CN218078424U - Purification equipment is used in antibody production with separation function - Google Patents

Abstract

The utility model discloses a purification equipment with separation function for antibody production, which comprises a supporting leg, a supporting plate and a supporting rod, wherein the supporting plate is arranged at the upper end of the supporting leg, the supporting rod is arranged at the upper end of the supporting plate, a transverse plate is arranged at the upper end of the supporting rod, a separation box is arranged at the upper end of the transverse plate, a crushing box is arranged at the upper end of the separation box, a filtering and separating plate is slidably arranged in the separation box, a guide groove is arranged in the left side of the separation box, and a discharging pipe is arranged on the left side of the guide groove; the lower end of the supporting plate is provided with a feeding box through a discharging pipe, the upper end in the supporting plate is provided with a filtering plate, the lower end of the filtering plate is provided with a guide plate through the feeding box, and the inner surface of the lower end of the feeding box is provided with an installation barrel; the utility model discloses dismantle abluent in-process to this equipment at the user, pull down sealed lid and can make the filtration separator plate follow the inside roll-off of separator box and rinse it, pull down the apron and can change the filter screen and rinse the rotary drum, through the washing to inside filtration, can effectively guarantee the filter effect of this equipment.

Description

Purification equipment is used in antibody production with separation function

Technical Field

The utility model relates to a purification equipment technical field is used in the antibody production, specifically is a purification equipment is used in antibody production with separation function.

Background

The antibody is a protein with a protective effect in the cell, and has an important medicinal value in the aspect of treating diseases, but nowadays, people always research and extract the antibody, and the antibody exists in the cell, the cell structure needs to be destroyed to extract the antibody in the cell tissue fluid, and a purifying device is used in the process of extracting the antibody in the cell tissue fluid, but a part of purifying devices for producing the antibody have certain use defects in the using process, such as the case;

the utility model discloses a purification equipment that biological antibody production of utility model application number CN202220075413.6 used separates the filtration to kibbling cell tissue through the separation filter screen in the process of purifying cell tissue liquid for tissue residue and tissue liquid separate, later utilizes first filter layer and second filter layer to filter the separation to cell tissue liquid, thereby obtains antibody solution;

however, the separation filter screen in the above document is fixed inside the connection box, after the separation filter screen is used for a period of time, more cell residues are adhered to the upper end of the separation filter screen, bacteria can be bred, the separation filter screen is blocked, and the subsequent separation and filtration efficiency is affected.

Aiming at the problems, innovative design is urgently needed on the basis of the structure of the original purification equipment.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a purification equipment is used in antibody production with separation function to its upper end can be stained with more cell residue after solving the use period that proposes in the above-mentioned background art, and can breed the bacterium, causes the separation filter screen to block up, is not convenient for dismantle first filtering layer and second filtering layer, leads to the problem that first filtering layer and second filtering layer filter effect descend easily at the in-process that uses.

In order to achieve the purpose, the utility model provides a purification equipment with separation function for antibody production, which comprises a supporting leg, a supporting plate and a supporting rod, wherein the supporting plate is installed at the upper end of the supporting leg, the supporting rod is installed at the upper end of the supporting plate, a transverse plate is installed at the upper end of the supporting rod, a separation box is installed at the upper end of the transverse plate, a crushing box is installed at the upper end of the separation box, a filtering and separating plate is slidably installed inside the separation box, a guide groove is installed inside the left side of the separation box, a discharging pipe is installed on the left side of the guide groove, and a storage box is installed at the lower end of the discharging pipe through the supporting plate; the lower extreme of backup pad is installed the feeding case through arranging the material pipe, and the inside upper end of backup pad installs the filter, and the lower extreme of filter installs the deflector through the feeding case to the lower extreme internally surface mounting of feeding case has the installation bucket.

Furtherly, row material pipe is installed to the inside lower extreme of separator box, and arranges the lower extreme of material pipe and install the processing box through the backup pad, and the internally mounted of processing box has the rotary drum to the through-hole has been seted up to the inside of rotary drum, and the internally surface mounting of rotary drum has the filter screen simultaneously, the motor is installed to the lower extreme of backup pad, and the upper end of motor installs differential mechanism through the output shaft to the upper end of differential mechanism and the lower extreme fixed connection of rotary drum, the motor carries out the in-process of working can make the rotary drum carry out the fast rotation through differential mechanism, thereby makes the antibody in the solution separate with other matter.

Furthermore, the inside of the front end of the separation box is provided with a first sealing strip and a first magnet, the outer side of the front end of the separation box is provided with a sealing cover, the inside of the sealing cover is provided with a second magnet, the separation box forms a sealing structure through the first sealing strip and the sealing cover, and the separation box can avoid the overflow of the solution in the separation box by forming the sealing structure through the first sealing strip and the sealing cover.

Furthermore, first magnet and second magnet are opposite magnetic poles, and first magnet and second magnet correspond the setting in the inside of separator box and sealed lid respectively, and first magnet and second magnet are opposite magnetic poles and can make first magnet and second magnet produce the power of attracting each other and make separator box and sealed lid closely laminate again in-process that is close to.

Further, the front end internally mounted of processing case has the second sealing strip, and the front end outside of processing case is provided with the apron to the apron passes through the bolt fastening in the front end outside of processing case, and the apron passes through the second sealing strip simultaneously and constitutes seal structure with the processing case, and the apron passes through the second sealing strip and constitutes seal structure with the processing case and can avoid the inside solution of processing case to spill over.

Further, the filter screen is connected with the internal surface bonding of rotary drum, and the inside of rotary drum all with seted up the through-hole, the filter screen can be changed used filter screen with the internal surface bonding of rotary drum.

Furthermore, the front end internally mounted of feeding case has the third sealing strip, and the front end of feeding case is inside to have seted up four sets of spacing grooves to the internally mounted of spacing groove has reset spring, and reset spring keeps away from the one end of spacing groove and installs the stopper, the front end outside of feeding case is provided with the closing plate to four sets of fixture blocks are installed in the rear end outside of closing plate, are convenient for carry out cleaning and disinfecting to the inside structure of feeding case.

Furthermore, the limiting block and the feeding box form an elastic structure through a reset spring, the limiting block and the clamping block form a clamping structure, the reset spring can push the limiting block to move inside the feeding box, and the limiting block and the clamping block form a clamping structure, so that the sealing plate can be fixed outside the feeding box through the clamping block.

Compared with the prior art, the utility model, have following advantage:

(1) The utility model discloses in the in-process of purifying to cell tissue liquid, the filtration separation board can make waste residue and cell tissue liquid separate, and the antibody in the tissue liquid can separate the inside of processing case through the filter screen in the process of motor rotation, and the filter can carry out the secondary filtration to the antibody solution that flows out inside the processing case, and cell tissue liquid passes through multiple filtration and centrifugal treatment to obtain high-purity antibody solution, the effectual separation effect who improves this equipment;

(2) The utility model discloses dismantle abluent in-process at the user to this equipment, pull down sealed lid can make the filtration separator plate follow the inside roll-off of separator box and rinse it, pull down the apron and can change the filter screen and rinse to the rotary drum, the user pulls down the closing plate and can take out the filter from the inside of feed box and rinse it, through the washing to the inside filtration of this equipment, can effectually guarantee the filter effect of this equipment to the effectual convenience that improves this equipment and use.

Drawings

FIG. 1 is a schematic front view of the present invention;

FIG. 2 is a schematic front sectional view of the present invention;

FIG. 3 is a schematic view of the front view structure of the separation box of the present invention;

FIG. 4 is a left sectional structural view of the separation box of the present invention;

FIG. 5 is a front view of the drum of the present invention;

FIG. 6 is a schematic view of the front view structure of the feeding box of the present invention;

fig. 7 is the left sectional structure diagram of the feeding box of the present invention.

In the figure: 1. supporting leg 2, backup pad 3, bracing piece 4, diaphragm 5, separator box 6, crushing case 7, filter separator plate 8, guide way 9, discharging pipe 10, storage case 11, first sealing strip 12, first magnet 13, second magnet 14, sealed lid 15, arrange material pipe 16, processing case 17, rotary drum 18, through-hole 19, filter screen 20, apron 21, second sealing strip 22, motor 23, differential mechanism 24, 25, filter 26, deflector 27, installing bucket 28, third sealing strip 29, spacing groove 30, reset spring 31, stopper 32, closing plate 33, the fixture block.

Detailed Description

The invention is further described below with reference to the accompanying drawings:

as shown in the accompanying drawings 1-7, the utility model provides a purification equipment is used in antibody production with separation function, including supporting leg 1, backup pad 2, bracing piece 3, diaphragm 4, separator box 5, smash case 6, filtering separation board 7, guide way 8, discharging pipe 9, storage case 10, first sealing strip 11, first magnet 12, second magnet 13, sealed lid 14, arrange material pipe 15, processing case 16, rotary drum 17, through-hole 18, filter screen 19, apron 20, second sealing strip 21, motor 22, differential mechanism 23, feeding case 24, filter 25, deflector 26, installing bucket 27, third sealing strip 28, spacing groove 29, reset spring 30, stopper 31, closing plate 32 and fixture block 33.

The upper end of the supporting leg 1 is provided with a supporting plate 2, the upper end of the supporting plate 2 is provided with a supporting rod 3, and the upper end of the supporting rod 3 is provided with a transverse plate 4, the upper end of the transverse plate 4 is provided with a separating box 5, the upper end of the separating box 5 is provided with a crushing box 6, and the inside of the separation box 5 is provided with a filtering separation plate 7 in a sliding way, meanwhile, the left side of the separation box 5 is provided with a guide groove 8 in the inside, the left side of the guide groove 8 is provided with a discharge pipe 9, and the lower end of the discharge pipe 9 is provided with a material storage box 10 through a support plate 2, the lower end of the support plate 2 is provided with a material feeding box 24 through a material discharging pipe 15, the upper end of the inside of the support plate 2 is provided with a filter plate 25, and the lower end of the filter plate 25 is provided with a guide plate 26 through the feed box 24, while the inner surface of the lower end of the feed box 24 is provided with a mounting barrel 27, the front end of the separation box 5 is internally provided with a first sealing strip 11 and a first magnet 12, and the outer side of the front end of the separation box 5 is provided with a sealing cover 14, and the second magnet 13 is installed inside the sealing cover 14, and the separation box 5 forms a sealing structure with the sealing cover 14 through the first sealing strip 11, the first magnet 12 and the second magnet 13 are opposite magnetic poles, the first magnet 12 and the second magnet 13 are respectively arranged in the separation box 5 and the sealing cover 14 correspondingly, the third sealing strip 28 is arranged in the front end of the feeding box 24, four groups of limiting grooves 29 are arranged in the front end of the feeding box 24, a return spring 30 is arranged in the limiting groove 29, a limiting block 31 is arranged at one end of the return spring 30 far away from the limiting groove 29, a sealing plate 32 is arranged at the outer side of the front end of the feeding box 24, four groups of fixture blocks 33 are mounted on the outer side of the rear end of the sealing plate 32, the limiting block 31 and the feeding box 24 form an elastic structure through the return spring 30, and the limiting block 31 and the fixture blocks 33 form a clamping structure;

as shown in FIGS. 1 and 2, in the case of using the purification apparatus for antibody production having a separation function, the apparatus is first placed at a place where work is required, in the process of purifying the antibody by using the device, a user needs to put purified cell tissues into the crushing box 6 for crushing treatment, the crushed cell tissues can enter the separation box 5 and fall to the upper end of the filtering and separating plate 7, waste residues can roll from the upper end of the inclined filtering and separating plate 7 and enter the discharging pipe 9 through the guide groove 8, and finally fall into the storage box 10, a small part of waste residues can stay at the upper end of the filtering and separating plate 7, the user can observe the amount of waste residues in the storage box 10 by installing a glass plate outside the storage box 10, and the waste residues in the storage box 10 can be cleaned in time, the cell tissue liquid passes through the filtering and separating plate 7 and enters the interior of the rotary drum 17 through the discharging pipe 15, then the motor 22 and the differential 23 work and drive the rotary drum 17 to rotate at a high speed, the antibody in the cell tissue liquid is separated from other substances in the rotating process of the rotary drum 17 and enters the interior of the processing box 16 through the filter screen 19 and the through hole 18, and then enters the interior of the feeding box 24 through the discharging pipe 15 arranged in the interior of the processing box 16, after entering the interior of the feeding box 24, the filter plate 25 will filter the cell tissue fluid again, and finally flow into the interior of the installation barrel 27 through the guide plate 26, so that the purification process of the antibody by the apparatus is completed, the cell tissue fluid is processed by multiple filtration and centrifugation, therefore, the antibody is separated from the cell tissue fluid, and a high-purity antibody solution is obtained, so that the separation effect of the device is effectively improved;

a discharge pipe 15 is installed at the lower end inside the separation box 5, a processing box 16 is installed at the lower end of the discharge pipe 15 through a support plate 2, a rotary drum 17 is installed inside the processing box 16, a through hole 18 is formed in the rotary drum 17, a filter screen 19 is installed on the inner surface of the rotary drum 17, a motor 22 is installed at the lower end of the support plate 2, a differential 23 is installed at the upper end of the motor 22 through an output shaft, the upper end of the differential 23 is fixedly connected with the lower end of the rotary drum 17, a second sealing strip 21 is installed inside the front end of the processing box 16, a cover plate 20 is arranged on the outer side of the front end of the processing box 16, the cover plate 20 is fixed on the outer side of the front end of the processing box 16 through bolts, the cover plate 20 and the processing box 16 form a sealing structure through the second sealing strip 21, the filter screen 19 is connected with the inner surface of the rotary drum 17 in an adhesive mode, and the through hole 18 is formed in the rotary drum 17;

as shown in fig. 1 to 7, after the apparatus is used for a period of time, the apparatus inside the apparatus needs to be cleaned, in the process, a user can directly take the sealing cover 14 off from the front end of the separation box 5, so as to conveniently take the filtering separation plate 7 out of the separation box 5, and the user can detach the filtering net 19 from the inside of the rotary drum 17 after detaching the bolt installed inside the cover plate 20, the user can extrude the stopper 31 in the detaching process of the sealing plate 32, the stopper 31 can move towards the inside of the limiting groove 29 and extrude the return spring 30 after being extruded, and when the stopper 33 is separated from the stopper 31, the return spring 30 can expand and push the stopper 31 to move, so that the sealing plate 32 can be detached at this time, the filtering plate 25 can be taken out of the inside of the feeding box 24, and then the detached structure can be cleaned or replaced, thereby effectively ensuring the filtering effect and increasing the overall practicability.

Those not described in detail in this specification are within the skill of the art.

The present invention is not limited by the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be equivalent replacement modes, and are all included in the protection scope of the present invention.

Claims (8)

1. The utility model provides an antibody production is with purification equipment with separation function, includes supporting leg (1), backup pad (2) and bracing piece (3), its characterized in that: the supporting device is characterized in that a supporting plate (2) is installed at the upper end of the supporting leg (1), a supporting rod (3) is installed at the upper end of the supporting plate (2), a transverse plate (4) is installed at the upper end of the supporting rod (3), a separating box (5) is installed at the upper end of the transverse plate (4), a crushing box (6) is installed at the upper end of the separating box (5), a filtering separating plate (7) is installed inside the separating box (5) in a sliding mode, a guide groove (8) is installed inside the left side of the separating box (5), a discharging pipe (9) is installed on the left side of the guide groove (8), and a material storage box (10) is installed at the lower end of the discharging pipe (9) through the supporting plate (2);

the lower extreme of backup pad (2) is installed feeding case (24) through arranging material pipe (15), and the inside upper end of backup pad (2) installs filter (25) to deflector (26) are installed through feeding case (24) to the lower extreme of filter (25), and the lower extreme internally surface mounting of feeding case (24) has installing bucket (27) simultaneously.

2. The purification apparatus for antibody production having a separation function according to claim 1, wherein: arrange material pipe (15) is installed to the inside lower extreme of separator box (5), and the lower extreme of arranging material pipe (15) installs processing case (16) through backup pad (2), and the internally mounted of processing case (16) has rotary drum (17) to through-hole (18) have been seted up to the inside of rotary drum (17), and the internally mounted of rotary drum (17) has filter screen (19) simultaneously, motor (22) are installed to the lower extreme of backup pad (2), and differential mechanism (23) are installed through the output shaft in the upper end of motor (22), and the upper end of differential mechanism (23) and the lower extreme fixed connection of rotary drum (17).

3. The purification apparatus for antibody production having a separation function according to claim 1, wherein: the front end of the separation box (5) is internally provided with a first sealing strip (11) and a first magnet (12), the outer side of the front end of the separation box (5) is provided with a sealing cover (14), the inside of the sealing cover (14) is provided with a second magnet (13), and the separation box (5) and the sealing cover (14) form a sealing structure through the first sealing strip (11).

4. The purification apparatus for antibody production having a separation function according to claim 3, characterized in that: the first magnet (12) and the second magnet (13) are opposite magnetic poles, and the first magnet (12) and the second magnet (13) are respectively arranged in the separation box (5) and the sealing cover (14) correspondingly.

5. The purification apparatus for antibody production having a separation function according to claim 2, characterized in that: the front end of the processing box (16) is internally provided with a second sealing strip (21), a cover plate (20) is arranged on the outer side of the front end of the processing box (16), the cover plate (20) is fixed on the outer side of the front end of the processing box (16) through a bolt, and meanwhile the cover plate (20) and the processing box (16) form a sealing structure through the second sealing strip (21).

6. The purification apparatus for antibody production having a separation function according to claim 2, characterized in that: the filter screen (19) is connected with the inner surface of the rotary drum (17) in an adhesive manner, and the inside of the rotary drum (17) is provided with a through hole (18).

7. The purification apparatus for antibody production having a separation function according to claim 1, wherein: the front end internally mounted of feeding case (24) has third sealing strip (28), and the front end of feeding case (24) is inside to be seted up four groups of spacing grooves (29) to the internally mounted of spacing groove (29) has reset spring (30), and reset spring (30) keep away from the one end of spacing groove (29) and install stopper (31), the front end outside of feeding case (24) is provided with closing plate (32) to four groups of fixture block (33) are installed in the rear end outside of closing plate (32).

8. The purification apparatus for antibody production having a separation function according to claim 7, wherein: the limiting block (31) and the feeding box (24) form an elastic structure through a return spring (30), and the limiting block (31) and the clamping block (33) form a clamping structure.

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