CN218106597U - Device for treating bacterial infectious diseases by ultrasonic synergistic medicine - Google Patents

Device for treating bacterial infectious diseases by ultrasonic synergistic medicine Download PDF

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Publication number
CN218106597U
CN218106597U CN202220825971.XU CN202220825971U CN218106597U CN 218106597 U CN218106597 U CN 218106597U CN 202220825971 U CN202220825971 U CN 202220825971U CN 218106597 U CN218106597 U CN 218106597U
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China
Prior art keywords
ultrasonic
treatment
ultrasound
infectious diseases
treating bacterial
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Expired - Fee Related
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CN202220825971.XU
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Chinese (zh)
Inventor
杨敏
席定友
黄万
余晨阳
谌涛
徐羽馨
胡璨
杜永洪
王智彪
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Chongqing Medical University
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Chongqing Medical University
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Abstract

The utility model belongs to the technical field of medical equipment, specifically disclose a device of supersound collaborative drug therapy bacterial infectious diseases, including host computer, first treatment head and data signal line, be equipped with ultrasonic generator and control processor in the host computer, first treatment head includes the focus ultrasonic transducer in casing and the casing, first treatment head treatment end is equipped with detachable spill ultrasonic focusing lens, the device is furnished with the ultrasonic focusing lens of a plurality of different ultrasonic wave focus regional scope specifications; the ultrasonic generator, the control processor and the ultrasonic transducer are connected through data signal lines. The device is used for treating bacterial infection by ultrasonic synergistic medicine, has short treatment course and good curative effect, and can treat various diseases; the first therapeutic head of the focused ultrasound adopted by the device can improve the treatment sensitivity and the treatment depth, and the ultrasound focusing lens can be replaced to adjust the effective focal area and realize the optimal treatment effect.

Description

Device for treating bacterial infectious diseases by ultrasonic synergistic medicine
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a device for treating bacterial infectious diseases by ultrasonic synergetic medicament.
Background
Biofilms, also known as biofilms, refer to organized populations of bacteria attached to the surface of animate or inanimate objects and surrounded by extracellular macromolecules of the bacteria. Biofilm bacteria are very resistant to antibiotics and host immune defense mechanisms. The presence of biofilm clinically makes the treatment of many bacterial infectious diseases very difficult, such as mycotic vaginitis, subcutaneous solid tuberculosis, postoperative wound infection, and infection of implanted medical devices. At present, the problem of bacterial drug resistance caused by a biological membrane is solved by using a drug therapy mode and an operation therapy mode in clinic, but no drug specially aiming at the bacterial biological membrane exists in clinic, and a long-term drug combination mode is mostly adopted, so that the problems of drug abuse, serious drug adverse reaction, urgent need for new drugs and the like are easily caused.
Ultrasonic waves are mechanical waves having mechanical effects, thermal effects, cavitation, and the like. The ultrasonic wave has the advantages of good penetrability and transmission directionality, no wound, no infection risk, environmental protection and the like, and is widely applied clinically, particularly in the field of ultrasonic synergistic drug therapy, researches prove that the ultrasonic wave can destroy an environment, namely a biological membrane, on which bacteria depend for survival, transmit drugs and synergistically sterilize, and the problem that the treatment of drug-resistant bacterial infection of the biological membrane is difficult is effectively solved.
The ultrasonic medicine guide instrument on the market is used for treating biomembrane related diseases, but the ultrasonic medicine guide instrument on the market has the defects of shallow treatment part, inaccurate effective treatment range, uncertain medicine action part and synergistic medicine treatment effect after the medicine penetrates through skin tissues, and the like.
SUMMERY OF THE UTILITY MODEL
In view of the above prior art's shortcoming, the utility model aims to provide a device of supersound cooperation drug therapy bacterial infectious diseases solves the shallow appearance in current supersound guide medicine appearance treatment position, and treatment is poor scheduling problem, and this device adopts supersound cooperation drug therapy scheme, thereby promotes the drug absorption through supersound physical chemistry effect and realizes that the medicine is high-efficient to disinfect, and utilizes supersound and the medicine combined action that has the sonosensitizer characteristic to produce active oxygen molecule and directly disinfect and realize synergia and disinfect. The ultrasonic waves penetrate into the body from the outside of the human body to generate a physical and chemical reaction with bacteria causing infection, and the biological membrane wrapped outside the bacteria is damaged through the mechanical effect, the cavitation effect, the acoustic flow effect and the like of the ultrasonic waves, so that pores are generated on the surface of the biological membrane, the drug permeability of the biological membrane is increased, and the drug absorption is promoted to realize the efficient sterilization of the drugs; meanwhile, sound energy is further accumulated to act with a drug with the characteristics of the sound-sensitive agent, and the transient physical and chemical behaviors of the sound-sensitive agent are induced by ultrasound to trigger the generation of active oxygen molecules and directly kill bacteria, so that synergistic sterilization is realized. The ultrasonic is cooperated with the medicine for treatment, and noninvasive, efficient and synergistic sterilization is realized through the physical and chemical reaction of the ultrasonic and the medicine sterilization effect, so that a treatment scheme with better curative effect is provided for solving the problem of drug-resistant infection of biomembrane bacteria, preventing or reversing the formation of drug-resistant strains and treating bacterial infectious diseases.
In order to achieve the above and other related objects, the present invention provides a device for treating bacterial infectious diseases by ultrasound-assisted drug therapy, which comprises a main machine, a first therapeutic head and a data signal line, wherein an ultrasound generator and a control processor are arranged in the main machine, and the control processor is used for receiving and reacting to external signals; the first treatment head comprises a shell and a focused ultrasonic transducer positioned in the shell, the first treatment head shell comprises a treatment end for treatment, the treatment end is provided with a concave ultrasonic focusing lens, the ultrasonic focusing lens is detachably connected with the first treatment head shell, and the device is provided with a plurality of ultrasonic focusing lenses with different ultrasonic focusing area range specifications; the ultrasonic generator, the control processor and the ultrasonic transducer are connected through data signal lines.
Further, the effective focal area of the ultrasonic focusing lens is 1-5 cm 2 The utility model discloses preliminary design has: d1 type, D2 type, D3 type, the effective focal region of D1 type is 1cm 2 And the effective focal region of D2 type is 2cm 2 And the effective focal region of D3 type is 4cm 2
Furthermore, the treatment end of the first treatment head is provided with a groove for fixedly mounting the ultrasonic focusing lens, and the size of the groove is the same as that of the ultrasonic focusing lens.
Further, the host computer includes the shell, ultrasonic generator and control processor set up in the shell.
Further, the ultrasonic focusing lens is made of epoxy resin or organic glass.
Furthermore, the focusing ultrasonic transducer can generate frequency of 40 KHz-1 MHz and sound intensity of 0.15-1W/cm 2 The continuously adjustable focused ultrasound transducer of (1).
Further, the device also comprises a second treatment head, wherein the second treatment head comprises a shell and a planar pulse ultrasonic transducer positioned in the shell.
Furthermore, the planar pulse ultrasonic transducer can generate frequency of 40 KHz-1 MHz and sound intensity of 0.15-1W/cm 2 The continuously adjustable planar pulsed ultrasonic transducer of (1).
Further, the first treatment head and the second treatment head are handle-type treatment heads.
Further, be equipped with display screen and control key on the host computer shell, the display screen is used for showing key parameter such as ultrasonic frequency, sound intensity irradiation time, the control key is used for controlling ultrasonic frequency and sound intensity.
As mentioned above, the device for treating bacterial infectious diseases by ultrasound and drug cooperation of the present invention has the following beneficial effects:
1. the device has the main effects that the device is used for treating bacterial infection by ultrasound and drugs in cooperation, and can effectively break a biological membrane formed by bacterial infection through the combined action of multiple effects such as mechanical effect, cavitation effect and the like of ultrasound, thereby generating favorable conditions for the drugs to play a role in sterilization.
2. The ultrasonic generator used by the device can generate the ultrasonic wave with the frequency of 40 KHz-1 MHz and the sound intensity of 0.15-1W/cm 2 The continuously adjustable focused ultrasound is used for synergistic drug therapy, the treatment course is short, the curative effect is good, the sterilization effect is effectively increased while the dosage of the drug is greatly reduced, and the treatment period is shortened to 9 days.
3. The device can treat various diseases under the synergistic action of different medicines, and can effectively play a role in high-efficiency sterilization by only replacing the medicines with treatment effects aiming at the diseases caused by different bacterial infections.
4. The first treatment head of the device adopts focused ultrasound, so that ultrasonic waves can be converged in a small area, the treatment sensitivity and the treatment depth are effectively improved, and the ultrasonic intensity in the treatment area is also improved, so that the bacterial infection of internal organs and tissues of a human body is ensured to generate effective treatment effect.
5. The device is provided with two treatment heads, wherein two types of focused ultrasonic transducers and planar pulse ultrasonic transducers are respectively adopted, and doctors can select to use the treatment heads according to different diseases so as to ensure the optimal treatment effect on patients.
6. The first treatment head and the second treatment head of the device are handle-type, so that the handheld operation of a user is facilitated.
7. The ultrasonic focusing lens used by the device is a replaceable original element and can be replaced under different use conditions so as to adjust the effective focusing area of ultrasonic waves and realize the optimal treatment effect.
Drawings
Fig. 1 is a schematic view showing the overall structure of an apparatus for treating bacterial infectious diseases by ultrasound-assisted drug therapy according to embodiment 1 of the present invention.
Fig. 2 is a schematic structural diagram of a first therapeutic head in the device for treating bacterial infectious diseases by ultrasound-assisted drug therapy according to embodiment 1 of the present invention.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will be readily apparent to those skilled in the art from the disclosure herein. The present invention can also be implemented or applied through other different specific embodiments, and various details in the present specification can be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.
It should be noted that the drawings provided in the present embodiment are only for illustrating the basic idea of the invention in a schematic manner, and only the components related to the invention are shown in the drawings rather than being drawn according to the number, shape and size of the components in actual implementation, and the form, quantity and proportion of the components in actual implementation may be changed at will, and the layout of the components may be more complicated. The structure, proportion, size and the like shown in the drawings attached to the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by people skilled in the art, and are not used for limiting the limit conditions of the present invention, so that the present invention does not have the essential significance in technology, and the modification of any structure, the change of proportion relation or the adjustment of size should still fall within the scope of the technical content disclosed in the present invention without affecting the function and the achievable purpose of the present invention. In addition, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in the present specification are used for clarity of description only, and are not used to limit the scope of the present invention, and the relative relationship between the terms may be changed or adjusted without substantial technical changes.
Description of the reference numerals:
the device comprises a main machine 1, a first treatment head 2 and an ultrasonic focusing lens 3.
Example 1
As shown in fig. 1, the present embodiment provides a device for treating bacterial infectious diseases by using ultrasound in cooperation with drugs, which includes a host 1, a first therapeutic head 2 and a data signal line, wherein the host 1 includes a housing, an ultrasound generator and a control processor are disposed in the housing, the first therapeutic head 2 includes a housing and a focused ultrasound transducer disposed in the housing, and the ultrasound generator, the control processor and the focused ultrasound transducer are connected by the data signal line. The ultrasonic generator is used for generating exciting current, converting direct current into ultrasonic oscillation current through an internal logic circuit and a driving circuit, and transmitting the ultrasonic oscillation current to the first treatment head 2 through a related circuit in a data signal line to excite the ultrasonic transducer to generate vibration with corresponding frequency. The control processor is a calculation processing unit, is used for receiving and reacting to external signals, and plays a key control role for the ultrasonic generator. The focused ultrasonic transducer comprises a ceramic wafer with the diameter of D30mm SR25, the ceramic wafer is vibrated by the action of the exciting current generated by the ultrasonic generator, and the focused ultrasonic transducer can generate the vibration with the frequency of 1MHz and the sound intensity of 0.15-1W/cm 2 And continuously adjustable focused ultrasound.
Further, a display screen and control keys are arranged on the shell of the host 1, the display screen is used for displaying key parameters such as ultrasonic frequency, sound intensity irradiation time and the like, and the control keys are used for controlling the frequency and the sound intensity of the ultrasonic frequency.
The first treatment head 2 in this embodiment is of a handle type. Referring to fig. 2, the first therapeutic head 2 comprises a therapeutic end for therapy, a concave ultrasonic focusing lens 3 is arranged at the therapeutic end, the ultrasonic focusing lens 3 is made of an acoustic lens material and has a focusing effect on ultrasonic waves, and the material is epoxy resin or organic glass.
The ultrasonic focusing lens 3 on the first treatment head 2 is detachably connected with the first treatment head 2 shell in the device, specifically, the treatment end of the first treatment head 2 is provided with a groove for fixedly mounting the ultrasonic focusing lens 3, and the diameter of the groove is the same as that of the ultrasonic focusing lens 3 so as to accommodate the ultrasonic focusing lens 3. During the use, aim at the supersound focus lens 3 recess and put into fixedly, when needing to change supersound focus lens 3, use the clip to prize the edge of supersound focus lens 3, make it become flexible, then press from both sides it out, or directly take out the recess, change the operation. Meanwhile, the device is matched with a plurality of ultrasonic focusing lenses 3 with different ultrasonic focusing area range specifications, and the effective focal area of the ultrasonic focusing lens 3 is 1-5 cm 2 In this embodiment, three different specifications are designed initially: d1 type, D2 type, D3 type, wherein the effective focal domain of D1 type is 1cm 2 And the effective focal region of D2 type is 2cm 2 And the effective focal region of D3 type is 4cm 2 . The ultrasonic focusing lens 3 in the device belongs to a replaceable element, different ultrasonic focusing lenses 3 can be used alternatively according to different disease conditions, and the range of the ultrasonic focusing area is changed to realize the optimal treatment effect.
The utility model provides a use method of device of ultrasonic cooperative medicine treatment bacterial infectious disease as follows:
(1) The lesion site of the patient due to bacterial infection is examined by conventional means.
(2) Physicians instruct patients to take medicines or inject medicines according to the patients' symptoms.
(3) The patient can recover the mood, and after having a rest for a period of time, the patient waits for the medicine to enter the focus part through the blood circulation.
(4) The doctor opens the device, adjusts the frequency and the sound intensity, aligns the head (namely the treatment end) of the first treatment head 2 to the lesion part of the patient after the adjustment, irradiates for 10 to 20 minutes, and finishes the first-stage treatment.
(5) The treatment can be repeated for a plurality of times according to the recovery condition of the patient until the disease disappears.
(6) Different ultrasonic focusing lenses 3 can be alternatively used according to different diseases so as to change the range of the ultrasonic focusing area and realize the optimal treatment effect.
Example 2
The structure of the device for treating bacterial infectious diseases by using ultrasound in cooperation with drugs in the present embodiment is substantially the same as that of the device for treating bacterial infectious diseases by using ultrasound in cooperation with drugs in embodiment 1, except that: the device for treating bacterial infectious diseases by using the ultrasonic and synergistic medicine in the embodiment further comprises a second treatment head, wherein the second treatment head is of a handle type, the shape of the second treatment head is the same as that of the first treatment head 2, the second treatment head comprises a shell and a planar pulse ultrasonic transducer positioned in the shell, and an ultrasonic generator, a control processor and the planar pulse ultrasonic transducer are connected through data signal lines. The focused ultrasonic transducer comprises a ceramic wafer with a diameter of 30mm, the ceramic wafer vibrates under the action of an excitation current generated by an ultrasonic generator and can generate a signal with a frequency of 1MHz and a sound intensity of 0.15-1W/cm 2 And continuously adjustable planar pulsed ultrasound.
The device for treating bacterial infectious diseases by using ultrasound and drugs in cooperation is provided with two-channel treatment heads, namely a focused ultrasound transducer and a planar pulse ultrasound transducer, and doctors can select different treatment heads to use according to different diseases so as to ensure the optimal treatment effect on patients.
The above embodiments are merely illustrative of the principles and effects of the present invention, and are not to be construed as limiting the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which may be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims (10)

1. The device for treating bacterial infectious diseases by using the ultrasonic cooperative medicine is characterized by comprising a host, a first treatment head and a data signal line, wherein an ultrasonic generator and a control processor are arranged in the host, and the control processor is used for receiving external signals and reacting to the external signals; the first treatment head comprises a shell and a focusing ultrasonic transducer positioned in the shell, the first treatment head shell comprises a treatment end used for treatment, a concave ultrasonic focusing lens is arranged at the treatment end, the ultrasonic focusing lens is detachably connected with the first treatment head shell, and the device is provided with a plurality of ultrasonic focusing lenses with different ultrasonic focusing area range specifications; the ultrasonic generator, the control processor and the ultrasonic transducer are connected through data signal lines.
2. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the effective focal area of the ultrasonic focusing lens is 1-5 cm 2
3. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the treatment end of the first treatment head is provided with a groove for fixedly mounting the ultrasonic focusing lens, and the size of the groove is the same as that of the ultrasonic focusing lens.
4. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the host computer includes the shell, ultrasonic generator and control processor set up in the shell.
5. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the ultrasonic focusing lens is made of epoxy resin or organic glass.
6. The device for treating bacterial infectious diseases by using ultrasound and drugs in cooperation with claim 1, wherein: the focusing ultrasonic transducer can generate frequency of 40 KHz-1 MHz and sound intensity of 0.15-1W/cm 2 The continuously adjustable focused ultrasound transducer of (1).
7. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the device also comprises a second treatment head which comprises a shell and a planar pulse ultrasonic transducer positioned in the shell.
8. The device for treating bacterial infectious diseases by using ultrasound and drugs in combination according to claim 7, wherein: the planar pulse ultrasonic transducer can generate frequency of 40 KHz-1 MHz and sound intensity of 0.15-1W/cm 2 The continuously adjustable planar pulsed ultrasonic transducer of (1).
9. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 7, is characterized in that: the first treatment head and the second treatment head are handle-type treatment heads.
10. The device for treating bacterial infectious diseases by using ultrasound in combination with drugs according to claim 1, is characterized in that: the host shell is provided with a display screen and a control key, the display screen is used for displaying key parameters such as ultrasonic frequency, sound intensity irradiation time and the like, and the control key is used for controlling the frequency and the sound intensity of the ultrasonic frequency.
CN202220825971.XU 2022-04-07 2022-04-11 Device for treating bacterial infectious diseases by ultrasonic synergistic medicine Expired - Fee Related CN218106597U (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202220800903 2022-04-07
CN2022208009038 2022-04-07

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Publication Number Publication Date
CN218106597U true CN218106597U (en) 2022-12-23

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Granted publication date: 20221223

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