CN217960986U - Ultrasonic endoscopic probe and acoustic dynamic treatment device - Google Patents

Abstract

The utility model discloses an endoscopic ultrasound probe, which belongs to the field of medical instruments and comprises a base, an imaging device and a sound wave excitation device, wherein the imaging device and the sound wave excitation device are fixed on the base, the sound wave excitation device excites and excites sound sensitive materials in a tumor area, the imaging device images the tumor area to present the gathering condition of sound sensitive medicines, and through the design, the endoscopic ultrasound probe is utilized to excite nano sound sensitive medicines to realize fixed-point release; and the ultrasonic endoscope is used for carrying out corresponding dynamic image evaluation on the treatment effect, so that accurate and controllable dynamic regulation and control in the treatment process of the digestive tract tumor are realized. The targeted quantitative release of the medicine is carried out through ultrasonic excitation, and the accurate striking of the tumor is realized, so that the medicine dosage is reduced, and the side effect is reduced. The utility model also relates to an acoustic power treatment device comprising the ultrasonic endoscopic probe.

Description

Ultrasonic endoscopic probe and acoustic power treatment device

Technical Field

The utility model relates to the field of medical equipment, especially, relate to probe and acoustic dynamic treatment device are peeped to supersound.

Background

Chemotherapy is one of the most important methods for treating malignant tumors at present, chemical drugs are injected or orally taken into the body to achieve the effect of killing or inhibiting the growth of cancerous cells, and the method belongs to systemic treatment. The medicine has obvious and quick effect, can kill normal immune cells while killing tumor cells, is a treatment method of jade club burn, and has great side effect. In-vitro experiments of most medicines show that the traditional Chinese medicine composition has a good killing effect on cancer cells, but the effect is often greatly different in clinical application, and the traditional chemotherapy still has a large improvement space.

The drug-loaded targeted sonosensitive nano material is combined with the traditional chemical treatment method, and the targeted quantitative release of the drug is carried out through ultrasonic excitation, so that the drug-loaded targeted sonosensitive nano material is applied to the treatment of malignant tumors, and is a new treatment mode. The drug-loaded targeted sound-sensitive nano material can carry chemotherapeutic drugs, is gathered at a tumor part through the targeted characteristic, excites the sound-sensitive drugs gathered in cancer cells by means of ultrasound, and induces the drugs to be released at fixed points by sound waves, thereby achieving the purpose of targeted killing of the tumor cells. Compared with the traditional methods such as chemotherapy and radiotherapy, the drug-loaded targeted acoustic sensitive nano material can be targeted and concentrated on a tumor area in modes such as blood delivery, the acoustic wave irradiation area is mainly concentrated on the tumor area, and when the drug is induced and released, the drug is concentrated on a tumor focus area, so that the damage to normal tissues is avoided. Moreover, because the medicine can be concentrated on the affected part in a large amount, the tumor is accurately beaten instead of being flooded by large water, the dosage can be lower, and the harm of the high-dosage medicine to the body is avoided. In addition, the size of the nano-scale sound-sensitive medicine is in the nano level, and the medicine with the size can enter the interior of tumor cells more easily due to the effects of sound-induced perforation, cavitation effect and the like during acoustic excitation, so that the medicine has stronger penetrability, and the treatment effect is further improved.

For tumors in the alimentary canal of a human body, the ultrasonic endoscopic technology is utilized to carry out fixed-point release excitation of nano sound-sensitive medicines and corresponding dynamic image evaluation of treatment effect, which is undoubtedly advantageous. Ultrasonic Endoscopy (EUS) is a technique that uses Ultrasound for examination of the digestive tract, in which a miniature ultrasonic probe is placed at the tip of the probe, and is inserted into a body cavity to perform real-time scanning using Ultrasound, thereby obtaining Ultrasound images of histological features of the hierarchical structure of the gastrointestinal tract and surrounding adjacent organs (such as pancreas, gall bladder, liver, and spleen). The ultrasonic endoscope can image the structures of the alimentary canal and the soft tissues around the pancreas, and can provide more clinical reference information for the depth of lesion, the origin of lesion and the extraluminal condition of the lesion.

The existing ultrasonic endoscope can not track the sound-sensitive medicine, so that the tumor treatment process can not be accurately controlled.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the prior art, one of the objects of the present invention is to provide an ultrasonic endoscopic probe capable of tracking the sound-sensitive drugs, so that the focusing condition of the sound-sensitive nano drugs inside the body can be observed in real time in the image during the treatment process.

In order to overcome the defects of the prior art, the second objective of the present invention is to provide an acoustic dynamic therapy apparatus which can track the sound sensitive drug and can observe the sound sensitive nano-drug in the image in real time in the therapy process.

The utility model discloses an one of the purpose adopts following technical scheme to realize:

an ultrasonic endoscopic probe comprises a base, an imaging device and a sound wave excitation device, wherein the imaging device and the sound wave excitation device are fixed on the base, the sound wave excitation device excites and excites sound sensitive materials in a tumor area, and the imaging device images the tumor area to show the gathering condition of sound sensitive medicines.

Further, the imaging device is a convex array imaging transducer.

Further, the convex array imaging transducer is arc-shaped.

Further, the acoustic wave excitation device is an excitation transducer.

Further, the acoustic wave excitation device includes first acoustic wave exciter and second acoustic wave exciter, first acoustic wave exciter and second acoustic wave exciter are located respectively imaging device's relative both sides.

Further, the first acoustic driver and the second acoustic driver are single element transducers.

Furthermore, the acoustic wave excitation device further comprises a third acoustic wave exciter, the third acoustic wave exciter is an array transducer, the third acoustic wave exciter is located on one side, far away from the imaging device, of the second acoustic wave exciter, and the third acoustic wave exciter faces the imaging device.

Further, the ultrasonic endoscopic probe also comprises a sleeve fixedly connected with the base, and the sleeve is provided with an injection structure which is arranged towards the imaging device.

The second purpose of the utility model is realized by adopting the following technical scheme:

an acoustic power treatment device comprises the ultrasonic endoscopic probe.

Compared with the prior art, the utility model discloses the sound wave excitation device of endoscopic probe is inhaled to the sound sensitive material in tumour area and is aroused and encourage, and imaging device images the tumour area to show the gathering condition of sound sensitive medicine, through above-mentioned design, utilize endoscopic ultrasonic probe to encourage nanometer sound sensitive medicine, realize the release of fixed point; and the ultrasonic endoscope is used for carrying out corresponding dynamic image evaluation on the treatment effect, so that accurate and controllable dynamic regulation and control in the treatment process of the digestive tract tumor are realized. The targeted quantitative release of the medicine is carried out through ultrasonic excitation, and the accurate striking of the tumor is realized, so that the medicine dosage is reduced, and the side effect is reduced.

Drawings

Fig. 1 is a perspective view of the ultrasonic endoscopic probe of the present invention.

In the figure: 10. a conduit; 20. a sleeve; 21. a mounting surface; 30. an injection structure; 40. a base; 50. an imaging device; 60. an acoustic wave excitation device; 61. a first acoustic wave exciter; 62. a second acoustic wave exciter; 63. a third acoustic wave exciter.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present, secured by intervening elements. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When an element is referred to as being "disposed on" another element, it can be directly disposed on the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Fig. 1 shows an ultrasonic endoscopic probe of the present invention, which includes a catheter 10, a sleeve 20, an injection structure 30, a base 40, an imaging device 50, and a sound wave excitation device 60.

The catheter 10 is used to extend an ultrasonic endoscopic probe into the interior of a human body.

A sleeve 20 is mounted to the end of the catheter 10. The end of the sleeve 20 remote from the conduit 10 is provided with a mounting surface 21, the mounting surface 21 is a sloping surface, and the mounting surface 21 is inclined.

The injection structure 30 is located on the mounting surface 21 of the sleeve 20. In the present embodiment, the injection structure 30 is an injection hole capable of allowing the needle-equipped catheter 10 to be inserted from the outside and injecting a medicine or saline to a specific site. The drug was used for imaging and the saline was used for washing.

The base 40 is fixed to the sleeve 20. In this embodiment, the base 40 is integrally formed with the sleeve 20. The upper end surface of the base 40 is convex arc-shaped.

The imaging device 50 is fixedly mounted to the base 40. The imaging device 50 is a convex array imaging transducer, which is an ultrasonic B-type imaging probe, and is used for imaging and monitoring a tumor region for multi-array element electronic scanning imaging. Since the sound-sensitive drug is distinguished from other signals in the echo signal, the aggregation of the sound-sensitive drug is analyzed by an image and the therapeutic effect thereof is analyzed.

The acoustic wave excitation device 60 is an excitation transducer. The acoustic wave excitation means 60 comprises a first acoustic wave exciter 61, a second acoustic wave exciter 62 and a third acoustic wave exciter 63. The first acoustic wave exciter 61 and the second acoustic wave exciter 62 are single-element transducers, the directivity is single, the reflection power is large, and the materials are mainly PZT4/PZT8 and other piezoelectric materials with large Q values; the excitation and excitation of the acoustic sensitive material of the tumor area in the forward direction is mainly accomplished. The first acoustic driver 61 and the second acoustic driver 62 are fixed to the base 40 and located on both sides of the imaging device 50, respectively. The third acoustic wave exciter 63 is an array transducer, is supplemented by the first acoustic wave exciter 61 and the second acoustic wave exciter 62, has a certain transmitting power, can point to a specific position through delay setting, makes up the problem that the first acoustic wave exciter 61 and the second acoustic wave exciter 62 are insufficient, excites the area which cannot be covered by the first acoustic wave exciter 61 and the second acoustic wave exciter 62, and further improves the release effect of the medicine.

When the ultrasonic endoscopic probe is used, the sound-sensitive targeted drug-loaded nanoparticles are injected into the tumor region of the digestive tract by combining the modes of intravenous injection, fixed-point injection and the like. Due to the targeting property of the drug-loaded nanoparticles, the drug is gradually enriched to the tumor region after a period of in vivo circulation. After the drugs are enriched in the tumor region, the ultrasonic endoscopic probe is sent to the vicinity of the tumor region through the conduit 10, and the sound wave excitation device 60 carried by the ultrasonic endoscopic probe is utilized to continuously excite the sound sensitive material so as to induce the sound sensitive drugs to act on the tumor cells. During the excitation process, ultrasound imaging is performed by the imaging device 50 carried by the probe to dynamically evaluate the therapeutic effect.

The utility model discloses the effect that realizes includes:

1. the nano-acoustic sensitive medicine is stimulated by utilizing the ultrasonic inner snooping head to realize fixed-point release;

2. and the ultrasonic endoscope is used for carrying out corresponding dynamic image evaluation on the treatment effect, so that accurate and controllable dynamic regulation and control in the treatment process of the digestive tract tumor are realized.

3. The targeted quantitative release of the medicine is carried out through ultrasonic excitation, and the accurate striking of the tumor is realized, so that the medicine dosage is reduced, and the side effect is reduced.

The utility model also relates to an acoustic power treatment device comprising the ultrasonic endoscopic probe.

Since the sound-sensitive medicine can emit echo signals different from body tissues when being excited by sound waves, the echo signals can be displayed in an image after being separated and processed. By using the method, a doctor can observe the aggregation condition of the sound-sensitive nano-drug in the body in real time in the image during the treatment process, and judge the optimal time of drug release according to the distributed image. After the drug is released, the doctor can evaluate the treatment effect through the change of the tumor boundary, so as to set the optimal treatment course for the patient.

The above embodiments only represent several embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the concept of the present invention, several modifications and improvements may be made, all according to the equivalent modifications and evolutions of the present invention, which are made to the above embodiments by the essential technology, and all belong to the protection scope of the present invention.

Claims (9)

1. An ultrasonic endoscopic probe, comprising a base, characterized in that: the ultrasonic endoscopic probe also comprises an imaging device and a sound wave exciting device, wherein the imaging device and the sound wave exciting device are fixed on the base, the sound wave exciting device excites and excites the sound-sensitive material in the tumor area, and the imaging device images the tumor area so as to present the aggregation condition of the sound-sensitive medicine.

2. The endoscopic ultrasound probe according to claim 1, wherein: the imaging device is a convex array imaging transducer.

3. The ultrasonic endoscopic probe of claim 2, wherein: the convex array imaging transducer is arc-shaped.

4. The ultrasonic endoscopic probe of claim 1, wherein: the acoustic wave excitation device is an excitation transducer.

5. The ultrasonic endoscopic probe of claim 4, wherein: the acoustic wave excitation device comprises a first acoustic wave exciter and a second acoustic wave exciter, and the first acoustic wave exciter and the second acoustic wave exciter are respectively positioned on two opposite sides of the imaging device.

6. The endoscopic ultrasound probe according to claim 5, wherein: the first acoustic wave exciter and the second acoustic wave exciter are single-element transducers.

7. The endoscopic ultrasound probe according to claim 5, wherein: the acoustic wave excitation device further comprises a third acoustic wave exciter, the third acoustic wave exciter is an array transducer, the third acoustic wave exciter is located on one side, far away from the imaging device, of the second acoustic wave exciter, and the third acoustic wave exciter faces the imaging device.

8. The ultrasonic endoscopic probe of claim 7, wherein: the ultrasonic endoscopic probe further comprises a sleeve, the sleeve is fixedly connected with the base, and an injection structure is arranged on the sleeve and faces the imaging device.

9. An acoustic dynamic therapy device characterized by: comprising an ultrasonic endoscopic probe according to any of claims 1 to 8.

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