CN217549339U - Control and purifier suitable for artifical material process high risk medicine dust of throwing - Google Patents

Abstract

The utility model provides a control and purification device for high-risk drug dust in a manual feeding process, which comprises a bracket, a cabin unit, a ventilation and air filtration unit, a non-exposure material inlet and outlet unit and an automatic control unit; the cabin unit comprises a transfer cabin and an operation cabin; the ventilation and air filtration unit comprises a cylinder type filter, a filter sleeve and a high-efficiency filter; the non-exposure type material inlet and outlet unit comprises a material inlet and outlet pipe, a bag pipe system pressing door and a bag sleeving interface; the utility model can realize the full-closed operation processes of material in and out, transfer, production and the like, and the negative pressure operation in the device can avoid the dust overflow; a plurality of high-efficiency air filters purify the air entering and exiting the device; the air exhausted by the device is discharged indoors, the air conditioning load in a clean workshop is not increased, the dust fall, dynamic monitoring and control, dirty air purification and drug dust recovery are facilitated, and the device has good effects on improving the working environment, ensuring the physical health of workers and protecting the environment.

Description

Control and purifier suitable for artifical material process high risk medicine dust of throwing

Technical Field

The utility model relates to a pharmaceutical equipment technical field specifically is a control and purifier suitable for manual work is thrown material process high risk medicine dust.

Background

The drug dust generated in the production process of Pharmaceutical enterprises has the characteristics of common dust, and meanwhile, as the drug dust contains Active Pharmaceutical Ingredients (API), the drug dust has specific drug toxicological performance even in a low-dose state, and the occupational hazard of the drug dust has the influence of the dust on the respiratory system and also has the pharmacological or toxicological effect of the API on a human body. APIs can cause hormonal changes, teratogenicity, cytotoxicity, respiratory allergies, dermatitis, and allergic reactions, and also cause major health effects in low concentration states, such as pharmaceutical compositions containing steroid hormones or antitumor drugs. The low activity drug dust can also cause harm to human body under long-term contact. And the additive and the API in the medicine product can have synergistic effect.

Modern pharmaceutical enterprises generally use clean rooms and biological safety cabinets to carry out medicine production in weighing, feeding and equipment cleaning links, and still cannot realize closed production due to the limitation of a production process and adopt an open operation mode, so that a large amount of medicine dust is diffused into an operation environment, and workers inevitably contact the medicine dust.

SUMMERY OF THE UTILITY MODEL

The technique that exists is not enough to the aforesaid, the utility model aims at providing a be applicable to artifical control and purifier who throws material process high-risk medicine dust to solve the problem of mentioning in the above-mentioned background art.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a control and purification device for high-risk drug dust suitable for a manual feeding process comprises a support, and a cabin unit, a ventilation and air filtration unit, a non-exposure material inlet and outlet unit and an automatic control unit which are arranged on the support;

the cabin unit comprises a transfer cabin and an operation cabin; the transfer cabin and the operation cabin are arranged at the same horizontal height position on the bracket; production operation gloves are arranged on the side wall of the operation cabin and connected to the operation cabin through sleeve rings;

the ventilation and air filtration unit comprises a cylinder type filter, two filter sleeves and three high-efficiency filters; the cartridge filter is connected between the transfer cabin and the operation cabin; the two filter sleeves are respectively connected to the upper parts of the transfer cabin and the operation cabin; one high-efficiency filter is arranged in a filter sleeve on the transfer cabin, and the other two high-efficiency filters are arranged in the filter sleeve of the operation cabin;

the non-exposure type material inlet and outlet unit comprises a material inlet and outlet pipe, a bag pipe system pressing door and a bag sleeving interface; the material inlet and outlet pipe is arranged on one side, far away from the transfer cabin, of the operation cabin in a penetrating manner; the bag pipe system pressing door and the bag sleeving interface are respectively arranged at two ends of the material inlet pipe and the material outlet pipe, the bag pipe system pressing door is positioned inside the operation cabin, and the bag sleeving interface is positioned outside the operation cabin;

the automatic control unit comprises a PLC controller, a pressure sensor and a touch screen; and the pressure sensor and the touch screen are respectively and electrically connected with the PLC.

Preferably, the transfer cabin and the operation cabin are both provided with inflatable airtight doors.

Preferably, the bottoms of the transfer cabin and the operation cabin are both provided with inclined planes and are respectively provided with a liquid discharge port; and a waste liquid tank communicated with the liquid outlet is arranged on the support.

Preferably, a valve is arranged on the liquid outlet.

Preferably, the operation cabin is internally integrated with a weighing device and a feeding port, and the bottom of the operation cabin is provided with a feeding barrel.

Preferably, a water-air dual-purpose spray gun is arranged in the operation cabin.

Preferably, the filter sleeve and the exterior of the cartridge filter are each provided with a protective housing.

Preferably, the upper part of the filter sleeve is provided with a pneumatic butterfly valve.

Preferably, the high efficiency filter is fixed inside the filter sleeve by a compression type sealing ring.

Preferably, the filter sleeve comprises a cylinder body, a limiting rod and a waterproof cover; the side part of the cylinder body is provided with an air inlet, and the side part of the cylinder body opposite to the air inlet is sequentially provided with a PAO smoke generating port, a first filter pressure taking port, a PAO sampling port and a second filter pressure taking port from top to bottom; the limiting rod penetrates through the bottom of the barrel; the waterproof cover is fixed at the bottom end of the cylinder body.

The design of the utility model has the technical characteristics of sealing, high-efficiency dust removal, energy conservation, environmental protection, strong ductility and the like; the full-closed operation of the material inlet and outlet, transfer, production and other operation processes can be realized, and the negative pressure operation in the device avoids the dust overflow; a plurality of high-efficiency air filters purify the air entering and exiting the device; the air exhausted by the device is discharged indoors, the air conditioning load in a clean workshop is not increased, the functions of dust fall, dynamic monitoring and control, dirty air purification, drug dust recovery and the like are favorably realized, and the device has good effects on improving the working environment, ensuring the physical health of workers and protecting the environment.

Drawings

Fig. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the filter cartridge according to the present invention;

fig. 3 is a schematic structural view of the middle non-exposure type material inlet and outlet unit of the present invention.

Wherein:

1. a support; 2. a pointer type differential pressure gauge; 3. a touch screen; 4. a printer; 5. a pneumatic butterfly valve; 6. a water-gas dual-purpose spray gun; 7. producing operating gloves; 8. the non-exposed material inlet and outlet unit; 9. an operation cabin; 10. a charging barrel; 11. a cartridge filter; 12. a waste liquid tank; 13. a transfer chamber; 14. a filter cartridge; 15. an air inlet; 16. a high efficiency filter; 17. a waterproof cover; 18. a limiting rod; 19. a second pressure taking port of the filter; 20. a PAO sampling port; 21. a first pressure taking port of the filter; 22. A PAO smoke outlet; 23. a material inlet pipe and a material outlet pipe; 24. a bagging port; 25. the bag tube system compresses the door.

Detailed Description

The present invention will be further explained with reference to the accompanying drawings.

As shown in figure 1, the control and purification device for high-risk drug dust suitable for a manual feeding process comprises a support 1, a cabin unit, a ventilation and air filtration unit, a non-exposure material inlet and outlet unit 8 and an automatic control unit, wherein the cabin unit, the ventilation and air filtration unit, the non-exposure material inlet and outlet unit and the automatic control unit are arranged on the support 1;

the cabin unit comprises a transfer cabin 13 and an operation cabin 9; the transfer cabin 13 and the operation cabin 9 are arranged at the same horizontal height position on the bracket 1; production operation gloves 7 are arranged on the side wall of one side of the operation cabin 9, the production operation gloves 7 are connected to the operation cabin 9 through sleeve rings, and therefore it is guaranteed that the hands of operators can touch all parts in the cabin body in the production process, and production requirements are met; the production operation gloves 7 are made of chlorosulfonated polyethylene materials, have the performances of tightness, firmness, softness and disinfectant corrosion resistance, and meet the use requirements of flexible hand movement, good touch and durability; a pointer type differential pressure gauge 2 is arranged on the operation cabin 9;

as shown in fig. 1 and 2, the ventilation and air filtration unit includes a cartridge filter 11, two filter cartridges 14, and three high efficiency filters 16; the top of the filter sleeve 14 is movably provided with a cover plate; the cylinder type filter 11 is connected between the transfer cabin 13 and the operation cabin 9, so that the negative pressure of the transfer cabin 13 is lower than that of the operation cabin 9, a pressure difference gradient and directional airflow are formed, the dust in the operation cabin 9 is strictly prevented from overflowing in the process of transferring articles, and the functions of air inlet and exhaust airflow channels and dust filtering and blocking are realized; two filter sleeves 14 are respectively connected to the upper parts of the transfer cabin 13 and the operation cabin 9; one of the high-efficiency filters 16 is arranged in a filter sleeve 14 on the transfer cabin 13 and serves as a push type air inlet high-efficiency filtering device, and the other two high-efficiency filters 16 are arranged in the filter sleeve 14 of the operation cabin 9 and serve as push type air exhaust high-efficiency filtering devices, so that the air exhaust safety is further improved; air is collected by a background room, firstly enters the transfer cabin 13 through the filter sleeve 14 and the high-efficiency filter 16 on the transfer cabin 13, then enters the operation cabin 9 through the cylindrical filter 11 between the transfer cabin 13 and the operation cabin 9, and is discharged through the filter sleeve 14 and the high-efficiency filter 16 on the operation cabin 9, so that the dust or toxic and harmful substances generated in an operation area are prevented from overflowing, and the function of protecting personnel is achieved; when the high-efficiency filter 16 is replaced, firstly, a sealing sleeve bag is sleeved at the bottom of the filter sleeve 14, then, a cover plate at the top is opened, a new high-efficiency filter 16 is arranged in an upper space in the filter sleeve 14, a matching tool is adopted to push the new high-efficiency filter 16 until the lowest high-efficiency filter 16 is ejected out, the sealing sleeve bag provided with the high-efficiency filter 16 is fastened, and the non-exposure replacement process of the high-efficiency filter 16 is completed; the pressure control is carried out by adopting a variable frequency centrifugal fan, the air volume can be controlled by an automatic control unit under the pressure maintaining state, and the adjustable pressure of the cabin unit relative to the room environment of-50 to-200 Pa is maintained;

as shown in fig. 1 and 3, in order to prevent dust contamination of the raw material, the raw material is supplied to the cabin unit in an unpacked state, and the packing bag is removed from the operation cabin 9. Meanwhile, in the process of feeding the raw material bag into the operation cabin 9, dust in the operation cabin 9 cannot leak out through the raw material inlet channel. Need take out the contaminated waste such as wrapping bag after operation cabin 9 bale breaking to guarantee that the interior dust of cabin is not excessive and the no exposure formula material of design passes in and out unit 8 includes: the material inlet and outlet pipe 23, the bag pipe system pressing door 25 and the bag sleeving connector 24; the material inlet and outlet pipe 23 is arranged on one side of the operation cabin 9 far away from the transfer cabin 13 in a penetrating way; the bag pipe system pressing door 25 and the bag sleeving interface 24 are respectively arranged at two ends of the material inlet and outlet pipe 23, the bag pipe system pressing door 25 is positioned inside the operation cabin 9, and the bag sleeving interface 24 is positioned outside the operation cabin 9; a continuous bagging pushing mode is adopted to prevent pollution to a workplace when materials enter and exit; during feeding: the cabin is kept in negative pressure operation, the bag pipe system compression door 25 is opened, materials to be transferred are placed into the cabin through a bag, the PE bags containing the materials are cut off through a bag clamping tool, the sealed PE bags are withdrawn out of the cabin, and the bag pipe system compression door 25 is closed; during discharging: keeping the negative pressure in the cabin, transmitting materials for surface packaging or cleaning, opening the bag pipe system pressing door 25, putting the materials into the material inlet and outlet pipe 23, cutting off the PE bag wrapped with the materials through a bag clamp tool, and closing the bag pipe system pressing door 25;

the materials are sent into the operation cabin 9 through the material inlet and outlet pipe 23, or the materials in the operation cabin 9 are put into material bags through the material inlet and outlet pipe 23, then the bag pipe system pressing door 25 is closed, and corresponding treatment is carried out;

the automatic control unit comprises a PLC controller, a pressure sensor and a touch screen 3; the pressure sensor and the touch screen 3 are respectively electrically connected with the PLC; the running of the device is controlled and displayed through the PLC and the touch screen 3; collecting the pressure value in the cabin through a pressure sensor, feeding the value back to a pressure regulating module to control the operating frequency of the variable-frequency centrifugal fan, and regulating the air quantity in the cabin unit so as to maintain the pressure in the cabin unit at a set value; the PLC controller collects signals and controls the opening and closing of each valve body through a flow; the PLC controller is also electrically connected with an audible and visual alarm.

Furthermore, inflatable airtight doors are arranged on the transfer cabin 13 and the operation cabin 9, and an integrally-formed silicon rubber sealing strip is used, so that the inflation pressure is 0.2Mpa, and the air tightness requirement of the device in a normal use state is ensured.

Further, the bottoms of the transfer cabin 13 and the operation cabin 9 are both provided with inclined planes and are respectively provided with a liquid discharge port; the bracket 1 is provided with a waste liquid tank 12 communicated with a liquid outlet.

Further, a valve is provided at the drain port to ensure the sealing at both ends when the waste liquid tank 12 is removed.

Furthermore, a weighing device and a feeding interface are integrated in the operation cabin 9, and a feeding barrel 10 is configured at the bottom; a feeding valve is arranged on the feeding interface.

Furthermore, a water-gas dual-purpose spray gun 6 is arranged in the operation cabin 9, so that the equipment can be cleaned on line; the device is reserved with process pipeline interfaces such as a gas circuit, a water source and the like, so that other external facilities can be conveniently accessed, and the requirement of normal operation is met; the power socket is arranged in the cabin body unit of the device, and the power consumption requirements of other equipment in the medicine dust purification device are met.

Further, the filter sleeve 14 and the cartridge filter 11 are provided with protective casings on the outside to prevent accidental contact or damage during cleaning.

Further, the upper part of the filter sleeve 14 is provided with a pneumatic butterfly valve 5, a normally closed state is preferably selected, and the valve is automatically closed when the equipment is not operated so as to ensure that air in the cabin does not overflow.

Further, the high efficiency filter 16 is fixed inside the filter sleeve 14 by a press-fit type seal ring.

Further, the filter sleeve 14 comprises a cylinder body, a limiting rod 18 and a waterproof cover 17; the side part of the cylinder body is provided with an air inlet 15, and the side part of the cylinder body opposite to the air inlet 15 is sequentially provided with a PAO smoke generating port 22, a first filter pressure taking port 21, a PAO sampling port 20 and a second filter pressure taking port 19 from top to bottom; the limiting rod 18 penetrates through the bottom of the barrel; the waterproof cover 17 is fixed at the bottom end of the cylinder body.

When the device is used, the variable-frequency centrifugal fan for exhausting air is started, so that the feeding operation can be carried out when the pressure in the cabin unit reaches a set value; when the device is closed, the feeding valve is closed first, feeding is stopped, and then the variable-frequency centrifugal fan is closed; the sealing inflation and deflation of the inflatable airtight door, the opening and closing of the valve of the pneumatic butterfly valve 5 of the cabin body and the control of the valve of the water-gas dual-purpose spray gun 6 are automatically carried out by a PLC controller; the running state of the device, the relative pressure in the cabin unit, the state of the valve and the opening and closing state of the inflatable airtight door are all displayed on the touch screen 3 in real time, and the change of the pressure is monitored in real time; the cabin unit is provided with a micro printer 4 which can print recorded operation data and can realize remote monitoring through a communication output interface; when parameters such as negative pressure of the cabin body, a compressed air source and the like deviate from a set range or receive an emergency stop signal, the automatic control unit can automatically send out an audible and visual alarm signal:

1) Leakage alarm and emergency air exhaust: when the device is in a normal operation state, the negative pressure in the cabin is automatically maintained at a set value. When the cabin unit leaks and the negative pressure of the device is less than a set value, the automatic control unit gives out sound and light alarm and automatically enters an emergency air exhaust program to increase the operating frequency of the fan and increase the discharge capacity; when the emergency air exhaust program runs, the air speed of the crack is ensured to be more than 0.5m/s.

2) And (3) alarming when the air source pressure is insufficient: when the air source pressure of the inflatable airtight door and the pneumatic butterfly valve 5 is lower than 0.4Mpa, the audible and visual alarm automatically gives out audible and visual alarm, and the equipment cannot be started.

3) Emergency stop alarm: the device is provided with an emergency stop button, and when the emergency stop button is pressed down, the audible and visual alarm gives out audible and visual alarm and automatically enters an emergency air exhaust program.

Evaluation of Properties

The key performance of the medicine dust control and purification device in the feeding process is tested under the device operation condition. (1) And (3) air tightness test: under the pressure of-200 Pa, the hourly volume leakage rate is 0.06-0.15%, which are all less than or equal to 0.25%; (2) and (3) testing the protection performance: adopting a substitute leakage test method, taking naproxen sodium as a substitute to test, simulating a general production process, wherein the peripheral leakage amount is less than 0.00186 mu g/m < 3 >, and the limit value requirement of less than 0.02 mu g/m < 3 > is met; (3) other tests: the noise of the operating position of a worker is 58-60 dB (A), and the noise is less than 68dB (A), and (4) the illuminance 508-510 LX in the main cabin is more than 500 LX. The results of the multiple tests are shown in table 1.

TABLE 1 device Performance test results

The test result shows that all technical performances of the device meet the design requirements, and the device not only has the conditions of strict sealing, negative pressure operation and no exposure of materials in and out, but also has the performance of exhaust purification.

Claims (10)

1. A control and purification device suitable for high-risk drug dust in a manual feeding process is characterized by comprising a bracket (1), a cabin unit, a ventilation and air filtration unit, a non-exposure type material inlet and outlet unit (8) and an automatic control unit, wherein the cabin unit, the ventilation and air filtration unit, the non-exposure type material inlet and outlet unit and the automatic control unit are arranged on the bracket (1);

the cabin unit comprises a transfer cabin (13) and an operation cabin (9); the transfer cabin (13) and the operation cabin (9) are arranged at the same horizontal height position on the bracket (1); production operation gloves (7) are arranged on the side wall of the operation cabin (9), and the production operation gloves (7) are connected to the operation cabin (9) through sleeve collars;

the ventilation and air filtration unit comprises a cartridge filter (11), two filter sleeves (14) and three high-efficiency filters (16); the cylinder type filter (11) is connected between the transfer cabin (13) and the operation cabin (9); two filter sleeves (14) are respectively connected to the upper parts of the transfer cabin (13) and the operation cabin (9); one of the high-efficiency filters (16) is arranged in a filter sleeve (14) on the transfer cabin (13), and the other two high-efficiency filters (16) are arranged in the filter sleeve (14) of the operation cabin (9);

the non-exposure type material inlet and outlet unit (8) comprises a material inlet and outlet pipe (23), a bag pipe system pressing door (25) and a bag sleeving interface (24); the material inlet and outlet pipe (23) is arranged on one side, far away from the transfer cabin (13), of the operation cabin (9) in a penetrating manner; the bag pipe system pressing door (25) and the bag sleeving interface (24) are respectively arranged at two ends of the material inlet pipe (23), the bag pipe system pressing door (25) is positioned inside the operation cabin (9), and the bag sleeving interface (24) is positioned outside the operation cabin (9);

the automatic control unit comprises a PLC controller, a pressure sensor and a touch screen (3); the pressure sensor and the touch screen (3) are respectively and electrically connected with the PLC.

2. The device for controlling and purifying high-risk drug dust in the manual feeding process according to claim 1, wherein the transfer cabin (13) and the operation cabin (9) are provided with inflatable airtight doors.

3. The device for controlling and purifying high-risk drug dust in the manual feeding process according to claim 1, wherein the bottom of the transfer cabin (13) and the bottom of the operation cabin (9) are provided with inclined planes and are respectively provided with a liquid discharge port; the support (1) is provided with a waste liquid tank (12) communicated with the liquid outlet.

4. The device for controlling and purifying high-risk drug dust in the manual feeding process as claimed in claim 3, wherein a valve is arranged on the liquid outlet.

5. The device for controlling and purifying high-risk drug dust in the manual feeding process according to claim 1, wherein the operation cabin (9) is internally integrated with a weighing device and a feeding port, and the bottom of the operation cabin is provided with a feeding barrel (10).

6. The device for controlling and purifying high-risk drug dust in the manual feeding process is characterized in that a water-air dual-purpose spray gun (6) is arranged in the operation cabin (9).

7. The device for controlling and purifying high-risk drug dust in the manual dosing process according to claim 1, wherein the filter sleeve (14) and the cartridge filter (11) are provided with a protective casing on the outside.

8. The device for controlling and purifying high-risk drug dust in the manual dosing process in claim 1, wherein the upper part of the filter sleeve (14) is provided with a pneumatic butterfly valve (5).

9. The device for controlling and purifying high-risk drug dust in the manual feeding process is characterized in that the high-efficiency filter (16) is fixed inside the filter sleeve (14) through a compression type sealing ring.

10. The device for controlling and purifying high-risk drug dust in the manual dosing process according to any one of claims 1 to 9, wherein the filter sleeve (14) comprises a cylinder body, a limiting rod (18) and a waterproof cover (17); an air inlet (15) is formed in the side part of the cylinder body, and a PAO fuming port (22), a first filter pressure sampling port (21), a PAO sampling port (20) and a second filter pressure sampling port (19) are sequentially formed in the side part of the cylinder body, which is opposite to the air inlet (15), from top to bottom; the limiting rod (18) penetrates through the bottom of the barrel; the waterproof cover (17) is fixed at the bottom end of the barrel.

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