CN217525389U - Knee joint cavity positioning device for stem cell injection - Google Patents
Knee joint cavity positioning device for stem cell injection Download PDFInfo
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- CN217525389U CN217525389U CN202120902136.7U CN202120902136U CN217525389U CN 217525389 U CN217525389 U CN 217525389U CN 202120902136 U CN202120902136 U CN 202120902136U CN 217525389 U CN217525389 U CN 217525389U
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- 210000000629 knee joint Anatomy 0.000 title claims abstract description 124
- 238000002347 injection Methods 0.000 title claims abstract description 50
- 239000007924 injection Substances 0.000 title claims abstract description 50
- 210000000130 stem cell Anatomy 0.000 title claims abstract description 28
- 210000004417 patella Anatomy 0.000 claims abstract description 25
- 210000000689 upper leg Anatomy 0.000 claims abstract description 7
- 238000003384 imaging method Methods 0.000 description 7
- 238000005452 bending Methods 0.000 description 5
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 241000984642 Cura Species 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 2
- 210000001699 lower leg Anatomy 0.000 description 2
- 238000010422 painting Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 210000000426 patellar ligament Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
A knee joint cavity positioning device for stem cell injection comprises a knee joint profiling component, wherein a positioning sleeve and a locking belt are fixedly arranged on the knee joint profiling component, the inner diameter of a positioning hole of the positioning sleeve is consistent with the outer diameter of an injector, a limiting table is arranged in the positioning sleeve, and the limiting table is positioned at the joint of the positioning sleeve and the knee joint profiling component; the knee joint profiling component and the limiting table are provided with through holes with the diameter larger than that of the syringe needle at the central line of the positioning sleeve; an inclined angle is formed between the positioning sleeve and the knee joint profiling component, and the central line of the positioning sleeve extends to a joint cavity between the patella and the femur. The utility model discloses simple structure, easily operation can accurately fix a position the injection, avoids the repeated injection.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a knee joint cavity positioning device for stem cell injection.
Background
The patent that relates to knee joint chamber puncture at present mainly focuses on the adjustment and the fixing of knee joint angle, guarantees the size in inboard or the outside joint clearance of patella ligament to in inject, but the success rate of injection still will see doctor's experience. And the prior art does not relate to a mode for positioning the injection point on the surface of the knee joint.
The patent No. 2019209305893, named as knee joint cavity injection positioning device, mainly solves the problem that the bending angle between the thigh and the shank can be adjusted before the injection of the joint cavity of the knee joint. The size of the joint gap at the inner side or the outer side of the patellar ligament is adjusted by adjusting the bending angle between the thigh part and the crus part, so that the effect of positioning before injection is realized.
The patent number 2017208576672 is a multifunctional medical chair particularly suitable for safe injection of knee joint cavities, and is mainly characterized in that a footrest on the upper layer of the existing injection chair is designed into a structure which can be opened and closed, can be externally rotated by 90 degrees, can be disassembled and can be lifted, so that patients with different heights can keep 90-degree knee bending seats, and can be prevented from being accidentally injured by obstacles when the patients get on or off the chair; meanwhile, in order to enable an injection doctor to insert a needle obliquely from the inner part to the upper part along the lower lateral gap of the patella and not to displace, the sitting surface of a patient needs to be about 25cm higher than the sitting surface of the doctor, so that the doctor can control the operation in the front sight line; the leg rest stool is fixed with the chair, so that the middle-aged and the elderly patients with knee OA can get on and off the chair safely and conveniently.
Patent number 2019204067884, the patent name is an automatic angle regulation's articular cavity puncture direction auxiliary device, be automatic angle regulation's articular cavity puncture direction auxiliary device, the adjustable angle structure of setting, can make things convenient for the bending degree that medical staff adjusted the knee joint according to patient's particular case is nimble, improve treatment, and running-board lift adjustment device has been set up in the movable support board, can adjust the height of running-board, make the knee joint be in suitable crooked position, be convenient for inject, high durability and convenient use, and running-board lift adjustment device can the patient adjust by oneself, can reach the most comfortable position, thereby guarantee good treatment.
It can be seen that the three patents are all used for adjusting the bending degree of the knee joint of the patient and fixing the knee joint, so as to facilitate the injection by the doctor, but whether the injection is accurate or not is required to be based on the experience of the doctor, and the operation is inconvenient.
Disclosure of Invention
Not enough to prior art, the utility model aims at providing a positioner who advances line location to knee joint surface injection site is the individualized knee joint chamber positioner who uses three-dimensional scanning and 3D to print the mode preparation to be fit for every patient, convenient operation, and the injection is accurate, remedies prior art's not enough.
In order to achieve the above object, the utility model provides a following technical scheme:
a preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling a patient to straighten the supine knee joint, and firstly adopting an imaging examination to obtain a preliminary knee joint three-dimensional model comprising bones and the body surface appearance of the knee joint; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component, wherein the bottom surface of the knee joint profiling component is consistent with the shape of the right front area of the knee joint and is attached to the right front area of the knee joint;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): obtaining a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector by using the 3-matic software according to the size of the injector, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle, and adjusting the proper position, angle and depth; according to the confirmed three-dimensional model of the injector with the position, the angle and the depth, a cylinder model of the positioning sleeve is established, and the inner diameter and the outer diameter of the positioning sleeve, the position of the limiting table and a through hole in the limiting table are arranged; moving the established cylinder model of the positioning sleeve to the three-dimensional injector model, combining the cylinder model with the knee joint profiling component, performing Boolean operation on the combined cylinder model and the three-dimensional injector model, and subtracting the three-dimensional injector model to obtain the three-dimensional model of the knee joint cavity positioning device for stem cell injection;
and step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
Preferably, the imaging examination in step 1) comprises CT or MRI.
Preferably, in the step 2), the knee joint profiling component is coated on the right front area of the knee joint to generate a covering layer, and then the covering layer and the surface model of the knee joint are used for performing Boolean operation.
Preferably, in the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
Preferably, in the step 4), the outer diameter of the positioning sleeve is 1.1-1.5 times of the diameter of the syringe, and the inner diameter of the positioning sleeve is consistent with the diameter of the syringe; and the limiting table is arranged to be attached to the end face of the syringe cylinder of the syringe, and the diameter of the through hole of the limiting table is larger than that of the syringe needle.
Preferably, the software in step 5) is converted into a format that can be run by the 3D printer, and the software comprises cura, simplify3D, 3dslicer and repetitier host.
The knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component, wherein a positioning sleeve and a locking belt are fixedly arranged on the knee joint profiling component, and the inner diameter of a positioning hole of the positioning sleeve is consistent with the outer diameter of a syringe needle cylinder; a limiting table is arranged in the positioning sleeve and is positioned at the joint of the positioning sleeve and the knee joint profiling component; the knee joint profiling component and the limiting table are provided with through holes with the diameter larger than that of the syringe needle at the central line of the positioning sleeve; an inclined angle is formed between the positioning sleeve and the knee joint profiling component, and the central line of the positioning sleeve extends to a joint cavity between the patella and the femur.
Preferably, the locating sleeve is located over the exterior or over the interior of the suprapatellar pole.
Preferably, the locating sleeve is held at 0 to 90 degrees to the coronal plane of articulation and at 0 to 75 degrees to the sagittal plane of articulation.
Preferably, the limiting table is perpendicular to the positioning sleeve.
Preferably, the end face of the syringe needle cylinder is attached to the limiting table.
Preferably, the outer diameter of the locating sleeve is 1.1-1.5 times the diameter of the syringe barrel.
Compared with the prior art, the utility model discloses the beneficial effect who reaches is:
through the mode that three-dimensional scanning and 3D printed, the knee joint characteristic according to everyone is modelled, can realize individualized knee joint chamber positioner, and the position and the direction of the control syringe that the position sleeve that sets up through three-dimensional modeling can be accurate inject, through the injection depth of spacing platform control syringe. The deviation is avoided, the injection is accurately positioned, the injection depth is controlled, and the operation is very convenient.
Drawings
FIG. 1 is a schematic 2D cross-sectional view of a knee joint cavity positioning device for stem cell injection;
FIG. 2 is a schematic 2D front view of a knee joint cavity positioning device for stem cell injection;
FIG. 3 is a schematic view of the needle insertion angle;
FIG. 4 is a 3D schematic view of the positioning sleeve located over and inside the upper patella pole;
FIG. 5 is a 3D schematic view of the alignment sleeve positioned over and outside the superior patella pole;
description of the reference numerals: 1. a knee joint contouring component; 2. a positioning sleeve; 3. a locking band; 4. an injector; 4-1 end face; 2-1, a limit table; 2-2, positioning holes; 2-3, through holes; 3-1, syringe needle.
Detailed Description
In order to make the technical means, creation features, achievement purposes and functions of the present invention easy to understand, the present invention is further described below with reference to the following embodiments.
According to the drawings shown in fig. 1, fig. 2 and fig. 3, the invention provides the following technical solutions:
example 1:
a preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component 1, wherein the bottom surface of the knee joint profiling component 1 is consistent with the shape of the right front area of the knee joint and is attached to the right front area of the knee joint;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
and step 4): acquiring a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector according to the size by using the 3-matic software, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle by using move and rotate operation, and adjusting the proper position, angle and depth; establishing a cylinder model of the positioning sleeve 2 by using create operation according to the three-dimensional model of the injector with the confirmed position, angle and depth, and setting the inner diameter and outer diameter of the positioning sleeve 2, the position of the limiting table 2-1 and a through hole 2-3 on the limiting table 2-1; moving the established cylinder model of the positioning sleeve 2 to the three-dimensional model of the injector through move operation, performing Boolean operation on the three-dimensional model of the injector after the cylinder model is combined with the knee joint profiling component 1, performing Boolean operation on the three-dimensional model of the injector, and subtracting the three-dimensional model of the injector to obtain the three-dimensional model of the knee joint cavity positioning device for stem cell injection;
and step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
The imaging examination in step 1) comprises CT or MRI.
In the step 2), the knee joint profiling component 1 is used for generating a covering layer after painting the right front area of the knee joint by using mark and wrap operations, and then performing Boolean operation by using the covering layer and a surface model of the knee joint. The covering layer is 2cm thick.
In the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
In the step 4), the outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe 4, and the inner diameter of the positioning sleeve 2 is consistent with the diameter of the syringe 4; and a limiting platform 2-1 is arranged to be attached to the end face 4-1 of the syringe 4 of the injector, and the diameter of a through hole 2-3 of the limiting platform 2-1 is larger than that of the needle head 5 of the injector.
And in the step 5), converting the format into a format which can be run by the 3D printer through software, wherein the software comprises cura, simplify3D, 3dslicer and repetitier host.
A knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component 1, wherein a positioning sleeve 2 and a locking belt 3 are fixedly arranged on the knee joint profiling component 1, the inner diameter of a positioning hole 2-2 of the positioning sleeve 2 is consistent with the outer diameter of an injector needle cylinder 4, and an injector can be placed and guided; a limiting table 2-1 is arranged in the positioning sleeve 2 and used for limiting the needle inserting depth of the injector. The limiting table 2-1 is positioned at the joint of the positioning sleeve 2 and the knee joint profiling component 1; the knee joint profiling component 1 and the limiting table 2-1 are provided with through holes 2-3 with the diameter larger than that of the syringe needle 5 at the central line of the positioning sleeve 2, so that the syringe needle can pass through smoothly; an inclined angle is formed between the positioning sleeve 2 and the knee joint profiling component 1, the central line of the positioning sleeve 2 extends to a joint cavity between a patella and a femur, and the knee joint profiling component 1 belongs to profiling and can be well attached to a knee joint.
The positioning sleeve 2 is positioned on the upper outer side or the upper inner side of the upper pole of the patella. The external upper part of the upper patella pole is near the junction point of the upper patella edge and the outer patella edge, and the internal upper part of the upper patella pole is near the junction point of the upper patella edge and the inner patella edge.
The positioning sleeve 2 keeps 0-90 degrees with the coronal joint plane and 0-75 degrees with the sagittal joint plane.
The limiting table 2-1 is perpendicular to the positioning sleeve 2.
The end surface 4-1 of the syringe needle cylinder 4 is jointed with the limiting table 2-1.
The outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe needle cylinder 4.
The locking strap 3 is used to secure the positioning device to the knee joint.
The syringe is a 2.5ml syringe, the length of the needle head is 30mm, the inner diameter of the positioning sleeve is 14mm, the outer diameter is 21mm, the top surface of the limiting table is 10mm away from the body surface, and the needle inserting depth is 20mm. The final needle insertion angle is 46 degrees relative to the coronal plane, 55 degrees relative to the sagittal plane, and the diameter of the through hole 2-3 is 5mm.
Example 2
A preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component 1, wherein the bottom surface of the knee joint profiling component 1 is consistent with the shape of the right front region of the knee joint and is attached to the bottom surface;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): acquiring a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector according to the size by using the 3-matic software, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle by using move and rotate operation, and adjusting the proper position, angle and depth; establishing a cylinder model of the positioning sleeve 2 by using create operation according to the three-dimensional model of the injector with confirmed position, angle and depth, and setting the size of the inner diameter and the outer diameter of the positioning sleeve 2, the position of the limiting table 2-1 and a through hole 2-3 on the limiting table 2-1; moving the established cylinder model of the positioning sleeve 2 to the three-dimensional injector model through move operation, performing Boolean operation on the cylinder model and the three-dimensional injector model, combining the cylinder model and the three-dimensional injector model with a Boolean operation, and subtracting the three-dimensional injector model to obtain the three-dimensional injector model of the knee joint cavity positioning device for stem cell injection;
step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
The imaging examination in step 1) comprises CT or MRI.
In the step 2), the knee joint profiling component 1 is used for generating a covering layer after painting the right front area of the knee joint by using mark and wrap operations, and then performing Boolean operation by using the covering layer and a surface model of the knee joint. The thickness of the covering layer is 2cm.
In the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
In the step 4), the outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe 4, and the inner diameter of the positioning sleeve 2 is consistent with the diameter of the syringe 4; and a limiting platform 2-1 is arranged to be attached to the end face 4-1 of the syringe 4, and the diameter of a through hole 2-3 of the limiting platform 2-1 is larger than that of a syringe needle 5.
And in the step 5), converting the format into a format which can be run by the 3D printer through software, wherein the software comprises cura, simplify3D, 3dslicer and repetitier host.
A knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component 1, wherein a positioning sleeve 2 and a locking belt 3 are fixedly arranged on the knee joint profiling component 1, the inner diameter of a positioning hole 2-2 of the positioning sleeve 2 is consistent with the outer diameter of an injector needle cylinder 4, and an injector can be placed and guided; a limiting table 2-1 is arranged in the positioning sleeve 2 and used for limiting the needle inserting depth of the injector. The limiting table 2-1 is positioned at the joint of the positioning sleeve 2 and the knee joint profiling component 1; the knee joint profiling component 1 and the limiting table 2-1 are provided with through holes 2-3 with the diameter larger than that of the syringe needle 5 at the central line of the positioning sleeve 2, so that the syringe needle can pass through smoothly; an inclination angle is formed between the positioning sleeve 2 and the knee joint profiling component 1, the center line of the positioning sleeve 2 extends to a joint cavity between a patella and a femur, and the knee joint profiling component 1 belongs to profiling and can be well attached to a knee joint.
The positioning sleeve 2 is positioned on the upper outer side or the upper inner side of the upper pole of the patella. The external upper part of the upper patella pole is near the junction point of the upper patella edge and the outer patella edge, and the internal upper part of the upper patella pole is near the junction point of the upper patella edge and the inner patella edge.
The positioning sleeve 2 keeps 0-90 degrees with the coronal joint plane and 0-75 degrees with the sagittal joint plane.
The limiting table 2-1 is perpendicular to the positioning sleeve 2.
The end surface 4-1 of the syringe needle cylinder 4 is jointed with the limiting table 2-1.
The outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe needle cylinder 4.
The locking strap 3 is used to secure the positioning device to the knee joint.
The syringe is a 10ml syringe, the length of the needle head is 30mm, the inner diameter of the positioning sleeve is 21mm, the outer diameter is 31.5mm, the distance between the top surface of the limiting table and the body surface is 9.5mm, and the depth of the needle insertion is 20.5mm. The final needle insertion angle is 47 degrees relative to the coronal joint plane, 48 degrees relative to the sagittal joint plane, and the diameter of the through hole 2-3 is 5mm.
The principle is as follows: the three-dimensional scanning is firstly carried out through imaging equipment or optical imaging equipment to obtain a three-dimensional model of the knee joint of a patient, then a knee joint cavity positioning device which is suitable for the patient and used for stem cell injection is established according to the three-dimensional model and the structure of an injector, and the knee joint cavity positioning device enables the patient to lie horizontally and enters a joint cavity from the external upper part or the internal upper part of the upper pole of the patella and the center of the patella joint in a slant manner. Before injection, the device is fixed on the knee joint of a patient through the locking belt 3, and then injection is carried out through the guiding and limiting of the positioning sleeve 2. The knee joint cavity positioning device can accurately control the position and the direction of an injector to inject through the positioning sleeve 2 arranged by three-dimensional modeling, and controls the injection depth through the limiting table. Thereby improving the injection accuracy and safety and avoiding the pain of the patient caused by repeated injection.
It is to be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component (1), wherein a positioning sleeve (2) and a locking belt (3) are fixedly arranged on the knee joint profiling component (1), and the inner diameter of a positioning hole (2-2) of the positioning sleeve (2) is consistent with the outer diameter of an injector needle cylinder (4); a limiting table (2-1) is arranged in the positioning sleeve (2), and the limiting table (2-1) is positioned at the joint of the positioning sleeve (2) and the knee joint profiling component (1); the knee joint profiling component (1) and the limiting table (2-1) are provided with through holes (2-3) with the diameter larger than that of the syringe needle (5) at the central line of the positioning sleeve (2); an inclined angle is formed between the positioning sleeve (2) and the knee joint profiling component (1), and the central line of the positioning sleeve (2) extends to a joint cavity between the patella and the femur.
2. Knee joint cavity positioning device for stem cell injection, according to claim 1, characterized in that said positioning sleeve (2) is located over the outer or over the inner of the suprapatellar pole.
3. A knee joint socket positioning device for stem cell injection according to claim 1, wherein the positioning sleeve (2) is held at 0 ° -90 ° to the coronal plane of articulation and 0 ° -75 ° to the sagittal plane of articulation.
4. The knee joint cavity positioning device for stem cell injection according to claim 1, wherein the limit table (2-1) is perpendicular to the positioning sleeve (2).
5. The knee joint cavity positioning device for stem cell injection according to claim 1, wherein the end face (4-1) of the syringe needle cylinder (4) is attached to the limit table (2-1).
6. The knee joint cavity positioning device for stem cell injection according to claim 1, wherein the outer diameter of the positioning sleeve (2) is 1.1-1.5 times the diameter of the syringe barrel (4).
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Effective date of registration: 20231113 Address after: 3/F, Building 5, No. 2289 Tianyuan East Road, Jiangning District, Nanjing City, Jiangsu Province, 211100 (Jiangning High tech Park) Patentee after: Nanjing Xili Biotechnology Co.,Ltd. Address before: 210008 No. 321, Gulou District, Jiangsu, Zhongshan Road, Nanjing Patentee before: NANJING DRUM TOWER Hospital |
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Effective date of registration: 20231128 Address after: 210003 No. 321, Zhongshan Road, Gulou District, Nanjing, Jiangsu Patentee after: NANJING DRUM TOWER Hospital Address before: 3/F, Building 5, No. 2289 Tianyuan East Road, Jiangning District, Nanjing City, Jiangsu Province, 211100 (Jiangning High tech Park) Patentee before: Nanjing Xili Biotechnology Co.,Ltd. |