CN217853275U - Tumor in-situ detection and photothermal treatment integrated optical fiber device - Google Patents
Tumor in-situ detection and photothermal treatment integrated optical fiber device Download PDFInfo
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- CN217853275U CN217853275U CN202220351510.3U CN202220351510U CN217853275U CN 217853275 U CN217853275 U CN 217853275U CN 202220351510 U CN202220351510 U CN 202220351510U CN 217853275 U CN217853275 U CN 217853275U
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Abstract
The utility model discloses a tumor in-situ detection and photothermal therapy integrated optical fiber device, which comprises an optical fiber, a tumor characteristic marker sensor and a photothermal photosensitizer. The optical fiber comprises a front end, and the front end is used for contacting a solid tumor to realize the tumor identification of the tumor characteristic marker sensor and the thermal killing of the photo-thermal photosensitizer to the tumor. The utility model discloses press close to tumour position with tumour normal position detection and light and heat treatment integration fiber optic device's front end to realized killing the tumour through light and heat photosensitizer and tumour characteristic marker sensor, guarantee the instant feedback and the security of information.
Description
Technical Field
The utility model relates to a technical field is diagnose to tumour optics, especially relates to a tumour normal position detects and light and heat treatment integration optic fibre device.
Background
According to the report of the world health organization, the number of deaths caused by cancer accounts for one sixth of the total number of deaths, and the cancer is the second most serious death disease in the world. In China, the incidence of cancer is rising year by year, and the cancer is growing at a rate of 10% per year, and the tumor diagnosis and treatment technology is one of the key factors for finally overcoming the cancer.
With the help of the continuous and deep research of optical technology and nano-drugs, the optical tumor treatment technology is also in a rapidly developing state. However, since human tissues generally have large absorption and scattering of light, the effective penetration depth of light energy to human tissues is often only a few millimeters, which is not good enough for the treatment requirements of deep human layers and internal organ tumors. In addition, although the photosensitive nano-drugs have been rapidly developed in recent years, since the interaction mechanism of the nano-drugs injected into the body with organs and tumors is not completely clear, the concern of biological safety still exists, and the clinical application of the nano-drugs is limited. Therefore, in the field of tumor treatment, surgical resection, radiotherapy and chemotherapy are still conventional means. In early stages of the tumor, patients often have conflicts with conventional treatment regimens due to inadequate diagnostic deficits; in addition, a considerable number of patients are affected by the characteristics of tumors and basic pathological changes of organs when diagnosed, and have poor tolerance to surgery and radiotherapy and chemotherapy.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model aims to provide an integrated optical fiber device for tumor in-situ detection and photothermal therapy.
In order to achieve the above object, the utility model provides a following scheme:
an integrated optical fiber device for in-situ tumor detection and photothermal therapy, comprising: optical fiber, tumor characteristic marker sensor and photo-thermal photosensitizer;
the optical fiber includes a front end; the photo-thermal photosensitizer is arranged inside the front end; the photo-thermal photosensitizer is used for receiving heating light and generating heat according to the heating light so as to heat the front end; the surface of the front end is provided with the tumor characteristic marker sensor; the front end is used for contacting a solid tumor to realize the identification of the tumor characteristic marker sensor to the tumor and the thermal sterilization of the photothermal photosensitizer to the tumor.
Preferably, the optical fiber comprises a core and a cladding structure surrounding the core; the fiber core is used for transmitting the heating light to the photothermal photosensitizer; the front end is an integral body formed by extending the fiber core out of the covering range of the cladding structure in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
Preferably, the optical fiber comprises a core, an inner cladding surrounding the core, and an outer cladding surrounding the inner cladding; the front end is a whole formed by extending the covering range of the outer cladding layer from the fiber core and the inner cladding layer in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
Preferably, the system also comprises an optical fiber temperature sensor used for monitoring the real-time temperature of the tumor thermal-killing process; the fiber optic temperature sensor is integrated inside the front end; the optical fiber temperature sensor is an optical fiber grating or a mode interferometer sensing structure.
Preferably, the tumor characteristic marker sensor is a tumor microenvironment-responsive fluorescent probe or a tumor marker fluorescent probe.
Preferably, the tumor microenvironment response fluorescent probe is a hypoxic fluorescent probe or a pH fluorescent probe; the tumor marker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe or a nucleic acid aptamer fluorescent probe.
Preferably, the method further comprises the following steps: noble metals or two-dimensional materials;
the noble metal or the two-dimensional material is arranged on the surface of the optical fiber and used for enhancing the detection fluorescence when the tumor marker fluorescence probe is detected.
Preferably, the method further comprises the following steps:
a first optical interface connected to the optical fiber for transmitting signals to the optical fiber;
the fiber bragg grating addressing module is used for transmitting fiber bragg grating addressing light to the fiber temperature sensor through the first optical interface and detecting a fiber bragg grating reflection signal returned by the fiber temperature sensor so as to realize real-time monitoring and feedback of temperature;
a heating light source module for transmitting heating light to the front end through the first optical interface to excite the photothermal photosensitizer to generate heat;
the first port of the first optical multiplexer/demultiplexer module is connected with the first optical interface, the second port of the first optical multiplexer/demultiplexer module is connected with the fiber grating addressing module, the third port of the first optical multiplexer/demultiplexer module is connected with the heating light source module, and the first optical multiplexer/demultiplexer module is used for combining or decomposing the heating light and the fiber grating addressing light.
Preferably, the method further comprises the following steps:
a second optical interface connected to the optical fiber for transmitting signals to the optical fiber;
a fluorescence excitation module for emitting excitation light to the tumor characteristic marker sensor through the second optical interface to excite the tumor characteristic marker sensor to generate tumor characteristic marker sensor signal light;
the fluorescence detection module is used for receiving and demodulating the signal light of the tumor feature marker sensor so as to realize in-situ detection of the tumor;
and a second optical multiplexer/demultiplexer module, a first port of which is connected to the second optical interface, a second port of which is connected to the fluorescence excitation module, a third port of which is connected to the fluorescence detection module, and the second optical multiplexer/demultiplexer module is used for combining or decomposing the excitation light and the signal light of the tumor feature marker sensor.
According to the utility model provides a concrete embodiment, the utility model discloses a following technological effect:
the utility model provides a tumour normal position detects and light and heat treatment integration optic fibre device, include: optical fiber, tumor feature marker sensor and photothermal photosensitizer; the optical fiber includes a front end; the photo-thermal photosensitizer is arranged inside the front end; the photo-thermal photosensitizer is used for receiving heating light and generating heat according to the heating light so as to heat the front end; the surface of the front end is provided with the tumor characteristic marker sensor; the front end is used for contacting a solid tumor to realize the identification of the tumor characteristic marker sensor to the tumor and the thermal sterilization of the photothermal photosensitizer to the tumor. The utility model discloses press close to the tumour position with tumour normal position detection and light and heat treatment integration optical fiber device's front end to optic fibre temperature sensor in through light and heat photosensitizer, tumour characteristic marker sensor ware and the embodiment has realized killing the tumour and the whole process of diagnosing carries out temperature monitoring, guarantees instant feedback and the security of information, and utilizes thermal excitation and detection module to control the optical fiber device in order to accomplish above-mentioned function in the embodiment. The utility model discloses can with the light energy with the mode of the endoscopic intervention of wicresoft internal and direct tumour focus, realize the effective killing to deep tumour to overcome conventional phototherapy to the not enough problem of deep tissue penetrating power, and effective treatment scope is wider, electric insulation, the wound is little, easy operation, the response is quick, treatment cycle is short.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive labor.
Fig. 1 is a schematic structural diagram of a device provided in an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a single-clad cylinder according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a single-clad cone structure according to an embodiment of the present invention;
fig. 4 is a schematic structural view of a single-clad conical cylinder according to an embodiment of the present invention;
FIG. 5 is a schematic view of a single-clad cone-shaped cylinder and a single-clad cone-shaped cylinder according to an embodiment of the present invention
Fig. 6 is a schematic view of a single-clad tapered cylinder and a single-clad tapered cylinder according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a double-clad cylinder according to an embodiment of the present invention;
FIG. 8 is a schematic diagram of a double-clad cone structure provided by an embodiment of the present invention;
fig. 9 is a schematic structural view of a double-clad conical cylinder according to an embodiment of the present invention;
FIG. 10 is a schematic view of a structure of a double-clad cone-shaped cylinder and a cylinder according to an embodiment of the present invention
Fig. 11 is a schematic view of a double-clad tapered cylinder and a tapered cylinder according to an embodiment of the present invention;
fig. 12 is a schematic structural diagram of a tumor treatment module and a tumor detection module according to an embodiment of the present invention.
Description of the symbols:
1-an optical fiber, 2-a fiber core, 3-an inner cladding, 4-an outer cladding, 5-a photo-thermal photosensitizer, 6-an optical fiber temperature sensor, 7-a tumor characteristic marker sensor, 8-a tumor characteristic marker sensor exciting light, 9-a tumor characteristic marker sensor signal light, 10-heating light, 11-a temperature sensing monitoring signal, 12-a front end cylinder structure of a single cladding optical fiber, 13-a front end cone structure of a single cladding optical fiber, 14-a front end tapered cylinder structure of a single cladding optical fiber, 15-a combination structure of a front end tapered cylinder and a cylinder of a single cladding optical fiber, 16-a combination structure of a front end tapered cylinder and a tapered cylinder of a single cladding optical fiber, 17-a front end cylinder structure of a double-clad optical fiber, 18-a front end cone structure of the double-clad optical fiber, 19-a front end conical cylinder structure of the double-clad optical fiber, 20-a front end conical cylinder and cylinder combined structure of the double-clad optical fiber, 21-a front end conical cylinder and conical cylinder combined structure of the double-clad optical fiber, 22-a first optical interface, 23-a heating light source module, 24-a fiber grating addressing module, 25-a first optical multiplexer/demultiplexer module, 26-a second optical interface, 27-a fluorescence excitation module, 28-a fluorescence detection module and 29-a second optical multiplexer/demultiplexer unit.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The utility model aims at providing a tumour normal position detects and light and heat treatment integration optical fiber device can insert the mode of intervention into internal and direct tumour focus in with the wicresoft, realizes effectively killing deep tumour to overcome conventional phototherapy to the not enough problem of deep tissue penetrating power, and effective treatment scope is wider, electric insulation, the wound is little, easy operation, the response is quick, treatment cycle is short.
In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention is described in detail with reference to the accompanying drawings and the detailed description.
Fig. 1 is the device structure schematic diagram provided by the embodiment of the present invention, as shown in fig. 1, an optical fiber device integrating tumor in-situ detection and photothermal therapy in this embodiment includes: the system comprises optical fibers, a tumor characteristic marker sensor 7, a photo-thermal photosensitizer 5 and an optical fiber temperature sensor 6;
the optical fiber includes a front end; the front end is provided with an optical fiber temperature sensor 6; the photo-thermal photosensitizer 5 is arranged inside the front end; the photo-thermal photosensitizer 5 is used for receiving heating light 10 and generating heat according to the heating light 10 so as to heat the front end; the surface of the front end is provided with the tumor characteristic marker sensor 7; the front end is used for contacting a solid tumor to realize the identification of the tumor by the tumor characteristic marker sensor 7 and the thermal sterilization of the tumor by the photothermal photosensitizer 5; the optical fiber temperature sensor 6 is used for monitoring the temperature of killing tumors.
Specifically, the front end is in contact with the outside, a tumor microenvironment specific response fluorescent probe or a tumor marker specific response fluorescent probe is arranged on the surface of the front end, a photothermal agent (photothermal photosensitizer 5) is arranged inside the front end, the front end can be contacted with the solid tumor through puncture or in-vivo guidance or inserted into the solid tumor, the fluorescent probe identifies the tumor, and the photothermal agent generates heat under the excitation of light introduced into the front end of the optical fiber to heat and kill the tumor.
Furthermore, the distal end of the optical fiber in this embodiment may contact or be inserted into the solid tumor by puncturing or in vivo guiding, the fluorescent probe identifies the tumor, and the photothermal agent generates heat under excitation of light introduced into the distal end of the optical fiber to heat the distal end and thus to thermally ablate the tumor.
Preferably, the tumor characteristic marker sensor 7 is a tumor microenvironment response fluorescent probe or a tumor marker fluorescent probe. The tumor microenvironment response fluorescent probe is a hypoxic fluorescent probe or a pH fluorescent probe; the tumor marker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe or a nucleic acid aptamer fluorescent probe.
Further, still include: noble metals or two-dimensional materials;
the noble metal or the two-dimensional material is arranged on the surface of the optical fiber, and the noble metal and the two-dimensional material are used for enhancing the detection fluorescence when the tumor marker fluorescent probe is detected.
Specifically, the tumor marker fluorescent probe can realize fluorescence enhancement by precious metal or two-dimensional material modified on the surface of the optical fiber.
In this embodiment, the front end has a photo-thermal agent therein, and the photo-thermal agent is a rare earth ion, a bismuth ion, or a cobalt ion.
In this example, the rare earth ions in the photo-thermal agent are erbium ions and ytterbium ions.
Preferably, the optical fiber comprises a core 2 and a cladding structure surrounding the core 2; the core is used for transmitting the heating light 10 to the photothermal photosensitizer 5; the front end is a whole formed by extending the fiber core 2 out of the coverage range of the cladding structure in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
Referring to fig. 2 to 6, the front end is a single-clad fiber front end cylindrical structure 12, a single-clad fiber front end conical structure 13, a single-clad fiber front end conical cylindrical structure 14, a single-clad fiber front end conical cylindrical and cylindrical combined structure 15, and a single-clad fiber front end conical cylindrical and conical combined structure 16, where the fiber core 2 extends out of the coverage of the cladding structure in the fiber length direction.
Specifically, in a single cladding fiber configuration, the fiber core 2 has a diameter of 30-1000 microns and the cladding has a radial thickness of 5-200 microns.
Further, the front end is 3-100 mm in length.
Preferably, the optical fiber includes a core 2, an inner cladding 3 surrounding the core 2, and an outer cladding 4 surrounding the inner cladding 3; the front end is a whole formed by extending the covering range of an outer cladding 4 from the fiber core 2 and the inner cladding 3 in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
Referring to fig. 7 to 11, the front end is a front end cylinder structure 17 of the double-clad fiber, a front end cone structure 18 of the double-clad fiber, a front end taper cylinder structure 19 of the double-clad fiber, a front end taper cylinder and cylinder combination structure 20 of the double-clad fiber, and a front end taper cylinder and taper cylinder combination structure 21 of the double-clad fiber, where the core 2 and the inner cladding 3 extend out of the coverage of the outer cladding 4 in the fiber length direction.
Specifically, in the double-clad optical fiber structure, the diameter of the fiber core 2 of the optical fiber is 3-60 microns, the radial thickness of the inner cladding 3 is 25-500 microns, and the radial thickness of the outer cladding 4 is 5-200 microns.
Further, the tumor feature marker sensor 7 is excited by the tumor feature marker sensor excitation light 8 traveling down the inner cladding 3. The tumor characteristic marker sensor signal light 9 of the tumor characteristic marker sensor 7 is transmitted upstream in the inner cladding 3.
Specifically, the excitation light 8 of the tumor characteristic marker sensor is 450nm blue-violet light.
Preferably, said fiber optic temperature sensor 6 is disposed inside said front end; the optical fiber temperature sensor 6 is an optical fiber grating or a mode interferometer sensing structure.
Specifically, the optical fiber temperature sensor 6 is a fiber bragg grating. The fiber optic temperature sensor 6 emits a temperature sensing monitoring signal 11 which is transmitted upstream in the fiber core 2.
Further, the operating band of the temperature sensing monitoring signal 11 is a C band.
In practical application, the following devices are also needed to implement, as shown in fig. 12:
a first optical interface 22 connected to the optical fiber for transmitting signals to the optical fiber;
the fiber grating addressing module 24 is configured to emit fiber grating addressing light to the fiber temperature sensor 6 through the first optical interface 22, and detect a fiber grating reflection signal returned by the fiber temperature sensor 6, so as to implement real-time monitoring and feedback of temperature;
a heating light source module 23 for transmitting heating light 10 to the front end through the first optical interface 22 to excite the photothermal photosensitizer 5 to generate heat;
a first optical multiplexer/demultiplexer module 25, a first port of the first optical multiplexer/demultiplexer module 25 is connected to the first optical interface 22, a second port of the first optical multiplexer/demultiplexer module 25 is connected to the fiber grating addressing module 23, a third port of the first optical multiplexer/demultiplexer module 25 is connected to the heating light 10 source module, and the first optical multiplexer/demultiplexer module 25 is configured to combine or decompose the heating light 10 and the fiber grating addressing light.
Specifically, the first optical interface 22, the fiber grating addressing module 24, the heating light source module 23, and the first optical multiplexer/demultiplexer module 25 constitute a tumor therapy module, wherein the fiber grating addressing module 24 is a fiber optical spectrum analyzer or an optical wavelength meter.
Preferably, the method further comprises the following steps:
a second optical interface 26 connected to the optical fiber and transmitting a signal to the optical fiber;
a fluorescence excitation module 27 for emitting the excitation light (tumor feature marker sensor excitation light 8) to the tumor feature marker sensor through the second optical interface 26 to excite the tumor feature marker sensor 7 to generate tumor feature marker sensor signal light 9;
a fluorescence detection module 28, configured to receive and demodulate the signal light 9 of the tumor feature marker sensor, so as to implement in-situ detection of a tumor;
a second optical multiplexer/demultiplexer module 29, a first port of the second optical multiplexer/demultiplexer module 29 is connected to the second optical interface 26, a second port of the second optical multiplexer/demultiplexer module 29 is connected to the fluorescence excitation module 27, a third port of the second optical multiplexer/demultiplexer module 29 is connected to the fluorescence detection module 28, and the second optical multiplexer/demultiplexer module 29 is configured to combine or decompose the excitation light and the tumor characteristic marker sensor signal light 9.
Specifically, the second optical interface 26, the fluorescence excitation module 27, the fluorescence detection module 28, and the second optical multiplexer/demultiplexer module 29 constitute a tumor therapy module, wherein the fluorescence detection module 28 is a fiber fluorescence spectrum analyzer.
It will be appreciated by those skilled in the art that when a double-clad fiber structure is used, the tumor signature sensor excitation light 8, the tumor signature sensor signal light 9, the heating light and the fiber grating addressing light are transmitted in the inner cladding of the fiber, the first optical interface 22 is coupled to the core of the double-clad fiber, the second optical interface is coupled to the inner cladding of the double-clad fiber, and the first optical interface 22 and the second optical interface 26 may be integrated.
The utility model has the advantages as follows:
1. the utility model provides a tumour normal position detects and light and heat treatment integration optical fiber device compares with the optics tumour diagnosis and treatment technique of conventionality, can insert the leading-in internal and direct tumour focus of the mode of intervention in with the wicresoft, realizes effectively killing and killing deep tumour to overcome the problem that conventional light therapy is not enough to deep tissue penetrating power.
2. The utility model provides a device is diagnose to optic fibre tumour can solve the electrified operation that exists in the present conventional endoscopic tumor ablation technique, effective treatment scope controllability not enough scheduling problem, has advantages such as electric insulation, wound are little, easy operation, response are quick, treatment cycle is short.
3. Different with conventional optic fibre light therapy, the utility model provides a device is diagnose to optic fibre tumour, the optic fibre that adopts is not only the conduction instrument of light, and it is diagnostic tool itself promptly, is treatment instrument again, has avoided the problem of multiple operation in the medical treatment, can effectively reduce the risk, raises the efficiency.
4. Different with conventional optic fibre light therapy, the utility model provides a device is diagnose to optic fibre tumour has fully excavated the structure and the material characteristic of optic fibre, utilizes modes such as the fixed surface of optic fibre and inside lattice doping, not only can be fixed in the optic fibre surface firmly with photosensitive drug material or seal inside optic fibre, reduces the internal risk of medicine retention, can also more fully and realize light energy conversion high-efficiently, and control total light irradiation power greatly improves the target ability and the security of diagnosing.
5. Different with conventional optic fibre light therapy, the utility model provides a device is diagnose to optic fibre tumour has adopted the design of double-clad optic fibre, can carry out the differentiation of uplink and downlink signal simultaneously from optical wavelength and space through the optical conduction device, improves the diagnostic and the precision of treatment.
6. Different with conventional optic fibre light therapy, the utility model provides a device is diagnose to optic fibre tumour when light and heat therapy, can utilize the temperature real time monitoring and the feedback of integrating in the inside temperature sensor realization treatment process of device, further improves medical safety nature.
7. The utility model provides a tumour normal position detects and light and heat treatment integration optical fiber device has higher expansibility in the aspect of wavelength, space and time selectivity etc. can combine multiple sensing detection and disease treatment technique, realizes diagnosing to the integration accuracy of deep tumour.
In the present specification, the embodiments are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principle and the implementation of the present invention are explained herein by using specific examples, and the above description of the embodiments is only used to help understand the method and the core idea of the present invention; meanwhile, for those skilled in the art, the idea of the present invention may be changed in the specific embodiments and the application range. In summary, the content of the present specification should not be construed as a limitation of the present invention.
Claims (9)
1. An integrated optical fiber device for tumor in-situ detection and photothermal therapy, which is characterized by comprising: optical fiber, tumor characteristic marker sensor, photo-thermal photosensitizer;
the optical fiber includes a front end; the photo-thermal photosensitizer is arranged inside the front end; the photo-thermal photosensitizer is used for receiving heating light and generating heat according to the heating light so as to heat the front end; the surface of the front end is provided with the tumor characteristic marker sensor; the front end is used for contacting a solid tumor to realize the identification of the tumor characteristic marker sensor to the tumor and the thermal sterilization of the photothermal photosensitizer to the tumor.
2. The integrated optical fiber device for tumor in-situ detection and photothermal therapy according to claim 1, wherein the optical fiber comprises a core and a cladding structure wrapping the core; the fiber core is used for transmitting the heating light to the photo-thermal photosensitizer; the front end is an integral body formed by extending the fiber core out of the covering range of the cladding structure in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
3. The integrated optical fiber device for tumor in-situ detection and photothermal therapy according to claim 1, wherein the optical fiber comprises a fiber core, an inner cladding layer wrapping the fiber core, and an outer cladding layer wrapping the inner cladding layer; the front end is a whole formed by extending the covering range of the outer cladding layer from the fiber core and the inner cladding layer in the length direction of the optical fiber; the space structure of the front end is a combined structure formed by connecting a cylinder structure, a cone structure or a plurality of cylinder structures in sequence.
4. The integrated optical fiber device for in situ tumor detection and photothermal therapy according to claim 1, further comprising an optical fiber temperature sensor for monitoring the real-time temperature during the thermal tumor killing process; the fiber optic temperature sensor is integrated inside the front end; the optical fiber temperature sensor is an optical fiber grating or a mode interferometer sensing structure.
5. The integrated optical fiber device for in situ tumor detection and photothermal treatment according to claim 1, wherein the tumor feature marker sensor is a tumor microenvironment response fluorescent probe or a tumor marker fluorescent probe.
6. The integrated optical fiber device for in situ tumor detection and photothermal treatment according to claim 5, wherein the tumor microenvironment response fluorescent probe is a hypoxic fluorescent probe or a pH fluorescent probe; the tumor marker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe or a nucleic acid aptamer fluorescent probe.
7. The integrated optical fiber device for tumor in-situ detection and photothermal therapy according to claim 5, further comprising: noble metals or two-dimensional materials;
the noble metal or the two-dimensional material is arranged on the surface of the optical fiber and used for enhancing the detection fluorescence when the tumor marker fluorescence probe is detected.
8. The integrated optical fiber device for tumor in-situ detection and photothermal therapy according to claim 4, further comprising:
a first optical interface connected to the optical fiber for transmitting signals to the optical fiber;
the fiber bragg grating addressing module is used for transmitting fiber bragg grating addressing light to the fiber temperature sensor through the first optical interface and detecting a fiber bragg grating reflection signal returned by the fiber temperature sensor so as to realize real-time monitoring and feedback of temperature;
a heating light source module for transmitting heating light to the front end through the first optical interface to excite the photothermal photosensitizer to generate heat;
the first port of the first optical multiplexer/demultiplexer module is connected with the first optical interface, the second port of the first optical multiplexer/demultiplexer module is connected with the fiber grating addressing module, the third port of the first optical multiplexer/demultiplexer module is connected with the heating light source module, and the first optical multiplexer/demultiplexer module is used for combining or decomposing the heating light and the fiber grating addressing light.
9. The integrated optical fiber device for tumor in-situ detection and photothermal therapy according to claim 1, further comprising:
a second optical interface connected to the optical fiber for transmitting signals to the optical fiber;
the fluorescence excitation module is used for emitting excitation light to the tumor characteristic marker sensor through the second optical interface so as to excite the tumor characteristic marker sensor to generate tumor characteristic marker sensor signal light;
the fluorescence detection module is used for receiving and demodulating the signal light of the tumor feature marker sensor so as to realize in-situ detection of the tumor;
and a second optical multiplexer/demultiplexer module, a first port of which is connected to the second optical interface, a second port of which is connected to the fluorescence excitation module, a third port of which is connected to the fluorescence detection module, and the second optical multiplexer/demultiplexer module is used for combining or decomposing the excitation light and the signal light of the tumor characteristic marker sensor.
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