CN217784640U

CN217784640U - Fixing device for surface targeting molecule mounting of liposome

Info

Publication number: CN217784640U
Application number: CN202220998356.9U
Authority: CN
Inventors: 杨静; 覃振达; 黄秋云; 周繁
Original assignee: Yichang Bolen Kairun Pharmaceutical Co ltd
Current assignee: Yichang Bolen Kairun Pharmaceutical Co ltd
Priority date: 2022-04-24
Filing date: 2022-04-24
Publication date: 2022-11-11
Anticipated expiration: 2032-04-24

Abstract

The utility model discloses a fixing device is used in surface target molecule carry of liposome, including fixed case, the both sides of fixed case all are equipped with the support frame, and the inside of fixed case is rotated and is connected with two-way lead screw, and the outside symmetric thread of two-way lead screw is connected with the movable block, and movable block and fixed case sliding connection No. one, and the inside sliding connection of two movable blocks has spacing slide bar, and spacing slide bar and fixed case fixed connection No. one, and one side of support frame is equipped with the motor, the output and the two-way lead screw fixed connection of motor, the beneficial effects of the utility model are that: through having added two-way lead screw, the output that has realized the motor drives the movable block through two-way lead screw and removes, and the movable block drives the stabilization box and carries out stabilization treatment to placing the molecule carry equipment of bench, through having added positioning mechanism, has realized that the oblique fixture block passes through the fixed slot and carries out stabilization treatment to the position of lifting plate, stabilizes the high position of placing the platform.

Description

Fixing device for surface targeting molecule mounting of liposome

Technical Field

The utility model relates to a fixing device technical field specifically is a fixing device is used in surface targeting molecule carry of liposome.

Background

Liposomes (liposomes) are artificial membranes. The hydrophilic head of phospholipid molecule is inserted into water, the hydrophobic tail of liposome extends to air, and after stirring, a spherical liposome with double-layer lipid molecules is formed, the diameter of which is different from 25-1000 nm. The liposome can be used for transgenosis or prepared drugs, and by utilizing the characteristic that the liposome can be fused with a cell membrane, when the existing liposome is treated, the liposome needs to be subjected to molecular mounting through surface-targeted molecular mounting equipment, but the existing surface-targeted molecular mounting equipment is usually directly placed, so that the surface-targeted molecular mounting equipment is inconvenient to fix and is unstable during working treatment.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a fixing device is used in surface targeting molecule carry of liposome to solve the current surface targeting molecule carry equipment that proposes in the above-mentioned background art and directly place usually, be not convenient for carry out the fixed processing to surface targeting molecule carry equipment, unstable problem when the job treatment.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a fixing device is used in surface targeting molecule carry of liposome, includes fixed case No. one, the both sides of fixed case all are equipped with the support frame, the inside of fixed case rotates and is connected with two-way lead screw, the outside symmetric thread of two-way lead screw is connected with the movable block, and movable block and fixed case sliding connection, two the inside sliding connection of movable block has spacing slide bar, and spacing slide bar and fixed case fixed connection No. one, one side of support frame is equipped with the motor, the output and the two-way lead screw fixed connection of motor, the inside sliding connection of fixed case No. one has the lifting plate, the top of lifting plate is equipped with places the platform, four fixed slots have been seted up to one side of lifting plate, the bottom of fixed case No. one be equipped with fixed slot complex positioning mechanism, the top symmetric sliding connection of fixed case has the stabilization case, movable block and stabilization case fixed connection, the inside of stabilization case is equipped with fixed establishment.

As a preferred scheme of the utility model: positioning mechanism includes No. two fixed casees, the outside sliding connection of lift plate has No. two fixed casees, and No. two fixed casees and a fixed case fixed connection, the inside sliding connection of No. two fixed casees has the sliding block, recess has been seted up to one side of sliding block, and lift plate and recess sliding connection, one side of sliding block is equipped with the spring, and the one end and No. two fixed casees fixed connection of spring, the inside of recess be equipped with fixed slot complex tapered callipers.

As a preferred embodiment of the present invention: one side of sliding block is equipped with the depression bar, and depression bar and No. two fixed case sliding connection, the outside threaded connection of depression bar has fixation nut.

As a preferred embodiment of the present invention: the bottom of placing the platform is equipped with two gag lever posts, and gag lever post and fixed case sliding connection No. one.

As a preferred embodiment of the present invention: the fixing mechanism comprises a rotating rod, the inner part of the stabilizing box is connected with the rotating rod in a rotating mode, a worm wheel is fixedly connected to the outer side of the rotating rod, a worm is connected to the inner part of the stabilizing box in a rotating mode, the worm is meshed with the worm wheel and connected, a threaded rod is connected to the inner part of the stabilizing box in a rotating mode, the rotating rod is fixedly connected with the threaded rod, an L-shaped fixing plate is connected to the outer side of the threaded rod in a threaded mode, the L-shaped fixing plate is connected with the stabilizing box in a sliding mode, limiting blocks are arranged on the two sides of the L-shaped fixing plate, a limiting sliding groove matched with the limiting blocks is formed in the inner part of the stabilizing box, the limiting blocks are connected with the limiting sliding groove in a sliding mode, the top of the stabilizing box is connected with a rotating block in a rotating mode, and the rotating block is fixedly connected with the worm.

As a preferred embodiment of the present invention: one side of support frame is equipped with control panel, motor and control panel electric connection.

Compared with the prior art, the beneficial effects of the utility model are that: the utility model discloses a two-way lead screw has been added, the output of having realized the motor drives the removal piece through two-way lead screw and has removed, the movable block drives the stabilization box and carries out stabilization treatment to placing the molecule carry equipment of placing the bench, through having added positioning mechanism, the oblique fixture block has been realized and has been carried out stabilization treatment through the fixed slot to the position of lifting plate, the high position to placing the platform is stabilized, through having added fixed establishment, it rotates to drive the bull stick through the worm wheel when having realized rotating the worm, the bull stick drives the threaded rod and drives L type fixed plate and carry out position control processing, fixed stability has been improved.

Drawings

FIG. 1 is a schematic view of the internal structure of the present invention;

fig. 2 is a schematic view of the internal structure of the lifting plate of the present invention;

FIG. 3 is an enlarged view of the point A of FIG. 1 according to the present invention;

FIG. 4 is a top view of the internal structure of the fixing mechanism of the present invention;

fig. 5 is a left side view of the stabilizing box of the present invention.

In the figure: 1. a first fixing box; 2. a support frame; 3. a motor; 4. a bidirectional screw rod; 5. a moving block; 6. a limiting slide bar; 7. a positioning mechanism; 71. a second fixing box; 72. a slider; 73. a groove; 74. a fixture block is inclined; 75. a spring; 8. a fixing mechanism; 81. a rotating rod; 82. a worm gear; 83. a threaded rod; 84. an L-shaped fixing plate; 9. a pressure lever; 10. fixing a nut; 11. a lifting plate; 12. fixing grooves; 13. a placing table; 14. a limiting rod; 15. a worm; 16. a limiting chute; 17. a limiting block; 18. rotating the block; 19. and (7) stabilizing the box.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-5, the present invention provides a technical solution: the utility model provides a surface targeting molecule of liposome carries and uses fixing device, including fixed case 1 No. one, the both sides of fixed case 1 all are equipped with support frame 2, the inside of fixed case 1 rotates and is connected with two-way lead screw 4, the outside symmetric thread of two-way lead screw 4 is connected with movable block 5, and movable block 5 and fixed case 1 sliding connection No. one, the inside sliding connection of two movable blocks 5 has spacing slide bar 6, and spacing slide bar 6 and fixed case 1 fixed connection No. one, spacing slide bar 6 is injectd the shift position of movable block 5, the stability that movable block 5 removed has been improved, one side of support frame 2 is equipped with motor 3, the output and two-way lead screw 4 fixed connection of motor 3, the inside sliding connection of fixed case 1 has lifting plate 11, lifting plate 11's top is equipped with places platform 13, adjust the height position of placing platform 13 through lifting plate 11, adjust the height position of fixed equipment, four fixed slots 12 have been seted up to one side of lifting plate 11, the bottom of fixed case 1 is equipped with fixed slot 12 complex positioning mechanism 7, the top symmetric connection of fixed case 1 has stabilization case 19, the inside sliding connection of movable block 5 is equipped with stabilization mechanism 19, stabilization case 8.

Wherein, positioning mechanism 7 includes fixed case 71 No. two, the outside sliding connection of lifting plate 11 has fixed case 71 No. two, and fixed case 71 No. two and fixed case 1 fixed connection, the inside sliding connection of fixed case 71 No. two has sliding block 72, one side of sliding block 72 is seted up flutedly 73, and lifting plate 11 and recess 73 sliding connection, one side of sliding block 72 is equipped with spring 75, and spring 75's one end and fixed case 71 fixed connection No. two, the inside of recess 73 is equipped with fixed slot 12 complex latch 74, fix the processing through latch 74 to fixed slot 12, thereby fix the processing through latch 74 to the position of lifting plate 11, the regulation efficiency has been improved.

Wherein, one side of sliding block 72 is equipped with depression bar 9, and depression bar 9 and No. two fixed case 71 sliding connection, and the outside threaded connection of depression bar 9 has fixation nut 10, carries out stabilization treatment through fixation nut 10 to the position of depression bar 9 to fix sliding block 72 through depression bar 9, improved fixed stability.

Wherein, the bottom of placing platform 13 is equipped with two gag lever posts 14, and gag lever post 14 and fixed case 1 sliding connection, stabilizes the processing through gag lever post 14 to the removal regulation of placing platform 13, has improved stability.

Wherein, fixed establishment 8 includes bull stick 81, the inside of stabilizing box 19 rotates and is connected with bull stick 81, the outside fixedly connected with worm wheel 82 of bull stick 81, the inside of stabilizing box 19 rotates and is connected with worm 15, and worm 15 is connected with worm wheel 82 meshing, the inside symmetry of stabilizing box 19 rotates and is connected with threaded rod 83, bull stick 81 and threaded rod 83 fixed connection, the outside threaded connection of threaded rod 83 has L type fixed plate 84, and L type fixed plate 84 and stabilizing box 19 sliding connection, the both sides of L type fixed plate 84 all are equipped with stopper 17, the inside of stabilizing box 19 has been seted up with stopper 17 complex spacing spout 16, and stopper 17 and spacing spout 16 sliding connection, the top of stabilizing box 19 rotates and is connected with rotor block 18, rotor block 18 and worm 15 fixed connection, rotate through worm 15 and drive worm wheel 82 and rotate, worm wheel 82 drives the threaded rod 83 of symmetry through bull stick 81 and rotates, worm wheel 83 drives L type fixed plate 84 and carries out the position control processing, thereby further stabilization processing is carried out to surface targeting molecule through L type fixed plate 84, fixed stability has been improved.

Wherein, one side of support frame 2 is equipped with control panel, motor 3 and control panel electric connection, and the control panel of being convenient for controls motor 3 and handles, has improved motor 3's work efficiency and security.

Specifically, when the device is used, the device is powered on by an external power supply, the fixing nut 10 is removed, the lifting plate 11 is pushed upwards, the fixing groove 12 on one side of the lifting plate 11 presses the inclined clamping block 74, the inclined clamping block 74 drives the sliding block 72 to move and press the spring 75, the inclined clamping block 74 leaves one of the fixing grooves 12, when the inclined clamping block is pushed to a proper height, the spring 75 resets and drives the sliding block 72 to reset, the sliding block 72 drives the inclined clamping block 74 to enter the fixing groove 12 at a proper position to stop pushing upwards, the position of the pressing rod 9 is stabilized by the fixing nut 10, the position of the sliding block 72 can be stabilized, the inclined clamping block 74 and the fixing groove 12 are stably fixed, when the inclined clamping block is moved downwards, the fixing nut 10 is removed, the pressing rod 9 is pushed inwards, the pressing rod 9 drives the inclined clamping block 74 to leave the fixing groove 12 through the sliding block 72, can adjust the processing, lift plate 11 drives and places platform 13 regulation suitable height, lift plate 11, gag lever post 14 and two-way lead screw 4 staggered position, do not influence respective work, to placing surface target molecule carry equipment on placing platform 13, through control panel starter motor 3, motor 3 drives two-way lead screw 4 and rotates, two-way lead screw 4 drives the movable block 5 in the outside and removes, movable block 5 drives the removal of ballast tank 19 and carries out stabilization treatment to surface target molecule carry equipment, through rotating turning block 18, rotating block 18 drives worm 15 and rotates, worm 15 drives bull stick 81 through worm wheel 82 and rotates, bull stick 81 drives threaded rod 83 and rotates, threaded rod 83 drives the inside adjusting position of L type fixed plate 84 and carries out further fixed processing to surface target molecule carry equipment.

In the description of the present invention, it is to be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "one side", "top", "inner", "front", "center", "both ends", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Furthermore, the terms "first", "second", "third", "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby the features defined as "first", "second", "third", "fourth" may explicitly or implicitly include at least one such feature.

In the present invention, unless otherwise explicitly specified or limited, the terms "mounted", "disposed", "connected", "fixed", "screwed" and the like are to be understood broadly, and may be, for example, a fixed connection, a detachable connection, or an integral body; can be mechanically or electrically connected; they may be directly connected or indirectly connected through an intermediate medium, and may be connected through the inside of two elements or in an interaction relationship between two elements, unless otherwise specifically defined, and the specific meaning of the above terms in the present invention will be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A fixing device for surface targeting molecule mounting of liposome comprises a first fixing box (1), it is characterized in that two sides of the first fixed box (1) are respectively provided with a support frame (2), the inside of the first fixed box (1) is rotationally connected with a bidirectional screw rod (4), the outer side of the bidirectional screw rod (4) is symmetrically connected with a moving block (5) through threads, the moving blocks (5) are connected with the first fixed box (1) in a sliding way, the inner parts of the two moving blocks (5) are connected with a limiting slide bar (6) in a sliding way, and the limit slide bar (6) is fixedly connected with the first fixed box (1), a motor (3) is arranged on one side of the support frame (2), the output end of the motor (3) is fixedly connected with a bidirectional screw rod (4), a lifting plate (11) is connected in the first fixed box (1) in a sliding way, a placing table (13) is arranged at the top of the lifting plate (11), four fixing grooves (12) are formed in one side of the lifting plate (11), the bottom of the first fixed box (1) is provided with a positioning mechanism (7) matched with the fixed groove (12), the top of the first fixed box (1) is symmetrically connected with a stable box (19) in a sliding way, the moving block (5) is fixedly connected with the stabilizing box (19), and a fixing mechanism (8) is arranged in the stabilizing box (19).

2. The liposome surface-targeted molecule-carrying immobilization device according to claim 1, wherein: positioning mechanism (7) are including No. two fixed casees (71), the outside sliding connection of lift plate (11) has No. two fixed casees (71), and No. two fixed casees (71) and fixed case (1) fixed connection, the inside sliding connection of No. two fixed casees (71) has sliding block (72), recess (73) are seted up to one side of sliding block (72), and lift plate (11) and recess (73) sliding connection, one side of sliding block (72) is equipped with spring (75), and the one end of spring (75) and No. two fixed case (71) fixed connection, the inside of recess (73) be equipped with fixed slot (12) complex oblique fixture block (74).

3. The liposome surface-targeted molecule-carrying immobilization device according to claim 2, wherein: one side of sliding block (72) is equipped with depression bar (9), and depression bar (9) and No. two fixed case (71) sliding connection, the outside threaded connection of depression bar (9) has fixation nut (10).

4. The immobilization device for liposome surface-targeted molecule mounting according to claim 1, wherein: two limiting rods (14) are arranged at the bottom of the placing table (13), and the limiting rods (14) are connected with the first fixing box (1) in a sliding mode.

5. The immobilization device for liposome surface-targeted molecule mounting according to claim 1, wherein: fixed establishment (8) are including bull stick (81), the inside rotation of stabilizing case (19) is connected with bull stick (81), outside fixedly connected with worm wheel (82) of bull stick (81), the inside rotation of stabilizing case (19) is connected with worm (15), and worm (15) are connected with worm wheel (82) meshing, the inside symmetry of stabilizing case (19) is rotated and is connected with threaded rod (83), bull stick (81) and threaded rod (83) fixed connection, the outside threaded connection of threaded rod (83) has L type fixed plate (84), and L type fixed plate (84) and stabilizing case (19) sliding connection, the both sides of L type fixed plate (84) all are equipped with stopper (17), the inside of stabilizing case (19) is seted up with stopper (17) complex spacing spout (16), and stopper (17) and spacing spout (16) sliding connection, the top of stabilizing case (19) is rotated and is connected with turning block (18), turning block (18) and worm (15) fixed connection.

6. The liposome surface-targeted molecule-carrying immobilization device according to claim 1, wherein: one side of the support frame (2) is provided with a control panel, and the motor (3) is electrically connected with the control panel.