CN217856047U

CN217856047U - Microfluidic device for preparing lipid nanoparticles

Info

Publication number: CN217856047U
Application number: CN202221407261.1U
Authority: CN
Inventors: 许春水
Original assignee: Nazhida Shanghai Nanotechnology Co ltd
Current assignee: Nazhida Shanghai Nanotechnology Co ltd
Priority date: 2022-06-07
Filing date: 2022-06-07
Publication date: 2022-11-22
Anticipated expiration: 2032-06-07

Abstract

The utility model discloses a micro-fluidic device for preparing lipid nanoparticle, the mounting panel comprises a mounting plate, the up end middle part fixedly connected with preparation section of thick bamboo of mounting panel, the surface left and right sides of preparation section of thick bamboo all has the injection tube through the fixed intercommunication of conveying pipeline, the equal fixedly connected with in one end that leaves of the injection tube on left and right sides pushes away the feed cylinder, when using, storage equipment is connected to the inlet pipe, later drive assembly drives the material pushing piece, piston rod and movable block move to the right side, storage equipment's raw materials will be inhaled under the effect of check valve and push away the feed cylinder, when needs injection raw materials, drive assembly will the antiport, the material pushing piece will move to preparation section of thick bamboo direction this moment, the raw materials will be injected in the preparation section of thick bamboo, the flowmeter of setting is used for detecting the raw materials velocity of flow in real time, when the velocity of flow is too fast or when too slow, the controller will control drive assembly's rotational speed, realize controlling feed rate.

Description

Microfluidic device for preparing lipid nanoparticles

Technical Field

The utility model relates to a medicine preparation technical field specifically is a micro-fluidic equipment for preparing lipid nanoparticle.

Background

The lipid nanoparticle is a novel drug delivery system which takes a biocompatible lipid material as a carrier and dissolves, wraps or attaches drugs or other bioactive substances on the surface of the lipid nanoparticle. The lipid nanoparticles can improve drug absorption, have the advantages of slow release, controlled release, improved drug stability, enhanced curative effect, reduced toxic and side effects and the like, and are stable in vivo and in the storage process. The carrier system is widely applied to genetic drugs, antitumor drugs, proteins, polypeptides and other drugs.

However, the existing lipid nanoparticle processing apparatus does not facilitate control of the feeding rate during the processing of lipid nanoparticles, and therefore, we propose a microfluidic apparatus for preparing lipid nanoparticles.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a micro-fluidic equipment for preparing lipid nanoparticle to solve the problem that proposes in the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme:

the utility model provides a micro-fluidic device for preparing lipid nanoparticle, includes the mounting panel, the up end middle part fixedly connected with preparation section of thick bamboo of mounting panel, the inside of preparation section of thick bamboo is formed with mixed runner, the front end fixed intercommunication of preparation section of thick bamboo has the stub bar, the surface left and right sides of preparation section of thick bamboo all has the injection tube through conveying pipeline fixed intercommunication, the equal fixedly connected with ejector sleeve of the equal fixedly connected with in one end of separating of the injection tube on left and right sides, the inside sliding connection of injection tube has the ejector pad, fixedly connected with piston rod on the ejector pad, the inside sliding connection of ejector pad has the movable block, the lead screw is worn to be equipped with by the equal screw thread in surface front and back side of movable block, the one end of lead screw is connected with the inner wall rotation that pushes away the material section of thick bamboo, the other end rotation of lead screw is stretched out the outside of ejector pad, and is connected with drive assembly between the lead screw of front and back side, the piston rod slides and stretches into the inside of ejector pad, and the piston rod keeps away from ejector pad's one end and movable block fixed connection, the intercommunication has the inlet pipe on inlet pipe and the conveying pipe, all install the check valve on inlet pipe, be connected with the flowmeter on the conveying pipe.

Preferably, the driving assembly comprises a miniature speed regulating motor, the output end of the miniature speed regulating motor is fixedly connected with the screw rod on the rear side, a driving gear is fixedly sleeved on the outer surface of the screw rod on the rear side, a driven gear is connected to the screw rod on the front side, and the driven gear is meshed with the driving gear.

Preferably, the mounting plate is provided with a controller, and the signal input end of the miniature speed regulating motor and the signal output end of the flowmeter are electrically connected.

Preferably, the outer surface of the preparation cylinder is fixedly sleeved with a heat conduction layer, the outer surface of the heat conduction layer is spirally sleeved with an electric heating wire, and the outer part of the electric heating wire is sleeved with a heat insulation layer.

Preferably, the heat conducting layer is made of heat conducting silica gel.

Preferably, the heat insulation layer is made of insulating ceramics,

preferably, the feeding pipe is connected with a plunger type constant flow pump, a pressure regulating valve is installed at the upper end of the mixing flow channel, and a plurality of pressure detection sensors are arranged inside the mixing flow channel.

Compared with the prior art, the beneficial effects of the utility model are that: the micro-fluidic device for preparing the lipid nanoparticles is convenient to use and simple in structure, when the micro-fluidic device is used, the feeding pipe is connected with the storage device, the micro speed regulating motor drives the screw rods on the front side and the rear side to rotate forwards at the same time, the screw rods drive the material pushing sheet, the piston rod and the moving block to move towards the right side when rotating forwards, the raw material of the storage device is sucked into the material pushing cylinder under the action of the one-way valve, when the raw material needs to be injected, the micro speed regulating motor rotates reversely, the material pushing sheet moves towards the preparation cylinder at the moment, the raw material is injected into the preparation cylinder, the flow meter is arranged and used for detecting the flow velocity of the raw material in real time, and when the flow velocity is too fast or too slow, the controller controls the rotating speed of the micro speed regulating motor to control the feeding rate; when the lipid nanoparticles are prepared, the electric heating wire is started to heat, heat during heating is transferred to the outside of the preparation cylinder through the heat conducting layer, the preparation efficiency can be further improved, and the arranged heat insulating layer is used for preserving heat of the preparation cylinder.

Drawings

Fig. 1 is a schematic front view of a main structure of a microfluidic device for preparing lipid nanoparticles;

fig. 2 is a schematic top cross-sectional view of the main structure of a microfluidic device for preparing lipid nanoparticles;

fig. 3 is an enlarged schematic view of a structure at a in fig. 2 of a microfluidic device for preparing lipid nanoparticles.

In the figure: the device comprises a mounting plate 1, a flowmeter 2, a mixing flow channel 3, a preparation barrel 4, a moving block 5, a controller 6, a heat insulation layer 7, a discharge head 8, a heat conduction layer 9, an electric heating wire 10, a piston rod 11, an injection barrel 12, a feed pipe 13, a check valve 14, a feed delivery pipe 15, a material pushing piece 16, a screw rod 17, a driving gear 18, a micro speed regulating motor 19, a driven gear 20 and a material pushing barrel 21.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.

Example 1: referring to fig. 1 to 3, a microfluidic device for preparing lipid nanoparticles includes a mounting plate 1, a preparation barrel 4 is fixedly connected to the middle of the upper end surface of the mounting plate 1, a mixing flow channel 3 is formed inside the preparation barrel 4, a discharge head 8 is fixedly connected to the front end of the preparation barrel 4, an injection barrel 12 is fixedly connected to the left and right sides of the outer surface of the preparation barrel 4 through a feed delivery pipe 15, a material pushing barrel 21 is fixedly connected to the separated end of the injection barrel 12 on the left and right sides, a material pushing sheet 16 is slidably connected to the inside of the injection barrel 12, a piston rod 11 is fixedly connected to the material pushing sheet 16, a moving block 5 is slidably connected to the inside of the material pushing barrel 21, lead screws 17 are threaded on the front and rear sides of the outer surface of the moving block 5, one end of the lead screw 17 is rotatably connected to the inner wall of the material pushing barrel 21, the other end of the lead screw 17 rotatably extends out of the material pushing barrel 21, a driving assembly is connected between the lead screws 17 on the front and rear sides, the piston rod 11 slidably extends into the material pushing barrel 21, one end of the piston rod 11 is fixedly connected to the feed pipe 5, a feed pipe 13 is connected to the feed pipe 13, and a one-way flow meter 14 is connected to the feed delivery pipe 15.

The driving assembly comprises a miniature speed regulating motor 19, the output end of the miniature speed regulating motor 19 is fixedly connected with a screw rod 17 on the rear side, a driving gear 18 is fixedly sleeved on the outer surface of the screw rod 17 on the rear side, a driven gear 20 is connected onto the screw rod 17 on the front side, and the driven gear 20 is meshed with the driving gear 18.

The mounting plate 1 is provided with a controller 6, and a signal input end of the miniature speed regulating motor 19 is electrically connected with a signal output end of the flowmeter 14.

When the device is used, the feeding pipe 13 is connected with a material storage device, then the micro speed regulating motor 19 drives the screw rod 17 on the front side and the rear side to rotate forwards simultaneously, the screw rod 17 drives the material pushing sheet 16, the piston rod 11 and the moving block 5 to move to the right side when rotating forwards, the raw material of the material storage device is sucked into the material pushing cylinder 21 under the action of the one-way valve 14, when the raw material needs to be injected, the micro speed regulating motor 19 rotates reversely, the material pushing sheet 16 moves towards the preparation cylinder 4 at the moment, the raw material is injected into the preparation cylinder 4, the arranged flowmeter 14 is used for detecting the flow rate of the raw material in real time, and when the flow rate is too fast or too slow, the controller 6 controls the rotating speed of the micro speed regulating motor 19 to realize the control of the feeding rate.

Example 2: referring to fig. 1 to 3, a microfluidic device for preparing lipid nanoparticles is different from example 1 in that a heat conducting layer 9 is fixedly sleeved on an outer surface of a preparation cylinder 4, an electric heating wire 10 is spirally sleeved on an outer surface of the heat conducting layer 9, and a heat insulating layer 7 is sleeved outside the electric heating wire 10.

When the lipid nanoparticles are prepared, the electric heating wire 10 is started to heat, the heat during heating is transferred to the outside of the preparation cylinder 4 through the heat conducting layer 9, the preparation efficiency can be further improved, and the arranged heat insulating layer 7 is used for preserving the heat of the preparation cylinder 4.

The heat conducting layer 9 is made of heat conducting silica gel, and the heat conducting silica gel has excellent heat conducting and insulating capabilities.

The heat insulation layer 7 is made of insulating ceramic, and the insulating ceramic has excellent heat insulation capability.

The feeding pipe 13 is connected with a plunger type constant flow pump, the upper end of the mixing flow channel 3 is provided with a pressure regulating valve, and a plurality of pressure detection sensors are arranged inside the mixing flow channel 3.

The pressure of the mixed fluid in the mixed flow 3 can be detected by a pressure sensor, the pressure in the mixed flow can be adjusted by a pressure adjusting valve, and the arranged plunger type constant flow pump can be used for injecting raw materials into the injection cylinder 12.

In the present invention, the terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, and are only the terms determined for convenience of describing the structural relationship of each component or element of the present invention, and are not specific to any component or element of the present invention, and are not to be construed as limiting the present invention.

Claims

1. A microfluidic device for the preparation of lipid nanoparticles, comprising a mounting plate (1), characterized in that: the mixing device is characterized in that a preparation barrel (4) is fixedly connected to the middle of the upper end face of the mounting plate (1), a mixing flow channel (3) is formed inside the preparation barrel (4), a discharge head (8) is fixedly communicated with the front end of the preparation barrel (4), injection barrels (12) are fixedly communicated with the left side and the right side of the outer surface of the preparation barrel (4) through feed delivery pipes (15), the separated ends of the injection barrels (12) on the left side and the right side are fixedly connected with a material pushing barrel (21), the inner sliding of the injection barrels (12) are connected with a material pushing sheet (16), piston rods (11) are fixedly connected to the material pushing sheet (16), a moving block (5) is connected to the inner sliding of the material pushing barrel (21), screw rods (17) penetrate through the front side and the rear side of the outer surface of the moving block (5), one end of each screw rod (17) is rotatably connected with the inner wall of the material pushing barrel (21), the other end of each screw rod (17) is rotatably extended out of the outer portion of the material pushing barrel (21), a driving assembly is connected between the front side and the back side of each screw rod (17), the piston rod (11) is connected with the material pushing barrel (16), a one end of each feed delivery pipe (13) which is fixedly connected with a feed delivery pipe (15), a feed pipe (13) is connected with the material delivery pipe (15), and a one end of the feed delivery pipe (13) are fixedly connected with the feed delivery pipe (15), and the material conveying pipe (15) is connected with a flowmeter (2).

2. A microfluidic device for the preparation of lipid nanoparticles according to claim 1, characterized in that: the driving assembly comprises a miniature speed regulating motor (19), the output end of the miniature speed regulating motor (19) is fixedly connected with a screw rod (17) on the rear side, a driving gear (18) is fixedly sleeved on the outer surface of the screw rod (17) on the rear side, a driven gear (20) is connected onto the screw rod (17) on the front side, and the driven gear (20) is meshed with the driving gear (18).

3. A microfluidic device for the preparation of lipid nanoparticles according to claim 2, characterized in that: the mounting plate (1) is provided with a controller (6), and the signal input end of the miniature speed regulating motor (19) and the signal output end of the flowmeter (2) are electrically connected.

4. A microfluidic device for the preparation of lipid nanoparticles according to claim 3, characterized in that: the outer fixed surface cover of preparation section of thick bamboo (4) is equipped with heat-conducting layer (9), the outer surface spiral cover of heat-conducting layer (9) is equipped with electric heating wire (10), the outside cover of electric heating wire (10) is equipped with insulating layer (7).

5. The microfluidic device for preparing lipid nanoparticles according to claim 4, wherein: and the heat conduction layer (9) adopts heat conduction silica gel.

6. A microfluidic device for the preparation of lipid nanoparticles according to claim 5, characterized in that: the heat insulation layer (7) is made of insulating ceramics.

7. The microfluidic device for the preparation of lipid nanoparticles according to claim 5, characterized in that: the feeding pipe (13) is connected with a plunger type constant flow pump, a pressure regulating valve is installed at the upper end of the mixing flow channel (3), and a plurality of pressure detection sensors are arranged inside the mixing flow channel (3).