 40 and the tank body 20, thereby facilitating mounting, fixing and dismounting of the filter plates. Particularly, the upper and lower both ends of jar body 20 all are equipped with the flange board, are equipped with the connecting hole on the flange board, and upper cover, lower cover all link to each other with jar body is fixed through flange board, bolt.
In one embodiment of the present application, it is preferable that one end of the rotation supporting shaft 21 is further provided with a turntable 22, thereby facilitating the receipt of the reversed can body 10, and specifically, a motor for driving the rotation supporting shaft 21 may be further provided at the other end of the rotation supporting shaft 21, thereby enabling the automatic reversal of the can body.
In an embodiment of the present application, preferably, the rotating support shaft 21 is further provided with a positioning plate 23, the positioning plate 23 is provided with a positioning hole 231, the bracket 10 is provided with a positioning block 11 corresponding to the positioning plate 23, and the positioning block 11 is provided with a positioning pin that can be inserted into the positioning hole 231, so that the can body can be locked by the positioning pin after the can body is turned over.
In one embodiment of the present application, preferably, an annular upper partition 63 and an annular lower partition 64 are further provided in the jacket 60, and a plurality of uniformly arranged through holes 66 are provided on each of the upper partition 63 and the lower partition 64, so that cold water or hot water can uniformly flow in the annular cavity, and the tank body can be uniformly cooled and heated. Preferably, a plurality of vertical partition plates 67 are uniformly arranged between the upper partition plate 63 and the lower partition plate 64, so that the cold water or the hot water uniformly moves along the axial direction in the annular cavity. Preferably, the inner side of the outer wall of the jacket 60 is also provided with an insulating layer 65, so that the jacket can reliably and efficiently cool or heat the tank body.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.
Claims (7)
1. A telmisartan intermediate filter-pressing and drying integrated machine comprises a support and a filter-pressing tank, and is characterized in that the filter-pressing tank comprises a tank body, an upper cover and a lower cover, a rotary supporting shaft is arranged in the middle of the tank body, and the tank body is rotatably mounted on the support through the rotary supporting shaft; the upper cover is provided with a mixed liquid inlet, a first nitrogen inlet and outlet and a discharge hole, and the discharge hole is positioned at the top of the upper cover; the lower cover is provided with a mother liquid outlet and a second nitrogen inlet and outlet, and the mother liquid outlet is positioned at the bottom of the lower cover; a filter plate is also arranged between the tank body and the lower cover; the outer side of the tank body is also provided with a jacket, an annular cavity is formed between the jacket and the outer wall of the tank body, the jacket is provided with a first connector and a second connector which are communicated with the annular cavity, the tank body can be cooled by injecting cold water into the annular cavity, and the tank body can be heated by injecting hot water into the annular cavity.
2. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 1, wherein: and one end of the rotary supporting shaft is also provided with a turntable.
3. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 2, wherein: the rotary support shaft is further provided with a positioning disc, positioning holes are formed in the positioning disc, positioning blocks corresponding to the positioning disc are arranged on the support, and positioning pins capable of being inserted into the positioning holes are arranged on the positioning blocks.
4. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 1, wherein: the filter plate is circular and outer along being equipped with annular mounting panel, be equipped with on the lower cover with the filter plate constant head tank of mounting panel adaptation, jar be equipped with on the body with the filter plate constant head tank of mounting panel adaptation, the lower cover with when jar body passes through bolt fastening and links to each other the mounting panel clamp is established the lower cover with between the jar body.
5. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 1, wherein: the clamp sleeve is also internally provided with an annular upper partition plate and an annular lower partition plate, and the upper partition plate and the lower partition plate are respectively provided with a plurality of through holes which are uniformly distributed.
6. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 5, wherein: a plurality of vertical partition plates which are uniformly arranged are also arranged between the upper partition plate and the lower partition plate.
7. The telmisartan intermediate filter-pressing and drying all-in-one machine as claimed in claim 5, wherein: and the inner side of the outer wall of the jacket is also provided with a heat-insulating layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222680205.1U CN218516219U (en) | 2022-10-12 | 2022-10-12 | Telmisartan intermediate filter-pressing and drying integrated machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222680205.1U CN218516219U (en) | 2022-10-12 | 2022-10-12 | Telmisartan intermediate filter-pressing and drying integrated machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218516219U true CN218516219U (en) | 2023-02-24 |
Family
ID=85248055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222680205.1U Active CN218516219U (en) | 2022-10-12 | 2022-10-12 | Telmisartan intermediate filter-pressing and drying integrated machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218516219U (en) |
-
2022
- 2022-10-12 CN CN202222680205.1U patent/CN218516219U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110917650B (en) | Ultrasonic pipeline type automatic circulation continuous traditional Chinese medicine extraction device | |
| CN101385962B (en) | Reaction filter drying apparatus with compression membrane | |
| CN112536006B (en) | Energy-concerving and environment-protective zinc sulfate apparatus for producing | |
| CN218516219U (en) | Telmisartan intermediate filter-pressing and drying integrated machine | |
| CN115487590A (en) | Three-in-one filtering device | |
| CN214020282U (en) | Dissolving device is used in chemical auxiliary production | |
| CN214111375U (en) | Single-screw extruder for pipe production line | |
| CN206424961U (en) | A kind of graphite intercalation reactor | |
| CN110757678A (en) | Hot melting device is used in production of thermoplastic polyurethane elastomer | |
| CN211477425U (en) | Heating tank with temperature monitoring and alarm system | |
| CN209790916U (en) | chemical solution crystallization purification device | |
| CN208711721U (en) | Highly effective reaction kettle | |
| CN220531559U (en) | Outer coil pipe type reaction kettle structure | |
| CN212987778U (en) | Drying equipment of DL-p-hydroxybenzene hydantoin production usefulness | |
| CN216678213U (en) | 5-fluorosalicylic acid catalytic synthesis device | |
| CN208449301U (en) | A kind of easy-to-dismount reaction kettle | |
| CN220345845U (en) | Lithium carbonate subsides extraction element | |
| CN214182015U (en) | Filter-pressing dissolver suitable for manganese sulfate high-temperature crystallization | |
| CN109080029A (en) | A kind of plastic melt device for processing plastic product | |
| CN214913532U (en) | 4-amino-pyrrolo [2,1-F ] [1,2,4] triazine crystallization device | |
| CN219964819U (en) | Ultrahigh pressure reaction kettle equipment | |
| CN216704378U (en) | Closed loop reation kettle suitable for disperse red 145 production | |
| CN218307936U (en) | Synthetic heat preservation synthesis kettle for flame retardant TBC | |
| CN220142641U (en) | Adjustable crystallization kettle | |
| CN215276037U (en) | Filter equipment is used in coolant liquid stirring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |