CN217443230U

CN217443230U - Right-angle flow cell for chromatographic system

Info

Publication number: CN217443230U
Application number: CN202123346018.1U
Authority: CN
Inventors: 石伟伟
Original assignee: Rj Bioprocess Suzhou Co ltd
Current assignee: Rj Bioprocess Suzhou Co ltd
Priority date: 2021-12-29
Filing date: 2021-12-29
Publication date: 2022-09-16
Anticipated expiration: 2031-12-29

Abstract

The utility model discloses a right angle flow-through cell for chromatographic system, characteristics are: the top face of circulation cell cavity is equipped with the response connector, and pressure sensor's electrode sees through the response connector and extends to linking up chamber way center department, is equipped with first overflow mouth and second overflow mouth on the both sides wall of circulation cell cavity respectively, first overflow mouth is linked together through the runner pipe that first overflow pipe, second overflow pipe and circulation cell cavity inside were equipped with respectively with the second overflow mouth, and first overflow mouth is connected with outer tube connector with the second overflow mouth respectively, and PH or CD electrode pass through the inlet intercommunication of protecting pipe and circulation cell cavity both sides and be connected. The present case is through changing traditional flow-through cell connection structure into the right angle form, reduces to occupy the height in order to improve the commonality, utilizes the fluid of right angle form input addition can effectively shorten the detention time of upper and lower runner, improves original measuring effect.

Description

Right-angle flow cell for chromatographic system

Technical Field

The utility model relates to an equipment that carries out multidirectional circulation to the reagent sample among the analytic system, especially a right angle flow-through cell for analytic system belongs to flow-through cell technical field.

Background

Column chromatography, also known as chromatography or chromatography, is a separation principle that a substance is separated according to different adsorption capacities of the substance on a stationary phase, generally, a substance with large polarity is easily adsorbed by the stationary phase, a substance with small polarity is not easily adsorbed by the stationary phase, and the column chromatography process is a process of adsorption, desorption, re-adsorption and re-desorption. At present, chromatographic systems derived from the mechanism of action of column chromatography are widely used in the fields of scientific research and production such as analytical chemistry, pharmaceutical chemistry, organic chemistry, bioscience, chemical and pharmaceutical engineering, and the like, and the chromatographic systems often use a PH & CD flow cell for sample flow operation.

However, the existing PH & CD flow cell occupies too large height, which not only affects the overall height of the system equipment, but also affects the measurement effect of direct flow of the upper and lower flow channels. Therefore, it is necessary to improve the structure of the flow cell to improve the usability of the flow cell.

Disclosure of Invention

The utility model aims at solving the above problem, provide a right angle circulation pond for analytic system to convenient reduction height that occupies avoids influencing the measuring effect of the direct circulation of upper and lower runner, improves the wholeness ability.

The technical solution of the utility model is that: the utility model provides a right angle flow cell for chromatographic system, includes pressure sensor, outer connector, PH or CD electrode, protecting tube, advances kind lid packing ring and flow cell cavity, pressure sensor's electrode extends to the inside linking chamber that is equipped with of flow cell cavity and says center department, outer connector sets up on flow cell cavity, PH or CD electrode pass through the protecting tube and are connected with flow cell cavity intercommunication, be provided with between protecting tube and the flow cell cavity and advance kind lid packing ring, its characteristics are: the preceding terminal surface of circulation cell cavity is equipped with the introduction port, and the top face of circulation cell cavity is equipped with the response connector, is equipped with first overflow mouth and second overflow mouth on the both sides wall of the circulation cell cavity adjacent with introduction port installation terminal surface respectively, first overflow mouth and second overflow mouth are linked together through the inside circulation pipeline's that is equipped with of first overflow pipe, second overflow pipe and circulation cell cavity entry, export respectively.

Further, the chromatography system described above uses a right-angle flow cell, wherein: four first screw holes are uniformly distributed on the periphery of the sample inlet at the same side of the cavity of the flow cell, and external screws penetrate through the sample injection cover gasket and are in locking connection with the first screw holes.

Further, the chromatography system described above uses a right-angle flow cell, wherein: the left end and the right end of the first overflow port are respectively provided with two second screw holes at the same side of the cavity of the flow cell, the inner side of the first overflow port is fixedly connected with the cavity of the flow cell through the first overflow pipe, and the outer joint is fixedly connected with the second screw holes through external fastening screws and is arranged at the outer side of the first overflow port.

Further, the chromatography system described above uses a right-angle flow cell, wherein: the left end and the right end of the second overflow port are respectively provided with two third screw holes at the same side of the cavity of the flow cell, the inner side of the second overflow port is fixedly connected with the cavity of the flow cell through the second overflow pipe, and the outer joint is fixedly installed at the outer side of the second overflow port through an external fastening screw.

Still further, the chromatography system described above uses a right-angle flow cell, wherein: the PH or CD electrodes, the protective sleeve and the sample injection cover gaskets are correspondingly and automatically formed into a group one by one, and the two groups are symmetrically arranged by taking the central axis of the cavity of the flow cell as a reference line.

Preferably, the first overflow pipe and the second overflow pipe are set to be the same in pipe diameter, and the pipe diameter of the PH or CD electrode is set to be 2 times that of the first overflow pipe and the second overflow pipe.

So, the present case is in the same place with pressure sensor integration, satisfies BPE about the requirement of arranging certainly, and the requirement of bubble discharge is satisfied to circulation pond upper portion tangential export, moreover, and this case can be replaced each other with the elbow, satisfies the high requirement of system's integrated level, effectively reduces the height. Adopt the technical scheme of the utility model, through PH or CD electrode with the required leading-in flow cell cavity of annotating liquid of chromatography system, utilize pressure sensor's electrode to say through linking up the chamber and detect with annotating the liquid contact, wait to detect after the result is qualified, the rethread flows through the inside circulation pipeline of flow cell cavity, the notes liquid dispersion after will detecting to first overflow pipe, in the second overflow pipe, through correspond first overflow mouth and the second overflow mouth of being connected with first overflow pipe, second overflow pipe and flow to the link of outer joint can.

Compared with the prior art, the utility model changes the traditional flow cell connecting structure into a right-angle form, and after the standard elbow is replaced, the occupied height is reduced to improve the universality; moreover, on the basis that the pressure sensor is integrated to measure the pressure, the fluid added in a right-angle mode can effectively shorten the detention time of the upper flow channel and the lower flow channel, and the original measuring effect is improved.

Drawings

Fig. 1 is a schematic overall structure diagram of the present invention;

FIG. 2 is an exploded view of the present invention;

FIG. 3 is a schematic structural view of the flow cell cavity of the present invention;

FIG. 4 is a front view of the cavity of the flow cell of the present invention;

FIG. 5 is a schematic sectional view of the flow cell cavity of the present invention;

FIG. 6 is a right side view of the cavity of the flow cell of the present invention;

FIG. 7 is a schematic right sectional view of the flow cell cavity of the present invention;

FIG. 8 is a schematic top cross-sectional view of the flow cell cavity of the present invention;

fig. 9 is a schematic view of the bottom structure of the cavity of the flow cell of the present invention.

The meaning of the reference symbols in the figures is: 1-a pressure sensor, 2-an external connector, 3-a PH or CD electrode, 4-a protective sleeve, 5-a sample injection cover gasket, 6-a flow cell cavity, 7-a sample injection port, 8-a first screw hole, 9-an induction connector, 10-a first overflow port, 11-a second screw hole, 12-a second overflow port, 13-a third screw hole, 14-a connection cavity channel, 15-a flow pipeline, 16-a first overflow pipe and 17-a second overflow pipe.

Detailed Description

The technical solution of the present invention is further explained below with reference to the accompanying drawings, so that it is easier to understand and grasp. The pressure sensor, the external pipe connector, the PH or CD electrode, the protecting pipe and the sample injection cover gasket are commonly known by the ordinary skilled in the art, and no special requirement is required.

As shown in fig. 1 and 2, a right angle flow cell for chromatographic system, including pressure sensor 1, external union coupling 2, PH or CD electrode 3, protecting pipe 4, advance kind lid packing ring 5 and flow cell cavity 6, pressure sensor 1's electrode extends to the inside linking chamber way 14 center department that is equipped with of flow cell cavity 6, external union coupling 2 sets up on flow cell cavity 6, PH or CD electrode 3 are connected with flow cell cavity 6 intercommunication through protecting pipe 4, be provided with between protecting pipe 4 and the flow cell cavity 6 and advance kind lid packing ring 5.

As shown in fig. 3-9, according to the utility model discloses technical scheme, the preceding terminal surface of circulation cell cavity 6 is equipped with introduction port 7, and the top terminal surface of circulation cell cavity 6 is equipped with response connector 9, is equipped with first overflow mouth 10 and second overflow mouth 12 on the both sides wall of circulation cell cavity 6 adjacent with introduction port 7 mounting surface respectively, first overflow mouth 10 and second overflow mouth 12 are linked together through the entry, the export of first overflow pipe 16, second overflow pipe 17 and the inside circulation pipeline 15 that is equipped with of circulation cell cavity 6 respectively.

Preferably, among the above structures: the left end and the right end of the first overflow port 10 are respectively provided with two second screw holes 11 at the same side of the flow cell cavity 6, the inner side of the first overflow port 10 is fixedly connected with the flow cell cavity 6 through a first overflow pipe 16, and the external pipe joint 2 is fixedly connected with the second screw holes 11 through external fastening screws and is arranged at the outer side of the first overflow port 10; two third screw holes 13 are respectively arranged at the left end and the right end of the second overflow port 12 at the same side of the flow cell cavity 6, the inner side of the second overflow port 12 is fixedly connected with the flow cell cavity 6 through a second overflow pipe 17, and the outer pipe joint 2 is fixedly installed at the outer side of the second overflow port 12 through an external fastening screw.

Preferably, among the above structures: four first screw holes 8 are uniformly distributed on the periphery of the sample inlet 7 at the same side of the flow cell cavity 6, and external screws penetrate through the sample inlet cover gasket 5 and are in locking connection with the first screw holes 8.

Specifically, in the structure of the right-angle flow cell for a chromatography system, the first overflow pipe 16 and the second overflow pipe 17 have the same pipe diameter, and the pipe diameter of the PH or CD electrode 3 is 2 times that of the first overflow pipe 16 and the second overflow pipe 17, so that the upper and lower flow channels directly flow, and the measurement effect is improved.

More specifically, the PH or CD electrode 3, the protecting sleeve 4 and the sample injection cover gasket 5 are in one-to-one correspondence and form a group, the two groups are symmetrically arranged by taking the central axis of the flow cell cavity 6 as a reference line, and the retention time of the combined structure of the PH or CD electrode 3, the protecting sleeve 4 and the sample injection cover gasket 5 in a right-angle form in the circulation of the injection fluid is short, so that the better dredging universality is realized.

The utility model discloses among the technical scheme, the flow cell cavity 6 that sets up the right angle form is technical key, and what the key show in the middle of 3 ~ 9 is that the relevant part that flow cell cavity 6 structure relates to, to parts such as pressure sensor 1, outer joint 2 and PH or CD electrode 3, the ordinary skilled person in the art carries out conventional setting according to prior art can, and there is not special requirement in the aspect of this case to its model selection and combined use.

So, adopt the utility model discloses technical scheme, with the required leading-in circulation cell cavity 6 of annotating liquid of chromatography system, utilize pressure sensor 1's electrode to detect through linking up chamber way 14 and annotating the liquid contact, wait to detect after the result is qualified, the rethread flows through circulation pipeline 15 inside through cell cavity 6 and disperses the notes liquid after detecting to first overflow pipe 16, in the second overflow pipe 17, through with first overflow pipe 16, the second overflow pipe 17 correspond first overflow mouth 10 of being connected and second overflow mouth 12 flow out to the link of external tap 2 can.

Through the above description, it can be found that the scheme and the pressure sensor are integrated together, the requirement of BPE on self-exhaustion is met, the requirement of bubble discharge is met through the tangential outlet at the upper part of the flow cell, and the scheme and the elbow can be replaced mutually, so that the requirement of high system integration level is met, and the height is effectively reduced. After the technical scheme of the utility model is adopted, the traditional flow cell connecting structure is changed into a right-angle form, and after a standard elbow is replaced, the occupied height is reduced to improve the universality; moreover, on the basis that the pressure sensor is integrated to measure the pressure, the fluid added in a right-angle mode can effectively shorten the detention time of the upper flow channel and the lower flow channel, and the original measuring effect is improved.

Above to the utility model discloses a technical scheme, working process and implementation effect have carried out detailed description, need to explain, what describe is the typical example of the utility model, in addition, the utility model discloses can also have other multiple concrete implementation modes, the technical scheme that all adopt to equate replacement or equivalent transform to form all falls within the utility model discloses within the scope of claiming.

Claims

1. The utility model provides a right angle flow-through cell for chromatographic system, includes pressure sensor (1), external nipple (2), PH or CD electrode (3), protecting pipe (4), advances kind lid packing ring (5) and flow-through cell cavity (6), the electrode of pressure sensor (1) extends to inside linking chamber way (14) the center department that is equipped with of flow-through cell cavity (6), external nipple (2) set up on flow-through cell cavity (6), PH or CD electrode (3) are connected through protecting pipe (4) and flow-through cell cavity (6) intercommunication, be provided with between protecting pipe (4) and flow-through cell cavity (6) and advance kind lid packing ring (5), its characterized in that: the preceding terminal surface of circulation cell cavity (6) is equipped with inlet port (7), and the top face of circulation cell cavity (6) is equipped with response connector (9), is equipped with first overflow mouth (10) and second overflow mouth (12) on the both sides wall of circulation cell cavity (6) adjacent with inlet port (7) mounting surface respectively, first overflow mouth (10) are linked together through the entry, the export of first overflow pipe (16), second overflow pipe (17) and circulation cell cavity (6) inside circulation pipeline (15) that is equipped with respectively with second overflow mouth (12).

2. A right-angle flow cell for chromatography systems according to claim 1, wherein: four first screw holes (8) are uniformly distributed on the periphery of the sample inlet (7) at the same side of the flow cell cavity (6), and external screws penetrate through the sample injection cover gasket (5) and are in locking connection with the first screw holes (8).

3. A right-angle flow cell for chromatography systems according to claim 1, wherein: both ends are equipped with two second screw holes (11) respectively in the homonymy of circulation pond cavity (6) about first overflow mouth (10), the inboard of first overflow mouth (10) is through first overflow pipe (16) and circulation pond cavity (6) fixed connection, and outer tube head (2) are through outside fastening screw and second screw hole (11) fixed connection to install in the outside of first overflow mouth (10).

4. A right-angle flow cell for chromatography systems according to claim 1, wherein: the both ends are equipped with two third screw holes (13) respectively in the homonymy of flow cell cavity (6) about second overflow mouth (12), and the inboard of second overflow mouth (12) is through second overflow pipe (17) and flow cell cavity (6) fixed connection, and outer tube head (2) are through the outside fastening screw and the outside fixed mounting of second overflow mouth (12).

5. A right-angle flow cell for chromatography systems according to claim 1, wherein: the first overflow pipe (16) and the second overflow pipe (17) are set to be the same in pipe diameter size.

6. A right-angle flow cell for chromatography systems according to claim 5, wherein: the pipe diameter of the PH or CD electrode (3) is set to be 2 times of that of the first overflow pipe (16) and the second overflow pipe (17).

7. A right-angle flow cell for a chromatography system according to claim 1, wherein: the PH or CD electrodes (3), the protective sleeves (4) and the sample injection cover gaskets (5) are correspondingly and automatically formed into a group one by one, and the two groups are symmetrically arranged by taking the central axis of the flow cell cavity (6) as a reference line.