CN218307945U - Synthesis device for preparing o-chlorobenzene glycine intermediate - Google Patents
Synthesis device for preparing o-chlorobenzene glycine intermediate Download PDFInfo
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- CN218307945U CN218307945U CN202222445400.6U CN202222445400U CN218307945U CN 218307945 U CN218307945 U CN 218307945U CN 202222445400 U CN202222445400 U CN 202222445400U CN 218307945 U CN218307945 U CN 218307945U
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Abstract
The utility model discloses a synthesis device for preparing an o-chlorobenzene glycine intermediate, which comprises a synthesis kettle, an acid regulating kettle, a washing kettle, a centrifuge, a condenser, a solvent receiving tank, a recovered solvent storage tank, a vacuum buffer tank and a vacuum pump, wherein the synthesis kettle, the acid regulating kettle, the washing kettle and the centrifuge are sequentially connected through pipelines; the condenser is connected with the acid adjusting kettle through a pipeline; the solvent receiving tank is connected with the condenser through a pipeline; the solvent receiving tank, the vacuum buffer tank and the vacuum pump are sequentially connected through pipelines; the recovered solvent storage tank is connected with the solvent receiving tank through a pipeline. The utility model discloses a combination of jar, centrifuge is received to multiple stirred tank, condenser and solvent can realize the industrial production of adjacent chlorobenzene glycine midbody adjacent chlorobenzene hydantoin, has established the basis for preparing adjacent chlorobenzene glycine, and wherein the condenser can make the solvent obtain the condensation and retrieve, puts into the solvent of retrieving at last and retrieves the solvent storage tank and can circulate and apply mechanically, practices thrift manufacturing cost.
Description
Technical Field
The utility model relates to a chemical production technical field, more specifically says so and relates to a synthesizer of preparation o-chlorobenzene glycine midbody.
Background
Clopidogrel was developed in 80 s of the 20 th century by the french company cenofil, and has a thiophene pyridine ring in its chemical structure, and the compound has high activity of inhibiting platelet aggregation and is an inhibitor of platelet aggregation. Is clinically used for treating and preventing atherosclerosis, cerebral infarction, myocardial infarction and other arteriovenous thrombosis, acute coronary syndrome and the like. The o-chlorophenyl glycine is used as an important intermediate for preparing clopidogrel, and the quality and the production cost directly influence the quality and the competitiveness of downstream medicines.
The quality of the o-chlorophenyl glycine also depends on the quality of the o-chlorophenyl hydantoin as an intermediate, and only the high-quality o-chlorophenyl glycine can be prepared from the high-content and high-quality intermediate.
In the prior art, the preparation devices of o-chlorophenylglycine are adopted, for example, a reaction kettle for preparing o-chlorophenylglycine is provided in CN201920735541.7, and the patent provides a reaction kettle and a temperature controller which are combined, so that the reaction temperature can be accurately controlled, and the reaction is uniformly heated; CN202120147989.4 an adjacent chlorobenzene glycine prepares uses agitated vessel, this patent proposes agitated vessel, including supporting platform and stirring shell to at parts such as supporting platform upper end fixedly connected with dead lever and biax motor, what this combination can be abundant stirs the reagent of preparation, has avoided stirring effect not good, leads to the reagent after the preparation to reach the condition of standard. These patents all show a device for preparing o-chlorophenylglycine, but do not show a device for preparing o-chlorophenylhydantoin as an intermediate thereof.
Therefore, it is an urgent problem to be solved by those skilled in the art to provide a synthesis apparatus for preparing o-chlorophenylglycine intermediate.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model provides a synthesizer of preparation o-chlorobenzene glycine midbody can realize the industrial production of o-chlorobenzene hydantoin of o-chlorobenzene glycine midbody.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a synthesis device for preparing an o-chlorobenzene glycine intermediate comprises a synthesis kettle, an acid regulating kettle, a water washing kettle, a centrifuge, a condenser, a solvent receiving tank, a recovered solvent storage tank, a vacuum buffer tank and a vacuum pump, wherein the synthesis kettle, the acid regulating kettle, the water washing kettle and the centrifuge are sequentially connected through pipelines; the condenser is connected with the acid adjusting kettle through a pipeline; the solvent receiving tank is connected with the condenser through a pipeline; the solvent receiving tank, the vacuum buffer tank and the vacuum pump are sequentially connected through pipelines; the recovered solvent storage tank is connected with the solvent receiving tank through a pipeline.
Through taking above scheme, the beneficial effects of the utility model are that:
the industrial production of the o-chlorophenylglycine intermediate o-chlorophenylhydantoin can be realized through the combination of various stirring kettles, condensers, solvent receiving tanks and centrifuges, and a foundation is laid for preparing o-chlorophenylglycine.
The device further comprises a filtrate storage tank and a washing water storage tank, wherein the synthesis kettle, the acid adjusting kettle, the washing kettle and the centrifuge are sequentially connected through a blanking pipeline from top to bottom; the filtrate storage tank and the washing water storage tank are respectively connected with the bottom of the centrifuge through blanking pipelines; the recovered solvent storage tank is connected with the bottom of the solvent receiving tank through a blanking pipeline; all the blanking pipelines are provided with first switch valves; the condenser is connected with the acid adjusting kettle through an ascending pipeline; the solvent receiving tank is connected with the condenser through a condensing pipeline.
Further, the top parts of the synthesis kettle, the acid regulating kettle and the washing kettle are all provided with a first feeding pipeline, and the first feeding pipeline is provided with a flow meter and a second switch valve; a second feeding pipeline is installed at the top of the centrifuge, and a third switch valve is installed on the second feeding pipeline.
Further, first jackets are respectively arranged outside the synthesis kettle and the acid regulating kettle, and the first jackets are respectively connected with a hot water pipeline and a circulating water pipeline; and a second jacket is arranged outside the washing kettle and is connected with a low-temperature water pipeline.
Furthermore, the hot water pipeline, the circulating water pipeline and the low-temperature water pipeline are all provided with regulating valves.
Further, the synthesis kettle, the acid adjusting kettle and the water washing kettle are internally provided with stirring devices.
The beneficial effect who adopts above-mentioned further technical scheme to produce does, makes the material stirring more even.
Further, temperature transmitters are arranged at the tops of the synthesis kettle, the acid adjusting kettle and the water washing kettle.
The beneficial effect that adopts above-mentioned further technical scheme to produce is, but the temperature in the real-time detection cauldron.
Furthermore, a PH meter is arranged at the top of the acid adjusting kettle.
The beneficial effect that adopts above-mentioned further technical scheme to produce is, conveniently control the interior pH valve of cauldron.
Further, the top of the synthesis kettle is provided with an inlet hole for feeding solid materials.
Further, a sight glass is installed on the condensation pipeline.
The beneficial effect that adopts above-mentioned further technical scheme to produce is, whether convenient observation solvent is except clean.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic diagram of a process flow of a synthesis apparatus for preparing an o-chlorobenzene glycine intermediate provided by the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1, the embodiment of the utility model discloses a synthesis device for preparing an o-chlorobenzene glycine intermediate, which comprises a synthesis kettle 1, an acid adjusting kettle 2, a washing kettle 3, a centrifuge 4, a condenser 5, a solvent receiving tank, a recovered solvent storage tank, a vacuum buffer tank 6 and a vacuum pump 7, wherein the synthesis kettle 1, the acid adjusting kettle 2, the washing kettle 3 and the centrifuge 4 are sequentially connected through pipelines; the condenser 5 is connected with the acid adjusting kettle 2 through a pipeline; the solvent receiving tank 11 is connected with the condenser 5 through a pipeline; the solvent receiving tank 11, the vacuum buffer tank 6 and the vacuum pump 7 are connected in sequence through pipelines; the recovered solvent storage tank 12 is connected to the solvent receiving tank 11 through a pipeline. The utility model discloses a multiple stirred tank (synthetic cauldron 1, transfer sour cauldron 2 and washing cauldron 3), condenser 5 and solvent receiving tank 11, centrifuge 4's combination can realize the industrial production of o-chlorobenzene glycine midbody o-chlorobenzene hydantoin, have established the basis for preparing o-chlorobenzene glycine, and wherein condenser 5 can make the solvent obtain the condensation and retrieve, and put into recovery solvent storage tank 12 with the solvent of retrieving at last and can circulate and apply mechanically, practices thrift manufacturing cost.
Specifically, the device also comprises a filtrate storage tank 10 and a washing water storage tank 13, wherein the synthesis kettle 1, the acid adjusting kettle 2, the washing kettle 3 and the centrifuge 4 are sequentially connected through a blanking pipeline 8 from top to bottom; the filtrate storage tank 10 and the washing water storage tank 13 are respectively connected with the bottom of the centrifuge 4 through a blanking pipeline 8; the recovered solvent storage tank 12 is connected with the bottom of the solvent receiving tank 11 through a blanking pipeline 8; all the blanking pipelines 8 are provided with first switch valves 19; the condenser 5 is connected with the acid adjusting kettle 2 through an ascending pipeline 9; the solvent receiving tank 11 is connected to the condenser 5 through a condensation line 14.
Specifically, the top parts of the synthesis kettle 1, the acid adjusting kettle 2 and the washing kettle 3 are all provided with a first feeding pipeline 17, and the first feeding pipeline 17 is provided with a flowmeter 18 and a second switch valve 19-1, so that the synthesis reaction is carried out more efficiently and stably; the top of the centrifuge 4 is provided with a second feeding pipeline 17-1, and the second feeding pipeline 17-1 is provided with a third on-off valve 19-2.
Specifically, a first jacket 15 is arranged outside the synthesis kettle 1 and the acid regulating kettle 2, and the first jacket 15 is respectively connected with a hot water pipeline and a circulating water pipeline; the outside of the water washing kettle 3 is provided with a second jacket 15-1, and the second jacket 15-1 is connected with a low-temperature water pipeline 16.
In particular, the hot water line, the recycle water line, and the low temperature water line 16 are each provided with a regulating valve 22.
For making material mixing more even, agitating unit is all installed to synthetic cauldron 1, the inside of adjusting sour cauldron 2 and washing cauldron 3, and agitating unit includes motor, (mixing) shaft and stirring vane, and the agitating unit structure is prior art, is not this application focus, no longer gives details here.
In order to detect the temperature in the kettle in real time, temperature transmitters 20 are arranged at the tops of the synthesis kettle 1, the acid adjusting kettle 2 and the water washing kettle 3.
In order to conveniently control the pH value in the kettle, a pH meter is arranged at the top of the acid adjusting kettle 2.
Specifically, the top of the synthesis reactor 1 has an inlet 21 for introducing solid materials.
In order to observe whether the solvent is completely removed, a sight glass 23 is installed on the condensation line 14.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A synthesis device for preparing an o-chlorobenzene glycine intermediate is characterized by comprising a synthesis kettle, an acid regulating kettle, a washing kettle, a centrifugal machine, a condenser, a solvent receiving tank, a recovered solvent storage tank, a vacuum buffer tank and a vacuum pump, wherein the synthesis kettle, the acid regulating kettle, the washing kettle and the centrifugal machine are sequentially connected through pipelines; the condenser is connected with the acid adjusting kettle through a pipeline; the solvent receiving tank is connected with the condenser through a pipeline; the solvent receiving tank, the vacuum buffer tank and the vacuum pump are sequentially connected through pipelines; the recovered solvent storage tank is connected with the solvent receiving tank through a pipeline.
2. The synthesis device for preparing the o-chlorobenzeneglycine intermediate as claimed in claim 1, further comprising a filtrate storage tank and a washing water storage tank, wherein the synthesis kettle, the acid adjusting kettle, the washing kettle and the centrifuge are connected in sequence from top to bottom through blanking pipelines; the filtrate storage tank and the washing water storage tank are respectively connected with the bottom of the centrifuge through blanking pipelines; the recovered solvent storage tank is connected with the bottom of the solvent receiving tank through a blanking pipeline; all the blanking pipelines are provided with first switch valves; the condenser is connected with the acid adjusting kettle through an ascending pipeline; the solvent receiving tank is connected with the condenser through a condensing pipeline.
3. The synthesis device for preparing the o-chlorobenzene glycine intermediate according to claim 2, wherein a first feeding pipeline is installed on the top of each of the synthesis kettle, the acid adjusting kettle and the water washing kettle, and a flow meter and a second switch valve are installed on each of the first feeding pipelines; a second feeding pipeline is installed at the top of the centrifuge, and a third switch valve is installed on the second feeding pipeline.
4. The synthesis device for preparing the o-chlorobenzeneglycine intermediate as claimed in claim 2, wherein the synthesis kettle and the acid adjusting kettle are externally provided with a first jacket, and the first jacket is respectively connected with a hot water pipeline and a circulating water pipeline; and a second jacket is arranged outside the washing kettle and is connected with a low-temperature water pipeline.
5. A synthesis device for preparing o-chlorobenzene glycine intermediate according to claim 4, characterized in that the hot water pipeline, the circulating water pipeline and the low temperature water pipeline are all provided with regulating valves.
6. The synthesis device for preparing the o-chlorobenzeneglycine intermediate as claimed in claim 2, wherein the synthesis kettle, the acid adjusting kettle and the water washing kettle are all internally provided with stirring devices.
7. The synthesis device for preparing the o-chlorobenzeneglycine intermediate as claimed in claim 2, wherein the synthesis kettle, the acid adjusting kettle and the water washing kettle are all provided with temperature transmitters at the top.
8. The synthesis device for preparing the o-chlorobenzeneglycine intermediate as claimed in claim 2, wherein the top of the acid adjusting kettle is provided with a pH meter.
9. The synthesis device for preparing the o-chlorobenzylglycine intermediate as claimed in claim 2, wherein the top of the synthesis kettle is provided with an inlet hole for feeding solid materials.
10. A synthesis device for preparing o-chlorophenylglycine intermediate according to claim 2, wherein a sight glass is installed on the condensation line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222445400.6U CN218307945U (en) | 2022-09-15 | 2022-09-15 | Synthesis device for preparing o-chlorobenzene glycine intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222445400.6U CN218307945U (en) | 2022-09-15 | 2022-09-15 | Synthesis device for preparing o-chlorobenzene glycine intermediate |
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| CN218307945U true CN218307945U (en) | 2023-01-17 |
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| CN202222445400.6U Active CN218307945U (en) | 2022-09-15 | 2022-09-15 | Synthesis device for preparing o-chlorobenzene glycine intermediate |
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| CN (1) | CN218307945U (en) |
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- 2022-09-15 CN CN202222445400.6U patent/CN218307945U/en active Active
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