CN113208744A - Knee joint cavity positioning device for stem cell injection and preparation method thereof - Google Patents

Knee joint cavity positioning device for stem cell injection and preparation method thereof Download PDF

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Publication number
CN113208744A
CN113208744A CN202110469028.XA CN202110469028A CN113208744A CN 113208744 A CN113208744 A CN 113208744A CN 202110469028 A CN202110469028 A CN 202110469028A CN 113208744 A CN113208744 A CN 113208744A
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knee joint
positioning sleeve
model
stem cell
dimensional
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蒋青
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Nanjing Drum Tower Hospital
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Nanjing Drum Tower Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates

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  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
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  • Molecular Biology (AREA)
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Abstract

A knee joint cavity positioning device for stem cell injection and a preparation method thereof comprise a knee joint profiling component, wherein a positioning sleeve and a locking belt are fixedly arranged on the knee joint profiling component, the inner diameter of a positioning hole of the positioning sleeve is consistent with the outer diameter of an injector, a limiting table is arranged in the positioning sleeve, and the limiting table is positioned at the joint of the positioning sleeve and the knee joint profiling component; the knee joint profiling component and the limiting table are provided with through holes with the diameter larger than that of the syringe needle at the central line of the positioning sleeve; an inclined angle is formed between the positioning sleeve and the knee joint profiling component, and the central line of the positioning sleeve extends to a joint cavity between the patella and the femur. The invention has simple structure and easy operation, can accurately carry out positioning injection and avoid repeated injection.

Description

Knee joint cavity positioning device for stem cell injection and preparation method thereof
Technical Field
The invention relates to the technical field of medical instruments, in particular to a knee joint cavity positioning device for stem cell injection and a preparation method thereof.
Background
The current patent related to knee joint cavity puncture mainly focuses on adjustment and fixation of knee joint angles, and guarantees the size of the inner side or outer side joint gap of patellar ligament so as to facilitate injection, but the success rate of injection still needs to see the experience of doctors. And the prior art does not relate to a mode for positioning the injection point on the surface of the knee joint.
Patent No. 2019209305893 entitled knee joint cavity injection positioning device, mainly solves the problem of being able to adjust the bending angle between the thigh and the lower leg before injecting the joint cavity of the knee joint. The size of the joint gap at the inner side or the outer side of the patellar ligament is adjusted by adjusting the bending angle between the thigh part and the crus part, so that the effect of positioning before injection is realized.
The patent No. 2017208576672, the patent name is a multifunctional medical chair especially suitable for knee joint cavity safety injection, mainly designs the footrest on the upper layer of the existing injection chair into a structure that can be opened and closed, can be externally rotated by 90 degrees, can be disassembled, and can be lifted, so that patients with different heights can keep 90-degree knee-bending seats, and can prevent the patients from being accidentally injured due to obstacles when getting on or off the chair; meanwhile, in order to enable an injection doctor to insert the needle obliquely from the inside to the top along the lower lateral gap of the patella and not to move, the sitting surface of a patient needs to be about 25cm higher than the sitting surface of the doctor, so that the doctor can control the operation in the front sight line of the chest; the leg rest stool is fixed with the chair, so that middle-aged and old patients with knee OA can get on and off the chair safely and conveniently.
Patent No. 2019204067884, the patent name is an automatic angle regulation's articular cavity puncture direction auxiliary device, be automatic angle regulation's articular cavity puncture direction auxiliary device, but the angle regulation structure of setting, can make things convenient for the bending degree that medical staff adjusted the knee joint according to patient's particular case is nimble, improve treatment, and the running-board lift adjusting device has been set up in the movable support board, can adjust the height of running-board, make the knee joint be in suitable bending position, be convenient for inject, high durability and convenient use, but running-board lift adjusting device patient adjusts by oneself, can reach the most comfortable position, thereby guarantee good treatment.
It can be seen that the three patents are all used for adjusting the bending degree of the knee joint of a patient and fixing the knee joint, so that the injection is convenient for a doctor to inject, but whether the injection is accurate or not is also required to be according to the experience of the doctor, and the operation is inconvenient.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a positioning device for positioning the injection site on the surface of the knee joint, which is a personalized knee joint cavity positioning device suitable for each patient and manufactured by using a three-dimensional scanning and 3D printing mode, is convenient to operate and accurate in injection, and overcomes the defects of the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component, wherein the bottom surface of the knee joint profiling component is consistent with the shape of the right front area of the knee joint and is attached to the right front area of the knee joint;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): obtaining a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector by using the 3-matic software according to the size of the injector, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle, and adjusting the proper position, angle and depth; according to the confirmed three-dimensional model of the injector with the position, the angle and the depth, a cylinder model of the positioning sleeve is established, and the inner diameter and the outer diameter of the positioning sleeve, the position of the limiting table and a through hole in the limiting table are arranged; moving the established cylinder model of the positioning sleeve to the three-dimensional injector model, combining the cylinder model with the knee joint profiling component, performing Boolean operation on the combined cylinder model and the three-dimensional injector model, and subtracting the three-dimensional injector model to obtain the three-dimensional model of the knee joint cavity positioning device for stem cell injection;
step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
Preferably, the imaging examination in step 1) comprises CT or MRI.
Preferably, in the step 2), the knee joint profiling component is coated on the right front area of the knee joint to generate a covering layer, and then the covering layer and the surface model of the knee joint are used for performing Boolean operation.
Preferably, in the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
Preferably, in the step 4), the outer diameter of the positioning sleeve is 1.1-1.5 times of the diameter of the syringe, and the inner diameter of the positioning sleeve is consistent with the diameter of the syringe; and the limiting table is arranged to be attached to the end face of the syringe cylinder of the syringe, and the diameter of the through hole of the limiting table is larger than that of the syringe needle.
Preferably, the software in step 5) is converted into a format that can be run by the 3D printer, and the software comprises cura, simplify3D, 3dslicer and repetier host.
The knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component, wherein a positioning sleeve and a locking belt are fixedly arranged on the knee joint profiling component, and the inner diameter of a positioning hole of the positioning sleeve is consistent with the outer diameter of a syringe needle cylinder; a limiting table is arranged in the positioning sleeve and is positioned at the joint of the positioning sleeve and the knee joint profiling component; the knee joint profiling component and the limiting table are provided with through holes with the diameter larger than that of the syringe needle at the central line of the positioning sleeve; an inclined angle is formed between the positioning sleeve and the knee joint profiling component, and the central line of the positioning sleeve extends to a joint cavity between the patella and the femur.
Preferably, the locating sleeve is located over the exterior or over the interior of the suprapatellar pole.
Preferably, the locating sleeve is maintained at 0-90 degrees with respect to the coronal plane of articulation and 0-75 degrees with respect to the sagittal plane of articulation.
Preferably, the limiting table is perpendicular to the positioning sleeve.
Compared with the prior art, the invention has the following beneficial effects:
through the mode that three-dimensional scanning and 3D printed, the knee joint characteristic according to everyone is modelled, can realize individualized knee joint chamber positioner, and the position and the direction of the control syringe that the position sleeve that sets up through three-dimensional modeling can be accurate inject, through the injection depth of spacing platform control syringe. The deviation is avoided, the injection is accurately positioned, the injection depth is controlled, and the operation is very convenient.
Drawings
FIG. 1 is a schematic 2D cross-sectional view of a knee joint cavity positioning device for stem cell injection;
FIG. 2 is a schematic 2D front view of a knee joint cavity positioning device for stem cell injection;
FIG. 3 is a schematic view of the needle insertion angle;
FIG. 4 is a 3D schematic view of the positioning sleeve located over and inside the superior patella pole;
FIG. 5 is a 3D schematic view of the alignment sleeve positioned over and outside the superior patella pole;
description of reference numerals: 1. a knee joint contouring component; 2. a positioning sleeve; 3. a locking band; 4. an injector; 2-1, a limit table; 2-2, positioning holes; 2-3, through holes; 3-1, syringe needle; 4-1, end face.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
According to the drawings shown in fig. 1, fig. 2 and fig. 3, the invention provides the following technical solutions:
example 1:
a preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component 1, wherein the bottom surface of the knee joint profiling component 1 is consistent with the shape of the right front area of the knee joint and is attached to the right front area of the knee joint;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): acquiring a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector according to the size by using the 3-matic software, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle by using move and rotate operation, and adjusting the proper position, angle and depth; establishing a cylinder model of the positioning sleeve 2 by using create operation according to the three-dimensional model of the injector with the confirmed position, angle and depth, and setting the inner diameter and outer diameter of the positioning sleeve 2, the position of the limiting table 2-1 and a through hole 2-3 on the limiting table 2-1; moving the established cylinder model of the positioning sleeve 2 to the three-dimensional injector model through move operation, performing Boolean operation on the cylinder model and the three-dimensional injector model, combining the cylinder model and the three-dimensional injector model with a Boolean operation, and subtracting the three-dimensional injector model to obtain the three-dimensional injector model of the knee joint cavity positioning device for stem cell injection;
step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
The imaging examination in step 1) comprises CT or MRI.
In the step 2), the knee joint profiling component 1 is used for generating a covering layer after painting the right front area of the knee joint by using mark and wrap operations, and then performing Boolean operation by using the covering layer and a surface model of the knee joint. The thickness of the covering layer is 2 cm.
In the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
In the step 4), the outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe 4, and the inner diameter of the positioning sleeve 2 is consistent with the diameter of the syringe 4; and a limiting platform 2-1 is arranged to be attached to the end face 4-1 of the syringe 4, and the diameter of a through hole 2-3 of the limiting platform 2-1 is larger than that of a syringe needle 5.
And in the step 5), converting the format into a format which can be operated by the 3D printer through software, wherein the software comprises cura, simplify3D, 3dslicer and repetitier host.
A knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component 1, wherein a positioning sleeve 2 and a locking belt 3 are fixedly arranged on the knee joint profiling component 1, the inner diameter of a positioning hole 2-2 of the positioning sleeve 2 is consistent with the outer diameter of an injector needle cylinder 4, and an injector can be placed and guided; a limiting table 2-1 is arranged in the positioning sleeve 2 and used for limiting the needle inserting depth of the injector. The limiting table 2-1 is positioned at the joint of the positioning sleeve 2 and the knee joint profiling component 1; the knee joint profiling component 1 and the limiting table 2-1 are provided with through holes 2-3 with the diameter larger than that of the syringe needle 5 at the central line of the positioning sleeve 2, so that the syringe needle can pass through smoothly; an inclination angle is formed between the positioning sleeve 2 and the knee joint profiling component 1, the center line of the positioning sleeve 2 extends to a joint cavity between a patella and a femur, and the knee joint profiling component 1 belongs to profiling and can be well attached to a knee joint.
The positioning sleeve 2 is positioned on the upper outer side or the upper inner side of the upper pole of the patella. The external upper part of the upper patella pole is near the junction point of the upper patella edge and the outer patella edge, and the internal upper part of the upper patella pole is near the junction point of the upper patella edge and the inner patella edge.
The positioning sleeve 2 keeps 0-90 degrees with the coronal joint plane and 0-75 degrees with the sagittal joint plane.
The limiting table 2-1 is perpendicular to the positioning sleeve 2.
The locking strap 3 is used to secure the positioning device to the knee joint.
The syringe is a 2.5ml syringe, the length of the needle head is 30mm, the inner diameter of the positioning sleeve is 14mm, the outer diameter is 21mm, the top surface of the limiting table is 10mm away from the body surface, and the depth of the needle insertion is 20 mm. The final needle insertion angle is 46 degrees relative to the coronal plane, 55 degrees relative to the sagittal plane, and the diameter of the through hole 2-3 is 5 mm.
Example 2
A preparation method of a knee joint cavity positioning device for stem cell injection comprises the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component 1, wherein the bottom surface of the knee joint profiling component 1 is consistent with the shape of the right front area of the knee joint and is attached to the right front area of the knee joint;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): acquiring a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector according to the size by using the 3-matic software, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle by using move and rotate operation, and adjusting the proper position, angle and depth; establishing a cylinder model of the positioning sleeve 2 by using create operation according to the three-dimensional model of the injector with the confirmed position, angle and depth, and setting the inner diameter and outer diameter of the positioning sleeve 2, the position of the limiting table 2-1 and a through hole 2-3 on the limiting table 2-1; moving the established cylinder model of the positioning sleeve 2 to the three-dimensional injector model through move operation, performing Boolean operation on the cylinder model and the three-dimensional injector model, combining the cylinder model and the three-dimensional injector model with a Boolean operation, and subtracting the three-dimensional injector model to obtain the three-dimensional injector model of the knee joint cavity positioning device for stem cell injection;
step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
The imaging examination in step 1) comprises CT or MRI.
In the step 2), the knee joint profiling component 1 is used for generating a covering layer after painting the right front area of the knee joint by using mark and wrap operations, and then performing Boolean operation by using the covering layer and a surface model of the knee joint. The thickness of the covering layer is 2 cm.
In the step 3), the needle inserting angle is kept between 0 and 90 degrees with the coronal joint plane and between 0 and 75 degrees with the sagittal joint plane.
In the step 4), the outer diameter of the positioning sleeve 2 is 1.5 times of the diameter of the syringe 4, and the inner diameter of the positioning sleeve 2 is consistent with the diameter of the syringe 4; and a limiting platform 2-1 is arranged to be attached to the end face 4-1 of the syringe 4, and the diameter of a through hole 2-3 of the limiting platform 2-1 is larger than that of a syringe needle 5.
And in the step 5), converting the format into a format which can be operated by the 3D printer through software, wherein the software comprises cura, simplify3D, 3dslicer and repetitier host.
A knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component 1, wherein a positioning sleeve 2 and a locking belt 3 are fixedly arranged on the knee joint profiling component 1, the inner diameter of a positioning hole 2-2 of the positioning sleeve 2 is consistent with the outer diameter of an injector needle cylinder 4, and an injector can be placed and guided; a limiting table 2-1 is arranged in the positioning sleeve 2 and used for limiting the needle inserting depth of the injector. The limiting table 2-1 is positioned at the joint of the positioning sleeve 2 and the knee joint profiling component 1; the knee joint profiling component 1 and the limiting table 2-1 are provided with through holes 2-3 with the diameter larger than that of the syringe needle 5 at the central line of the positioning sleeve 2, so that the syringe needle can pass through smoothly; an inclination angle is formed between the positioning sleeve 2 and the knee joint profiling component 1, the center line of the positioning sleeve 2 extends to a joint cavity between a patella and a femur, and the knee joint profiling component 1 belongs to profiling and can be well attached to a knee joint.
The positioning sleeve 2 is positioned on the upper outer side or the upper inner side of the upper pole of the patella. The external upper part of the upper patella pole is near the junction point of the upper patella edge and the outer patella edge, and the internal upper part of the upper patella pole is near the junction point of the upper patella edge and the inner patella edge.
The positioning sleeve 2 keeps 0-90 degrees with the coronal joint plane and 0-75 degrees with the sagittal joint plane.
The limiting table 2-1 is perpendicular to the positioning sleeve 2.
The locking strap 3 is used to secure the positioning device to the knee joint.
The syringe is a 10ml syringe, the length of the needle head is 30mm, the inner diameter of the positioning sleeve is 21mm, the outer diameter is 31.5mm, the distance between the top surface of the limiting table and the body surface is 9.5mm, and the depth of the needle insertion is 20.5 mm. The final needle insertion angle is 47 degrees relative to the coronal joint plane, 48 degrees relative to the sagittal joint plane, and the diameter of the through hole 2-3 is 5 mm.
The principle is as follows: the knee joint cavity positioning device is suitable for a patient and is used for stem cell injection, and the knee joint cavity positioning device enables the patient to lie horizontally and enters a joint cavity from the upper outer upper part or the upper inner upper part of a patella and the center of an oblique patella joint. Before injection, the device is fixed on the knee joint of a patient through the locking belt 3, and then injection is carried out through the guiding and limiting of the positioning sleeve 2. The knee joint cavity positioning device can accurately control the position and the direction of an injector to inject through the positioning sleeve 2 arranged by three-dimensional modeling, and controls the injection depth through the limiting table. Thereby improving the injection accuracy and safety and avoiding the pain of the patient caused by repeated injection.
It is to be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (10)

1. A preparation method of a knee joint cavity positioning device for stem cell injection is characterized by comprising the following steps:
step 1): enabling the supine knee joint of a patient to be straightened, and firstly, obtaining a preliminary knee joint three-dimensional model including the skeleton and the body surface appearance of the knee joint by adopting the imaging examination; then, obtaining an accurate three-dimensional model of the body surface appearance of the knee joint by combining a three-dimensional scanner, and fitting the space coordinates of the two three-dimensional models by using mimics software to obtain a final three-dimensional model of the knee joint;
step 2): importing the final knee joint three-dimensional model into 3-matic software to design a knee joint profiling component (1), wherein the bottom surface of the knee joint profiling component (1) is consistent with the shape of the region right in front of the knee joint and is attached;
step 3): preliminarily confirming the needle inserting angle and the needle inserting position on the outer surface of the knee joint according to the knee joint three-dimensional model;
step 4): obtaining a three-dimensional model of the injector by using a three-dimensional scanner, introducing the three-dimensional model into 3-matic software or modeling the injector by using the 3-matic software according to the size of the injector, placing the three-dimensional model of the injector according to the preliminarily confirmed needle inserting position and angle, and adjusting the proper position, angle and depth; according to the confirmed three-dimensional model of the injector with the position, the angle and the depth, a cylinder model of the positioning sleeve (2) is established, and the inner diameter and the outer diameter of the positioning sleeve (2), the position of the limiting table (2-1) and a through hole (2-3) on the limiting table (2-1) are set; moving the established cylinder model of the positioning sleeve (2) to the three-dimensional injector model, performing Boolean operation on the cylinder model and the knee joint profiling component (1), combining the cylinder model and the three-dimensional injector model, performing Boolean operation on the cylinder model and the three-dimensional injector model, and subtracting the three-dimensional injector model to obtain the three-dimensional injector model of the knee joint cavity positioning device for stem cell injection;
step 5): exporting the three-dimensional model of the knee joint cavity positioning device for stem cell injection into an STL format, directly importing the three-dimensional model into a 3D printer or converting the three-dimensional model into a format which can be operated by the 3D printer through software, importing the three-dimensional model into the 3D printer, and printing the three-dimensional model of the knee joint cavity positioning device for stem cell injection through the 3D printer.
2. The method for preparing a knee joint cavity positioning device for stem cell injection according to claim 1, wherein the imaging examination in step 1) comprises CT or MRI.
3. The method for preparing the knee joint cavity positioning device for stem cell injection according to claim 1, wherein the knee joint profiling component (1) in the step 2) is coated on the right front area of the knee joint to generate a covering layer, and then the covering layer and a surface model of the knee joint are used for performing Boolean operation.
4. The method for preparing a knee joint cavity positioning device for stem cell injection according to claim 1, wherein in step 3), the needle insertion angle is maintained between 0 ° and 90 ° with respect to the coronal joint plane and between 0 ° and 75 ° with respect to the sagittal joint plane.
5. The preparation method of the knee joint cavity positioning device for stem cell injection according to claim 1, wherein in step 4), the outer diameter of the positioning sleeve (2) is 1.1-1.5 times of the diameter of the syringe needle cylinder (4), and the inner diameter of the positioning sleeve (2) is consistent with the diameter of the syringe needle cylinder (4); and a limiting platform (2-1) is arranged to be attached to the end face (4-1) of the syringe (4), and the diameter of a through hole (2-3) of the limiting platform (2-1) is larger than that of the syringe needle (5).
6. The method for preparing the knee joint cavity positioning device for stem cell injection according to claim 1, wherein the step 5) is converted into a format capable of being operated by a 3D printer through software, wherein the software comprises cura, simplify3D, 3dslicer and repetier host.
7. The knee joint cavity positioning device for stem cell injection is characterized by comprising a knee joint profiling component (1), wherein a positioning sleeve (2) and a locking belt (3) are fixedly arranged on the knee joint profiling component (1), and the inner diameter of a positioning hole (2-2) of the positioning sleeve (2) is consistent with the outer diameter of an injector needle cylinder (4); a limiting table (2-1) is arranged in the positioning sleeve (2), and the limiting table (2-1) is positioned at the joint of the positioning sleeve (2) and the knee joint profiling component (1); the knee joint profiling component (1) and the limiting table (2-1) are provided with through holes (2-3) with the diameter larger than that of the syringe needle (5) at the central line of the positioning sleeve (2); an inclined angle is formed between the positioning sleeve (2) and the knee joint profiling component (1), and the central line of the positioning sleeve (2) extends to a joint cavity between the patella and the femur.
8. Knee joint cavity positioning device for stem cell injection according to claim 1, characterized by the fact that the positioning sleeve (2) is located externally or internally above the suprapatellar pole.
9. Knee joint cavity positioning device for stem cell injection according to claim 1, characterized in that the positioning sleeve (2) is maintained at 0 ° -90 ° to the coronal plane of articulation and 0 ° -75 ° to the sagittal plane of articulation.
10. The knee joint cavity positioning device for stem cell injection according to claim 1, wherein the limit table (2-1) is perpendicular to the positioning sleeve (2).
CN202110469028.XA 2021-04-29 2021-04-29 Knee joint cavity positioning device for stem cell injection and preparation method thereof Pending CN113208744A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024042432A1 (en) * 2022-08-22 2024-02-29 Janssen Biotech, Inc. Accessory for injection device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024042432A1 (en) * 2022-08-22 2024-02-29 Janssen Biotech, Inc. Accessory for injection device

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