CN217542869U - Antigen fast detection device based on lateral fluorescence chromatography technology - Google Patents
Antigen fast detection device based on lateral fluorescence chromatography technology Download PDFInfo
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- CN217542869U CN217542869U CN202220814980.9U CN202220814980U CN217542869U CN 217542869 U CN217542869 U CN 217542869U CN 202220814980 U CN202220814980 U CN 202220814980U CN 217542869 U CN217542869 U CN 217542869U
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Abstract
The utility model discloses an antigen fast detection device based on lateral fluorescence chromatography technology, the method comprises the following steps: the device comprises a detection reagent card box, lateral fluorescence chromatography test paper and a light-emitting mechanism. The detection reagent card box comprises a box cover and a box bottom, the box cover is arranged on the box bottom, and the top of the box cover is provided with a sample adding pool and an interpretation window. The lateral fluorescence chromatography test paper is arranged between the box cover and the box bottom and consists of a sample pad, a combination pad, a nitrocellulose membrane and an absorption pad. The light emitting mechanism is capable of emitting a source of ultraviolet light. The position of the interpretation window is opposite to the nitrocellulose membrane of the lateral fluorescence chromatography test paper, and the position of the sample adding pool is opposite to the sample pad of the lateral fluorescence chromatography test paper. The light-emitting mechanism is used for emitting ultraviolet light towards the interpretation window of the detection reagent card box, so that a user can interpret the test result. Therefore, the utility model discloses a device is examined soon to antigen based on side direction fluorescence chromatography technique, it is easy and simple to handle, be fit for the family self-test, and the convenience is high, the reliability is high, the accuracy is high.
Description
Technical Field
The utility model relates to a biological detection technical field especially relates to an antigen short-term test device based on side direction fluorescence chromatography technique.
Background
Adopt the detect reagent box of side direction fluorescence chromatography technique in the existing market, all need supporting instrument to detect, no matter be desk-top instrument or hand-held type instrument, the cost of all meeting greatly increased family self-test increases the convenience of non professional's use, is not convenient for the family self-test market to promote greatly.
The existing detection comprises nucleic acid detection, antibody detection and antigen detection, wherein the antibody detection is used for detecting an antibody generated after infection and belongs to indirect detection; and nucleic acid detection and antigen detection belong to direct virus detection, and the direct virus detection has the advantage of being discovered earlier.
Nucleic acid detection requires specialized PCR laboratories, specialized operators, and 30-120 minutes of amplification. In the case of regional large-scale virus outbreak, the nucleic acid detection speed cannot meet the detection requirement. The rapid detection method for antigen detection is lateral immunochromatography, is distinguished from tracer substances, and can be further divided into a fluorescence immunochromatography method, a latex method and a colloidal gold method, wherein the detection limit of the fluorescence immunochromatography method is 3 times that of the latex method and 10 times that of the colloidal gold method, so that the method is a more accurate selection suitable for home self-detection, but a rapid and convenient detection device based on the lateral fluorescence immunochromatography method is not available in the market at present.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information constitutes prior art already known to a person skilled in the art.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a device is examined soon to antigen based on side direction fluorescence chromatography technique, it is easy and simple to handle, be fit for the family self-test, and the convenience is high, the reliability is high, the accuracy is high.
In order to achieve the above object, the utility model provides an antigen fast detection device based on lateral fluorescence chromatography technique includes: the device comprises a detection reagent card box, lateral fluorescence chromatography test paper and a light-emitting mechanism. The detection reagent card box comprises a box cover and a box bottom, wherein the box cover is arranged on the box bottom, and the top of the box cover is provided with a sample adding pool and an interpretation window. The lateral fluorescence chromatography test paper is arranged between the box cover and the box bottom and consists of a sample pad, a combination pad, a nitrocellulose membrane and an absorption pad. The light emitting mechanism is capable of emitting a source of ultraviolet light. The position of the interpretation window is opposite to the nitrocellulose membrane of the lateral fluorescence chromatography test paper, and the position of the sample adding pool is opposite to the sample pad of the lateral fluorescence chromatography test paper. Wherein, the light-emitting mechanism is used for emitting ultraviolet light towards the interpretation window of the detection reagent card box, thereby leading a user to interpret the test result.
The utility model discloses an among the embodiment, the antigen based on side direction fluorescence chromatography technique examines device soon still includes sampling swab and schizolysis bottle, and the sampling swab is used for supplying the user to sample the swab sampling, and the sampling swab after the sampling is put into the schizolysis bottle and is split the preset time, and detects in the application of sample pond that drips into the detect reagent card box with the liquid in the schizolysis bottle after the schizolysis is accomplished.
In an embodiment of the present invention, the light emitting mechanism is a portable flashlight or a portable key ring.
In one embodiment of the present invention, the light emitting mechanism can emit 365nm ultraviolet light.
The utility model discloses an among the embodiment, the antigen based on side direction fluorescence chromatography technique examines device soon still includes the packing carton, and the packing carton is the rectangle, and the bottom of packing carton has seted up first opening, and the second opening has been seted up at the top, and the third opening has been seted up to one side. Wherein, the first opening is used for placing the detection reagent card box in the packing box. Wherein the position of the second opening is opposite to the interpretation window of the detection reagent card box. The third opening is used for the light-emitting mechanism to irradiate and excite the nitrocellulose membrane of the lateral fluorescence chromatography test paper.
Compared with the prior art, according to the utility model discloses antigen short-term test device based on side direction fluorescence chromatography technique, easy and simple to handle is fit for the family self-test, and the convenience is high, the reliability is high, the accuracy is high, provides powerful technical support and protection for national epidemic prevention, epidemic prevention.
Drawings
FIG. 1 is a schematic perspective view of a reagent cartridge of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
FIG. 2 is a schematic view of another perspective structure of the detection reagent cartridge of the rapid antigen detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a light-emitting mechanism of an antigen rapid detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of another light-emitting mechanism of the antigen rapid detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
fig. 5 is a schematic perspective view of a packaging box of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
fig. 6 is another schematic perspective view of the packaging box of the antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a usage state of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention;
description of the main reference numbers:
1-detection reagent card box, 2-box cover, 3-box bottom, 4-sample adding pool, 5-interpretation window, 6-luminous mechanism, 7-packaging box, 8-first opening, 9-second opening and 10-third opening.
Detailed Description
The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited by the following detailed description.
Throughout the specification and claims, unless explicitly stated otherwise, the term "comprise" or variations such as "comprises" or "comprising", etc., will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
Fig. 1 is a schematic perspective view of a detection reagent cartridge of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 2 is another schematic perspective view of the detection reagent cartridge of the antigen rapid detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 3 is a schematic structural diagram of a light-emitting mechanism of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 4 is a schematic structural diagram of another light-emitting mechanism of the antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 5 is a schematic perspective view of a packaging box of an antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 6 is another schematic perspective view of the packaging box of the antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention. Fig. 7 is a schematic structural diagram of a usage state of the antigen rapid-detection device based on lateral fluorescence chromatography according to an embodiment of the present invention.
As shown in fig. 1 to 7, an antigen rapid-detection device based on lateral fluorescence chromatography according to a preferred embodiment of the present invention includes: the kit comprises a detection reagent card box 1, a lateral fluorescence chromatography test paper and a light-emitting mechanism 6. Detection reagent card box 1 includes lid 2 and box bottom 3, and lid 2 lid is located on box bottom 3, and the top of lid 2 has seted up application of sample pond 4 and interpretation window 5. The lateral fluorescence chromatography test paper is arranged between the box cover 2 and the box bottom 3 and consists of a sample pad, a combination pad, a nitrocellulose membrane and an absorption pad. The light emitting mechanism 6 is capable of emitting an ultraviolet light source. Wherein, the position of the interpretation window 5 is opposite to the nitrocellulose membrane of the lateral fluorescence chromatography test paper, and the position of the sample adding pool 4 is opposite to the sample pad of the lateral fluorescence chromatography test paper. Wherein, the light emitting mechanism 6 is used for emitting ultraviolet light towards the interpretation window 5 of the detection reagent card box 1, so that the user can interpret the test result.
The utility model discloses an among the embodiment, the antigen based on side direction fluorescence chromatography technique examines device soon still includes sampling swab and schizolysis bottle, and the sampling swab is used for supplying the user to sample the swab sampling, and the sampling swab after the sampling is put into the schizolysis bottle and is split the preset time, and the liquid in the schizolysis bottle instils into the application of sample pond 4 of detect reagent card box 1 after the schizolysis is accomplished and detect.
In an embodiment of the present invention, the light emitting mechanism 6 is a portable flashlight or a portable key ring. The light emitting means 6 is capable of emitting an ultraviolet light source of 365nm wavelength.
The utility model discloses an in the embodiment, the antigen based on side direction fluorescence chromatography technique examines device soon still includes packing carton 7, and packing carton 7 is the rectangle, and packing carton 7's bottom has seted up first opening 8, and second opening 9 has been seted up at the top, and third opening 10 has been seted up to one side. Wherein, the first opening 8 is used for placing the detection reagent card box 1 in the packing box 7. Wherein the second opening 9 is positioned opposite to the interpretation window 5 of the detection reagent cartridge 1. The third opening 10 is used for the light-emitting mechanism 6 to irradiate and excite the nitrocellulose membrane of the lateral fluorescence chromatography test paper.
Example 1, the specific steps in use include: and S1, completely inserting a disposable sampling swab into the throat from the oral cavity of a human body, slowly rotating and wiping the tonsils of both sides of the pharynx and the rear wall of the pharynx, and collecting oropharyngeal mucosa liquid. And S2, putting the sampling swab into a lysis bottle containing a sample extracting solution, fully and uniformly mixing the sample, and standing for 5 minutes to lyse the virus. And S3, dripping the uniformly mixed sample in the cracking bottle into the sample adding pool 4 of the detection reagent card box 1, and waiting for 15 minutes for detection. And S4, irradiating the interpretation window 5 of the detection reagent card box 1 by using the light-emitting mechanism 6, and judging a detection result according to the detection C and T lines through the interpretation window 5.
In an embodiment of the present invention, the light emitting mechanism 6 is a portable flashlight or a portable key ring, and the light emitting mechanism 6 can emit an ultraviolet light source with a wavelength of 365 nm.
The utility model discloses an in the embodiment, the antigen based on side direction fluorescence chromatography technique examines device soon still includes packing carton 7, and packing carton 7 is the rectangle, and packing carton 7's bottom has seted up first opening 8, and second opening 9 has been seted up at the top, and third opening 10 has been seted up to one side. Wherein, the first opening 8 is used for placing the detection reagent card box 1 in the packing box 7. Wherein the second opening 9 is positioned opposite to the interpretation window 5 of the detection reagent cartridge 1. The third opening 10 is used for the light-emitting mechanism 6 to irradiate and excite the nitrocellulose membrane of the lateral fluorescence chromatography test paper.
Example 2, the specific steps in use include: and S1, inserting a disposable sampling swab into the nasal cavity in a direction vertical to the nose, and collecting nasal mucosa liquid. And S2, putting the sampling swab into a lysis bottle containing the sample extracting solution, fully and uniformly mixing the sample, and standing for 5 minutes to lyse the virus. And S3, dropping the uniformly mixed sample in the cracking bottle into the sample adding pool 4 of the detection reagent card box 1 for detection. And S4, irradiating the interpretation window 5 of the detection reagent card box 1 by using the light-emitting mechanism 6, and judging a detection result according to the detection C and T lines through the interpretation window 5. Wherein, the step S1 specifically comprises the following steps: from insertion into the nasal cavity until the inner turbinate (insertion depth of about 40 mm for an adult, nasopharyngeal swab; about 13-25 mm for a child), the nasal cavity is scraped for about 10 seconds, and the procedure is repeated with another nasal cavity.
In an embodiment of the present invention, the light emitting mechanism 6 is a portable flashlight or a portable key ring, and the light emitting mechanism 6 can emit an ultraviolet light source with a wavelength of 365 nm.
In practical application, the utility model discloses device is examined soon to antigen based on side direction fluorescence chromatography technique adopts the ultraviolet light source of two kinds of portable 365nm wavelength, is the key ring formula and miniature flashlight formula respectively, and two kinds of light sources adopt battery powered. The detection reagent card box 1 in each packing box 7 is provided with a light source at most 25 persons, and batteries of the two light sources can meet the requirement of 125 times of observation and are enough for observation of one detection reagent box. Because the ultraviolet ray of 365nm wavelength receives various light source interferences such as sunshine, LED lamp, halogen tungsten lamp easily, so the utility model discloses design into simple and easy shading viewing device with detect reagent box, be convenient for under various complex environment, carry out the accuracy interpretation to fluorescence immunochromatography's antigen detect result.
In detail: the rapid test device generally comprises a test card, a nasal/pharyngeal swab, and a lysis vial (liquid). After sampling by a user through a nose/pharynx swab, putting the nasal/pharynx swab into a lysis bottle (liquid) for lysis for 5 minutes, then dripping 42-3 drops of the sample adding pool of the detection reagent card box 1, after 15 minutes, irradiating the interpretation window 5 through the light-emitting mechanism 6, displaying only one C line which represents that the detection result is negative, and if the C line and the T line are displayed simultaneously, representing that the detection result is positive.
When the reagent is positioned outdoors and is interfered by sunlight or indoors and is interfered by a strong light source, the packing box 7 of the reagent can be quickly transformed into the packing box 7. The first step, the reagent box is inverted and is buckled along the dotted line in the middle of the bottom to form a rectangle, and the position of the detection reagent card box 1 can be placed and fixed. And secondly, rightly placing the kit, and buckling the dotted lines on the top and the side to form two circles. And thirdly, flatly placing the test card to be interpreted after 2-3 drops of the sample are added for 15 minutes on a desktop, aligning the bottom rectangle of the packing box 7, and finally irradiating and exciting from the side by using a portable flashlight, so that human eyes interpret the detection result from a top observation port.
When the detected person belongs to the early stage of virus infection or is asymptomatic, the T line of the detection result is relatively shallow, and when the packaging box 7 is used, the interference of ambient light is eliminated, a dark room is formed, and the relatively shallow T line is easier to observe. Use the utility model discloses a examine the device soon, 2-3 add samples drop 15 minutes after, use the light source irradiation of luminous mechanism 6, can observe C line T line and carry out negative and positive judgement.
In a word, the utility model discloses antigen short-term test device based on side direction fluorescence chromatography technique, it is easy and simple to handle, be fit for the family self-test, and the convenience is high, the reliability is high, the accuracy is high, provides powerful technical support and protection for national epidemic prevention, antiepidemic.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. An antigen rapid detection device based on lateral fluorescence chromatography technology is characterized by comprising:
the detection reagent card box comprises a box cover and a box bottom, wherein the box cover is arranged on the box bottom in a covering manner, and the top of the box cover is provided with a sample adding pool and an interpretation window;
the lateral fluorescence chromatography test paper is arranged between the box cover and the box bottom and consists of a sample pad, a combination pad, a nitrocellulose membrane and an absorption pad; and
a light emitting mechanism capable of emitting an ultraviolet light source;
wherein the position of the interpretation window is over against the nitrocellulose membrane of the lateral fluorescent chromatography test paper, and the position of the sample adding pool is over against the sample pad of the lateral fluorescent chromatography test paper;
wherein, the light-emitting mechanism is used for emitting ultraviolet light towards the interpretation window of the detection reagent card box, thereby enabling a user to interpret the test result.
2. The lateral fluorescence chromatography-based antigen rapid detection device according to claim 1, further comprising a sampling swab and a lysis bottle, wherein the sampling swab is used for a user to sample the sampling swab, the sampled sampling swab is placed in the lysis bottle to be lysed for a predetermined time, and after the lysis is completed, the liquid in the lysis bottle is dropped into the sample adding well of the detection reagent cartridge for detection.
3. The lateral fluorescence chromatography-based antigen rapid detection device according to claim 1, wherein the light-emitting mechanism is a portable flashlight or a portable key ring.
4. The lateral fluorescence tomography-based antigen rapid detection device as claimed in claim 1, wherein the light emitting mechanism can emit 365nm ultraviolet light.
5. The lateral fluorescence chromatography-based antigen rapid detection device as claimed in claim 1, further comprising a rectangular packaging box, wherein the packaging box is provided with a first opening at the bottom, a second opening at the top and a third opening at one side;
wherein the first opening is used for placing the detection reagent card box in the packaging box;
wherein the second opening is positioned opposite to the interpretation window of the detection reagent cartridge;
the third opening is used for enabling the light-emitting mechanism to irradiate and excite the nitrocellulose membrane of the lateral fluorescence chromatography test paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220814980.9U CN217542869U (en) | 2022-04-11 | 2022-04-11 | Antigen fast detection device based on lateral fluorescence chromatography technology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220814980.9U CN217542869U (en) | 2022-04-11 | 2022-04-11 | Antigen fast detection device based on lateral fluorescence chromatography technology |
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| Publication Number | Publication Date |
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| CN217542869U true CN217542869U (en) | 2022-10-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220814980.9U Active CN217542869U (en) | 2022-04-11 | 2022-04-11 | Antigen fast detection device based on lateral fluorescence chromatography technology |
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| CN (1) | CN217542869U (en) |
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