CN217856255U

CN217856255U - Sample tube

Info

Publication number: CN217856255U
Application number: CN202222332882.4U
Authority: CN
Inventors: 牛建会; 黄勃
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2022-08-31
Filing date: 2022-08-31
Publication date: 2022-11-22
Anticipated expiration: 2032-08-31

Abstract

The utility model discloses a sample tube for bear sample liquid, sample tube include the outer tube with set up in inner tube in the outer tube, the outer tube is located part on the inner tube is as collection portion, all the other parts as the supporting part, the internal face of collection portion with the internal face of inner tube encloses into the space that holds sample liquid jointly, is at least be provided with on the internal face of collection portion and be used for promoting sample liquid to the hydrophobic layer that the inner tube assembles effectively avoids sample liquid to remain on the pipe wall of outer tube for the sample liquid of capacity can assemble the inner tube in order to satisfy sample detection's needs.

Description

Sample tube

Technical Field

The utility model relates to the technical field of medical equipment, especially, relate to a sample tube.

Background

The change of human physiology and pathology can often cause the change of body fluid (such as blood, urine, etc.) components, and the detection and analysis of body fluid samples, especially blood samples, can provide the basis for diagnosis and treatment of diseases.

Generally, the blood sample is collected by using a vacuum test tube to perform intravenous blood collection, which can ensure sufficient blood collection (usually about 500-1500 ul), and can also avoid interference of other substances such as interstitial fluid and the like, thereby ensuring the reliability of sample detection. However, in particular groups of anemic patients, infants and the like, it is often difficult to ensure that sufficient venous blood is collected due to the particularity of blood vessels and blood cells, so peripheral blood collection is also required clinically, and the blood collection amount is generally not more than 200ul.

However, when the conventional test tube is used for collecting peripheral blood, part of blood remains on the tube wall and is difficult to gather at the tube bottom, so that the blood which can be sucked from the test tube by the sampling needle cannot reach the dosage of sample detection, and the sample detection is influenced.

Disclosure of Invention

Accordingly, a sample tube capable of effectively preventing the sample liquid from remaining on the tube wall is provided.

A sample tube is used for carrying sample liquid and comprises an outer tube and an inner tube arranged in the outer tube, wherein the part of the outer tube positioned above the inner tube is used as a collecting part, the rest part of the outer tube is used as a supporting part, the inner wall surface of the collecting part and the inner wall surface of the inner tube jointly enclose a space for containing the sample liquid, and at least a hydrophobic layer used for promoting the sample liquid to be gathered towards the inner tube is arranged on the inner wall surface of the collecting part.

In some embodiments, the hydrophobic layer is a coating or a film provided on an inner wall surface of the collecting part.

In some embodiments, the hydrophobic layer is a hydrophobic surface formed by surface roughening of an inner wall surface of the collecting portion.

In some embodiments, the contact angle of the sample liquid when on the hydrophobic layer is greater than or equal to 120 degrees.

In some embodiments, the contact angle of the sample liquid when on the hydrophobic layer is greater than or equal to 150 degrees.

In some embodiments, the roll angle of the sample liquid when on the hydrophobic layer is less than or equal to 10 degrees.

In some embodiments, the inner tube has a tapered structure tapering downward, and the inner wall surface of the inner tube is not provided with a hydrophobic layer.

In some embodiments, the inner tube is connected to the outer tube at a middle position, and the bottom end of the support portion is lower than the bottom end of the inner tube.

In some embodiments, the apparatus further comprises a cap covering the collecting portion of the outer tube, and the cap is provided with a hydrophobic layer facing an inner wall surface of the inner tube.

In some embodiments, the sample tube is a peripheral blood tube for collecting peripheral blood.

Compared with the prior art, the utility model discloses the sample pipe sets up the hydrophobic layer at the internal face of the collection portion of its outer tube, can effectively avoid sample liquid to remain on the pipe wall of outer tube for the sample liquid of capacity can assemble the needs to inner tube in order to satisfy sample detection, and the guarantee sample detection smoothly goes on and the testing result is accurate effective.

Drawings

Fig. 1 is a cross-sectional view of an embodiment of the sample tube of the present invention.

Fig. 2 is a schematic diagram of the contact angle of the sample liquid on the tube wall of the sample tube.

Fig. 3 is a schematic view of the roll angle of the sample liquid on the tube wall of the sample tube.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. One or more embodiments of the present invention are illustrated in the accompanying drawings to provide a more accurate and thorough understanding of the disclosed embodiments. It should be understood, however, that the present invention may be embodied in many different forms and is not limited to the embodiments described below.

The same or similar reference numerals in the drawings of the utility model correspond to the same or similar parts; in the description of the present invention, it should be understood that if there are the terms "upper", "lower", "left", "right", etc. indicating the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, it is only for convenience of description and simplification of the description, but it is not intended to indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limitations of the present patent, and specific meanings of the above terms can be understood according to specific situations by those of ordinary skill in the art.

The utility model provides a sample tube mainly is applied to among the sample detection, as the body fluid sample that awaits measuring, like the carrier of blood sample, urine sample etc.. The utility model discloses the sample tube includes the outer tube and sets up the inner tube in the outer tube, and the part that the outer tube is located on the inner tube is as collection portion, all the other parts as the supporting part, and the internal face of collection portion and the internal face of inner tube enclose into the space that holds sample liquid jointly, are provided with the hydrophobic layer at least on the internal face of collection portion in order to make sample liquid to the inner tube assembles, through the self-cleaning ability in surface of hydrophobic layer, can effectively avoid sample liquid to remain on the pipe wall of outer tube for the sample liquid of capacity can assemble to the inner tube in order to satisfy sample detection's needs, and the guarantee sample detection smoothly goes on and the testing result is accurate effective.

Fig. 1 shows an embodiment of the sample tube of the present invention, which comprises a tube body 10 and a cap 20 covering the tube body 10.

The tube body 10 comprises an outer tube 12 and an inner tube 14, wherein the outer tube 12 is a hollow circular tube structure, and the size of the outer tube can be standardized so as to meet the automation requirement of sample detection; the inner tube 14 is a tapered structure that tapers downward, is located inside the outer tube 12, and is integrally connected to the outer tube 12. The upper end of the outer tube 12, i.e., the portion located above the inner tube 14, serves as a collecting portion 121 for introduction of the sample liquid; the lower end of the outer tube 12, i.e., the portion not exceeding the inner tube 14, serves as a support portion 123, facilitating placement of the sample tube. The inner wall surface 125 of the collection portion 121 of the outer tube 12 and the inner wall surface 141 of the inner tube 14 together enclose a space 16 for containing the sample liquid. When the collection amount of the sample liquid is small, the collected sample liquid is converged into the inner tube 14; when the amount of the collected sample liquid is large, the collected sample liquid may be partially contained in the collecting portion 121 of the outer tube 12.

The inner tube 14 may vary slightly in size, shape, and location depending on the application requirements. The sample tube of the illustrated embodiment is a peripheral blood test tube for collecting a sample of peripheral blood, and the inner tube 14 is connected to the middle position of the outer tube 12, so that the path of the peripheral blood flowing to the inner tube 14 can be shortened to some extent, and the convergence of the peripheral blood to the inner tube 14 can be accelerated; the tapered configuration of the inner tube 14 also provides some guidance and acceleration to the pooling of peripheral blood so that the peripheral blood can quickly reach the bottom of the inner tube 14. The utility model discloses sample tube is in other application scenarios, if be applied to the sample collection of venous blood, because the blood sampling dose is great, inner tube 14 also can be close to the bottom setting of outer tube 12, increases the inside size that holds space 16 of sample liquid of body 10, does not use concrete embodiment as the limit.

In the illustrated embodiment, the bottom end of the supporting portion 123 of the outer tube 12 is open to facilitate the manufacturing and forming of the tube body 10; meanwhile, the end face of the supporting part 123 is a flat circular ring, the sample tube can be stably placed on a desktop or other supports without toppling over, a tube frame or the like is not needed as a support, and the use convenience is improved. The bottom of the inner tube 14 is higher than the bottom of the outer tube 12 so that the inner tube 14 of the sample tube is not touched when the sample tube is placed, and the use safety is improved. Preferably, the supporting portion 123 of the outer tube 12 is a transparent glass tube, a transparent plastic tube, etc., so that a user can directly observe the concentration of the sample liquid in the tube 10 through the supporting portion 123. When the convergence condition of the sample liquid in the individual sample tube does not meet the requirement, the sample tube can be removed and the user is informed to collect the sample liquid again.

The inner wall surface 125 of the collecting part 121 of the outer tube 12 is provided with the hydrophobic layer 127, and through the surface self-cleaning capability of the hydrophobic layer 127, the sample liquid can be effectively prevented from remaining on the inner wall surface 125 of the collecting part 121, so that the collected sample liquid can be gathered to the inner tube 14, more total samples are formed, the requirement of sample detection is met, the sample detection is smoothly carried out, and the detection result is accurate and effective. The water-repellent layer 127 may be a coating layer formed by applying a paint to the inner wall surface 125 of the collecting portion 121, or may be a thin film deposited on the inner wall surface 125 by plating or the like. The thickness of the hydrophobic layer 127 is typically on the order of nanometers, and the material used may be a fluorocarbon polymer or the like. In some embodiments, the hydrophobic layer 127 may also be a hydrophobic surface formed by the inner wall surface 125 of the collecting portion 121 being subjected to a surface roughening treatment.

In some embodiments, the inner wall surface 22 of the tube cap 20 (i.e., the surface facing the inner tube 14) is also provided with a hydrophobic layer 24, which hydrophobic layer 24 may be a coating formed by applying a coating onto the inner wall surface 22; alternatively, it may be a thin film deposited on the inner wall surface 22; alternatively, the inner wall surface 22 may be a hydrophobic surface formed by surface roughening treatment. During use, the sample tube may be accidentally tilted or even tipped over, causing sample fluid that would otherwise pool at the inner tube 14 to flow onto the cap 20. The hydrophobic layer 24 is arranged to enable the sample liquid to automatically flow back and converge to the inner tube 14 again after the sample tube is in the right position, so that the sample liquid is effectively prevented from remaining on the tube cap 20. The thickness of the

hydrophobic layers

127, 24 is exaggerated in the illustration for clarity of illustration, and should not be construed as limiting the application.

In some embodiments, the inner wall surface 141 of the inner tube 14 is not provided with a hydrophobic layer. For example, in the detection of a blood sample, it is usually necessary to spray an anticoagulant on the inner wall surface 141 of the inner tube 14 to prevent the blood sample from coagulating after being left for a certain period of time, and further to prevent the sampling needle from being blocked to affect the detection of the sample. The inner wall surface 141 of the inner tube 14 is not provided with a hydrophobic layer, and the adhesion of the anticoagulant to the inner wall surface 141 can be prevented from being affected. Of course, it can be understood that, on the premise that the collected blood sample meets the use requirement, the inner wall surface 141 of the inner tube 14 may also be provided with a hydrophobic layer for improving the effectiveness of blood sample collection.

To improve the hydrophobic property of the hydrophobic layer 127, as shown in fig. 2, the contact angle θ of the droplet 30 of the sample liquid on the hydrophobic layer 127 may be designed to be 120 degrees or more. The contact angle θ refers to an included angle from a solid-liquid interface to a gas-liquid interface through the inside of liquid at a three-phase boundary of solid, liquid and gas, is an important parameter for representing the wettability of the surface of the material, and can be calculated according to a Young's formula (Young Equation):

Cosθ＝(δsq-δsl)/δlg，

where δ sq is the interfacial tension between the solid and gas (i.e., the water-repellent layer 127 and the air), δ sl is the interfacial tension between the solid and liquid (i.e., the water-repellent layer 127 and the liquid droplet 30), and δ lg is the interfacial tension between the gas and liquid (i.e., the air and the liquid droplet 30). When the contact angle θ is not less than 90 °, the inner wall surface 125 of the outer tube 12 is hardly wetted with the sample liquid. In some embodiments, the contact angle θ of the droplet 30 when on the hydrophobic layer 127 can be designed to be greater than or equal to 150 degrees for optimal hydrophobicity.

To further improve the hydrophobic property of the hydrophobic layer 127, as shown in fig. 3, the roll angle α of the droplet 30 of the sample liquid on the hydrophobic layer 127 may be designed to be 10 degrees or less. The rolling angle α is the angle formed by the inclined surface and the horizontal plane just when the liquid drop 30 rolls on the inclined surface, and is also an important parameter for characterizing the wettability of the material surface. The rolling angle α is related to the difference between the advancing angle θ a and the receding angle θ r, where the advancing angle θ a is a contact angle at which the three-phase line, which contacts the liquid droplet 30 with the hydrophobic layer 127, will move and not move when the volume of the liquid droplet 30 is increased; the receding angle θ r is a contact angle in a state where the three-phase line of the liquid droplet 30 in contact with the water-repellent layer 127 will move and not move when the volume of the liquid droplet 30 is reduced.

It should be understood that the hydrophobic layer 24 of the inner wall surface 22 of the cap 20 and the hydrophobic layer 127 of the inner wall surface 125 of the collector 121 may be of the same design, i.e. the contact angle of the liquid droplet 30 on the hydrophobic layer 24 is greater than or equal to 120 degrees, preferably greater than or equal to 120 degrees; the roll-off angle of the droplets 30 when on the hydrophobic layer 24 is less than or equal to 10 degrees.

When the sample tube is used for collecting peripheral blood, the collected peripheral blood may be directly scraped off by the collecting portion 121 of the outer tube 12 with the cap 20 removed, or the collected peripheral blood may be introduced into the collecting portion 121 into which a capillary tube for collecting peripheral blood is inserted. When the sample tube is used for collecting venous blood, the tube body 10 may be evacuated and sealed with the tube cap 20, and then a puncture needle may be inserted into the collection portion 121 to introduce the collected venous blood. After the collection and introduction of the sample liquid are completed, the cap 20 seals the collecting part 121, and prevents the collected sample liquid from being contaminated by the external environment. The cap 20 is preferably made of an elastic material, such as plastic, and a thin blocking portion 26 is formed at the center to facilitate the puncture of the puncture needle, to achieve the introduction of the sample liquid and the suction of the sample liquid during the sample detection process, and to support the sample analyzer with full automatic sample introduction.

The utility model discloses the sample pipe forms the hydrophobic layer 127 at the internal face 125 of the collection portion 121 of its outer pipe 12, through the self-cleaning ability in surface of hydrophobic layer 127, can effectively avoid sample liquid to remain on the pipe wall of outer pipe 12 for the sample liquid of capacity can assemble the needs in order to satisfy sample detection to inner tube 14, guarantee that sample detection smoothly goes on and the testing result is accurate effective, the less application scene of specially adapted sample liquid collection volume, like the sample collection of tip blood etc. Even to the great application scene of volume is gathered to the specimen fluid, use like the sample collection of venous blood the utility model discloses the sample tube can avoid blood to remain on the pipe wall of outer tube 12 and cause a certain amount of blood extravagant, improves the utilization ratio of blood, reduces the blood sampling burden of patient.

It should be noted that the present invention is not limited to the above embodiments, and other changes can be made by those skilled in the art according to the inventive spirit of the present invention, and all changes made according to the inventive spirit of the present invention should be included in the scope of the claimed invention.

Claims

1. The sample tube is characterized by comprising an outer tube and an inner tube arranged in the outer tube, wherein the part of the outer tube positioned above the inner tube is used as a collecting part, the rest part of the outer tube is used as a supporting part, the inner wall surface of the collecting part and the inner wall surface of the inner tube jointly enclose a space for containing sample liquid, and at least a hydrophobic layer for promoting the sample liquid to be gathered towards the inner tube is arranged on the inner wall surface of the collecting part.

2. The sample tube according to claim 1, wherein the hydrophobic layer is a coating or a thin film provided on an inner wall surface of the collecting portion.

3. The sample tube according to claim 1, wherein the hydrophobic layer is a hydrophobic surface formed by roughening an inner wall surface of the collecting portion.

4. The sample tube of claim 1, wherein a contact angle of the sample liquid on the hydrophobic layer is greater than or equal to 120 degrees.

5. The sample tube of claim 4, wherein a contact angle of the sample liquid on the hydrophobic layer is greater than or equal to 150 degrees.

6. The sample tube of claim 1, wherein a roll angle of the sample liquid on the hydrophobic layer is less than or equal to 10 degrees.

7. The sample tube according to claim 1, wherein the inner tube has a tapered structure which is tapered downward, and an inner wall surface of the inner tube is not provided with a hydrophobic layer.

8. The sample tube according to claim 7, wherein the inner tube is connected to the outer tube at a middle position, and a bottom end of the support portion is lower than a tube bottom of the inner tube.

9. The sample tube according to any one of claims 1 to 8, further comprising a cap covering the collection portion of the outer tube, the cap being provided with a hydrophobic layer facing an inner wall surface of the inner tube.

10. A sample tube as claimed in any one of claims 1 to 8, wherein the sample tube is a peripheral blood tube for collecting peripheral blood.