CN218248736U - Separation and purification equipment for recombinant human-like collagen - Google Patents
Separation and purification equipment for recombinant human-like collagen Download PDFInfo
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- CN218248736U CN218248736U CN202221621621.8U CN202221621621U CN218248736U CN 218248736 U CN218248736 U CN 218248736U CN 202221621621 U CN202221621621 U CN 202221621621U CN 218248736 U CN218248736 U CN 218248736U
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Abstract
The utility model relates to a class human collagen separation and purification technical field discloses a reorganization class human collagen's separation and purification equipment, including the knockout drum, feed inlet is installed to top one side of knockout drum, the bottom center department of knockout drum installs the unloading pipe, the top symmetry of knockout drum installs a pair of spacing slide rail, two the equal sliding connection in opposite sides of spacing slide rail has spacing slider, installs rotating electrical machines between two the spacing slider, the top center department of knockout drum installs the interior screw thread seat, the inside threaded connection of interior screw thread seat has with the reciprocating screw rod of the output transmission connection of rotating electrical machines; the bottom end of the reciprocating screw rod extends into the separating tank, and a plurality of separating blades are arranged on the bottom end of the reciprocating screw rod. The utility model discloses the vertical reciprocating motion is made at the inside rotatory in-process of knockout drum to the separation leaf, and the liquid of the needs purification of different aspect is conveniently stirred, promotes separation efficiency.
Description
Technical Field
The utility model relates to a class human collagen separation and purification technical field specifically is a reorganization class human collagen's separation and purification equipment.
Background
The human-like collagen is obtained by gene recombination and bioengineering technology. mRNA of human collagen is reversely transcribed into cDNA, a section of gene after enzyme digestion is recombined in E.coli, and the macromolecular biological protein is produced through high-density fermentation, separation, renaturation and purification processes. The main production raw materials are glucose and inorganic salt. The human-like collagen is derived from human genes, has the same amino acid composition and tissue structure as skin tissues, and is genetically engineered single-cell protein.
After the production, the human-like collagen needs to be separated and purified, so that the purity of the human-like collagen is improved, and the human-like collagen is convenient to use in later period. Chinese patent CN214680302U discloses a separation and purification device for collagen, which comprises a purification box, wherein a servo motor is installed at the top of the purification box, a support column is installed at the bottom of the purification box, a discharge tube is installed at the bottom of the front surface of the purification box, a first control switch, a second control switch, an electromagnetic valve, a first filter plate and a second filter plate are installed on the side surface of the purification box, a stirring rod is installed inside the purification box, and an inclined block is installed at the bottom inside the purification box. Can only be through servo motor drive puddler in the constant high-speed rotation of the fixed position of purification incasement portion in the above-mentioned patent, need long-time work can separate completely, work efficiency is low. Therefore, it is necessary to design an apparatus for separating and purifying recombinant human-like collagen.
SUMMERY OF THE UTILITY MODEL
To the aforesaid condition, for overcoming prior art's defect, the utility model provides a separation and purification equipment of reorganization class human collagen, the utility model discloses the vertical reciprocating motion is done at the rotatory in-process in inside of knockout drum to the separation leaf, and the convenient liquid that purifies the needs of different aspect stirs, promotes separation efficiency.
In order to achieve the above object, the utility model provides a following technical scheme: the separation and purification equipment for the recombinant human collagen comprises a separation tank, wherein a feed inlet is arranged on one side of the top of the separation tank, a blanking pipe is arranged at the center of the bottom of the separation tank, a pair of limiting slide rails are symmetrically arranged at the top of the separation tank, limiting slide blocks are respectively connected to the opposite sides of the two limiting slide rails in a sliding manner, a rotating motor is arranged between the two limiting slide blocks, an internal thread seat is arranged at the center of the top of the separation tank, and a reciprocating lead screw in transmission connection with the output end of the rotating motor is in threaded connection with the inside of the internal thread seat; the bottom end of the reciprocating screw rod extends into the separating tank, and a plurality of separating leaves are installed on the bottom end of the reciprocating screw rod.
Optionally, a shaft sleeve is fixed at the output end of the rotating motor, the shaft sleeve is sleeved at the top end of the reciprocating screw rod, and two sides of the shaft sleeve are screwed and fixed with a jacking screw.
Optionally, the tail end of the feeding pipe is connected with a purifier, and the purifier comprises a purification tank, a filter screen frame and a bottom cover;
the purification tank is fixed at the tail end of the feeding pipe; the bottom cover is screwed with the bottom opening of the purification tank and is used for supporting the filter screen frame; a discharge pipe is arranged at the center of the bottom cover; first filter screen and second filter screen are installed to last extremely down in proper order of following on the filter screen frame, the mesh of second filter screen is less than the mesh of first filter screen.
Optionally, the outer walls of the first filter screen and the second filter screen are both fixed with a sealing ring contacting with the inner wall of the purification tank.
Optionally, an end cover is screwed and fixed on the feeding hole, and an electromagnetic valve is installed on the discharging pipe;
at least three supporting legs are arranged at the bottom of the separating tank, and a control board used for being electrically connected with the rotating motor is arranged on one side of the top end of one of the supporting legs; the outer wall of the purifier is fixedly connected with at least three supporting legs through the positioning frame.
The utility model has the advantages that:
the rotating motor rotates through the driving screw rod, and then can drive the separation blade to do up-and-down reciprocating motion in the process of the rotation of the inside of the separation tank, so that the liquid required to be purified on different layers can be conveniently stirred, and the separation efficiency can be improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without inventive exercise.
FIG. 1 is a schematic view of the overall front plan structure of the present invention;
FIG. 2 is a schematic view of the installation plane structure of the separation blade of the present invention;
FIG. 3 is a schematic sectional plan view of the purifier of the present invention;
the reference numbers in the figures: 1. a separation tank; 2. a feed inlet; 3. an end cap; 4. supporting legs; 5. a positioning frame; 6. a discharging pipe; 7. an electromagnetic valve; 8. a purifier; 9. a control panel; 10. an internal thread seat; 11. a reciprocating screw rod; 12. a limiting slide rail; 13. a limiting slide block; 14. a rotating electric machine; 15. jacking the screw tightly; 16. a shaft sleeve; 17. separating leaves; 18. a purification tank; 19. a screen frame; 20. a first filter screen; 21. a second filter screen; 22. a seal ring; 23. a bottom cover; 24. a discharge pipe.
Detailed Description
To make the objects, features and advantages of the present invention more obvious and understandable, the embodiments of the present invention are clearly and completely described in the embodiments of the present invention with reference to the drawings, and obviously, the embodiments described below are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
The technical solution of the present invention is further explained by the following embodiments with reference to the accompanying drawings.
In the description of the present invention, it should be understood that the terms "upper", "lower", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.
The technical solution of the present invention will be clearly and completely described with reference to the accompanying drawings.
Example one
Given by fig. 1 and fig. 2, the utility model provides the following technical solutions: a separation and purification device for recombinant human collagen comprises a separation tank 1, wherein a feed inlet 2 is arranged on one side of the top of the separation tank 1, a blanking pipe 6 is arranged at the center of the bottom of the separation tank 1, a pair of limiting slide rails 12 are symmetrically arranged on the top of the separation tank 1, limiting slide blocks 13 are respectively connected on the opposite sides of the two limiting slide rails 12 in a sliding manner, a rotating motor 14 is arranged between the two limiting slide blocks 13, an internal thread seat 10 is arranged at the center of the top of the separation tank 1, and a reciprocating screw rod 11 in transmission connection with the output end of the rotating motor 14 is in threaded connection with the internal thread of the internal thread seat 10; the bottom end of the reciprocating screw rod 11 extends into the separating tank 1 and is provided with a plurality of separating blades 17.
Specifically, an end cover 3 is screwed and fixed on the feeding hole 2, and an electromagnetic valve 7 is installed on the discharging pipe 6;
at least three supporting legs 4 are arranged at the bottom of the separating tank 1, and one side of the top end of one supporting leg 4 is provided with a control board 9 which is electrically connected with a rotating motor 14; preferably, the outer wall of purifier 8 is fixedly connected with at least three supporting legs 4 through positioning frames 5, so that the stability of installation of purifier 8 is ensured.
When using, in the fluid inflow knockout drum 1 that will need the purification through feed inlet 2, drive the detached leaf 17 through rotating electrical machines 14 and stir, open solenoid valve 7 afterwards, to transfer through unloading pipe 6 through the liquid of stirring and make liquid filter through clarifier 8, liquid after the filtration goes on discharging through row material pipe 24 and discharges, collect can, rotating electrical machines 14 work, the reciprocal lead screw 11 high-speed rotation of drive, because the limiting displacement of inner screw base 10, make reciprocal lead screw 11 rise or the descending motion at the rotatory in-process of the inside of inner screw base 10, thereby drive detached leaf 17 and do reciprocating motion from top to bottom at the rotatory in-process of the inside of knockout drum 1, the liquid of the needs purification of different aspect is conveniently stirred, separation efficiency is promoted.
Example two
Referring to fig. 2, as another preferred embodiment, the difference from the first embodiment is that a shaft sleeve 16 is fixed at the output end of the rotating electrical machine 14, the shaft sleeve 16 is sleeved on the top end of the reciprocating screw rod 11, tightening screws 15 are screwed and fixed on both sides of the shaft sleeve 16, and after the reciprocating screw rod 11 is inserted into the shaft sleeve 16, the tightening screws 15 are used for reinforcement, so that not only is the installation stability good, but also the installation and disassembly are convenient.
EXAMPLE III
Referring to fig. 1 and 3, as another preferred embodiment, the difference from the first embodiment is that a purifier 8 is connected to the tail end of the blanking pipe 6, and the purifier 8 comprises a purification tank 18, a filter screen frame 19 and a bottom cover 23;
the purification tank 18 is fixed at the tail end of the blanking pipe 6; the bottom cover 23 is screwed with the bottom opening of the secondary purification tank 18 and is used for supporting the filter screen frame 19; a discharge pipe 24 is arranged at the center of the bottom cover 23; the filter screen frame 19 is sequentially provided with a first filter screen 20 and a second filter screen 21 from top to bottom, and the meshes of the second filter screen 21 are smaller than those of the first filter screen 20.
Preferably, the outer walls of the first filter screen 20 and the second filter screen 21 are fixed with sealing rings 22 contacting with the inner wall of the purification tank 18, and the sealing performance of the connection between the first filter screen 20 and the purification tank 18 and the connection between the second filter screen 21 and the purification tank 18 are improved through the arranged sealing rings 22.
The working principle is as follows:
when using, in the liquid inflow knockout drum 1 that will need the purification through feed inlet 2, drive separation leaf 17 through rotating electrical machines 14 and stir, open solenoid valve 7 afterwards, liquid through the stirring is transferred through unloading pipe 6 and is made liquid filter through clarifier 8, liquid after the filtration goes on discharging through row material pipe 24 and discharges, collect can, rotating electrical machines 14 work, the reciprocal lead screw 11 high-speed rotation of drive, because the limiting displacement of inner screw base 10, make reciprocal lead screw 11 rise or the descending motion at the inside rotatory in-process of inner screw base 10, thereby drive separation leaf 17 and do reciprocating motion from top to bottom at the inside rotatory in-process of knockout drum 1, the convenient liquid to the needs purification of different aspect stirs, promote separation efficiency.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.
Claims (5)
1. The utility model provides a separation and purification equipment of reorganization class human collagen, includes knockout drum (1), feed inlet (2) are installed to top one side of knockout drum (1), blanking pipe (6), its characterized in that are installed to the bottom center department of knockout drum (1): a pair of limiting slide rails (12) are symmetrically installed at the top of the separation tank (1), limiting slide blocks (13) are connected to opposite sides of the two limiting slide rails (12) in a sliding mode, a rotating motor (14) is installed between the two limiting slide blocks (13), an internal thread seat (10) is installed at the center of the top of the separation tank (1), and a reciprocating screw rod (11) in transmission connection with the output end of the rotating motor (14) is connected to the internal thread seat (10) in a threaded mode; the bottom end of the reciprocating screw rod (11) extends into the separating tank (1) and is provided with a plurality of separating leaves (17).
2. The apparatus for separating and purifying recombinant human-like collagen according to claim 1, wherein: the output end of the rotating motor (14) is fixed with a shaft sleeve (16), the shaft sleeve (16) is sleeved on the top end of the reciprocating screw rod (11), and two sides of the shaft sleeve (16) are fixedly screwed with jacking screws (15).
3. The apparatus for separating and purifying recombinant human-like collagen according to claim 1, wherein: the tail end of the feeding pipe (6) is connected with a purifier (8), and the purifier (8) comprises a purifying tank (18), a filter screen frame (19) and a bottom cover (23);
the purification tank (18) is fixed at the tail end of the blanking pipe (6); the bottom cover (23) is screwed with the bottom opening of the purification tank (18) and is used for supporting the filter screen frame (19); a discharge pipe (24) is arranged at the center of the bottom cover (23); install first filter screen (20) and second filter screen (21) from last to down in proper order on filter screen frame (19), the mesh of second filter screen (21) is less than the mesh of first filter screen (20).
4. The apparatus for separating and purifying recombinant human-like collagen according to claim 3, wherein: and sealing rings (22) which are in contact with the inner wall of the purification tank (18) are fixed on the outer walls of the first filter screen (20) and the second filter screen (21).
5. The apparatus for separating and purifying recombinant human-like collagen according to claim 3, wherein: an end cover (3) is rotationally connected and fixed on the feeding hole (2), and an electromagnetic valve (7) is installed on the blanking pipe (6);
at least three supporting legs (4) are arranged at the bottom of the separating tank (1), and a control board (9) used for being electrically connected with the rotating motor (14) is arranged on one side of the top end of one of the supporting legs (4); the outer wall of the purifier (8) is fixedly connected with at least three supporting legs (4) through a positioning frame (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221621621.8U CN218248736U (en) | 2022-06-27 | 2022-06-27 | Separation and purification equipment for recombinant human-like collagen |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221621621.8U CN218248736U (en) | 2022-06-27 | 2022-06-27 | Separation and purification equipment for recombinant human-like collagen |
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| CN218248736U true CN218248736U (en) | 2023-01-10 |
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| CN202221621621.8U Active CN218248736U (en) | 2022-06-27 | 2022-06-27 | Separation and purification equipment for recombinant human-like collagen |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117160852A (en) * | 2023-11-02 | 2023-12-05 | 好棣(山东)生物科技有限公司 | Separation and purification equipment for collagen peptide |
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2022
- 2022-06-27 CN CN202221621621.8U patent/CN218248736U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117160852A (en) * | 2023-11-02 | 2023-12-05 | 好棣(山东)生物科技有限公司 | Separation and purification equipment for collagen peptide |
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