CN218121108U - Liquid micro-flow calibration device based on injection pump - Google Patents
Liquid micro-flow calibration device based on injection pump Download PDFInfo
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- CN218121108U CN218121108U CN202222068821.1U CN202222068821U CN218121108U CN 218121108 U CN218121108 U CN 218121108U CN 202222068821 U CN202222068821 U CN 202222068821U CN 218121108 U CN218121108 U CN 218121108U
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- syringe pump
- electronic balance
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- 239000007788 liquid Substances 0.000 title claims abstract description 84
- 238000002347 injection Methods 0.000 title claims abstract description 35
- 239000007924 injection Substances 0.000 title claims abstract description 35
- 238000001704 evaporation Methods 0.000 claims abstract description 22
- 230000008020 evaporation Effects 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000002265 prevention Effects 0.000 claims abstract description 7
- 238000005259 measurement Methods 0.000 claims description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000741 silica gel Substances 0.000 claims description 7
- 229910002027 silica gel Inorganic materials 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims 1
- 238000005303 weighing Methods 0.000 abstract description 5
- 239000013589 supplement Substances 0.000 abstract 1
- 238000000691 measurement method Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The utility model discloses a small flow calibrating device of liquid based on syringe pump, including host computer, modularization syringe pump, high accuracy electronic balance, multichannel switching-over valve and water tank. The modularized injection pump is controlled by the upper computer to accurately and quantitatively control the small liquid flow, the liquid flow flows into the evaporation prevention device in the high-precision electronic balance through the multi-channel reversing valve, and the timer is started and measures the mass of the liquid flowing out in unit time through the high-precision electronic balance. The utility model adopts the modularized injection pump, which improves the stability of the low flow lower limit drive; the evaporation prevention device avoids evaporation of the calibration liquid, overcomes weighing uncertainty of the liquid outlet pipe to the high-precision electronic balance, and improves weighing precision; the multi-channel reversing valve is connected with the water tank, so that automatic liquid supplement is realized, and the repeatability of the device is improved.
Description
Technical Field
The utility model belongs to the liquid measurement field especially relates to a small flow calibrating device of liquid based on syringe pump.
Background
With the development of new technology, the demand of micro flow measurement in liquid flow measurement in the field of biological medicine is more and more obvious, the measurement requirement is higher and higher, and the requirement of measurement accuracy is more prominent particularly in the fields of life medical treatment, biology, various chemical pharmaceutical process control and the like. However, since the research on the liquid flow standard device for micro flow measurement is started later in China, and the micro flow measurement has higher complexity compared with the conventional flow measurement, many micro flow standard devices developed at present have larger uncertainty and lower stability and reliability, and can only detect part of micro flow meters or instruments due to low range ratio, the flow range of the detection can not meet the range of the micro flow meters or instruments, and the domestic flow meters or instruments for micro flow measurement are difficult to trace to the source effectively.
At present, the domestic liquid micro-flow standard device adopts two main volume measurement standards and measurement methods: firstly, a single piston cylinder (or a single plunger) standard is adopted; and secondly, adopting a standard combining weighing and density measurement. The first measurement method has the advantage of directly obtaining the volume flow of the liquid, but once the single piston cylinder (or single plunger) is processed, the size and the volume are fixed, the range is also fixed due to the limitation of the upper and lower limit rotation ranges of the servo (or stepping) motor, and a device with a wide range cannot be built. The second measurement method has high accuracy and wider range of measurement although the device is bulky. With the development of high-precision electronic balances, the precision and the measuring range of the high-precision electronic balances are further improved, and the high-precision electronic balances tend to develop precisely.
The utility model discloses on the basis of second kind of measuring method, the factor that the further research influences the small flow standard device accuracy nature of liquid is from aspects such as evaporation problem when the stability of liquid flow, experiment repeatability measure, liquid quality measurement, develop measurement technique and application research, has improved the measurement accuracy of the small flow standard device of liquid.
Disclosure of Invention
In order to solve the above problems, an object of the present invention is to provide a device for calibrating the small flow rate of liquid based on a syringe pump, which has a high calibration result accuracy.
The utility model provides a technical scheme that its technical problem adopted is:
the liquid micro-flow calibration device based on the injection pump comprises an upper computer, a flow output module, a quality measurement module, a multi-channel reversing valve and a water tank.
The flow output module comprises a modular syringe pump; the quality measurement module comprises a high-precision electronic balance and an evaporation prevention device; the flow output module, the water tank, the high-precision electronic balance and the multi-channel reversing valve are connected through a silica gel hose; the upper computer is in communication connection with the multi-channel reversing valve, the flow output module and the quality measurement module.
The sample injection needle is arranged on the modularized injection pump.
Furthermore, the sample injection needle is connected with the silica gel hose through a luer connector.
Further, the evaporation prevention device is arranged in the high-precision electronic balance.
Further, the evaporation-proof device comprises a second collecting barrel and a first collecting barrel which are communicated through a large-diameter overflow pipe and a small-diameter overflow pipe; the first collecting barrel is arranged in the second collecting barrel.
Furthermore, the calibration liquid surfaces in the second collecting bucket and the first collecting bucket are both covered with oil films.
Furthermore, a first collecting barrel support is arranged in the second collecting barrel and used for fixing the first collecting barrel.
To sum up, the utility model discloses following beneficial effect has:
1. the utility model discloses the evaporation proof device of development has effectively avoided the evaporation of calibration liquid, has overcome the uncertainty of weighing that the drain pipe brought high accuracy electronic balance, has promoted and has weighed the precision.
2. The utility model discloses an adopt luer, guaranteed the leakproofness of pipeline intercommunication.
3. The utility model discloses a water tank is connected to multichannel switching-over valve, has realized the automatic replenishment of liquid, has improved the repeatability of device.
4. The utility model discloses a modularization syringe pump has promoted the measurement level and the driven stability of low discharge lower limit.
5. The utility model discloses a high accuracy electronic balance measures, has promoted measurement accuracy.
6. The utility model discloses can be used to the uncertainty model research.
Drawings
In order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described as follows:
fig. 1 is a schematic structural diagram of the device for calibrating the small flow rate of liquid based on the injection pump of the present invention.
Fig. 2 is the utility model discloses a small flow calibrating device's of liquid anti-evaporation device schematic diagram based on syringe pump.
Fig. 3 is a flow chart of the device for calibrating the small flow rate of liquid based on the injection pump of the present invention.
Wherein the reference numbers are as follows: 1. a modular syringe pump; 2. a sample injection needle; 3, a multi-channel reversing valve; 4. a water tank; 5. a high-precision electronic balance; 6. an anti-evaporation device; 7. a second collection barrel; 8. a large diameter overflow tube; 9. a small diameter overflow tube; 10. a first collector barrel support; 11. a liquid outlet pipe; 12. a first collection barrel; 13. an oil film in the first collecting barrel; 14. calibrating liquid in the first collecting barrel; 15. an oil film in the second collecting barrel; 16. the second collection tank contains a calibration fluid.
Detailed Description
In order to make the above objects, features and advantages of the present invention more clearly understood, the present invention will be described in detail with reference to the accompanying drawings and detailed description. In addition, the embodiments and features of the embodiments of the present application may be combined with each other without conflict. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, and the described embodiments are merely some embodiments, rather than all embodiments, of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The technical solution of the present invention is further specifically described below by way of specific embodiments and with reference to the accompanying drawings.
The liquid micro-flow calibration device based on the injection pump comprises an upper computer, a flow output module, a quality measurement module and a multi-channel reversing valve. The multi-channel reversing valve is used for controlling the flow direction of liquid flow and is connected with a 24V driving power supply. As shown in fig. 1, the flow output module comprises a modular syringe pump 1; the mass measurement module comprises a high-precision electronic balance 5 and an anti-evaporation device 6, wherein the anti-evaporation device 6 is arranged on the high-precision electronic balance 5; the utility model discloses still include water tank 4.
In the liquid micro-flow calibration device based on the injection pump, the modular injection pump 1 is adopted as a power source device, and the modular injection pump 1 injects and extracts solution at a non-pulse, reproducible and stable flow rate through an advanced micro stepping motor, so that accurate liquid flow is provided for various applications. The modular syringe pump 1 has a minimum flow value of 0.0001μLMin, maximum flow value 86μLAnd min, the lower limit measurement level of the device is effectively improved, and the design requirement of the device is met.
A high precision electronic balance 5 in the mass measurement module will be used to feed back in real time the mass of the injected liquid collected in the anti-evaporation device 6.
The modularized injection pump 1, the water tank 4 and the high-precision electronic balance 5 are all connected with the multi-channel reversing valve 3 through silica gel hoses to circulate liquid. The sample injection needle 2 is arranged on the modular injection pump 1, and the sample injection needle 2 can be controlled to stably convey micro liquid with corresponding volume. For the experiment, a 25ml sample injection needle (but not limited to this type) may be used. In order to ensure the liquid tightness, the silica gel hose is connected with the sample injection needle 2 by a luer connector and is directly connected with the multifunctional reversing valve 3 through an external thread connector. The utility model discloses preferred luer connects as its main jointing equipment, luer connects is a standardized trace and does not have the joint that oozes, has advantages such as compatibility between the simplicity of connection and the different products, can prevent that drip and infiltration phenomenon from appearing in the junction.
By the evaporation plant that prevents in the injection liquid inflow high accuracy electronic balance, the drip appears for the liquid outlet that prevents the small flow calibrating device of liquid, the utility model discloses the mode of exploring into the calibration liquid with the drain pipe is solved, nevertheless when the liquid outlet deepened below the liquid level, need consider again that the buoyancy that calibration liquid deepened below the liquid level to the drain pipe produced influences. In order to eliminate this effect, in the evaporation-preventing device 6 shown in fig. 2, the liquid outlet pipe 11 is inserted into a first collecting barrel 12 (a special collecting barrel) in an overflow state, so that the depth of the liquid outlet pipe 11 inserted into the liquid surface in the calibration process will be kept constant, and the buoyancy generated by the calibration liquid on the part of the liquid outlet pipe 11 inserted into the liquid surface will be kept constant, so that the influence of the buoyancy generated by the calibration liquid on the part of the liquid outlet pipe 11 inserted into the liquid surface can be eliminated.
In order to collect the calibration liquid overflowing from the first collection vessel 12, a second collection vessel 7 (a common collection vessel) is disposed outside the first collection vessel 12, that is, the first collection vessel 12 is fixed on the first collection vessel support 10 inside the second collection vessel 7. While passing through the large-diameter overflow pipe 8 and the small-diameter overflow pipe 9 as a flow conduit between the second collection vessel 7 and the first collection vessel 12. Wherein, the liquid level of the calibration liquid 14 in the first collecting barrel and the bottom surface of the large-diameter overflow pipe 8 are in the same horizontal plane; when the liquid injected from the liquid outlet pipe 11 raises the level of the calibration liquid 14 in the first collecting barrel, the calibration liquid 14 in the first collecting barrel is caused to flow to the calibration liquid 16 in the second collecting barrel 7 through the large-diameter overflow pipe 8 and the small-diameter overflow pipe 9, so that the collection and measurement of the liquid are realized, and the measurement accuracy of the device is improved.
In addition, for preventing calibration liquid from evaporating at the collection in-process, the utility model discloses utilize the oil film to be difficult to the characteristics of evaporation, adopt the mode that covers the oil film on calibration liquid surface to reduce calibration liquid's evaporation capacity.
In fig. 2, the second collecting vessel 7 contains a second collecting vessel calibration liquid 16, and the upper surface of the second collecting vessel calibration liquid 16 is covered with a second collecting vessel oil film 15. The first collecting barrel 12 is filled with a first collecting barrel inner calibration liquid 14, and the upper surface of the first collecting barrel inner calibration liquid 14 is covered with a first collecting barrel inner oil film 13.
As shown in fig. 3, the liquid transmission is performed between the modular syringe pump, the water tank, the high-precision electronic balance and the multi-channel reversing valve. And the multi-channel reversing valve, the modular injection pump and the upper computer are connected by RS-232.
The working process of the device is as follows:
when the upper computer sends a control instruction, the modular injection pump receives the instruction through the communication serial port, the motor of the modular injection pump starts to drive the sample injection needle to inject liquid, and at the moment, the timer starts to time.
After the injection liquid flows to the multi-channel reversing valve through the silica gel hose, the multi-channel reversing valve stably conveys the liquid flow into an evaporation prevention device in the high-precision electronic balance.
If the sample injection needle needs to be tested for multiple times of experiments, the multi-channel reversing valve can be used for reversing the channel to the channel port connected with the water tank, meanwhile, the function of the modular injection pump is adjusted to be in an extraction mode, and the modular injection pump is started to pull back the piston in the sample injection needle so as to extract liquid in the water tank. And the water tank is higher than the modular injection pump and the injection needle to reduce air bubbles in the liquid.
And finally, weighing the mass of the liquid to be measured in the evaporation prevention device in unit time by using a high-precision electronic balance to obtain the real-time measured flow.
The above only is the preferred embodiment of the present invention, not limiting the scope of the present invention, all the equivalent structures or equivalent flow changes made by the contents of the specification and the drawings, or directly or indirectly applied to other related technical fields, are included in the same way in the protection scope of the present invention.
Claims (6)
1. Little flow calibrating device of liquid based on syringe pump, its characterized in that:
the device comprises an upper computer, a flow output module, a quality measuring module, a multi-channel reversing valve and a water tank;
the flow output module comprises a modular syringe pump;
the quality measurement module comprises a high-precision electronic balance and an evaporation prevention device;
the flow output module, the water tank, the high-precision electronic balance and the multi-channel reversing valve are connected through a silica gel hose;
the upper computer is in communication connection with the multi-channel reversing valve, the flow output module and the quality measurement module;
the sample injection needle is arranged on the modularized injection pump.
2. The syringe pump based liquid micro flow calibration device according to claim 1, wherein:
the sampling needle is connected with the silica gel hose through a luer connector.
3. The syringe pump based liquid micro flow calibration device according to claim 1, wherein:
the evaporation preventing device is arranged in the high-precision electronic balance.
4. The syringe pump based liquid micro flow calibration device according to claim 3, wherein:
the evaporation preventing device comprises a second collecting barrel and a first collecting barrel which are communicated through a large-diameter overflow pipe and a small-diameter overflow pipe;
the first collecting barrel is arranged in the second collecting barrel.
5. The syringe pump based liquid micro flow calibration device according to claim 4, wherein:
the surfaces of the calibration liquid in the second collecting barrel and the first collecting barrel are both covered with oil films.
6. The syringe pump based liquid micro flow calibration device according to claim 4, wherein:
and a first collecting barrel support is arranged in the second collecting barrel and used for fixing the first collecting barrel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222068821.1U CN218121108U (en) | 2022-08-08 | 2022-08-08 | Liquid micro-flow calibration device based on injection pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222068821.1U CN218121108U (en) | 2022-08-08 | 2022-08-08 | Liquid micro-flow calibration device based on injection pump |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218121108U true CN218121108U (en) | 2022-12-23 |
Family
ID=84522840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222068821.1U Expired - Fee Related CN218121108U (en) | 2022-08-08 | 2022-08-08 | Liquid micro-flow calibration device based on injection pump |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218121108U (en) |
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2022
- 2022-08-08 CN CN202222068821.1U patent/CN218121108U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20221223 |